High diversity of the immune repertoire in humanized NOD.SCID.gamma c-/- mice.

abstract：:The present report describes functional characteristics of a monoclonal antibody (mAb), TA/211, which is reactive with a common determinant of the human CD45 molecules. When added to purified testing human T cells, TA/211, which is itself not mitogenic, leads to a strong proliferative response in combination with subm...

journal_title：European journal of immunology

authors： Schraven B,Roux M,Hutmacher B,Meuer SC

更新日期：1989-02-01 00:00:00

abstract：:Antigens in the form of immune complexes are retained on the membranes of follicular dendritic cells (FDC) for long periods of time. To examine how immune complexes reach germinal centers, where FDC are located, we injected mice with anti-2,4-dinitrophenyl (DNP) antibodies complexed to DNP-myoglobin-coated gold partic...

journal_title：European journal of immunology

authors： Heinen E,Braun M,Coulie PG,Van Snick J,Moeremans M,Cormann N,Kinet-Denoël C,Simar LJ

更新日期：1986-02-01 00:00:00

abstract：:The genetic control of in vitro primary syngeneic sensitization on monolayers of thyroid epithelial cells was investigated both at the level of the responder lymphocytes and that of stimulator thyroid epithelial cells using congenic resistant strains of mice. It clearly appears that similar to the in vivo model of exp...

journal_title：European journal of immunology

authors： Salamero J,Charreire J

更新日期：1983-11-01 00:00:00

abstract：:The CD4 and CD8 coreceptor molecules on immature thymocytes participate in T cell repertoire selection. To examine more definitively the role of CD4 and CD8 in the negative and positive selection of immature thymocytes, we generated transgenic mice with elevated surface CD4 expression and mated them with mice expressi...

journal_title：European journal of immunology

authors： Van Oers NS,Garvin AM,Davis CB,Forbush KA,Carlow DA,Littman DR,Perlmutter RM,Teh HS

更新日期：1992-03-01 00:00:00

abstract：:Muramyl peptides are the building blocks of bacterial peptidoglycan, and their biological functions in mammals have been extensively studied. In particular, muramyl peptides trigger inflammation, contribute to host defense against microbial infections, and modulate the adaptive immune response to antigens. These bacte...

journal_title：European journal of immunology

authors： Magalhaes JG,Lee J,Geddes K,Rubino S,Philpott DJ,Girardin SE

更新日期：2011-05-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants worldwide. The immunological factors responsible for RSV susceptibility in infants are poorly understood. Here, we used the BALB/c mouse model of neonatal RSV infection to study the mechanisms leading to severe disease upon reexposure to the viru...

journal_title：European journal of immunology

authors： Remot A,Descamps D,Jouneau L,Laubreton D,Dubuquoy C,Bouet S,Lecardonnel J,Rebours E,Petit-Camurdan A,Riffault S

更新日期：2016-04-01 00:00:00

abstract：:The involvement of the CD2 (T11) molecule, an alternative activation pathway for T lymphocytes, in the regulation of tumor necrosis factor (TNF)-alpha/TNF receptor system in human T lymphocytes has been investigated. It has been found that both TNF-alpha synthesis and secretion were induced after incubation of purifie...

journal_title：European journal of immunology

authors： Santis AG,Campanero MR,Alonso JL,Sánchez-Madrid F

更新日期：1992-12-01 00:00:00

abstract：:A human IgE-producing myeloma has been cultivated in vitro as a continuous cell line (U-266) since 1968. Analysis of immunoglobulin production during early passages of the cell line demonstrated a high synthesis rate of monoclonal IgE. Analysis of late passages, cultivated after 1980, revealed a 3-6-fold lower rate of...

journal_title：European journal of immunology

authors： Hellman L,Josephson S,Jernberg H,Nilsson K,Pettersson U

更新日期：1988-06-01 00:00:00

abstract：:Bacterial antigens recognized by CD8(+) T cells in the context of MHC class I are thought to play a crucial role in protection against pathogenic intracellular bacteria. Here, we demonstrate the induction of HLA-A*0201-restricted CD8(+) T cell responses against six new high-affinity HLA-A*0201-binding CTL epitopes, en...

journal_title：European journal of immunology

authors： Charo J,Geluk A,Sundbäck M,Mirzai B,Diehl AD,Malmberg KJ,Achour A,Huriguchi S,van Meijgaarden KE,Drijfhout JW,Beekman N,van Veelen P,Ossendorp F,Ottenhoff TH,Kiessling R

更新日期：2001-12-01 00:00:00

abstract：:IL-6-specific autoantibodies (aAb-IL-6) have been reported in diseased and healthy individuals. We recently established a model for aAb-IL-6 in different mouse strains, based on vaccination with immunogenic IL-6 analogues, in which titers of aAb-IL-6 above 1,000 resulted in an in vivo IL-6 deficiency. Here, we examine...

journal_title：European journal of immunology

authors： Galle P,Svenson M,Bendtzen K,Hansen MB

更新日期：2004-11-01 00:00:00

abstract：:The interaction between T cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) antigens can lead to varying degrees of agonism (T cell activation), or antagonism. The P14 TCR recognises the lymphocytic choriomeningitis virus (LCMV)-derived peptide, gp33 residues 33-41 (KAVYNFATC), presented in the ...

journal_title：European journal of immunology

authors： Boulter JM,Schmitz N,Sewell AK,Godkin AJ,Bachmann MF,Gallimore AM

更新日期：2007-03-01 00:00:00

abstract：:The MHC class II molecule H2-A(s), expressed in the SJL mouse strain, is the principle restriction element of autoreactive CD4(+) T cells mediating experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. We deduced the H2-A(s) ligand motif from the analysis of naturally processed self peptide...

journal_title：European journal of immunology

authors： Kalbus M,Fleckenstein BT,Offenhäusser M,Blüggel M,Melms A,Meyer HE,Rammensee HG,Martin R,Jung G,Sommer N

更新日期：2001-02-01 00:00:00

abstract：:The mechanisms responsible for major histocompatibility complex (MHC)-linked unresponsiveness are still poorly understood. Here we examine the cellular events that follow when B10. A mice are immunized with cow insulin, an antigen to which they make no apparent immunologic response. Despite the fact that there is no d...

journal_title：European journal of immunology

authors： Abromson-Leeman S,Laning J,Cantor H,Dorf ME

更新日期：1988-01-01 00:00:00

abstract：:PA28alpha/beta is a regulatory complex of the 20S proteasome which consists of two IFN-gamma inducible subunits. Both subunits, alpha and beta, contribute equally to the formation of hexa- or heptameric rings which can associate with the 20S proteasome. Previously, we have shown that overexpression of the PA28alpha su...

journal_title：European journal of immunology

authors： Schwarz K,Eggers M,Soza A,Koszinowski UH,Kloetzel PM,Groettrup M

更新日期：2000-12-01 00:00:00

abstract：:A T3 complex-bearing subpopulation was characterized within an in vivo cycling T4-8- early thymocyte compartment which contains cells constitutively expressing interleukin 2 and transferrin receptors. We show differentiation in vitro of both mature subsets of thymocytes (T3+4+8- and T3+4-8+) from the above T4-8- compa...

journal_title：European journal of immunology

authors： De la Hera A,Toribio ML,Marquez C,Marcos MA,Cabrero E,Martinez-A C

更新日期：1986-06-01 00:00:00

abstract：:Pre-graft priming of heart allograft recipients with donor strain blood induces tolerance in 100% of adult rats in the congenic LEW.1W to LEW.1A combination. This tolerant state is specific for donor MHC antigens as third-party blood transfusions fail to induce tolerance, and third-party skin grafts are promptly rejec...

journal_title：European journal of immunology

authors： van Denderen B,Pêche H,Gagne K,Usal C,Cuturi MC,Soulillou JP

更新日期：2001-05-01 00:00:00

abstract：:Upon treatment with lipopolysaccharide (LPS), primary B cells proliferate and differentiate into plasma cells with concomitant up-regulation of immunoglobulin (Ig) gene expression. Here we examine the role of the Igkappa 3' enhancer in this process using a kappa3'-enhancer-driven beta-globin reporter gene in transgeni...

journal_title：European journal of immunology

authors： Meyer KB

更新日期：1999-03-01 00:00:00

abstract：:Changes in endothelial permeability are crucial in the pathogenesis of many diseases. Adenosine is one of the endogenous mediators controlling endothelial permeability under normal conditions, and an endothelial cell surface enzyme CD73 is a key regulator of adenosine production. Here we report that IFN-beta is a nove...

journal_title：European journal of immunology

authors： Kiss J,Yegutkin GG,Koskinen K,Savunen T,Jalkanen S,Salmi M

更新日期：2007-12-01 00:00:00

abstract：:The presentation of islet antigens in the pancreatic LNs (PLNs) of mice is a developmentally regulated process. It has been hypothesized that, during physiological tissue remodeling, a wave of neonatal β-cell apoptosis may initiate diabetes in autoimmune-prone strains of mice. If true, increasing or decreasing physiol...

journal_title：European journal of immunology

authors： Carrington EM,Kos C,Zhan Y,Krishnamurthy B,Allison J

更新日期：2011-08-01 00:00:00

abstract：:The encephalitogenic peptide pMOG 35-55 from the myelin oligodendrocyte glycoprotein was used to induce experimental autoimmune encephalomyelitis (EAE) in H-2b mice with the interleukin-6 (IL-6) gene intact or disrupted. The IL-6+/+ mice developed a chronic form of EAE ascending paralysis, whereas the IL-6-/- mice wer...

journal_title：European journal of immunology

authors： Mendel I,Katz A,Kozak N,Ben-Nun A,Revel M

更新日期：1998-05-01 00:00:00

abstract：:Vitamin A and its metabolite retinoic acid influence various aspects of immunity. Although the capacity of vitamin A to condition intestinal CD103(+) DCs to imprint tissue-specific homing programs onto activated lymphocytes is well documented, it is unclear whether vitamin A also regulates DC populations in other tiss...

journal_title：European journal of immunology

authors： Stock AT,Bedoui S

更新日期：2013-06-01 00:00:00

abstract：:Mycoplasma arthritidis produces an as yet undefined soluble molecule (MAS) that has a potent mitogenic effect on T cells of several species. We have used cloned human cytotoxic and proliferative T lymphocytes to dissect the molecular mechanism of T cell activation by this mitogen. Reactivity to MAS is clonally express...

journal_title：European journal of immunology

authors： Matthes M,Schrezenmeier H,Homfeld J,Fleischer S,Malissen B,Kirchner H,Fleischer B

更新日期：1988-11-01 00:00:00

abstract：:The potential of synthetic peptides as vaccines is restricted by their frequent lack of immunogenicity. As with haptens, coupling to a carrier protein is usually required to provide T cell help to anti-peptide antibody-producing B cells. In spite of their short length, a few natural or synthetic peptides are immunogen...

journal_title：European journal of immunology

authors： Borras-Cuesta F,Petit-Camurdan A,Fedon Y

更新日期：1987-08-01 00:00:00

abstract：:Cofilin, an actin-depolymerizing protein, is essential for the functional dynamics of the actin cytoskeleton and for cell viability. In unstimulated human peripheral blood T lymphocytes cofilin is phosphorylated and localized in the cytoplasm. Following co-stimulation through accessory receptors (e.g. CD2 or CD28) - h...

journal_title：European journal of immunology

authors： Ambach A,Saunus J,Konstandin M,Wesselborg S,Meuer SC,Samstag Y

更新日期：2000-12-01 00:00:00

abstract：:The anti-PC antibodies of BALB/c origin bear predominantly the idiotype characteristic of the phosphorylcholine (PC)-binding T15 idiotype than sera from adult mice, and, unlike the latter, they also contain detectable amounts of anti-T15 antibodies. By 2 weeks of age the anti-T15 antibodies are no longer detectable wh...

journal_title：European journal of immunology

authors： Augustin A,Cosenza H

更新日期：1976-07-01 00:00:00

abstract：:Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake. Cycling thymocytes, which have the CD4-8-3-, CD4-8+3-, or CD4+8+3- phenotypes, also express CD71. The importance of CD71-mediated iron uptake for proliferation and maturation of thymocytes was s...

journal_title：European journal of immunology

authors： Brekelmans P,van Soest P,Leenen PJ,van Ewijk W

更新日期：1994-11-01 00:00:00

abstract：:A panel of HLA-DRB1*0401-restricted CD4+ mouse T cell hybridomas specific for bovine type II collagen were generated from transgenic mice expressing the human HLA-DRA1*0101/-DRB1*0401 and CD4 molecules. The vast majority recognized a single peptide determinant corresponding to residues 261-273 (CII 261-273). This dete...

journal_title：European journal of immunology

authors： Fugger L,Rothbard JB,Sonderstrup-McDevitt G

更新日期：1996-04-01 00:00:00

abstract：:Act1 is a negative regulator of B-cell activation factor of the TNF family (BAFF) and CD40L-induced signaling. BALB/C mice lacking Act1 develop systemic autoimmunity resembling systemic lupus erythematosus (SLE) and Sjögren's syndrome (SjS). SLE and SjS are characterized by anti-nuclear IgG autoantibody (ANA-IgG) prod...

journal_title：European journal of immunology

authors： Johnson AC,Davison LM,Giltiay NV,Vareechon C,Li X,Jørgensen TN

更新日期：2012-07-01 00:00:00

abstract：:Activation of invariant natural killer T (iNKT) cells by treatment with their α-galactosyl ceramide ligand provides therapeutic benefits in several immune inflammatory settings. Given the artificial nature of this stimulation, the natural regulatory functions of iNKT remain uncertain. Addressing this issue in a mouse ...

journal_title：European journal of immunology

authors： Bourgeois EA,Levescot A,Diem S,Chauvineau A,Bergès H,Milpied P,Lehuen A,Damotte D,Gombert JM,Schneider E,Girard JP,Gourdy P,Herbelin A

更新日期：2011-02-01 00:00:00

abstract：:We have previously shown, through transfection experiments, that the murine B7 (mB7) molecule, a ligand for the CD28 and CTLA-4 receptors, is a sufficient costimulatory signal for the antigen-specific and major histocompatibility complex (MHC)-restricted activation of murine CD4+ T lymphocytes. In addition to mB7, ano...

journal_title：European journal of immunology

authors： Razi-Wolf Z,Falo LD Jr,Reiser H

更新日期：1994-04-01 00:00:00