Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis.

abstract：:One of the clear paradoxes in tumor immunology is the fact that cross-presentation of cell-associated tumor antigens to CD8(+) T cells is efficient, yet CTL generation is weak, and tumors continue to grow. We examined, for the first time whether this may be due to alterations in the phenotype or function of cross-pres...

journal_title：European journal of immunology

authors： McDonnell AM,Prosser AC,van Bruggen I,Robinson BW,Currie AJ

更新日期：2010-06-01 00:00:00

abstract：:We have utilized the sensitive polymerase chain reaction (PCR) to determine whether cytotoxic T lymphocyte (CTL) hybridomas generated from peritoneal exudate lymphocytes (PEL) and mixed lymphocyte cultures (MLC) express transcripts for perforin and the cytotoxic cell proteinases CCP1 to CCP5. We could readily detect l...

journal_title：European journal of immunology

authors： Helgason CD,Prendergast JA,Berke G,Bleackley RC

更新日期：1992-12-01 00:00:00

abstract：:We have explored how IL-15 influences Th1 or Th2 type immune response in vivo. Intraperitoneal application of an IL-15-IgG2b fusion protein (FP) to mice did neither significantly affect the footpad swelling nor the production of hemagglutinizing antibodies in a delayed type hypersensitivity reaction to sheep red blood...

journal_title：European journal of immunology

authors： Rückert R,Herz U,Paus R,Ungureanu D,Pohl T,Renz H,Bulfone-Paus S

更新日期：1998-10-01 00:00:00

abstract：:The murine X-linked lymphoproliferative disease scurfy is similar to the Wiskott-Aldrich syndrome in humans. Disease in scurfy (sf) mice is mediated by CD4+ T cells. Based on similarities in scurfy mice and transgenic mice that overexpress specific cytokine genes, we evaluated the expression of cytokines in the lesion...

journal_title：European journal of immunology

authors： Kanangat S,Blair P,Reddy R,Daheshia M,Godfrey V,Rouse BT,Wilkinson E

更新日期：1996-01-01 00:00:00

abstract：:Macrophage precursor cells were cultured from the bone marrow of mice in a liquid culture system in the presence of conditioned medium. To separate their different maturation stages, they were passed through a discontinuous Ficoll density gradient, treated with iron plus magnet or passed through glass bead columns. Th...

journal_title：European journal of immunology

authors： Domzig W,Lohmann-Matthes ML

更新日期：1979-04-01 00:00:00

abstract：:To estimate the extent of the TRG gamma variable (V) gene repertoire used in human T cell ontogeny, we have analyzed the variety of V gamma gene rearrangements in a large series of T and non-T acute and chronic leukemias. A limited heterogeneity of rearranged fragments was observed: only 13 types of differently rearra...

journal_title：European journal of immunology

authors： Migone N,Casorati G,Di Celle PF,Lusso P,Foa R,Lefranc MP

更新日期：1988-01-01 00:00:00

abstract：:Chronic skin inflammation resulting from a defective epidermal barrier is a hallmark of atopic dermatitis (AD). We previously demonstrated that mice lacking FGF receptors 1 and 2 in keratinocytes (K5-R1/R2 mice) develop an AD-like chronic dermatitis as a result of an impaired epidermal barrier. Here, we show that γδ T...

journal_title：European journal of immunology

authors： Sulcova J,Maddaluno L,Meyer M,Werner S

更新日期：2015-09-01 00:00:00

abstract：:Expression and function of the fractalkine receptor CX3CR1 by T lymphocyte subpopulations was evaluated in healthy individuals. In CD8(+) T lymphocytes, CX3CR1 was expressed by and functional in both CD45RO(-) and CD45RO(+) cells. In CD4(+) T lymphocytes, CX3CR1 was expressed mainly by CD45RO(+) cells, and almost excl...

journal_title：European journal of immunology

authors： Foussat A,Coulomb-L'Hermine A,Gosling J,Krzysiek R,Durand-Gasselin I,Schall T,Balian A,Richard Y,Galanaud P,Emilie D

更新日期：2000-01-01 00:00:00

abstract：:The entry of neutrophils into inflamed tissues is initiated by cell rolling on the blood vessel wall followed by arrest and transendothelial migration. Rolling is mediated by the selectins, while the two subsequent steps require activated beta 2-integrins. We have investigated whether the binding of P-selectin to mous...

journal_title：European journal of immunology

authors： Blanks JE,Moll T,Eytner R,Vestweber D

更新日期：1998-02-01 00:00:00

abstract：:Eight isogeneic anti-idiotypic hybridomas were raised against BALB/c myeloma protein MOPC 104E and one against J558. Both myelomas react specifically with the alpha(1----3) glucosidic linkage of dextran B1355 fraction S (Dex). Six anti-MOPC 104E proteins were IgG1, one was IgG2b and one IgM. The anti-J558 protein was ...

journal_title：European journal of immunology

authors： Wilke J,Weiler E

更新日期：1987-02-01 00:00:00

abstract：:Recent studies have shown that in humans the germinal center reactions produce three types of V(D)J mutated B cells in similar proportions, i.e. Ig-switched, IgD-IgM+ (IgM-only) and IgD+IgM+ cells, and that together they form the CD27+ compartment of recirculating B cells. We investigated the Ig isotype switch capacit...

journal_title：European journal of immunology

authors： Werner-Favre C,Bovia F,Schneider P,Holler N,Barnet M,Kindler V,Tschopp J,Zubler RH

更新日期：2001-01-01 00:00:00

abstract：:In order to analyze the effect of a high local concentration of macrophage colony-stimulating factor (M-CSF; CSF-1) on tumor growth, the plasmacytoma cell line J558L was transfected with the human M-CSF gene and injected into syngeneic BALB/c mice. In contrast to the parental tumors, M-CSF transfectants were heavily i...

journal_title：European journal of immunology

authors： Dorsch M,Hock H,Kunzendorf U,Diamantstein T,Blankenstein T

更新日期：1993-01-01 00:00:00

abstract：:New Zealand Black (NZB) mice spontaneously develop an autoimmune hemolytic anemia together with a markedly increased production of polyclonal antibodies. The spontaneous generation of anti-mouse red blood cells (MRBC), anti-bromelain-treated MRBC (BrMRBC) and anti-DNA autoantibodies was compared to the polyclonal anti...

journal_title：European journal of immunology

authors： Reininger L,Shibata T,Schurmans S,Merino R,Fossati L,Lacour M,Izui S

更新日期：1990-11-01 00:00:00

abstract：:The present experiments address functional antibody diversity and clonal distribution in murine available repertoires. IgM-containing supernatants were prepared by unbiased, polyclonal stimulation of resting splenic B cells from C57BL/6 mice, to ensure similar numbers of responding clones/culture and equivalent growth...

journal_title：European journal of immunology

authors： Nobrega A,Grandien A,Haury M,Hecker L,Malanchère E,Coutinho A

更新日期：1998-04-01 00:00:00

abstract：:The induction of B cell tolerance to 2,4-dinitrophenyl conjugates of polysaccharide antigens (levan or dextran) was studied in mice primed with keyhole limpet hemocyanin (KLH) or 2,4,6-trinitrophenylated KLH. The relationship of the epitope density of the tolerogen with avidity of B cell receptors (as judged indirectl...

journal_title：European journal of immunology

authors： Desaymard C,Pearce B,Feldmann M

更新日期：1976-09-01 00:00:00

abstract：:Immunotherapy generally fails to induce tumour regression in spontaneously arising tumours. Failure is attributed to both tumour-related factors and an ineffective immune response. As a model of tumour immunotherapy, without the confounding effects of potential tumour-determined mechanisms of immune evasion, we studie...

journal_title：European journal of immunology

authors： Zhong J,Hadis U,De Kluyver R,Leggatt GR,Fernando GJ,Frazer IH

更新日期：2008-01-01 00:00:00

abstract：:Cellular metabolism is dynamically regulated in NK cells and strongly influences their responses. Metabolic dysfunction is linked to defective NK cell responses in diseases such as obesity and cancer. The transcription factors, sterol regulatory element binding protein (SREBP) and cMyc, are crucial for controlling NK ...

journal_title：European journal of immunology

authors： O'Brien KL,Assmann N,O'Connor E,Keane C,Walls J,Choi C,Oefner PJ,Gardiner CM,Dettmer K,Finlay DK

更新日期：2020-09-18 00:00:00

abstract：:The TORC1 pathway is necessary for ribosomal biogenesis and initiation of protein translation. Furthermore, the differentiation of Th1 and Th17 cells requires TORC1 activity. To investigate the role of the TORC1 pathway in the differentiation of Th1 and/or Th17 cells in more detail, we compared the differentiation cap...

journal_title：European journal of immunology

authors： Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

更新日期：2016-01-01 00:00:00

abstract：:Fc gamma receptor I-positive (CD64+) and Fc gamma receptor I-negative (CD64-) monocytes were prepared from highly purified (elutriation-derived) human monocytes by cytofluorograph cell sorting, and a phenotypical and functional dissociation of the isolated CD64+ and CD64- monocyte subsets is demonstrated. Surface anal...

journal_title：European journal of immunology

authors： Grage-Griebenow E,Lorenzen D,Fetting R,Flad HD,Ernst M

更新日期：1993-12-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine kinase and is crucial for cellular energy homeostasis. The exact role of AMPK during memory CD8(+) T-cell differentiation, a process that changes from the metabolically active state of effector T cells to one of quiescence in memory cells is...

journal_title：European journal of immunology

authors： Araki K,Ahmed R

更新日期：2013-04-01 00:00:00

abstract：:GTPase immune-associated proteins (Gimap) genes encode evolutionarily conserved GTP-binding proteins that are preferentially expressed in immune cells. Specific members have been shown to be involved in lymphocyte development, or are associated with inflammatory and autoimmune diseases. However, the function of these ...

journal_title：European journal of immunology

authors： Ciucci T,Bosselut R

更新日期：2014-02-01 00:00:00

abstract：:Specific monoclonal antibodies (mAb) directed against the CD23 antigen were used to study human interleukin 4 (hIL4)-induced IgE production by blood and tonsillar mononuclear cells. Both peripheral blood and tonsillar mononuclear cells stimulated by hIL4 expressed membrane CD23 as detected by the binding of all anti-C...

journal_title：European journal of immunology

authors： Bonnefoy JY,Shields J,Mermod JJ

更新日期：1990-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants worldwide. The immunological factors responsible for RSV susceptibility in infants are poorly understood. Here, we used the BALB/c mouse model of neonatal RSV infection to study the mechanisms leading to severe disease upon reexposure to the viru...

journal_title：European journal of immunology

authors： Remot A,Descamps D,Jouneau L,Laubreton D,Dubuquoy C,Bouet S,Lecardonnel J,Rebours E,Petit-Camurdan A,Riffault S

更新日期：2016-04-01 00:00:00

abstract：:Collagen type II-induced arthritis (CIA) is an experimental model of arthritis that has been successfully used to dissect the pathogenesis of human rheumatoid arthritis and to identify potential therapeutic targets. We have used this model to evaluate the role of T cell co-stimulation in both disease development and p...

journal_title：European journal of immunology

authors： Webb LM,Walmsley MJ,Feldmann M

更新日期：1996-10-01 00:00:00

abstract：:Using a model of 2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity (CHS) we found that, as compared with wild-type mice, IL-15 receptor alpha chain (IL-15Ralpha)-deficient mice showed significantly less ear swelling. This decreased response was associated with diminished expression of CCL5/RANTES and CXCL10...

journal_title：European journal of immunology

authors： Chen JP,Liao NS,Lai SL,Hsu L,Mao WY,Ku MC,Liao F

更新日期：2005-03-01 00:00:00

abstract：:The immune system has developed several regulatory mechanisms to maintain homeostasis of adaptive immune responses. T-cell programmed death (PD)-1 recognition of B7-H1 (PD-L1) expressed on APC and non-lymphoid tissue regulates T-cell activation. We show that B7-H1(-/-) mice exhibit exacerbated proteoglycan (PG)-induce...

journal_title：European journal of immunology

authors： Hamel KM,Cao Y,Wang Y,Rodeghero R,Kobezda T,Chen L,Finnegan A

更新日期：2010-11-01 00:00:00

abstract：:Since the discovery of antibody-producing B cells in chickens six decades ago, chickens have been a model for B-cell development in gut-associated lymphoid tissue species. Here we describe targeting of the immunoglobulin light chain locus by homologous recombination in chicken primordial germ cells (PGCs) and generati...

journal_title：European journal of immunology

authors： Schusser B,Collarini EJ,Pedersen D,Yi H,Ching K,Izquierdo S,Thoma T,Lettmann S,Kaspers B,Etches RJ,van de Lavoir MC,Harriman W,Leighton PA

更新日期：2016-09-01 00:00:00

abstract：:Membrane-bound immunoglobulins of the IgM and IgD class are expressed on the B cell surface in association with a disulfide-linked heterodimer consisting of alpha and beta subunits. While the alpha component of the IgM antigen receptor (IgM-alpha, 34 kDa) is encoded by the B cell-specific gene mb-1, the gene coding fo...

journal_title：European journal of immunology

authors： Wienands J,Reth M

更新日期：1991-10-01 00:00:00

abstract：:The most common reason for heart failure in young adults is dilated cardiomyopathy often resulting from myocarditis. Clinical studies and animal models provide evidence that an autoimmune response against heart myosin is the underlying reason for the disease. IL-12 has been suggested to play a key role in development ...

journal_title：European journal of immunology

authors： Sonderegger I,Röhn TA,Kurrer MO,Iezzi G,Zou Y,Kastelein RA,Bachmann MF,Kopf M

更新日期：2006-11-01 00:00:00

abstract：:The initiation of CD8(+) T cell (CTL) immune responses can occur via cross-priming. Recent data suggested a relationship between cross-presentation and immunodominance of epitope-specific T cells. To test this association, we evaluated the efficacy of cross-presentation for several virus epitopes in vitro and examined...

journal_title：European journal of immunology

authors： Alatery A,Tarrab E,Lamarre A,Basta S

更新日期：2010-08-01 00:00:00