Expression of heavy chain-only antibodies can support B-cell development in light chain knockout chickens.

abstract：:NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 in...

journal_title：European journal of immunology

authors： Campos PC,Gomes MTR,Marinho FAV,Guimarães ES,de Moura Lodi Cruz MGF,Oliveira SC

更新日期：2019-07-01 00:00:00

abstract：:The CBA/N mouse carries the X-linked immunodeficiency xid, resulting in defective B cell development. B cells from these animals cannot mount antibody responses to type 2 T-independent antigens, and do not synthesize DNA when stimulated with anti-immunoglobulin (Ig) antibodies which are mitogenic for normal B cells. T...

journal_title：European journal of immunology

authors： Hasbold J,Klaus GG

更新日期：1994-01-01 00:00:00

abstract：:CD30 is a costimulatory molecule of the TNF receptor superfamily, expressed on activated T and B cells. Previously, we have shown in a murine asthma model the crucial role of CD30 signaling for the development of this Th2-cell-mediated disease. In the present study, we investigated the role of CD30 in the maintenance ...

journal_title：European journal of immunology

authors： Polte T,Fuchs L,Behrendt AK,Hansen G

更新日期：2009-07-01 00:00:00

abstract：:T lymphocyte subsets expressing either T cell receptor alpha/beta or gamma/delta were selected from human peripheral blood T cells and proliferative responses to molecular mass-fractionated mycobacterial lysates were determined. alpha/beta T cells primarily responded to fractions greater than 30 kDa whereas gamma/delt...

journal_title：European journal of immunology

authors： Pfeffer K,Schoel B,Gulle H,Kaufmann SH,Wagner H

更新日期：1990-05-01 00:00:00

abstract：:APO-1/Fas (CD95) is a transmembrane receptor that transduces apoptotic signals within various cells including T and B cells. The APO-1 gene was found to be defective in lpr mice. In these mice insertion of a retrotransposon gives rise to transcription of an abnormal mRNA and only a fraction of wild-type APO-1 mRNA. It...

journal_title：European journal of immunology

authors： Mariani SM,Matiba B,Armandola EA,Krammer PH

更新日期：1994-12-01 00:00:00

abstract：:Dendritic cells isolated from sheep afferent lymph were examined for their ability to bind soluble protein and peptide antigens labeled with fluorescein both in in vitro assays and following intradermal injection of antigen in vivo. Analysis of dendritic cells by flow cytometry revealed weak direct binding of proteins...

journal_title：European journal of immunology

authors： Harkiss GD,Hopkins J,McConnell I

更新日期：1990-11-01 00:00:00

abstract：:Pathogens have developed a plethora of strategies to undermine host immune defenses in order to guarantee their survival. For large DNA viruses, these immune evasion mechanisms frequently rely on the expression of genes acquired from host genomes. Horizontally transferred genes include members of the immunoglobulin su...

journal_title：European journal of immunology

authors： Farré D,Martínez-Vicente P,Engel P,Angulo A

更新日期：2017-05-01 00:00:00

abstract：:Cells present in the polyoma virus-induced murine ascites tumor SEYF-a showed the capacity to fix soluble immune complexes of ovalbumin anti-ovalbumin. The fixation could be inhibited by preincubating the cells with antisera directed against H-2 antigens and with syngeneic anti-tumor antibodies. The latter did not rea...

journal_title：European journal of immunology

authors： Braslawsky GR,Serban D,Witz IP

更新日期：1976-08-01 00:00:00

abstract：:The concept that naive CD4+ and CD8+ T cells require co-stimulatory signals for activation and proliferation is well documented. Less clear is the need for co-stimulation during the effector phase of the T cell response. Here we examined the influence of B7-1 (CD80) during the effector phase of an autoimmune response ...

journal_title：European journal of immunology

authors： Allison J,Stephens LA,Kay TW,Kurts C,Heath WR,Miller JF,Krummel MF

更新日期：1998-03-01 00:00:00

abstract：:T cell stimulation of B cell proliferation during T-B collaboration requires membrane-bound stimulatory ligands, such as CD40 ligand and the secretion of soluble cytokines, such as IL-4. Nevertheless, it remains unclear whether T cell contact is required to provoke each consecutive B cell division, or whether B cells ...

journal_title：European journal of immunology

authors： Rush JS,Hodgkin PD

更新日期：2001-04-01 00:00:00

abstract：:Anti-idiotypes produced against monoclonal anti-H-2 antibodies have been used to examine idiotope sharing among a panel of anti-major histocompatibility complex (MHC) antibodies detecting the same and different specificities. Both xenogeneic anti-100-30 and anti-3-83, which did not react with predominant idiotypes in ...

journal_title：European journal of immunology

authors： Bluestone JA,Auchincloss H Jr,Sachs DH,Fibi M,Hämmerling GJ

更新日期：1983-06-01 00:00:00

abstract：:The use of fetal bovine serum (FBS) for the culture and expansion of mesenchymal stromal cells (MSCs) limits their possible clinical applications. Although some recent studies recommended substituting FBS with human platelet lysate (HPL) for the expansion of MSCs for clinical use, the functional capacity of the expand...

journal_title：European journal of immunology

authors： Abdelrazik H,Spaggiari GM,Chiossone L,Moretta L

更新日期：2011-11-01 00:00:00

abstract：:An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells and regulates activation and migration of immune cells through activating Ras-related C3 botulinum toxin substrate (Rac). Dock2 was shown to be critical in the development of various inflammatory diseases, including allergic di...

journal_title：European journal of immunology

authors： Chen Y,Meng F,Wang B,He L,Liu Y,Liu Z

更新日期：2018-06-01 00:00:00

abstract：:Prostaglandins (PG) are important modulators of immune and inflammatory responses. We recently demonstrated that the production of PGD(2) by the helminthic parasite Schistosoma mansoni inhibits the migration of epidermal Langerhans cells (LC) to the draining lymph nodes (DLN). Here, we identify the responsible parasit...

journal_title：European journal of immunology

authors： Hervé M,Angeli V,Pinzar E,Wintjens R,Faveeuw C,Narumiya S,Capron A,Urade Y,Capron M,Riveau G,Trottein F

更新日期：2003-10-01 00:00:00

abstract：:T lymphocytes can be activated and induced to proliferate through stimulation of the CD2 glycoprotein with functional combinations of CD2 antibodies. However, this mechanism of signal transduction via CD2 is still not fully understood. We have investigated which molecules on the T cell surface preferentially associate...

journal_title：European journal of immunology

authors： Castro MA,Tavares PA,Almeida MS,Nunes RJ,Wright MD,Mason D,Moreira A,Carmo AM

更新日期：2002-05-01 00:00:00

abstract：:CTLA-4 is a crucial immune regulator that mediates both negative costimulation signals to T cells, and regulatory T (Treg)-cell extrinsic control of effector responses. Here we present evidence supporting a novel mechanism for this extrinsic suppression, executed by the alternatively spliced soluble CTLA-4 isoform (sC...

journal_title：European journal of immunology

authors： Ward FJ,Dahal LN,Wijesekera SK,Abdul-Jawad SK,Kaewarpai T,Xu H,Vickers MA,Barker RN

更新日期：2013-05-01 00:00:00

abstract：:The role of complement receptors on the localization of T and B cells in the spleen of mice was studied using short-term homing experiments in cobra venom factor (CoF)-treated animals. The localization ratio of B and T cells in the spleen of CoF-treated mice decreased significantly compared to control recipients. No c...

journal_title：European journal of immunology

authors： Kraal G,Van Hoogstraten I,Klerx JP,Van Dijk H

更新日期：1985-07-01 00:00:00

abstract：:We have produced a chimeric single-chain T cell receptor (TcR) that combines the specific antibody recognition function and TcR/CD3 signaling properties within the same polypeptide chain. This hybrid molecule consisted of a single-chain antibody combining site that was connected over a short spacer to the transmembran...

journal_title：European journal of immunology

authors： Brocker T,Peter A,Traunecker A,Karjalainen K

更新日期：1993-07-01 00:00:00

abstract：:The diversity of cytokine production patterns displayed by T cells activated in vivo was investigated by analyzing short-term antigen-specific CD4+ T cell clones and single CD4+ T cells derived from draining lymph nodes of mice undergoing a T helper 2 (Th2)-like response to keyhole limpet hemocyanin (KLH). On average,...

journal_title：European journal of immunology

authors： Kelso A,Groves P,Troutt AB,Francis K

更新日期：1995-05-01 00:00:00

abstract：:Levamisole, an anti-anergic chemotherapeutic agent, is shown to depress the azathioprine sensitivity of rosette-forming cells (RFC) in the spleen of normal mice, and to restore the azathioprine sensitivity of RFC in the spleen of adult thymectomized mice. Using the fully active dose of 1.25 mg/kg i.v., the restoration...

journal_title：European journal of immunology

authors： van Ginckel RF,Hoebeke J

更新日期：1976-04-01 00:00:00

abstract：:Upon antigen-specific or allogeneic activation, T cells sharply increase their metabolic activity to cope with augmented needs for proliferation and effector functions. Therefore, enzymes involved in energy metabolism constitute attractive targets to modulate the activity of pathogenic effector T cells in the setting ...

journal_title：European journal of immunology

authors： Raha S,Raud B,Oberdörfer L,Castro CN,Schreder A,Freitag J,Longerich T,Lochner M,Sparwasser T,Berod L,Koenecke C,Prinz I

更新日期：2016-09-01 00:00:00

abstract：:At the surface of the murine T lymphoma cell line RMA-S, the expression of "empty" class I molecules can be dramatically enhanced by culture at 26 degrees C. These class I molecules are unstable following transfer to 37 degrees C unless they are loaded with exogenously added peptides. Class I heterodimers that have fa...

journal_title：European journal of immunology

authors： Neefjes JJ,Smit L,Gehrmann M,Ploegh HL

更新日期：1992-06-01 00:00:00

abstract：:Previous studies suggested that trinitrophenyl (TNP)-modified syngeneic red cells induced humoral autoimmune response in mice with defective T cell function but not in normal mice. The ability of modified self antigen to induce autoimmune response in immunodeficient mice was further explored using the delayed-type hyp...

journal_title：European journal of immunology

authors： Tarcic N,Naor D

更新日期：1982-11-01 00:00:00

abstract：:A serological cross-reactivity between env gp120 glycoprotein of the human immunodeficiency virus (HIV) and a human cellular surface protein has been defined by a monoclonal antibody (M38) raised against HIV. The cellular antigen is a protein of ca. 80 kDa expressed on a small fraction of mononuclear cells in peripher...

journal_title：European journal of immunology

authors： Beretta A,Grassi F,Pelagi M,Clivio A,Parravicini C,Giovinazzo G,Andronico F,Lopalco L,Verani P,Buttò S

更新日期：1987-12-01 00:00:00

abstract：:The poxvirus A39R protein is a member of the semaphorin family that binds to Plexin C1, a molecule expressed on neutrophils and dendritic cells (DC). We previously showed that binding of A39R to Plexin C1 induces local rearrangement of the actin cytoskeleton and inhibits integrin-mediated adhesion, leading to cell ret...

journal_title：European journal of immunology

authors： Walzer T,Galibert L,De Smedt T

更新日期：2005-02-01 00:00:00

abstract：:As shown recently, CD3+/TcR+ functional T lymphocytes can be derived in culture from embryonic liver cell precursors at a gestational age (6-8 weeks) preceding the colonization of the epithelial thymus. In this report, we analyzed the V beta repertoire of T lymphocytes derived from embryonic liver by applying a quanti...

journal_title：European journal of immunology

authors： Poggi A,Demarest JF,Costa P,Biassoni R,Pella N,Pantaleo G,Mingari MC,Moretta L

更新日期：1994-09-01 00:00:00

abstract：:Heavy chain diseases (HCD) are neoplastic proliferations of B cells which secrete truncated immunoglobulin heavy chains without associated light chains. These proteins are encoded by mutated genes which may also give rise to truncated membrane immunoglobulins. The neoplastic cells proliferate in vivo although they can...

journal_title：European journal of immunology

authors： Corcos D,Iglesias A,Dunda O,Bucchini D,Jami J

更新日期：1991-11-01 00:00:00

abstract：:Sequential development of antibody titer, functional avidity, helper and suppressor activities were investigated in rhesus monkeys. These were immunized with a single dose of 0.1 microgram to 10 mg of a streptococcal protein antigen (SA) in aluminium hydroxide. The IgG antibody titers followed the classical pattern fi...

journal_title：European journal of immunology

authors： Lehner T,Caldwell J,Avery J

更新日期：1984-09-01 00:00:00

abstract：:Dendritic cells (DCs) are the key APCs not only for the priming of naïve T cells, but also for the induction and maintenance of peripheral T-cell tolerance. We have recently shown that cognate interactions between Foxp3(+) Tregs and steady-state DCs are crucial to maintain the tolerogenic potential of DCs. Using DIETE...

journal_title：European journal of immunology

authors： Muth S,Schütze K,Hain T,Yagita H,Schild H,Probst HC

更新日期：2014-04-01 00:00:00

abstract：:We have previously shown, through transfection experiments, that the murine B7 (mB7) molecule, a ligand for the CD28 and CTLA-4 receptors, is a sufficient costimulatory signal for the antigen-specific and major histocompatibility complex (MHC)-restricted activation of murine CD4+ T lymphocytes. In addition to mB7, ano...

journal_title：European journal of immunology

authors： Razi-Wolf Z,Falo LD Jr,Reiser H

更新日期：1994-04-01 00:00:00