Expression of a wide T cell receptor V beta repertoire in human T lymphocytes derived in vitro from embryonic liver cell precursors.

abstract：:Mycoplasma arthritidis produces in culture a polyclonal mitogen which is active for murine and human T lymphocytes in the presence of accessory cells (AC). We studied the requirements for processing and presentation by AC of Mycoplasma arthritidis supernatant (MAS) mitogen to human T cells. As inhibitors of AC process...

journal_title：European journal of immunology

authors： Bauer A,Rutenfranz I,Kirchner H

更新日期：1988-12-01 00:00:00

abstract：:LL-37, derived from human cathelicidin, stimulates immune responses in neutrophils. Although FPR2 and P2X7 were proposed as LL-37 receptors, we have shown that among 21 neutrophil receptors only CXCR2 was down-regulated by LL-37. LL-37 functions similarly to CXCR2-specific chemokines CXCL1 and CXCL7 in terms of recept...

journal_title：European journal of immunology

authors： Zhang Z,Cherryholmes G,Chang F,Rose DM,Schraufstatter I,Shively JE

更新日期：2009-11-01 00:00:00

abstract：:In the lung, dendritic cells (DC) are key antigen-presenting cells capable of triggering specific cellular responses to inhaled pathogens, and thus, they may be important in the initiation of an early response to mycobacterial infections. The ability of DC to enhance antigen presentation to naive T cells within the lu...

journal_title：European journal of immunology

authors： Demangel C,Bean AG,Martin E,Feng CG,Kamath AT,Britton WJ

更新日期：1999-06-01 00:00:00

abstract：:Naive T cells do not proliferate but remain alive in vivo. In contrast, naive T cells rapidly die in an in vitro culture, suggesting that some factors that are present at the sites of naive T cell circulation in vivo but missing in the bovine serum-containing culture medium, are necessary for their survival. The prese...

journal_title：European journal of immunology

authors： Endharti AT,Zhou YW,Nakashima I,Suzuki H

更新日期：2005-01-01 00:00:00

abstract：:The immune system has developed several regulatory mechanisms to maintain homeostasis of adaptive immune responses. T-cell programmed death (PD)-1 recognition of B7-H1 (PD-L1) expressed on APC and non-lymphoid tissue regulates T-cell activation. We show that B7-H1(-/-) mice exhibit exacerbated proteoglycan (PG)-induce...

journal_title：European journal of immunology

authors： Hamel KM,Cao Y,Wang Y,Rodeghero R,Kobezda T,Chen L,Finnegan A

更新日期：2010-11-01 00:00:00

abstract：:Antigen-specific immunotherapy is an attractive strategy for cancer control. In the context of antiviral vaccines, adenoviral vectors have emerged as a favorable means for immunization. Therefore, we chose a strategy combining use of these vectors with another successful approach, namely linkage of the vaccine antigen...

journal_title：European journal of immunology

authors： Sorensen MR,Holst PJ,Pircher H,Christensen JP,Thomsen AR

更新日期：2009-10-01 00:00:00

abstract：:We have utilized the sensitive polymerase chain reaction (PCR) to determine whether cytotoxic T lymphocyte (CTL) hybridomas generated from peritoneal exudate lymphocytes (PEL) and mixed lymphocyte cultures (MLC) express transcripts for perforin and the cytotoxic cell proteinases CCP1 to CCP5. We could readily detect l...

journal_title：European journal of immunology

authors： Helgason CD,Prendergast JA,Berke G,Bleackley RC

更新日期：1992-12-01 00:00:00

abstract：:Current concepts on the pathogenesis of chronic asthma emphasize the role of several inflammatory cell populations and their respective mediators that interact in a complex network. However, beside inflammatory cells, lymphocytes are also present in asthmatic airways. Although little is known about their involvement i...

journal_title：European journal of immunology

authors： Lassalle P,Delneste Y,Gosset P,Gras-Masse H,Wallaert B,Tonnel AB

更新日期：1993-04-01 00:00:00

abstract：:An inhibitor of the cytotoxic functions (ICF) mediated by human immunodeficiency virus (HIV)- or HLA-specific cytotoxic T lymphocytes, natural killer and lymphokine-activated killer (LAK) cells is secreted by CD8+CD57+ T lymphocytes, a subset expanded during infection with HIV and after bone marrow transplantation. We...

journal_title：European journal of immunology

authors： Sadat-Sowti B,Debré P,Mollet L,Quint L,Hadida F,Leblond V,Bismuth G,Autran B

更新日期：1994-11-01 00:00:00

abstract：:From human precursor B cells which had both immunoglobulin (Ig) heavy (H) chain loci in germ-line configuration, various IgH chain germ-line transcripts were isolated and sequenced. These transcripts were shown to contain sequences derived from the JH region, the IgH chain enhancer element or the Ig switch region. A n...

journal_title：European journal of immunology

authors： Thompson A,Timmers E,Schuurman RK,Hendriks RW

更新日期：1995-01-01 00:00:00

abstract：:Low zone tolerance (LZT) to contact allergens is induced by epicutaneous exposure to haptens in subsensitizing doses resulting in an inhibition of contact hypersensitivity (CHS), which, in contrast, occurs after sensitization with immunogenic doses of allergens. Performing the protocol of tolerance induction resulted ...

journal_title：European journal of immunology

authors： Seidel-Guyenot W,Alt R,Perschon S,Knop J,Steinbrink K

更新日期：2004-11-01 00:00:00

abstract：:The multimeric Fc gamma RIIIA (CD16) complex is expressed on the surface of natural killer (NK) cells and is composed of a 50-70-kDa transmembrane glycoprotein Fc gamma receptor (CD16), the T cell receptor (TCR)-zeta chain, and the Fc epsilon RI gamma chain. Cross-linking Fc gamma RIIIA initiates the rapid tyrosine ph...

journal_title：European journal of immunology

authors： Cone JC,Lu Y,Trevillyan JM,Bjorndahl JM,Phillips CA

更新日期：1993-10-01 00:00:00

abstract：:The zinc-finger transcription factor GATA3 serves as a master regulator of T-helper-2 (Th2) differentiation by inducing expression of the Th2 cytokines IL-4, IL-5 and IL-13 and by suppressing Th1 development. Here, we investigated how GATA3 affects Th17 differentiation, using transgenic mice with enforced GATA3 expres...

journal_title：European journal of immunology

authors： van Hamburg JP,de Bruijn MJ,Ribeiro de Almeida C,van Zwam M,van Meurs M,de Haas E,Boon L,Samsom JN,Hendriks RW

更新日期：2008-09-01 00:00:00

abstract：:Autoantigenic epitope mapping represents a critical issue in autoimmune diseases. The islet tyrosine phosphatase-like protein IA-2/ICA512bdc is a major autoantigen in type 1 diabetes (IDDM), but the epitopes responsible for autoantibody binding have been only partially defined. The aim of our study was to identify ICA...

journal_title：European journal of immunology

authors： Farilla L,Tiberti C,Luzzago A,Yu L,Eisenbarth GS,Cortese R,Dotta F,Di Mario U

更新日期：2002-05-01 00:00:00

abstract：:Interleukin-12 (IL-12) has been shown to be produced by monocytes by the ligation of CD40. In the present experiments, IL-12 is shown to be produced by murine spleen antigen-presenting cells (APC) by interaction with T helper 1 (Th1) clones through CD40-CD40 ligand (CD40L) interaction, but not with Th2 clones. The IL-...

journal_title：European journal of immunology

authors： Hino A,Nariuchi H

更新日期：1996-03-01 00:00:00

abstract：:Following antigen encounter and subsequent resolution of the immune response, a single naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic and functional properties and gene expression profiles. Single-cell technologies, first and foremost flow cytometry, have revealed the com...

journal_title：European journal of immunology

authors： Mahnke YD,Brodie TM,Sallusto F,Roederer M,Lugli E

更新日期：2013-11-01 00:00:00

abstract：:The MHC-related 1 (MR1) protein is a monomorphic, evolutionarily conserved MHC class I-like molecule, which is necessary for the development and functions of mucosal-associated invariant T (MAIT) cells, a new subset of innate-like lymphocytes. Multiple isoforms of the MR1 gene are naturally transcribed, but only the f...

journal_title：European journal of immunology

authors： Lion J,Debuysscher V,Wlodarczyk A,Hodroge A,Serriari NE,Choteau L,Ouled-haddou H,Plistat M,Lassoued K,Lantz O,Treiner E

更新日期：2013-05-01 00:00:00

abstract：:TGF-beta1 was examined for the ability to regulate Ag-presentation by B cells, using A20-HL B lymphoma cells bearing TNP-specific IgM receptors. Treatment of A20-HL cells with TGF-beta1 at 1 ng/ml, a concentration that inhibited proliferation, enhanced presentation of Ag internalized via surface IgM (sIgM), but not vi...

journal_title：European journal of immunology

authors： Arai C,Ichijo T,Tanaka Y,Okada Y,Umeda M,Uchida T,Kiniwa M,Kakiuchi T

更新日期：2003-07-01 00:00:00

abstract：:Tumor-specific helper T cell activity was detected in the spleens of tumor-bearing mice using a sensitive, simple and reproducible in vitro assay based on those previously described for soluble hapten-carrier antigens. Helper activity disappears when the tumor is large. This is coincident with the appearance of two di...

journal_title：European journal of immunology

authors： Howie S,McBride WH

更新日期：1982-08-01 00:00:00

abstract：:B cells have multiple functions in adaptive immunity, including antibody production, antigen presentation and regulation of T-cell responses. Recent evidences indicate that B cells have more subsets than previously thought and may have non-classical functions, such as involvement in innate immunity and immune regulati...

journal_title：European journal of immunology

authors： Bao Y,Han Y,Chen Z,Xu S,Cao X

更新日期：2011-03-01 00:00:00

abstract：:Indirect immunofluorescence revealed that 13% of BALB/c and 33% of CBA spleen cells of B type carry specific binding sites at their surface for double-stranded poly(I).poly(C). Pretreatment of BALB/c spleen cells with anti-mouse immunoglobulin serum increased the number of B cells capable of binding poly(I).poly(C) in...

journal_title：European journal of immunology

authors： Diamantstein T,Bittstein-Willinger E

更新日期：1978-12-01 00:00:00

abstract：:T90/44 is a cell surface antigen which is present on human T cells of the helper and cytotoxic subsets and which binds the 9.3 monoclonal antibody (9.3 mAb). It is expressed in the form of 90-kDa disulfide-bonded dimers of a 44-kDa polypeptide and of free 44-kDa subunits. The function of T90/44 was investigated in a s...

journal_title：European journal of immunology

authors： Lesslauer W,Koning F,Ottenhoff T,Giphart M,Goulmy E,van Rood JJ

更新日期：1986-10-01 00:00:00

abstract：:It has been shown previously that three different H-2-associated genes control the resistance to viremia and leukemia in Moloney virus-infected mice: Rmv. 1, mapping to the I-A or less probably K regions; Rmv. 2, mapping to the I-C, S or G regions and Rmv. 3, mapping to the D or T regions. Experiments have been perfo...

journal_title：European journal of immunology

authors： Debré P,Boyer B,Gisselbrecht S,Bismuth A,Lévy JP

更新日期：1980-12-01 00:00:00

abstract：:Since the discovery of antibody-producing B cells in chickens six decades ago, chickens have been a model for B-cell development in gut-associated lymphoid tissue species. Here we describe targeting of the immunoglobulin light chain locus by homologous recombination in chicken primordial germ cells (PGCs) and generati...

journal_title：European journal of immunology

authors： Schusser B,Collarini EJ,Pedersen D,Yi H,Ching K,Izquierdo S,Thoma T,Lettmann S,Kaspers B,Etches RJ,van de Lavoir MC,Harriman W,Leighton PA

更新日期：2016-09-01 00:00:00

abstract：:MICA and MICB (MHC-class-I-related chain A/B) are transmembrane proteins expressed in pathological conditions that are ligands for NKG2D, an activating receptor found on cytotoxic lymphocytes. The recognition on target cells of NKG2D ligands leads to the activation of lysis and cytokine secretion by NK cells and T cel...

journal_title：European journal of immunology

authors： Agüera-González S,Gross CC,Fernández-Messina L,Ashiru O,Esteso G,Hang HC,Reyburn HT,Long EO,Valés-Gómez M

更新日期：2011-12-01 00:00:00

abstract：:Transcription factors (TFs) regulate cell-type-specific gene expression programs by combinatorial binding to cis-genomic elements, particularly enhancers, subsequently leading to the recruitment of cofactors, and the general transcriptional machinery to target genes. Using data integration of genome-wide TF binding pr...

journal_title：European journal of immunology

authors： Fang Z,Hecklau K,Gross F,Bachmann I,Venzke M,Karl M,Schuchhardt J,Radbruch A,Herzel H,Baumgrass R

更新日期：2015-11-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) caused by donor T cells attacking recipient tissues is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (alloSCT). Studies have shown that effector memory T (T(EM) ) cells do not cause GVHD but are capable of immune functions post-tr...

journal_title：European journal of immunology

authors： Anderson BE,Tang AL,Wang Y,Froicu M,Rothstein D,McNiff JM,Jain D,Demetris AJ,Farber DL,Shlomchik WD,Shlomchik MJ

更新日期：2011-09-01 00:00:00

abstract：:Two different subpopulations of anti-acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin-binding site of the receptor might...

journal_title：European journal of immunology

authors： Zurn AD,Fulpius BW

更新日期：1977-08-01 00:00:00

abstract：:T and B cells continually migrate around the body by recirculating between blood and lymph via lymphoid tissues. This is an important way of fostering the cell-cell interactions required for the initiation of an immune response. Data from previous studies of T and B cell recirculation, based on relatively complex appr...

journal_title：European journal of immunology

authors： Reynolds JD,Chin W,Shmoorkoff J

更新日期：1988-06-01 00:00:00

abstract：:We previously demonstrated that cholera toxin (CT) is highly efficient as a combined carrier and adjuvant for dendritic cell (DC) vaccination, inducing strong Th1-dominated B cell and CD4(+) T cell responses. In this study we show that vaccination with DC pre-pulsed ex vivo with CT-conjugated OVA (OVA-CT) gives rise t...

journal_title：European journal of immunology

authors： Eriksson K,Sun JB,Nordström I,Fredriksson M,Lindblad M,Li BL,Holmgren J

更新日期：2004-05-01 00:00:00