Negative feedback mechanism suppresses interleukin-12 production by antigen-presenting cells interacting with T helper 2 cells.


:Interleukin-12 (IL-12) has been shown to be produced by monocytes by the ligation of CD40. In the present experiments, IL-12 is shown to be produced by murine spleen antigen-presenting cells (APC) by interaction with T helper 1 (Th1) clones through CD40-CD40 ligand (CD40L) interaction, but not with Th2 clones. The IL-12 production induced by the Th1 clone interaction was inhibited by the addition of exogenous IL-10. Th2 clones were shown to produce a sufficient amount of IL-10 to inhibit the IL-12 production induced by Th1 clones. In the presence of anti-IL-10 monoclonal antibodies splenic APC interacting with Th2 clones produced IL-12. These results indicate that IL-10 produced by Th2 cells stimulated with antigen suppress IL-12 production of APC interacting with Th2 cells. IL-12 is composed of two subunits, p35 and p40. In our experiments, p40 mRNA accumulation was shown to be affected by IL-10 more severely than the accumulation of p35 mRNA, indicating that IL-10 regulates IL-12 production by APC mainly by affecting p40 mRNA accumulation.


Eur J Immunol


Hino A,Nariuchi H




Has Abstract


1996-03-01 00:00:00












  • Role of epitope density in the induction of tolerance and immunity with thymus-independent antigens. III. Interaction of epitope density and receptor avidity.

    abstract::The induction of B cell tolerance to 2,4-dinitrophenyl conjugates of polysaccharide antigens (levan or dextran) was studied in mice primed with keyhole limpet hemocyanin (KLH) or 2,4,6-trinitrophenylated KLH. The relationship of the epitope density of the tolerogen with avidity of B cell receptors (as judged indirectl...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Desaymard C,Pearce B,Feldmann M

    更新日期:1976-09-01 00:00:00

  • Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes.

    abstract::The murine X-linked lymphoproliferative disease scurfy is similar to the Wiskott-Aldrich syndrome in humans. Disease in scurfy (sf) mice is mediated by CD4+ T cells. Based on similarities in scurfy mice and transgenic mice that overexpress specific cytokine genes, we evaluated the expression of cytokines in the lesion...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Kanangat S,Blair P,Reddy R,Daheshia M,Godfrey V,Rouse BT,Wilkinson E

    更新日期:1996-01-01 00:00:00

  • Autoimmune murine thyroiditis IX. Relationship of humoral and cellular immunity to thyroiditis in high and low responder mice.

    abstract::Good responder (C57/Br/cd) and poor responder (C57BL/10) mice were immunized with mouse thyroid extract in Freund's complete adjuvant. The good responder mice first showed antibody to thyroglobulin on the seventh day while the poor responder animals had slightly lower titers and antibody did not appear until day 12. T...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Tomazic V,Rose NR

    更新日期:1977-01-01 00:00:00

  • In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S.

    abstract::The invariant chain (Ii) is a chaperone that regulates assembly and transport of class II MHC molecules. In the absence of the lysosomal protease cathepsin S (CatS), degradation of Ii is impaired and an Ii remnant that extends from the N terminus to about residue 110 accumulates in class II MHC-positive endosomal comp...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Boes M,van der Wel N,Peperzak V,Kim YM,Peters PJ,Ploegh H

    更新日期:2005-09-01 00:00:00

  • Intestinal parasitism terminates self tolerance and enhances neonatal induction of autoimmune disease and memory.

    abstract::Genetic and environmental factors both influence autoimmune disease occurrence, but the identity and mechanism of action of environmental factors are poorly understood. Here we show that pinworm-infected neonatal but not adult mice, injected with an ovarian self peptide of the zona pellucida protein 3 (pZP3) in water ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Agersborg SS,Garza KM,Tung KS

    更新日期:2001-03-01 00:00:00

  • Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients.

    abstract::The CD4+ T cell response is of critical importance in determining the fate of many viral infections. Clearance of HCV has a strong association with the MHC class II antigen HLA-DR11 suggesting a key role for CD4+ T cells. We used an epitope-prediction program to identify multiple novel HLA-DR11-restricted epitopes der...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Godkin A,Jeanguet N,Thursz M,Openshaw P,Thomas H

    更新日期:2001-05-01 00:00:00

  • Tertiary lymphoid organs in renal allografts can be associated with donor-specific tolerance rather than rejection.

    abstract::Tertiary lymphoid organs can form at sites of chronic inflammation. Their presence has been mainly associated with tissue destruction. In transplantation, there is a dynamic immune response as in chronic inflammation. Indeed, the presence of tertiary lymphoid organs has been associated with chronic rejection. In addit...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Brown K,Sacks SH,Wong W

    更新日期:2011-01-01 00:00:00

  • Impaired dendritic cell differentiation of CD16-positive monocytes in tuberculosis: role of p38 MAPK.

    abstract::Tuberculosis (TB) is one of the world's most pernicious diseases mainly due to immune evasion strategies displayed by its causative agent Mycobacterium tuberculosis (Mtb). Blood monocytes (Mos) represent an important source of DCs during chronic infections; consequently, the alteration of their differentiation constit...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Balboa L,Romero MM,Laborde E,Sabio Y García CA,Basile JI,Schierloh P,Yokobori N,Musella RM,Castagnino J,de la Barrera S,Sasiain MC,Alemán M

    更新日期:2013-02-01 00:00:00

  • Clonal analysis of human T cell activation by the Mycoplasma arthritidis mitogen (MAS).

    abstract::Mycoplasma arthritidis produces an as yet undefined soluble molecule (MAS) that has a potent mitogenic effect on T cells of several species. We have used cloned human cytotoxic and proliferative T lymphocytes to dissect the molecular mechanism of T cell activation by this mitogen. Reactivity to MAS is clonally express...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Matthes M,Schrezenmeier H,Homfeld J,Fleischer S,Malissen B,Kirchner H,Fleischer B

    更新日期:1988-11-01 00:00:00

  • Fetal VDJ gene repertoire in rabbit: evidence for preferential rearrangement of VH1.

    abstract::B cells in rabbit preferentially utilize the 3'-most VH gene, VH1, in VDJ genes. To determine whether the preferential utilization of VH1 results from preferential rearrangement, we examined VH gene usage in nonproductive VDJ gene rearrangements, genes that would not be influenced by antigen selection. Since nonproduc...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Tunyaplin C,Knight KL

    更新日期:1995-09-01 00:00:00

  • Human cytotoxic T cell structures associated with expression of cytolysis. I. Analysis at the clonal cell level of the cytolysis-inhibiting effect of 7 monoclonal antibodies.

    abstract::Monoclonal antibodies (mAb) derived from BALB/c mice immunized with human anti-HLA-A2 cloned cytotoxic T lymphocytes (CTL) were screened for their ability to block, in the absence of complement, the cytolytic activity of the immunizing CTL clone. Eight cytolysis-inhibiting mAb have been derived. One of these was direc...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Malissen B,Rebai N,Liabeuf A,Mawas C

    更新日期:1982-09-01 00:00:00

  • Signaling through CD19, Fc receptors or transforming growth factor-beta: each inhibits the activation of resting human B cells differently.

    abstract::To understand further the roles that negative regulatory signals may play in B cell immune responses, we compared three inhibitors of B cell proliferation: cross-linking CD19 with monoclonal antibody (mAb), signaling through Fc receptors by intact anti-mu mAb, and transforming growth factor-beta (TGF-beta). Each agent...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Barrett TB,Shu GL,Draves KE,Pezzutto A,Clark EA

    更新日期:1990-05-01 00:00:00

  • CMV and natural killer cells: shaping the response to vaccination.

    abstract::Cytomegaloviruses (CMVs) are highly prevalent, persistent human pathogens that not only evade but also shape our immune responses. Natural killer (NK) cells play an important role in the control of CMV and CMVs have in turn developed a plethora of immunoevasion mechanisms targeting NK cells. This complex interplay can...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Goodier MR,Jonjić S,Riley EM,Juranić Lisnić V

    更新日期:2018-01-01 00:00:00

  • Murine CXCR3+CD27bright NK cells resemble the human CD56bright NK-cell population.

    abstract::Human NK cells can be subdivided into CD56(dim) and CD56(bright) NK cells, which exhibit different phenotypical and functional characteristics. As murine NK cells lack CD56 or a distinct correlate, direct comparative studies of NK cells in mice and humans are limited. Although CD27 is currently proposed as a feasible ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Marquardt N,Wilk E,Pokoyski C,Schmidt RE,Jacobs R

    更新日期:2010-05-01 00:00:00

  • Identification of immunodominant donor MHC peptides following rejection and donor strain transfusion-induced tolerance of heart allografts in adult rats.

    abstract::Pre-graft priming of heart allograft recipients with donor strain blood induces tolerance in 100% of adult rats in the congenic LEW.1W to LEW.1A combination. This tolerant state is specific for donor MHC antigens as third-party blood transfusions fail to induce tolerance, and third-party skin grafts are promptly rejec...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: van Denderen B,Pêche H,Gagne K,Usal C,Cuturi MC,Soulillou JP

    更新日期:2001-05-01 00:00:00

  • Carbon monoxide-treated dendritic cells decrease β1-integrin induction on CD8⁺ T cells and protect from type 1 diabetes.

    abstract::Carbon monoxide (CO) treatment improves pathogenic outcome of autoimmune diseases by promoting tolerance. However, the mechanism behind this protective tolerance is not yet defined. Here, we show in a transgenic mouse model for autoimmune diabetes that ex vivo gaseous CO (gCO)-treated DCs loaded with pancreatic β-cell...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Simon T,Pogu S,Tardif V,Rigaud K,Rémy S,Piaggio E,Bach JM,Anegon I,Blancou P

    更新日期:2013-01-01 00:00:00

  • Gimap and T cells: a matter of life or death.

    abstract::GTPase immune-associated proteins (Gimap) genes encode evolutionarily conserved GTP-binding proteins that are preferentially expressed in immune cells. Specific members have been shown to be involved in lymphocyte development, or are associated with inflammatory and autoimmune diseases. However, the function of these ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ciucci T,Bosselut R

    更新日期:2014-02-01 00:00:00

  • Mast cell heterogeneity: two-dimensional gel electrophoretic analyses of rat peritoneal and intestinal mucosal mast cells.

    abstract::Peritoneal mast cells (PMC) and intestinal mucosal mast cells (IMMC) were purified from rats infected with the nematode Nippostrongylus brasiliensis. Overall protein constituents of both mast cell subtypes were analyzed by two-dimensional gel electrophoresis using either nonequilibrium pH gradient electrophoresis (NEP...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Abe T,Swieter M,Imai T,Hollander ND,Befus AD

    更新日期:1990-09-01 00:00:00

  • Identification and characterization of Xenopus CD8+ T cells expressing an NK cell-associated molecule.

    abstract::Growing evidence suggests that some immune responses are mediated not only by conventional and distinct NK cells and CTL, but also by T cell subsets expressing NK receptors and NK cell-associated molecules. Consistent with our previously published finding that the mAb 1F8 identifies non-T/non-B cells in Xenopus that e...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Rau L,Gantress J,Bell A,Stewart R,Horton T,Cohen N,Horton J,Robert J

    更新日期:2002-06-01 00:00:00

  • A pseudosymmetric cell adhesion regulatory domain in the beta7 tail of the integrin alpha4beta7 that interacts with focal adhesion kinase and src.

    abstract::The beta7 integrins alpha4beta7 and alphaEbeta7 play key roles in forming the gut-associated lymphoid tissue, and contribute to chronic inflammation. The alpha4beta7 integrin-mediated adhesion of activated lymphocytes is largely due to a transient increase in avidity from ligand-induced clustering of alpha4beta7 at th...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Krissansen GW,Singh J,Kanwar RK,Chan YC,Leung E,Lehnert KB,Kanwar JR,Yang Y

    更新日期:2006-08-01 00:00:00

  • Adaptive reconfiguration of the human NK-cell compartment in response to cytomegalovirus: a different perspective of the host-pathogen interaction.

    abstract::As discussed in this review, human cytomegalovirus (HCMV) infection in healthy individuals is associated with a variable and persistent increase of NK cells expressing the CD94/NKG2C activating receptor. The expansion of NKG2C(+) NK cells reported in other infectious diseases is systematically associated with HCMV co-...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Muntasell A,Vilches C,Angulo A,López-Botet M

    更新日期:2013-05-01 00:00:00

  • Immunosuppressor cells from newborn mouse spleen are macrophages differentiating in vitro from monoblastic precursors.

    abstract::Newborn mouse spleen, whose cells strongly suppress the in vitro humoral response of adult spleen cells, is essentially a hematopoietic organ. It contains a large percentage of proliferating cells, among which about 50% are erythroblasts (identified by their spectrin content) and about 15% are cells of the myelocytic ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Piguet PF,Irle C,Vassalli P

    更新日期:1981-01-01 00:00:00

  • Myeloid-derived suppressor cells in inflammation: uncovering cell subsets with enhanced immunosuppressive functions.

    abstract::Although originally described in tumor-bearing hosts, myeloid-derived suppressor cells (MDSC) have been detected under numerous pathological situations that cause enhanced demand of myeloid cells. Thus, MDSC might be part of a conserved response to different endogenous and exogenous stress signals, including inflammat...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章


    authors: Bronte V

    更新日期:2009-10-01 00:00:00

  • Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II.

    abstract::A cDNA encoding the human beta Fc gamma receptor II (FcRII) was isolated from a placental cDNA library. Analysis of the predicted amino acid sequence indicates that this receptor is synthesized with a 42-amino acid leader sequence. The mature protein consists of 249 amino acids. The leader sequence and the cytoplasmic...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Engelhardt W,Geerds C,Frey J

    更新日期:1990-06-01 00:00:00

  • Rapid IgE desensitization is antigen specific and impairs early and late mast cell responses targeting FcεRI internalization.

    abstract::Rapid IgE desensitization provides temporary tolerization for patients who have presented severe hypersensitivity reactions to food and drugs, protecting them from anaphylaxis, but the underlying mechanisms are still incompletely understood. Thus, here we develop an effective and reproducible in vitro model of rapid I...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Sancho-Serra Mdel C,Simarro M,Castells M

    更新日期:2011-04-01 00:00:00

  • Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse Langerhans cells.

    abstract::The cell surface expression and biosynthesis of Langerhans cells (LC)-derived major histocompatibility complex (MHC) class II molecules from epidermal cells (EC) prepared freshly and cultured for up to 3 days was investigated. Based on the constitutive expression of MHC class II determinants by LC, a panning and magne...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Becker D,Reske-Kunz AB,Knop J,Reske K

    更新日期:1991-05-01 00:00:00

  • Isolation of the intact white pulp. Quantitative and qualitative analysis of the cellular composition of the splenic compartments.

    abstract::The spleen is anatomically and functionally divided into two compartments: the red pulp, where particles are effectively removed from the blood, and the white pulp, where specific immune responses are generated. Here the isolation of white pulp from red pulp is described, allowing a detailed analysis of the cellular c...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Nolte MA,Hoen EN,van Stijn A,Kraal G,Mebius RE

    更新日期:2000-02-01 00:00:00

  • Systemic immunization induces protective CD4+ and CD8+ T cell-mediated immune responses in murine Listeria monocytogenes meningoencephalitis.

    abstract::The immune mechanisms underlying immunization-induced protection of mice from lethal central nervous system (CNS) listeriosis were evaluated by immunohistochemistry, flow cytometry of leukocytes isolated from the brain, reverse transcription-polymerase chain reaction analysis of intracerebral (i.c.) tumor-necrosis fac...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Schlüter D,Oprisiu SB,Chahoud S,Weiner D,Wiestler OD,Hof H,Deckert-Schlüter M

    更新日期:1995-08-01 00:00:00

  • Neuronal interferon-gamma immunoreactive molecule: bioactivities and purification.

    abstract::An interferon (IFN)-gamma immunoreactive molecule, localized to small neurons in peripheral sensory ganglia (N-IFN-gamma), has been detected with two mouse monoclonal antibodies (DB1 and DB16) directed against different epitopes of rat IFN-gamma. To define N-IFN-gamma with regard to its protein characteristics and bio...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Olsson T,Kelic S,Edlund C,Bakhiet M,Höjeberg B,van der Meide PH,Ljungdahl A,Kristensson K

    更新日期:1994-02-01 00:00:00

  • TWEAK can induce cell death via endogenous TNF and TNF receptor 1.

    abstract::TWEAK is a recently cloned novel member of the TNF ligand family. Here we show that soluble TWEAK is sufficient to induce apoptosis in Kym-1 cells within 18 h. TWEAK-induced apoptosis is indirect and is mediated by the interaction of endogenous TNF and TNF receptor (TNFR)1, as each TNFR1-Fc, neutralizing TNF-specific ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Schneider P,Schwenzer R,Haas E,Mühlenbeck F,Schubert G,Scheurich P,Tschopp J,Wajant H

    更新日期:1999-06-01 00:00:00