T and B cells have similar recirculation kinetics in sheep.

abstract：:On the premise that an individual with an intact immune system has the capability to develop both cellular and antibody immune responses supported by the balance between the lymphokines secreted by T helper (Th) cells, we studied the interaction between different types of Th cell clones in vivo and the parameters that...

journal_title：European journal of immunology

authors： Rizzo LV,DeKruyff RH,Umetsu DT,Caspi RR

更新日期：1995-03-01 00:00:00

abstract：:Lymphoid follicles of the ileal Peyer's patch (PP) of young sheep function as the major source of B cells and a site of immunoglobulin (Ig) receptor diversification. However, extensive cell death in culture has restricted investigations of ileal PP follicular (iPf)B cell biology. We investigated the possibility that s...

journal_title：European journal of immunology

authors： Griebel PJ,Ferrari G

更新日期：1994-02-01 00:00:00

abstract：:Accumulating evidence suggests that Th17 cells and Tregs may exhibit development plasticity and that CD4(+) Tregs can differentiate into IL-17-producing T cells; however, whether Th17 cells can reciprocally convert into Tregs has not been described. In this study, we generated Th17 clones from tumor-infiltrating T lym...

journal_title：European journal of immunology

authors： Ye J,Su X,Hsueh EC,Zhang Y,Koenig JM,Hoft DF,Peng G

更新日期：2011-04-01 00:00:00

abstract：:CD27, which belongs to the tumor necrosis factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsi...

journal_title：European journal of immunology

authors： Lens SM,Keehnen RM,van Oers MH,van Lier RA,Pals ST,Koopman G

更新日期：1996-05-01 00:00:00

abstract：:Two out of five murine IgG3 anti-trinitrophenyl (TNP) monoclonal antibodies (mAb) obtained either by immunization with TNP-keyhole limpet hemocyanin (KLH) (CB1, CB5, CB6 and 4H10) or with dinitrophenyl-lipopolysaccharide (9A6), exhibited anti-IgG rheumatoid factor (RF) activity (CB6 and 4H10). The anti-IgG activity of...

journal_title：European journal of immunology

authors： Reininger L,Spertini F,Shibata T,Jaton JC,Izui S

更新日期：1989-11-01 00:00:00

abstract：:The ganglioside GD3 has been described as a membrane component of human T cells which is involved in T cell growth. In the present study the activating function of GD3 for human CD4+ and CD8+ T cells was analyzed by five different monoclonal antibodies (mAb) directed against the GD3 molecule. Three mAb U5, Z21 and R24...

journal_title：European journal of immunology

authors： Claus C,Schlaak J,Dittmayer M,Meyer zum Büschenfelde K,Dippold W

更新日期：1994-05-01 00:00:00

abstract：:An interferon (IFN)-gamma immunoreactive molecule, localized to small neurons in peripheral sensory ganglia (N-IFN-gamma), has been detected with two mouse monoclonal antibodies (DB1 and DB16) directed against different epitopes of rat IFN-gamma. To define N-IFN-gamma with regard to its protein characteristics and bio...

journal_title：European journal of immunology

authors： Olsson T,Kelic S,Edlund C,Bakhiet M,Höjeberg B,van der Meide PH,Ljungdahl A,Kristensson K

更新日期：1994-02-01 00:00:00

abstract：:The host protective immune response to blood stage malaria infection was studied using Plasmodium chabaudi chabaudi (P.chabaudi) in NIH mice. It has been shown previously that CD4+ cells are critically required for protection against erythrocytic infection. Mice lacking a functional CD4+ cell compartment suffer unremi...

journal_title：European journal of immunology

authors： Taylor-Robinson AW,Phillips RS

更新日期：1994-01-01 00:00:00

abstract：:The extracellular domain of the lymphocyte surface antigen CD38 has been recently shown to share a high sequence homology with a nicotinamide adenine dinucleotide (NAD+)-specific hydrolyzing enzyme cloned from the ovotestis of the gastropod Aplysia (E. States, D.J., Walseth, T.F., Lee, H. C., Trends Biochem. Sci. 1992...

journal_title：European journal of immunology

authors： Gelman L,Deterre P,Gouy H,Boumsell L,Debré P,Bismuth G

更新日期：1993-12-01 00:00:00

abstract：:Interleukin-15 (IL-15) is an inflammatory cytokine whose role in autoimmune diseases has not been fully elucidated. Th17 cells have been shown to play critical roles in experimental autoimmune encephalomyelitis (EAE) models. In this study, we demonstrate that blockade of IL-15 signaling by TMβ-1 mAb treatment aggravat...

journal_title：European journal of immunology

authors： Yu P,Bamford RN,Waldmann TA

更新日期：2014-11-01 00:00:00

abstract：:The initiation of CD8(+) T cell (CTL) immune responses can occur via cross-priming. Recent data suggested a relationship between cross-presentation and immunodominance of epitope-specific T cells. To test this association, we evaluated the efficacy of cross-presentation for several virus epitopes in vitro and examined...

journal_title：European journal of immunology

authors： Alatery A,Tarrab E,Lamarre A,Basta S

更新日期：2010-08-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis, an experimental murine model for multiple sclerosis, is induced by stimulation of myelin-specific T lymphocytes. Myelin oligodendrocyte glycoprotein (MOG), a minor component of myelin proteins, is a potent autoantigen which contributes extensively to the anti-myelin response....

journal_title：European journal of immunology

authors： Fazilleau N,Delarasse C,Sweenie CH,Anderton SM,Fillatreau S,Lemonnier FA,Pham-Dinh D,Kanellopoulos JM

更新日期：2006-03-01 00:00:00

abstract：:Current concepts of activation of the alternative pathway of complement (APC) focus on the central role of an amplification mechanism triggered by C3b which is covalently bound to the surfact of activating substances. Using sulfated polyanions as model substances, an efficient fluid-phase activation of complement is d...

journal_title：European journal of immunology

authors： Bitter-Suermann D,Burger R,Hadding U

更新日期：1981-04-01 00:00:00

abstract：:A cell surface lectin found on activated human lymphoid cells has been identified and characterized using membrane glycoprotein micelles as probes. These micelles, which are large, water-soluble aggregates, are composed of glycoproteins isolated from detergent-solubilized membranes of human B lymphoblastoid cell lines...

journal_title：European journal of immunology

authors： Apgar JR,Cresswell P

更新日期：1982-07-01 00:00:00

abstract：:Listeria monocytogenes induces the formation of inflammasomes and subsequent caspase-1 activation, and the adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is crucial for this response. However, the role of ASC in L. monocytogenes infection in vivo is unclear. In this study, we demonstrate that ...

journal_title：European journal of immunology

authors： Tsuchiya K,Hara H,Fang R,Hernandez-Cuellar E,Sakai S,Daim S,Chen X,Dewamitta SR,Qu H,Mitsuyama M,Kawamura I

更新日期：2014-12-01 00:00:00

abstract：:The production of IL-10, a potent immunosuppressive cytokine, must be strictly regulated to ensure a balanced immune response. IFN-γ, a key cytokine in multiple immune processes and pathologies, is known as an inhibitor of IL-10 production by monocytes and macrophages, but also has some regulatory functions. In the pr...

journal_title：European journal of immunology

authors： Imbrechts M,De Samblancx K,Fierens K,Brisse E,Vandenhaute J,Mitera T,Libert C,Smets I,Goris A,Wouters C,Matthys P

更新日期：2018-09-01 00:00:00

abstract：:Despite all the structural and functional data that have been accumulated regarding major histocompatibility complex (MHC) class II molecules during recent years, the relative contribution of putative T cell receptor (TcR)-contacting residues and peptide-binding MHC polymorphisms to MHC-restricted and allospecific T c...

journal_title：European journal of immunology

authors： Coppin HL,Carmichael P,Lombardi G,L'Faqihi FE,Salter R,Parham P,Lechler RI,de Preval C

更新日期：1993-02-01 00:00:00

abstract：:Antigen-free (AGF) and germ-free (GF) mice, although essentially free of serum IgG, maintain normal levels of circulating IgM. Using a quantitative immunoblot assay, we have now analyzed the repertoire of serum IgM from AGF, GF, and specific pathogen-free (SPF) BALB/c mice, on large panels of natural antigens from hom...

journal_title：European journal of immunology

authors： Haury M,Sundblad A,Grandien A,Barreau C,Coutinho A,Nobrega A

更新日期：1997-06-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are specialized in massive production of type I interferons (IFN) upon viral infections. Activation of IFN regulatory factor (IRF)-7 is critically required for the synthesis of type I IFN in pDC. IRF-7 is highly expressed by resting pDC and translocates into the nucleus to initiate t...

journal_title：European journal of immunology

authors： Danis B,George TC,Goriely S,Dutta B,Renneson J,Gatto L,Fitzgerald-Bocarsly P,Marchant A,Goldman M,Willems F,De Wit D

更新日期：2008-02-01 00:00:00

abstract：:Orally administrated iron is suspected to increase susceptibility to enteric infections among children in infection endemic regions. Here we investigated the effect of dietary iron on the pathology and local immune responses in intestinal infection models. Mice were held on iron-deficient, normal iron, or high iron di...

journal_title：European journal of immunology

authors： Kortman GA,Mulder ML,Richters TJ,Shanmugam NK,Trebicka E,Boekhorst J,Timmerman HM,Roelofs R,Wiegerinck ET,Laarakkers CM,Swinkels DW,Bolhuis A,Cherayil BJ,Tjalsma H

更新日期：2015-09-01 00:00:00

abstract：:Alum has been the only adjuvant licensed for human vaccines for decades and is still widely used, but its mechanism of action remains obscure. Recently, the NLRP3 inflammasome has been linked to the immunostimulatory properties of alum and other particulate adjuvants, although it is disputed to what degree NLRP3 is ge...

journal_title：European journal of immunology

authors： Spreafico R,Ricciardi-Castagnoli P,Mortellaro A

更新日期：2010-03-01 00:00:00

abstract：:Durch Pflanzenkrankheiten entstehen weltweit hohe Ernteverluste. Eine der häufigsten Infektionen in der Familie der Kreuzb&luml;tengewächse wird durch den Pilz Plasmodiophora brassicae verursacht. Die Krankheit äußert sich in Form von Wurzeltumoren, den "Kohlherniegallen". Da es auf verseuchten Böden zu hohen Ernteaus...

journal_title：European journal of immunology

authors： Ludwig-Müller J

更新日期：2000-01-01 00:00:00

abstract：:Expression and function of the fractalkine receptor CX3CR1 by T lymphocyte subpopulations was evaluated in healthy individuals. In CD8(+) T lymphocytes, CX3CR1 was expressed by and functional in both CD45RO(-) and CD45RO(+) cells. In CD4(+) T lymphocytes, CX3CR1 was expressed mainly by CD45RO(+) cells, and almost excl...

journal_title：European journal of immunology

authors： Foussat A,Coulomb-L'Hermine A,Gosling J,Krzysiek R,Durand-Gasselin I,Schall T,Balian A,Richard Y,Galanaud P,Emilie D

更新日期：2000-01-01 00:00:00

abstract：:The binding of antigen to the multicomponent T cell antigen receptor (TcR)-CD3 complex leads to the activation of several signal transduction pathways which result in T lymphocyte proliferation and lymphokine secretion by molecular mechanisms and catalytic molecules as yet poorly defined. One of the earliest events th...

journal_title：European journal of immunology

authors： Gassmann M,Guttinger M,Amrein KE,Burn P

更新日期：1992-01-01 00:00:00

abstract：:Using sheep erythrocytes (SRBC) as the antigen, two subpopulations of spleen antigen-binding lymphocytes could be distinguished by a marked difference in the susceptibility of their receptors to trypsin. In unimmunized animals, 30% of the antigen-binding cells were trypsin-resistant, whereas at 5 days after immunizati...

journal_title：European journal of immunology

authors： Ashman RF

更新日期：1976-06-01 00:00:00

abstract：:Thymocytes of T cell receptor transgenic mice with nonselecting and RAG-2 -/- backgrounds were developmentally arrested at the CD4+CD8+ stage before positive selection. These thymocytes underwent lineage commitment upon transient stimulation with a combination of ionomycin, a calcium ionophore, and phorbol 12-myristat...

journal_title：European journal of immunology

authors： Iwata M,Kuwata T,Mukai M,Tozawa Y,Yokoyama M

更新日期：1996-09-01 00:00:00

abstract：:Prostein is a prostate tissue-specific protein that is uniquely and abundantly expressed in normal and cancerous prostate tissues. Due to this expression profile, we examined the immunogenicity of prostein as a potential vaccine candidate for prostate cancer. To determine the presence of CD8 T cells specific for natur...

journal_title：European journal of immunology

authors： Friedman RS,Spies AG,Kalos M

更新日期：2004-04-01 00:00:00

abstract：:In mouse Peyer's patches (PP), dendritic cells (DC) are localized in T cell areas as NLDC145+ CD11c+ cells, and in the dome and corona region of the follicle as NLDC145- CD11c+ cells, respectively, suggesting the presence of two different DC populations with distinct roles in antigen uptake, processing, and presentati...

journal_title：European journal of immunology

authors： Ruedl C,Hubele S

更新日期：1997-06-01 00:00:00

abstract：:Upon transplantation of T cells from a CD28 superagonist (CD28-SA) treated donor into an irradiated allogeneic host, the CD28-SA-induced activation and expansion of Treg cells inhibits acute graft versus host disease (aGvHD), while not abrogating the desired graft versus tumor effect. Human peripheral blood CD4(+) T c...

journal_title：European journal of immunology

authors： Beyersdorf N,Werner S,Wolf N,Hünig T,Kerkau T

更新日期：2015-07-01 00:00:00

abstract：:Cyclopentenone prostaglandins (CP-PG), such as prostaglandin A1 (PGA1) or 15-deoxy-Delta(12,14)-prostaglandin J2 (PGJ2), induce apoptosis in different cell types. PGJ2 is also a potent activator of the peroxisome proliferator-activated receptor-gamma (PPARgamma). We investigated whether PPARgamma regulates CP-PG-induc...

journal_title：European journal of immunology

authors： Erl W,Weber C,Zernecke A,Neuzil J,Vosseler CA,Kim HJ,Weber PC

更新日期：2004-01-01 00:00:00