Neuronal interferon-gamma immunoreactive molecule: bioactivities and purification.

abstract：:In previous studies, Saimiri sciureus boliviensis monkeys have been immunized with four recombinant proteins reproducing part of the circumsporozoite (CS) protein of Plasmodium vivax sporozoites (NS1(81) V20, rPvCS-1, rPvCS-2, rPv-CS-3), or with irradiated sporozoites of P. vivax Salvador I strain. To analyze the anti...

journal_title：European journal of immunology

authors： Millet P,Chizzolini C,Wirtz RA,Bathurst I,Broderson JR,Campbell GH,Collins WE

更新日期：1992-02-01 00:00:00

abstract：:Chemokines are chemotactic cytokines with a key role in the control of cell trafficking and positioning under homeostatic and inflammatory conditions. D6 is a promiscuous 7-transmembrane-domain receptor expressed on lymphatic vessels which recognizes most inflammatory, but not homeostatic, CC chemokines. In vitro expe...

journal_title：European journal of immunology

authors： Martinez de la Torre Y,Locati M,Buracchi C,Dupor J,Cook DN,Bonecchi R,Nebuloni M,Rukavina D,Vago L,Vecchi A,Lira SA,Mantovani A

更新日期：2005-05-01 00:00:00

abstract：:Recognition of foreign DNA by cytosolic innate immune receptors triggers the production of IFN-beta. However, it is unclear whether different types of DNA ligands are recognized by similar receptors and whether the resulting response is distinct from the endosomal TLR response. To address these questions, we compared ...

journal_title：European journal of immunology

authors： Karayel E,Bürckstümmer T,Bilban M,Dürnberger G,Weitzer S,Martinez J,Superti-Furga G

更新日期：2009-07-01 00:00:00

abstract：:Under physiological conditions, activation of CD4+ T cells by major histocompatibility complex (MHC)antigen complexes requires engagement of both the T cell receptor and the CD4 molecule. However, CD4 ligands binding to the CD4 molecule has also been shown to inhibit T cell proliferation and interleukin (IL)-2 product...

journal_title：European journal of immunology

authors： Jabado N,Pallier A,Jauliac S,Fischer A,Hivroz C

更新日期：1997-02-01 00:00:00

abstract：:Immunodominant T cell epitopes from the autoantigen human cartilage glycoprotein 39 have previously been mapped in the context of HLA-DR*0401 and *0402, using mice expressing HLA-DR4 transgenes. We measured the dissociation rates of these epitopes from soluble recombinant DR*0401 and DR*0402 to assess the relationship...

journal_title：European journal of immunology

authors： Hall FC,Rabinowitz JD,Busch R,Visconti KC,Belmares M,Patil NS,Cope AP,Patel S,McConnell HM,Mellins ED,Sonderstrup G

更新日期：2002-03-01 00:00:00

abstract：:Germinal centers support the differentiation of memory B cells and long-lived antibody-secreting cells during infection or upon vaccination. Here, we constructed mice with T cells that selectively lack the chemokine receptor CXCR5 to determine if expression of this receptor by T cells is mandatory for germinal center ...

journal_title：European journal of immunology

authors： Arnold CN,Campbell DJ,Lipp M,Butcher EC

更新日期：2007-01-01 00:00:00

abstract：:Glycosylphosphatidylinositol-anchored (GPI)-Db molecules are defective in mediating cytotoxic T lymphocytes (CTL) lysis of transfected lymphoma cells, compared to their transmembrane (TM) counterpart. This defect is manifest when antigenic peptide must be processed and presented through the endogenous pathway. These s...

journal_title：European journal of immunology

authors： Cariappa A,Flyer DC,Rollins CT,Roopenian DC,Flavell RA,Brown D,Waneck GL

更新日期：1996-09-01 00:00:00

abstract：:Precursor CD4-CD8- (DN) thymocytes rearrange their TCR-beta genes, and only those which succeed in beta-selection subsequently expand and differentiate into immature CD4+CD8+ (DP) thymocytes. The cell subsets corresponding to the successive steps of this transition can be defined in terms of CD44 and CD25 expression. ...

journal_title：European journal of immunology

authors： Vasseur F,Le Campion A,Pénit C

更新日期：2001-10-01 00:00:00

abstract：:In this report, we demonstrate that gp40, a molecule previously shown to be expressed by thymic epithelial cell lines in vitro and by thymic epithelial cells in vivo, is the murine homolog of human Ep-CAM, a calcium-independent homotypic adhesion molecule. gp40 is also expressed at low levels by thymocytes and periphe...

journal_title：European journal of immunology

authors： Nelson AJ,Dunn RJ,Peach R,Aruffo A,Farr AG

更新日期：1996-02-01 00:00:00

abstract：:Peptides presented by MHC class I molecules are mostly derived from proteins synthesized by the antigen-presenting cell itself, while peptides presented by MHC class II molecules are predominantly from materials acquired by endocytosis. External antigens can also be presented by MHC class I molecules in a process refe...

journal_title：European journal of immunology

authors： Hari A,Ganguly A,Mu L,Davis SP,Stenner MD,Lam R,Munro F,Namet I,Alghamdi E,Fürstenhaupt T,Dong W,Detampel P,Shen LJ,Amrein MW,Yates RM,Shi Y

更新日期：2015-02-01 00:00:00

abstract：:Infection with parasitic worms (helminths) alters host immune responses and can inhibit pathogenic inflammation. Helminth infection promotes a strong Th2 and T regulatory response while suppressing Th1 and Th17 function. Th2 responses are largely dependent on transcriptional programs directed by Stat6-signaling. We ex...

journal_title：European journal of immunology

authors： Metwali A,Winckler S,Urban JF Jr,Kaplan MH,Ince MN,Elliott DE

更新日期：2020-10-16 00:00:00

abstract：:Monoclonal antibodies MRC-OX6 and MRC-OX3 were used to define biosynthetically inter-related subsets of I-A-equivalent class II molecules from Lewis rat spleen cells. MRC-OX6 was shown to recognize specifically multiple forms of the class II molecule arising along its maturation pathway from the origin of polypeptide ...

journal_title：European journal of immunology

authors： Reske K,Weitzel R

更新日期：1985-12-01 00:00:00

abstract：:The murine monoclonal antibody (mAb) CB43, raised against the K-562 erythroleukemia line, reacts with monocytes, tissue macrophages, thymocytes and with all the human lines tested but not with resting lymphocytes, large granular lymphocytes, granulocytes and erythrocytes. However, activated lymphocytes and natural kil...

journal_title：European journal of immunology

authors： Bellone G,Alloatti G,Levi R,Geuna M,Tetta C,Peruzzi L,Letarte M,Malavasi F

更新日期：1989-01-01 00:00:00

abstract：:We provide a robust four-color fluorescence-based flow cytometry protocol that distinguishes viable dividing plasmablasts from nondividing plasma cells and, based on CD19 surface abundance, identifies two mature plasma cell populations in the spleen and the bone marrow of mice. ...

journal_title：European journal of immunology

authors： Pracht K,Meinzinger J,Daum P,Schulz SR,Reimer D,Hauke M,Roth E,Mielenz D,Berek C,Côrte-Real J,Jäck HM,Schuh W

更新日期：2017-08-01 00:00:00

abstract：:Brain invasion by Borrelia burgdorferi, the agent of Lyme disease, results in an inflammatory and neurodegenerative disorder called neuroborreliosis. In humans, neuroborreliosis has been correlated with enhanced concentration of glial fibrillary acidic protein in the cerebrospinal fluid, a sign of astrogliosis. Rhesus...

journal_title：European journal of immunology

authors： Ramesh G,Alvarez AL,Roberts ED,Dennis VA,Lasater BL,Alvarez X,Philipp MT

更新日期：2003-09-01 00:00:00

abstract：:Reciprocal expression of CD45RA and CD45RO in human CD4+ T cells defines populations understood to be naive cells (CD45RA+CD45RO-) and memory cells (CD45RA-CD45RO+). We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright a...

journal_title：European journal of immunology

authors： Horgan KJ,Tanaka Y,Luce GE,van Seventer GA,Nutman TB,Shaw S

更新日期：1994-05-01 00:00:00

abstract：:Immunoglobulin (Ig) production by lipopolysaccharide (LPS)-stimulated cells in the presence of various combinations of interleukin (IL)2, IL4 and IL5 was examined. IgG1, IgM and IgE secretion was studied using a 3T3-fibroblast filler cell-supported B cell culture system, either at low cell density to support maximal I...

journal_title：European journal of immunology

authors： McHeyzer-Williams MG

更新日期：1989-11-01 00:00:00

abstract：:IL-15 induces proliferation, inhibits apoptosis and increases IL-4 production in murine mast cells. There is evidence that these activities are mediated via the uncharacterised receptor, IL-15R-X, rather than the classical three-chain IL-15 receptor. Effects of IL-15 on important aspects of mast cell biology, such as ...

journal_title：European journal of immunology

authors： Jackson NE,Wang HW,Tedla N,McNeil HP,Geczy CL,Collins A,Grimm MC,Hampartzoumian T,Hunt JE

更新日期：2005-08-01 00:00:00

abstract：:To study allelic exclusion of TcR genes we analyzed two types (I and II) of TcR beta transgenic mice. T cells derived from both types of mice contained similar amounts of transgenic RNA transcripts; however, surface expression of the transgenic beta chain was drastically reduced in type II compared to type I. In type ...

journal_title：European journal of immunology

authors： Pircher H,Ohashi P,Miescher G,Lang R,Zikopoulos A,Bürki K,Mak TW,MacDonald HR,Hengartner H

更新日期：1990-02-01 00:00:00

abstract：:Helicobacter pylori is a Gram-negative bacterium that causes a variety of gastrointestinal diseases, such as duodenal ulcer and gastric carcinoma. The T cell response against H. pylori is thought to contribute to the pathogenesis of these diseases. Here, we show that mouse-adapted H. pylori is able to polyclonally act...

journal_title：European journal of immunology

authors： Rosenplänter C,Sommer F,Kleemann P,Belkovets A,Schmidt A,Lohoff M

更新日期：2007-07-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class II region is assumed to influence autoimmune diseases such as rheumatoid arthritis. In the mouse, the H-2q haplotype is associated with susceptibility to collagen-induced arthritis, while the H-2p haplotype is not. The class II A molecules of these haplotypes differ by ...

journal_title：European journal of immunology

authors： Brunsberg U,Gustafsson K,Jansson L,Michaëlsson E,Ahrlund-Richter L,Pettersson S,Mattsson R,Holmdahl R

更新日期：1994-07-01 00:00:00

abstract：:The structure of immunological synapses formed between murine naive T cells and mature dendritic cells has been subjected to a quantitative analysis. Immunofluorescence images of synapses formed in the absence of antigen show a diffuse synaptic accumulation of CD3 and LFA-1. In electron microscopy, these antigen-free ...

journal_title：European journal of immunology

authors： Brossard C,Feuillet V,Schmitt A,Randriamampita C,Romao M,Raposo G,Trautmann A

更新日期：2005-06-01 00:00:00

abstract：:Stimulation of human peripheral blood lymphocytes via T cell receptor/CD3 complex resulted in a bimodal activation of protein kinase(s) C (PKC). Within 10 min of stimulation PKC-alpha was translocated to, and thus activated in, the plasma membranes of human lymphocytes, followed by a fast dissociation of this isotype ...

journal_title：European journal of immunology

authors： Szamel M,Bartels F,Resch K

更新日期：1993-12-01 00:00:00

abstract：:The distribution of idiotype-positive plaques in mice of various strains injected with T-independent (TI) and T-dependent conjugates of p-azobenzenearsonate (Ars) has been investigated. With maturation of the responses there is a progressive loss of dominance of the major cross-reactive idiotype (CRI) in A/J and C.AL-...

journal_title：European journal of immunology

authors： Henry C,Lucas A

更新日期：1982-03-01 00:00:00

abstract：:T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture system in which Lineage(-) Sca1(+)c-kit(+) BM hematopoietic progenitors very efficiently differ...

journal_title：European journal of immunology

authors： Gehre N,Nusser A,von Muenchow L,Tussiwand R,Engdahl C,Capoferri G,Bosco N,Ceredig R,Rolink AG

更新日期：2015-03-01 00:00:00

abstract：:Spleen cells from BALB/c mice were fused with the nonsecreting myeloma line X63.Ag8.6.5.3 seven days after immunization with NP-CG (4-hydroxy-3-nitrophenyl) acetyl-chicken gamma-globulin. The hybrid cell lines obtained were analyzed for heavy and light chain distribution, fine specificity, and idiotype. The majority o...

journal_title：European journal of immunology

authors： White-Scharf ME,Imanishi-Kari T

更新日期：1981-11-01 00:00:00

abstract：:Accumulating evidence suggest that infection with Chlamydia pneumoniae is associated with atherosclerosis, but the mechanisms involved remain unclear. Inflammation is important in the initial phase of atherogenesis, and cytokines are important in the initiation and progression of inflammation. The aim of this study wa...

journal_title：European journal of immunology

authors： Netea MG,Selzman CH,Kullberg BJ,Galama JM,Weinberg A,Stalenhoef AF,Van der Meer JW,Dinarello CA

更新日期：2000-02-01 00:00:00

abstract：:In this report we investigated the production and role of interleukin (IL)2 and IL4 in the generation of antigen-specific cytotoxic T cells (CTL). We used as our model the ultraviolet-light-induced epithelial tumor 1591, a highly immunogenic regressor tumor which evokes a strong cell-mediated immune response leading t...

journal_title：European journal of immunology

authors： Horvat B,Loukides JA,Anandan L,Brewer E,Flood PM

更新日期：1991-08-01 00:00:00

abstract：:In viral meningitis the inflammatory response involves activated T cells and monocytes which are recruited into the subarachnoid space. To identify the chemotactic signals attracting the cells to the site of infection in the meninges, we measured the levels of two CXC chemokines, interferon-gamma (IFN-gamma) inducible...

journal_title：European journal of immunology

authors： Lahrtz F,Piali L,Nadal D,Pfister HW,Spanaus KS,Baggiolini M,Fontana A

更新日期：1997-10-01 00:00:00

abstract：:Membrane-bound IgG was found only on old populations of platelets from normal individuals. This IgG could be dissociated from senescent cells by repeatedly heating the cells. Heat-eluted IgG (He-IgG) prepared from senescent red blood cells was capable of binding to either heat-treated old platelets or Vibrio cholerae ...

journal_title：European journal of immunology

authors： Khansari N,Fudenberg HH

更新日期：1983-12-01 00:00:00