Abstract:
:The major histocompatibility complex (MHC) class II region is assumed to influence autoimmune diseases such as rheumatoid arthritis. In the mouse, the H-2q haplotype is associated with susceptibility to collagen-induced arthritis, while the H-2p haplotype is not. The class II A molecules of these haplotypes differ by only four amino acids in the first domain of the beta chain. To test if this difference accounts for the MHC influence on susceptibility to collagen-induced arthritis, H-2p mice were made transgenic with an Abp gene altered to resemble the Abq gene. The transgenic A beta chain hybridized with the A alpha p chain and was shown to be physiologically expressed by testing antigen-presentation capacity to Aq-restricted T cell hybridomas and with FACS analyses. These transgenic mice developed an autoimmune response to type II collagen and also collagen-induced arthritis. The data unequivocally suggest the Ab gene as a major genetic susceptibility locus for autoimmune collagen-induced arthritis.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Brunsberg U,Gustafsson K,Jansson L,Michaëlsson E,Ahrlund-Richter L,Pettersson S,Mattsson R,Holmdahl Rdoi
10.1002/eji.1830240736subject
Has Abstractpub_date
1994-07-01 00:00:00pages
1698-702issue
7eissn
0014-2980issn
1521-4141journal_volume
24pub_type
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