当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity.

NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity.

Abstract：

:The NKG2D receptor is expressed by human NK, gammadelta T and alpha/beta T lymphocytes and its engagement results in the stimulation of effector cells. We evaluated the role of NKG2D receptor in anti-colorectal cancer (CRC) immune response. The cell surface expression of stress-inducible NKG2D ligands MICA/B (MHC class I-related chain molecules A/B) and ULBP (UL16 binding protein) by a panel of CRC lines was evaluated by flow cytometry. MICA and ULBP2/3 were widely expressed by the analyzed lines, with a minority of them being also ULBP-1+, whereas MICB was undetectable. CD8+ and CD4+ HLA-restricted anti-tumor T cell clones of a CRC patient were used to evaluate whether NKG2D engagement could mediate tumor recognition. Three out of four CD8+ T cell clones recognized the autologous tumor with a marginal NKG2D engagement, a finding that was correlated with the weak expression of NKG2D ligands by the autologous tumor. On the contrary, NKG2D triggering of these CD8+ T cell clones induced recognition of allogeneic CRC lines showing high expression of MICA and ULBP. A costimulatory role of NKG2D was observed with one CD4+/NKG2D+ T cell clone when stimulated by tumors sharing the HLA class II alleles and expressing NKG2D ligands. Taken together these data indicate that the engagement of NKG2D, depending on the expression of its ligands by target cells, can influence the pattern of anti-tumor reactivity by T lymphocytes.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Maccalli C,Pende D,Castelli C,Mingari MC,Robbins PF,Parmiani G

doi

10.1002/eji.200323909

keywords:

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

2033-43

issue

7

eissn

0014-2980

issn

1521-4141

journal_volume

33

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Soluble anti-mu monoclonal antibodies prime resting B cells to secrete immunoglobulins in response to interleukins-4 and -5.

    abstract：:Soluble anti-immunoglobulin (Ig) antibodies have been generally found to inhibit Ig secretion in B cells, via largely unknown mechanisms. To investigate this phenomenon further a two-step culture system was used in which B cells are primed for 24-72 h with various soluble monoclonal or polyclonal anti-Ig antibodies: a...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830220629

    authors： Phillips C,Klaus GG

    更新日期：1992-06-01 00:00:00

  • Clonal expansions of V delta 1+ and V delta 2+ cells increase with age and limit the repertoire of human gamma delta T cells.

    abstract：:We have investigated the complexity of the human gamma delta T cell repertoire by means of a VJ heteroduplex analysis method. cDNA obtained from peripheral blood mononuclear cells was amplified with V delta 1-C delta or V delta 2-C delta primers. The product was denatured and renatured to allow random reannealing of t...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240830

    authors： Giachino C,Granziero L,Modena V,Maiocco V,Lomater C,Fantini F,Lanzavecchia A,Migone N

    更新日期：1994-08-01 00:00:00

  • Frequency, heterogeneity and encephalitogenicity of T cells specific for myelin oligodendrocyte glycoprotein in naive outbred primates.

    abstract：:Auto-reactive T cells present in healthy subjects remain in a state of unresponsiveness, but may trigger autoimmunity under various situations. Although myelin oligodendrocyte glycoprotein (MOG) is a potential target antigen in multiple sclerosis (MS), MOG-reactive T cell responses are present in the blood of both hea...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(2001010)31:10<2942::aid-immu2942

    authors： Villoslada P,Abel K,Heald N,Goertsches R,Hauser SL,Genain CP

    更新日期：2001-10-01 00:00:00

  • IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.

    abstract：:Mast cells are important cellular constituents of epithelial-mesenchymal interactions, densely located at sites of microbial entry into the host where they are continuously exposed to products from commensals. In order to avoid excessive activation and the associated pathology, mast cell responses to TLR agonists must...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201242786

    authors： Sandig H,Jobbings CE,Roldan NG,Whittingham-Dowd JK,Orinska Z,Takeuchi O,Akira S,Bulfone-Paus S

    更新日期：2013-04-01 00:00:00

  • Signaling through CD19, Fc receptors or transforming growth factor-beta: each inhibits the activation of resting human B cells differently.

    abstract：:To understand further the roles that negative regulatory signals may play in B cell immune responses, we compared three inhibitors of B cell proliferation: cross-linking CD19 with monoclonal antibody (mAb), signaling through Fc receptors by intact anti-mu mAb, and transforming growth factor-beta (TGF-beta). Each agent...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200516

    authors： Barrett TB,Shu GL,Draves KE,Pezzutto A,Clark EA

    更新日期：1990-05-01 00:00:00

  • Rheumatoid factors and secondary immune responses in the mouse. I. Frequent occurrence of hybridomas secreting IgM anti-IgG1 autoantibodies after immunization with protein antigens.

    abstract：:The involvement of rheumatoid factor (RF)-secreting cells in normal immune responses was examined by screening hybridomas derived from 129/Sv mice during primary and secondary immune responses against foreign proteins. No RF-secreting cells were detected during primary responses, but up to 10% of the total number of c...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830131106

    authors： Van Snick J,Coulie P

    更新日期：1983-11-01 00:00:00

  • Defective T-cell receptor-induced apoptosis of T cells and rejection of transplanted immunogenic tumors in p53(-/-) mice.

    abstract：:Mice lacking the tumor suppressor gene p53 spontaneously develop T-cell lymphomas at a high rate, suggesting that in these mice lymphomas arise due to defective apoptosis mechanisms in T cells mediated by p53. However, a role of p53 in regulation of T-cell responses or apoptosis has been poorly defined. TCR-mediated s...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200939736

    authors： Singh N,Huang L,Qin H

    更新日期：2010-02-01 00:00:00

  • Antigen-specific T cell receptor antagonism by antigen-presenting cells treated with the hemolysin of Listeria monocytogenes: a novel type of immune escape.

    abstract：:We have examined the influence of listeriolysin O (LLO), the hemolysin secreted by the pathogenic bacterium Listeria monocytogenes, on major histocompatibility complex class II-dependent T cell activation. Stimulation of T cells by native antigens but not by peptides is inhibited upon pretreatment of antigen-presentin...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270716

    authors： Darji A,Stockinger B,Wehland J,Chakraborty T,Weiss S

    更新日期：1997-07-01 00:00:00

  • Cyclosporin A inhibits the delayed-type hypersensitivity reaction: impaired production of early pro-inflammatory mediator(s).

    abstract：:The effect of cyclosporin A (CsA) on the delayed-type hypersensitivity (DTH) elicited in mice by sheep red blood cells was investigated. Evidence is presented that a single injection of CsA adversely affects the inflammatory reaction. Sensitized T lymphocytes initiate the DTH reaction by their recruiting activity on p...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830140407

    authors： Shidani B,Milon G,Marchal G,Truffa-Bachi P

    更新日期：1984-04-01 00:00:00

  • Development of a novel Ag-specific immunotherapy using CpG oligodeoxynucleotides in a new, unique mouse cutaneous eosinophilic inflammation model.

    abstract：:The number of patients with severe atopic dermatitis (AD) has been on the rise recently. We are therefore urgently in need of a treatment that can suppress Th2 cell-mediated responses in an Ag-specific fashion. Oligodeoxynucleotides (ODN)containing CpG motifs (CpG ODN) have been highlighted as immunomodulators that re...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200526274

    authors： Kootiratrakarn T,Fujimura T,Sano K,Okuyama R,Aiba S,Tagami H,Terui T

    更新日期：2005-11-01 00:00:00

  • Clonal analysis of human T cell activation by the Mycoplasma arthritidis mitogen (MAS).

    abstract：:Mycoplasma arthritidis produces an as yet undefined soluble molecule (MAS) that has a potent mitogenic effect on T cells of several species. We have used cloned human cytotoxic and proliferative T lymphocytes to dissect the molecular mechanism of T cell activation by this mitogen. Reactivity to MAS is clonally express...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830181112

    authors： Matthes M,Schrezenmeier H,Homfeld J,Fleischer S,Malissen B,Kirchner H,Fleischer B

    更新日期：1988-11-01 00:00:00

  • Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity.

    abstract：:Mast cells are widely distributed in tissues, particularly near surfaces exposed to the environment. Mast cells can be activated to secrete diverse mediators and cytokines by IgE and specific Ag and many other stimuli, including products derived from either pathogens or the host during innate immune responses. Althoug...

    journal_title：European journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1002/eji.201040559

    authors： Galli SJ,Tsai M

    更新日期：2010-07-01 00:00:00

  • Subclasses of T cells with different sensitivities to cytotoxic antibody in the presence of anesthetics.

    abstract：:When cytotoxic titrations were made of rabbit anti-mouse brain and anti-Thy-1.2 sera against mouse lymphoid cells in the presence of sodium barbital or xylocaine, it was observed that a proportion of T cells were much more sensitive (50 x) than the remainder. This effect could be detected with ethidium or fluorescein ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830050408

    authors： Lee SK,Singh J,Taylor RB

    更新日期：1975-04-01 00:00:00

  • The transcription factor Pit-1/GHF-1 is expressed in hemopoietic and lymphoid tissues.

    abstract：:The expression of the Pit-1/GHF-1 transcription factor (hereafter Pit-1), which controls the expression of growth hormone (GH) and prolactin (PRL) in the pituitary gland, has been documented in human and rat hemopoietic and lymphoid tissues and cell lines. Pit-1 mRNA was detected by in situ hybridization in about 1% o...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830230428

    authors： Delhase M,Vergani P,Malur A,Hooghe-Peters EL,Hooghe RJ

    更新日期：1993-04-01 00:00:00

  • Tertiary lymphoid organs in renal allografts can be associated with donor-specific tolerance rather than rejection.

    abstract：:Tertiary lymphoid organs can form at sites of chronic inflammation. Their presence has been mainly associated with tissue destruction. In transplantation, there is a dynamic immune response as in chronic inflammation. Indeed, the presence of tertiary lymphoid organs has been associated with chronic rejection. In addit...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201040759

    authors： Brown K,Sacks SH,Wong W

    更新日期：2011-01-01 00:00:00

  • α-Galactosylceramide-activated murine NK1.1(+) invariant-NKT cells in the myometrium induce miscarriages in mice.

    abstract：:Innate immunity, which is unable to discriminate self from allo-antigens, is thought to be important players in the induction of miscarriages. Here, we show that the administration of IL-12 to syngeneic-mated C57BL/6 mice on gestation day 7.5 (Gd 7.5), drives significant miscarriages in pregnant females. Furthermore, ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201545923

    authors： Ichikawa T,Negishi Y,Shimizu M,Takeshita T,Takahashi H

    更新日期：2016-08-01 00:00:00

  • Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules.

    abstract：:Lipid antigens are presented to T cells by the non-polymorphic MHC class I-related CD1 molecules. Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident chaperone that has been shown to lipidate the group 2 CD1 molecule CD1d and thus to regulate its function. We now report that MTP al...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200738102

    authors： Kaser A,Hava DL,Dougan SK,Chen Z,Zeissig S,Brenner MB,Blumberg RS

    更新日期：2008-08-01 00:00:00

  • Inhibition of clonal expansion by Foxp3 expression as a mechanism of controlled T-cell responses and autoimmune disease.

    abstract：:The essential role of the transcription factor Foxp3 in the development and function of Treg has been well documented. The role of Foxp3 in non-Treg, however, is not fully understood. Emerging evidence indicates that Foxp3 expression is not confined to CD4+CD25+ Treg. The present study shows that in Foxp3 transgenic (...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200939404

    authors： Guo L,Tian J,Marinova E,Zheng B,Han S

    更新日期：2010-01-01 00:00:00

  • Cytotoxic T cell response against lymphoblasts infected with Moloney (Abelson) murine leukemia virus. Methodological aspects and H-2 requirements.

    abstract：:A method for infection of lymphocytes with Moloney(Abelson) murine leukemia virus [M(A)-MuLV] is described. Only lymphoblasts obtained after stimulation of normal spleen cells by the B cell mitogen lipopolysaccharide (LPS) were satisfactory targets for virus-specific, secondary cytotoxic T lymphocytes (CTL), whereas s...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830110316

    authors： Stukart MJ,Vos A,Melitef CJ

    更新日期：1981-03-01 00:00:00

  • Paxillin phosphorylation by JNK and p38 is required for NFAT activation.

    abstract：:Paxillin is an adaptor protein associated with focal adhesion complex, and is activated by tyrosine phosphorylation through focal adhesion kinase (FAK) and Src kinase. Recent studies reveal that serine phosphorylation of paxillin by JNK and p38 MAPK is essential for cell migration or neurite extension, but their cellu...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201142192

    authors： Lee YC,Chang AY,Lin-Feng MH,Tsou WI,Chiang IH,Lai MZ

    更新日期：2012-08-01 00:00:00

  • Redirecting soluble antigen for MHC class I cross-presentation during phagocytosis.

    abstract：:Peptides presented by MHC class I molecules are mostly derived from proteins synthesized by the antigen-presenting cell itself, while peptides presented by MHC class II molecules are predominantly from materials acquired by endocytosis. External antigens can also be presented by MHC class I molecules in a process refe...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201445156

    authors： Hari A,Ganguly A,Mu L,Davis SP,Stenner MD,Lam R,Munro F,Namet I,Alghamdi E,Fürstenhaupt T,Dong W,Detampel P,Shen LJ,Amrein MW,Yates RM,Shi Y

    更新日期：2015-02-01 00:00:00

  • R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T cell clonal anergy.

    abstract：:R24 is a monoclonal antibody directed against the cell surface ganglioside GD3. It can detect GD3 on the surface of a subset of T lymphocytes and can stimulate proliferation and secretion of cytokines in vitro. In the present report, we examined the effects of the R24 antibody upon antigen-specific T cell response, em...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260928

    authors： Boussiotis VA,Pardo NA,Collins H,Houghton A,Ritz J,Nadler LM,Soiffer RJ

    更新日期：1996-09-01 00:00:00

  • Persisting alloantigen prevents primed CD45RC- CD4 T cells from inducing allograft rejection: implications for immunological memory.

    abstract：:Antigen stimulation induces specific CD4 T cells to change from a resting phenotype (CD45RC+) to a "memory" phenotype (CD45RC-), an isoform switch that is reversible and regulated by persisting antigen. We show here that CD4 T cells responsible for mediating allograft rejection undergo a similar CD45RC+ to CD45RC- swi...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199907)29:07<2177::AID-IMM

    authors： Yang CP,Bell EB

    更新日期：1999-07-01 00:00:00

  • Binding of Coprococcus comes to the Fc portion of IgG. A possible role in the pathogenesis of Crohn's disease?

    abstract：:Previous studies have shown that the fecal flora of patients with Crohn's disease (CD) differed from the flora of healthy subjects by a higher number of anaerobic gram-positive coccoid rods. Sera from patients with CD agglutinated four strains of coccoid rods (Me44, C18, Me46 and Me47) more frequently and stronger tha...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830150823

    authors： Van de Merwe JP,Stegeman JH

    更新日期：1985-08-01 00:00:00

  • Curative treatment of experimental autoimmune thyroiditis by in vivo administration of plasmid DNA coding for interleukin-10.

    abstract：:The autoimmune response in experimental autoimmune thyroiditis (EAT) is characterized by a lymphocyte infiltration of the thyroid gland and by the appearance of circulating autoantibodies to thyroglobulin (Tg). Cytokines play a crucial role in the immunoregulation and pathology of EAT. Systemic administration of IL-10...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199903)29:03<958::AID-IMMU

    authors： Batteux F,Trebeden H,Charreire J,Chiocchia G

    更新日期：1999-03-01 00:00:00

  • Mycobacterium tuberculosis RpfE promotes simultaneous Th1- and Th17-type T-cell immunity via TLR4-dependent maturation of dendritic cells.

    abstract：:Reciprocal induction of the Th1 and Th17 immune responses is essential for optimal protection against Mycobacterium tuberculosis (Mtb); however, only a few Mtb antigens are known to fulfill this task. A functional role for resuscitation-promoting factor (Rpf) E, a latency-associated member of the Rpf family, in promot...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201445329

    authors： Choi HG,Kim WS,Back YW,Kim H,Kwon KW,Kim JS,Shin SJ,Kim HJ

    更新日期：2015-07-01 00:00:00

  • Cartilage-specific autoimmunity in rheumatoid arthritis: characterization of a triple helical B cell epitope in the integrin-binding-domain of collagen type II.

    abstract：:Cartilage-specific proteins are considered potential autoantigens that could continuously fuel autoimmune responses directed to the joints in rheumatoid arthritis (RA). Using recombinant chimeric collagen type II we have identified one major type II collagen (CII) epitope (denoted U1) recognized by RA sera. The U1 epi...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200106)31:6<1666::aid-immu1666>3

    authors： Kraetsch HG,Unger C,Wernhoff P,Schneider C,Kalden JR,Holmdahl R,Burkhardt H

    更新日期：2001-06-01 00:00:00

  • TCR-beta chains derived from peripheral gammadelta T cells can take part in alphabeta T-cell development.

    abstract：:Between 10 and 20% of the peripheral gammadelta T cells express cytoplasmic TCR-beta proteins, but whether such TCR-beta chains can partake in alphabeta T-cell development has never been systematically investigated. Therefore, we reconstituted the T-cell compartment of CD3epsilon-deficient mice with Pax5-TCR-beta defi...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200838668

    authors： Bosco N,Engdahl C,Bénard A,Rolink J,Ceredig R,Rolink AG

    更新日期：2008-12-01 00:00:00

  • Evidence for the stochastic acquisition of cytokine profile by CD4+ T cells activated in a T helper type 2-like response in vivo.

    abstract：:The diversity of cytokine production patterns displayed by T cells activated in vivo was investigated by analyzing short-term antigen-specific CD4+ T cell clones and single CD4+ T cells derived from draining lymph nodes of mice undergoing a T helper 2 (Th2)-like response to keyhole limpet hemocyanin (KLH). On average,...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830250506

    authors： Kelso A,Groves P,Troutt AB,Francis K

    更新日期：1995-05-01 00:00:00

  • Protective anti-mycobacterial T cell responses through exquisite in vivo activation of vaccine-targeted dendritic cells.

    abstract：:Vaccine efficacy largely depends upon DC targeting and activation. The most potent TLR soluble ligands induce diffuse DC activation, which may be associated with marked pro-inflammatory responses and possibly adverse effects. This raises the concern that effective vaccine adjuvants may similarly rely on widespread DC ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200737889

    authors： Kamath AT,Valenti MP,Rochat AF,Agger EM,Lingnau K,von Gabain A,Andersen P,Lambert PH,Siegrist CA

    更新日期：2008-05-01 00:00:00