Cytotoxic T cell response against lymphoblasts infected with Moloney (Abelson) murine leukemia virus. Methodological aspects and H-2 requirements.

abstract：:Germinal centers support the differentiation of memory B cells and long-lived antibody-secreting cells during infection or upon vaccination. Here, we constructed mice with T cells that selectively lack the chemokine receptor CXCR5 to determine if expression of this receptor by T cells is mandatory for germinal center ...

journal_title：European journal of immunology

authors： Arnold CN,Campbell DJ,Lipp M,Butcher EC

更新日期：2007-01-01 00:00:00

abstract：:Upon antigen-specific or allogeneic activation, T cells sharply increase their metabolic activity to cope with augmented needs for proliferation and effector functions. Therefore, enzymes involved in energy metabolism constitute attractive targets to modulate the activity of pathogenic effector T cells in the setting ...

journal_title：European journal of immunology

authors： Raha S,Raud B,Oberdörfer L,Castro CN,Schreder A,Freitag J,Longerich T,Lochner M,Sparwasser T,Berod L,Koenecke C,Prinz I

更新日期：2016-09-01 00:00:00

abstract：:Twenty-seven B cell hybridomas derived from spleen cells of nonimmunized, 6-day-old BALB/c mice and previously characterized serologically were screened for VH-gene expression: hybridomas expressing the two most D-proximal VH-gene families, 7183 and QUPC 52 were over-represented in this sample. Strikingly, clones sero...

journal_title：European journal of immunology

authors： Holmberg D

更新日期：1987-03-01 00:00:00

abstract：:Intravenous immunoglobulins (IVIgs) efficiently suppress a variety of autoimmune diseases. Over the past few years several potential mechanisms underlying this antiinflammatory activity have become apparent. Among these, terminal sialic acid residues in the sugar moiety of the immunoglobulin G constant fragment have b...

journal_title：European journal of immunology

authors： Schwab I,Seeling M,Biburger M,Aschermann S,Nitschke L,Nimmerjahn F

更新日期：2012-12-01 00:00:00

abstract：:Although most cells of the T cell receptor (TcR) gamma/delta lineage are CD4-CD8-, some gamma/delta cells express CD8. We show here that mouse thymic gamma/delta cells express CD8 following in vitro activation by concanavalin A. Staining with monoclonal and polyclonal antibodies to the CD8 alpha (Ly-2) and CD8 beta (L...

journal_title：European journal of immunology

authors： MacDonald HR,Schreyer M,Howe RC,Bron C

更新日期：1990-04-01 00:00:00

abstract：:H-2 gene-dependent nonresponsiveness and responsiveness to H-2-matched male cells can be observed in cytotoxic assays in several mouse strains. H-2 genes of several low responder strains can complement each other in cis or trans position to produce high responders. One of the H-2 gene products functions at the level o...

journal_title：European journal of immunology

authors： von Boehmer H,Fathman CG,Haas W

更新日期：1977-07-01 00:00:00

abstract：:The MRC OX-47 monoclonal antibody recognizes a membrane antigen present at low levels on many lymphocytes but whose expression is markedly increased on activation with mitogens. cDNA clones for the OX-47 antigen were isolated from an expression library and the protein sequence deduced. It contains a leader sequence gi...

journal_title：European journal of immunology

authors： Fossum S,Mallett S,Barclay AN

更新日期：1991-03-01 00:00:00

abstract：:To investigate the effect of HIV-specific CD8(+) T cells on viral plasma load and disease progression, we enumerated HLA-A2-, B8- and B57-restricted CD8(+) T cells directed against several HIV epitopes in a total of 54 patients by the use of tetrameric HLA-peptide complexes. In patients with high CD4(+) T cell numbers...

journal_title：European journal of immunology

authors： Kostense S,Ogg GS,Manting EH,Gillespie G,Joling J,Vandenberghe K,Veenhof EZ,van Baarle D,Jurriaans S,Klein MR,Miedema F

更新日期：2001-03-01 00:00:00

abstract：:The 20S proteasome is a protease complex of functional importance for antigen processing. Two of the 14 proteasome subunits, delta and MB1, can be replaced by the major histocompatibility complex (MHC)-encoded and interferon-gamma (IFN-gamma)-inducible subunits LMP2 and LMP7, respectively. LMP2 and LMP7 alter the clea...

journal_title：European journal of immunology

authors： Groettrup M,Kraft R,Kostka S,Standera S,Stohwasser R,Kloetzel PM

更新日期：1996-04-01 00:00:00

abstract：:CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of resting B cells, immunoglobulin (Ig) secretion from B cells cultured with cytokines and cytokine secretion and tumoricidal activity from monocytes. In this report...

journal_title：European journal of immunology

authors： Armitage RJ,Tough TW,Macduff BM,Fanslow WC,Spriggs MK,Ramsdell F,Alderson MR

更新日期：1993-09-01 00:00:00

abstract：:Two interleukin 5 (IL5)-specific retroviral expression vectors have been constructed containing the neomycin gene as selectable marker and either the mouse IL5 cDNA region or the rat genomic IL5 gene under the control of the thymidine kinase promoter. High viral titer supernatants derived from the transfected or infec...

journal_title：European journal of immunology

authors： Blankenstein T,Li WQ,Uberla K,Qin ZH,Tominaga A,Takatsu K,Yamaguchi N,Diamantstein T

更新日期：1990-12-01 00:00:00

abstract：:A comparison of the clonal nature of the immune response to phosphorylcholine (PC) was made in nine different inbred mouse strains. Quantitative idiotypic analysis showed that anti-PC antibodies from each strain were composed of antibodies bearing binding-site idiotypic determinants indistinguishable from two differen...

journal_title：European journal of immunology

authors： Claflin JL

更新日期：1976-10-01 00:00:00

abstract：:The germ-line V gene segments encoding the subgroups A and G of the BALB/c V kappa 21 family were cloned and assigned to the previously described 30-kb cluster of the V kappa 21 family. Sequence comparison revealed close homology between the two gene segments at the DNA and the predicted amino acid sequence level, ind...

journal_title：European journal of immunology

authors： Alanen A,Weiss S

更新日期：1989-10-01 00:00:00

abstract：:We have previously reported the development of a two-step culture system in which soluble anti-mu monoclonal antibodies prime small resting murine B cells to secrete immunoglobulin (Ig) in response to restimulation with a mixture of interleukin-4 (IL-4) and IL-5. Here we have extended these studies to investigate the ...

journal_title：European journal of immunology

authors： Phillips C,Klaus GG

更新日期：1993-02-01 00:00:00

abstract：:Immune enhancement is desirable in situations where decreased immunity results in increased morbidity. We investigated whether blocking the surface inhibitory receptor PD-1 and/or p38 MAP kinase could enhance the proliferation of the effector memory CD8(+) T-cell subset that re-expresses CD45RA (EMRA) and exhibits cha...

journal_title：European journal of immunology

authors： Henson SM,Macaulay R,Riddell NE,Nunn CJ,Akbar AN

更新日期：2015-05-01 00:00:00

abstract：:IL-18 was originally described as a cytokine which induced IFN-gamma production by established Th1 cells in an IL-12-independent manner. However, subsequent studies demonstrated that exogenous IL-18 in the absence of IL-12 failed to drive Th1 differentiation of naive cells and induced IFN-gamma from established Th1 ce...

journal_title：European journal of immunology

authors： Chang JT,Segal BM,Nakanishi K,Okamura H,Shevach EM

更新日期：2000-04-01 00:00:00

abstract：:Dopamine by itself has not up to now been reported to activate T cell function. We show here that dopamine interacts directly with dopaminergic receptors on normal human T cells and triggers beta1 integrin-mediated T cell adhesion to a major extracellular matrix component, fibronectin (FN). Such adhesion is a characte...

journal_title：European journal of immunology

authors： Levite M,Chowers Y,Ganor Y,Besser M,Hershkovits R,Cahalon L

更新日期：2001-12-01 00:00:00

abstract：:A small dose of the IgG1 fraction of anti-idiotypic antibody (aId1) raised in guinea pigs against a strain A/J antibody specific for streptococcal Group A carbohydrate sensitizes A/J mice against Group A streptococci. This is opposed to the previously established suppressive function of anti-idiotypic antibody of the ...

journal_title：European journal of immunology

authors： Eichmann K,Rajewsky K

更新日期：1975-10-01 00:00:00

abstract：:Stromal elements are major components of lymphoid tissues contributing to both tissue architecture and function. In this study we report on the phenotype and function of fibroblast-like stromal cells obtained from human spleen. These cells express high levels of CD44 and ICAM-1 and moderate levels of VLA-4, VCAM, CD40...

journal_title：European journal of immunology

authors： Skibinski G,Skibinska A,Stewart GD,James K

更新日期：1998-12-01 00:00:00

abstract：:The role of mineralocorticoid receptors (MRs) in human T-cell migration is not yet understood. We have recently shown that the MR antagonist spironolactone selectively increases the numbers of circulating naïve and central memory T cells during early sleep, which is the time period in the 24 h cycle hallmarked by pred...

journal_title：European journal of immunology

authors： Besedovsky L,Linz B,Born J,Lange T

更新日期：2014-06-01 00:00:00

abstract：:A detailed restriction map of a 430-kb contig comprising the single Ckappa, the 5 Jkappa and the adjoining 22 Vkappa gene segments is presented. The first 12 Vkappa genes following the JkappaCkappa region belong to the Vkappa21 family, the subsequent ones to the closely related families Vkappa8 and Vkappal 9/ 28. Prev...

journal_title：European journal of immunology

authors： Kirschbaum T,Pourrajabi S,Zocher I,Schwendinger J,Heim V,Röschenthaler F,Kirschbaum V,Zachau HG

更新日期：1998-05-01 00:00:00

abstract：:Peritoneal macrophages from C57BL/6 mice process antigens from bacteria or coated on polystyrene beads for presentation by major histocompatibility complex (MHC) class I molecules. To investigate this antigen processing pathway, peritoneal macrophages from homozygous TAP1-/- mice, which lack the transporter associated...

journal_title：European journal of immunology

authors： Wick MJ,Pfeifer JD

更新日期：1996-11-01 00:00:00

abstract：:Expression of activation markers and proliferative status were measured in peripheral CD4+ and CD8+ T cells of various T cell receptor (TCR)-transgenic mice either before or after intentional antigenic stimulation. In the absence of intentional immunization, CD4+ T cells persisted as resting or partially activated and...

journal_title：European journal of immunology

authors： Bruno L,von Boehmer H,Kirberg J

更新日期：1996-12-01 00:00:00

abstract：:Alkaline phosphatases (APases, EC 3.1.3.1) are ecto-enzymes bound to cell membranes by a phosphatidyl-inositol anchor. We have previously shown that APase is present on activated murine B cells and its expression correlates with the process of B cell differentiation into immunoglobulin secretion. Recently, a monoclona...

journal_title：European journal of immunology

authors： Márquez C,De la Hera A,Leonardo E,Pezzi L,Strasser A,Martínez-A C

更新日期：1990-04-01 00:00:00

abstract：:The autoimmune disease systemic lupus erythematosus is characterized by loss of tolerance to nuclear Ags and a heightened inflammatory environment, which together result in end organ damage. Lyn-deficient mice, a model of systemic lupus erythematosus, lack an inhibitor of B-cell and myeloid cell activation. This resul...

journal_title：European journal of immunology

authors： Gutierrez T,Mayeux JM,Ortega SB,Karandikar NJ,Li QZ,Rakheja D,Zhou XJ,Satterthwaite AB

更新日期：2013-02-01 00:00:00

abstract：:IL-12 is an important immunomodulatory cytokine that induces tyrosine phosphorylation and activation of the signal transducer and activator of transcription (STAT)4. IL-12 induces sustained activation and nuclear translocation of STAT4 and this regulatory process is coupled to both tyrosine and serine phosphorylation ...

journal_title：European journal of immunology

authors： Athié-M V,Flotow H,Hilyard KL,Cantrell DA

更新日期：2000-05-01 00:00:00

abstract：:Dermal and mucosal lymphocyte infiltrates in patients with lichen ruber planus and chronic graft-vs.-host disease exhibited reactivity with anti-fibronectin antibodies. This reactivity was associated with the lymphocytes and localized pericellularly. In contrast, biopsy areas outside lymphocyte accumulations were rela...

journal_title：European journal of immunology

authors： Sundqvist KG,Wanger L,Heimdahl A,Lönnqvist B,Hauzenberger D

更新日期：1991-02-01 00:00:00

abstract：:High-dose infusion of IgG (IVIG) is used to treat autoimmune and inflammatory diseases, including Kawasaki disease (KD). Although the immunomodulatory effects of IVIG on blood cells such as macrophages have been well studied, its effects on tissue cells remain unclear. Here, we show that high-dose IgG specifically and...

journal_title：European journal of immunology

authors： Matsuda A,Morita H,Unno H,Saito H,Matsumoto K,Hirao Y,Munechika K,Abe J

更新日期：2012-08-01 00:00:00

abstract：:Cyclosporin A (CsA), an immunosuppressive drug which completely suppresses the humoral response to thymus-dependent antigens, does not affect the generation of T helper (Th) cells during an in vitro stimulation of murine spleen cells with sheep red blood cells. The appearance of Th cells depends on time and their deve...

journal_title：European journal of immunology

authors： Motta I,Colle JH,Shidani B,Truffa-Bachi P

更新日期：1991-03-01 00:00:00

abstract：:Cytomegaloviruses (CMVs) are highly prevalent, persistent human pathogens that not only evade but also shape our immune responses. Natural killer (NK) cells play an important role in the control of CMV and CMVs have in turn developed a plethora of immunoevasion mechanisms targeting NK cells. This complex interplay can...

journal_title：European journal of immunology

authors： Goodier MR,Jonjić S,Riley EM,Juranić Lisnić V

更新日期：2018-01-01 00:00:00