Interleukin 2/interleukin 4-independent T helper cell generation during an in vitro antigenic stimulation of mouse spleen cells in the presence of cyclosporin A.

abstract：:Naive and central memory CD8 T cells use CCR7 to recirculate through T cell zones of secondary lymphoid organs where they can encounter antigen. Here we describe a subset of human CD8 T cells expressing CXCR5 which enables homing in response to CXCL13 produced within B cell follicles. CXCR5+ CD8 T cells were found in ...

journal_title：European journal of immunology

authors： Quigley MF,Gonzalez VD,Granath A,Andersson J,Sandberg JK

更新日期：2007-12-01 00:00:00

abstract：:To investigate the effect of HIV-specific CD8(+) T cells on viral plasma load and disease progression, we enumerated HLA-A2-, B8- and B57-restricted CD8(+) T cells directed against several HIV epitopes in a total of 54 patients by the use of tetrameric HLA-peptide complexes. In patients with high CD4(+) T cell numbers...

journal_title：European journal of immunology

authors： Kostense S,Ogg GS,Manting EH,Gillespie G,Joling J,Vandenberghe K,Veenhof EZ,van Baarle D,Jurriaans S,Klein MR,Miedema F

更新日期：2001-03-01 00:00:00

abstract：:The variable region nucleotide sequences of seven (five IgM and two IgG) anti-histone monoclonal antibodies from a single MRL/Mp-lpr/lpr mouse have been determined. These antibodies are not clonally related and used diverse V, D and J genes. However, six of the seven antibodies have VH segments encoded by genes from t...

journal_title：European journal of immunology

authors： Monestier M

更新日期：1991-07-01 00:00:00

abstract：:The effect of cyclosporin A (CsA) on the delayed-type hypersensitivity (DTH) elicited in mice by sheep red blood cells was investigated. Evidence is presented that a single injection of CsA adversely affects the inflammatory reaction. Sensitized T lymphocytes initiate the DTH reaction by their recruiting activity on p...

journal_title：European journal of immunology

authors： Shidani B,Milon G,Marchal G,Truffa-Bachi P

更新日期：1984-04-01 00:00:00

abstract：:Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that activate innate immune inflammatory responses, however, mechanism(s) by which SFAs control inflamma...

journal_title：European journal of immunology

authors： Davis FM,denDekker A,Joshi AD,Wolf SJ,Audu C,Melvin WJ,Mangum K,Riordan MO,Kunkel SL,Gallagher KA

更新日期：2020-12-01 00:00:00

abstract：:Colony-stimulating factors are required for survival proliferation, differentiation and functional activation of granulocytes, macrophages and their precursor cells. In the present report, however, we demonstrate antiproliferative activity of recombinant human (rh) granulocyte-macrophage colony-stimulating factor (GM-...

journal_title：European journal of immunology

authors： Lindemann A,Riedel D,Oster W,Mertelsmann R,Herrmann F

更新日期：1988-03-01 00:00:00

abstract：:Mice lacking the tumor suppressor gene p53 spontaneously develop T-cell lymphomas at a high rate, suggesting that in these mice lymphomas arise due to defective apoptosis mechanisms in T cells mediated by p53. However, a role of p53 in regulation of T-cell responses or apoptosis has been poorly defined. TCR-mediated s...

journal_title：European journal of immunology

authors： Singh N,Huang L,Qin H

更新日期：2010-02-01 00:00:00

abstract：:Endoglin is an homodimeric membrane antigen with capacity to bind transforming growth factor-beta (TGF-beta) and whose expression is up-regulated on myeloid cells upon differentiation to macrophages. We have isolated full-length cDNA clones from a lambda gt 10 library, prepared from phorbol 12-myristate 13-acetate-dif...

journal_title：European journal of immunology

authors： Bellón T,Corbí A,Lastres P,Calés C,Cebrián M,Vera S,Cheifetz S,Massague J,Letarte M,Bernabéu C

更新日期：1993-09-01 00:00:00

abstract：:At the surface of the murine T lymphoma cell line RMA-S, the expression of "empty" class I molecules can be dramatically enhanced by culture at 26 degrees C. These class I molecules are unstable following transfer to 37 degrees C unless they are loaded with exogenously added peptides. Class I heterodimers that have fa...

journal_title：European journal of immunology

authors： Neefjes JJ,Smit L,Gehrmann M,Ploegh HL

更新日期：1992-06-01 00:00:00

abstract：:A human lymphoid cell ine (S95) with surface-located IgG is described. The line was derived from a patient with Hodgkin's disease and is aneuploid. Its characteristics are suggestive of a malignant B lymphocyte derivation, but no ultimate proof of malignancy can be forwarded. The line produces immunoglobulin (IgG) whi...

journal_title：European journal of immunology

authors： Nilsson K,Ghetie V,Sjöquist J

更新日期：1975-08-01 00:00:00

abstract：:Leishmaniases are a major international public health problem, and macrophages are crucial for host resistance to this parasite. To determine if phosphatase and tensin homologue deleted on chromosome ten (Pten), a negative regulator of the PI3K pathway, plays a role in macrophage-mediated resistance to Leishmania, we ...

journal_title：European journal of immunology

authors： Kuroda S,Nishio M,Sasaki T,Horie Y,Kawahara K,Sasaki M,Natsui M,Matozaki T,Tezuka H,Ohteki T,Förster I,Mak TW,Nakano T,Suzuki A

更新日期：2008-05-01 00:00:00

abstract：:Young (less than 3 months of age) and old (greater than 1 year of age) C.B-17 scid/scid mice were tested for the presence of immunoglobulin in serum and CD3+ T cells in spleen and peritoneal cavity. In all old severe combined immune deficiency (scid) mice tested we found detectable, but very variable levels of serum i...

journal_title：European journal of immunology

authors： Rudolphi A,Spiess S,Conradt P,Claësson MH,Reimann J

更新日期：1991-02-01 00:00:00

abstract：:We have investigated perforin and granzyme B expression in graft-infiltrating lymphocytes of patients who underwent heart transplantation. Those proteins are commonly present in the cytoplasmic granules of cytotoxic T lymphocytes and are released upon effector-target cell interaction. From 28 patients 103 endomyocardi...

journal_title：European journal of immunology

authors： Legros-Maïda S,Soulié A,Benvenuti C,Wargnier A,Vallée N,Berthou C,Guillet J,Sasportes M,Sigaux N

更新日期：1994-01-01 00:00:00

abstract：:Natural killer (NK) cell activity can be stimulated by different surface receptors. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating human NK cell cytotoxicity and cytokine production. Here we show that stimulation of human NK cells by anti...

journal_title：European journal of immunology

authors： Sandusky MM,Messmer B,Watzl C

更新日期：2006-12-01 00:00:00

abstract：:The presentation of islet antigens in the pancreatic LNs (PLNs) of mice is a developmentally regulated process. It has been hypothesized that, during physiological tissue remodeling, a wave of neonatal β-cell apoptosis may initiate diabetes in autoimmune-prone strains of mice. If true, increasing or decreasing physiol...

journal_title：European journal of immunology

authors： Carrington EM,Kos C,Zhan Y,Krishnamurthy B,Allison J

更新日期：2011-08-01 00:00:00

abstract：:Recent studies have suggested that T cell memory for recall antigens resides in clones of primed T cells with a short inter-mitotic half-life. In humans such cells express an isoform of the leukocyte common antigen termed CD45RO. Nevertheless, little is known of the fate of these primed T cells after initial activatio...

journal_title：European journal of immunology

authors： Salmon M,Pilling D,Borthwick NJ,Viner N,Janossy G,Bacon PA,Akbar AN

更新日期：1994-04-01 00:00:00

abstract：:DC-based vaccination against Leishmania major induces a parasite-specific Th1 response and long-lasting protective immunity in susceptible mice. Since distinct DC subsets have been proposed to direct the predominant development of either Th1 or Th2 cells, we analyzed the capability of plasmacytoid DC (pDC) to induce p...

journal_title：European journal of immunology

authors： Remer KA,Apetrei C,Schwarz T,Linden C,Moll H

更新日期：2007-09-01 00:00:00

abstract：:The infiltration and activation of monocytes is a hallmark of chronic inflammation, including that associated with a variety of disease states such as rheumatoid arthritis, atherosclerosis, and various autoimmune conditions. Recently, a family of small molecular mass proteins has been described which appear to have in...

journal_title：European journal of immunology

authors： Schall TJ,Simpson NJ,Mak JY

更新日期：1992-06-01 00:00:00

abstract：:The studies described in this report were designed to investigate factors that could influence the behavior of erythrocytes following their interaction with monoclonal antibodies (mAb) in a fully homologous experimental opsonization system in vivo. The clearance profiles and tissue distribution of target erythrocytes ...

journal_title：European journal of immunology

authors： Yousaf N,Howard JC,Williams BD

更新日期：1991-04-01 00:00:00

abstract：:A number of applications of antibodies in diagnosis and therapy require multivalent reagents either because of the polymeric nature of the antigens or because biological activity depends on an effect on the formation of homodimeric species. Here, we report a procedure for mass screening of phage-derived monomeric anti...

journal_title：European journal of immunology

authors： Zaccolo M,Griffiths AP,Prospero TD,Winter G,Gherardi E

更新日期：1997-03-01 00:00:00

abstract：:Transcription of the gene encoding the transcriptional coactivator Oct-binding factor 1 (OBF-1)/OCA-B/Bob.1 is largely restricted to B cells. During B cell development OBF-1 expression shows two peaks, one in immature B cells in the bone marrow and the other in germinal center B cells. Promoter analysis has identified...

journal_title：European journal of immunology

authors： Massa S,Junker S,Schubart K,Matthias G,Matthias P

更新日期：2003-10-01 00:00:00

abstract：:The analysis of an Ia specificity was performed in several H-2 haplotypes by evaluating the affinity of the binding to mouse spleen cells of a monoclonal anti-Ia alloantibody. We used the monoclonal antibody 10-2.16 (Oi et al., Curr. Top. Microbiol. Immunol. 1978. 81: 115.) which recognizes on I-A gene products a publ...

journal_title：European journal of immunology

authors： Birnbaum D,Kourilsky FM

更新日期：1981-09-01 00:00:00

abstract：:The present report describes functional characteristics of a monoclonal antibody (mAb), TA/211, which is reactive with a common determinant of the human CD45 molecules. When added to purified testing human T cells, TA/211, which is itself not mitogenic, leads to a strong proliferative response in combination with subm...

journal_title：European journal of immunology

authors： Schraven B,Roux M,Hutmacher B,Meuer SC

更新日期：1989-02-01 00:00:00

abstract：:Studies of experimental autoimmune encephalomyelitis (EAE) in rodents have revealed that encephalitogenic T cell lines reactive with myelin basic protein (BP) are frequently dominated by clones expressing a restricted T cell receptor repertoire. Using the rat EAE model, we have begun to examine the basis for clonal do...

journal_title：European journal of immunology

authors： Sun D,Hu XZ,Coleclough C

更新日期：1995-01-01 00:00:00

abstract：:The fine specificity of murine B 10.A/SgSn (B 10.A) T cells reactive with hen egg-white lysozyme (HEL) has been studied through the use of reduced, carboxymethylated HEL, a set of peptides encompassing the entire molecule, and a set of variant lysozymes from other species. Cells were taken from the lymph nodes drainin...

journal_title：European journal of immunology

authors： Maizels RM,Clarke JA,Harvey MA,Miller A,Sercarz EE

更新日期：1980-07-01 00:00:00

abstract：:T cell stimulation of B cell proliferation during T-B collaboration requires membrane-bound stimulatory ligands, such as CD40 ligand and the secretion of soluble cytokines, such as IL-4. Nevertheless, it remains unclear whether T cell contact is required to provoke each consecutive B cell division, or whether B cells ...

journal_title：European journal of immunology

authors： Rush JS,Hodgkin PD

更新日期：2001-04-01 00:00:00

abstract：:The production of IL-10, a potent immunosuppressive cytokine, must be strictly regulated to ensure a balanced immune response. IFN-γ, a key cytokine in multiple immune processes and pathologies, is known as an inhibitor of IL-10 production by monocytes and macrophages, but also has some regulatory functions. In the pr...

journal_title：European journal of immunology

authors： Imbrechts M,De Samblancx K,Fierens K,Brisse E,Vandenhaute J,Mitera T,Libert C,Smets I,Goris A,Wouters C,Matthys P

更新日期：2018-09-01 00:00:00

abstract：:We have previously reported the development of a two-step culture system in which soluble anti-mu monoclonal antibodies prime small resting murine B cells to secrete immunoglobulin (Ig) in response to restimulation with a mixture of interleukin-4 (IL-4) and IL-5. Here we have extended these studies to investigate the ...

journal_title：European journal of immunology

authors： Phillips C,Klaus GG

更新日期：1993-02-01 00:00:00

abstract：:It is widely accepted that females have superior immune responses than males, but the ways by which sex hormones may enhance T cell responses are still poorly understood. In the present study, we analyzed the effect of estrogens on CD4 T cell activation and differentiation after immunization with exogenous antigens. W...

journal_title：European journal of immunology

authors： Maret A,Coudert JD,Garidou L,Foucras G,Gourdy P,Krust A,Dupont S,Chambon P,Druet P,Bayard F,Guéry JC

更新日期：2003-02-01 00:00:00

abstract：:Injection of M-1 (Cmu), G-1 (Cgamma) heterozygous chickens on the day of hatch with anti-IgM-1 antiserum induced allotype suppression from which chickens recovered over a period of approximately 4 months. The suppression of the serum IgM-1 levels was matched by a decrease in the number of splenic and peripheral blood ...

journal_title：European journal of immunology

authors： Ratcliffe MJ,Ivanyi J

更新日期：1981-04-01 00:00:00