CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles.

abstract：:The effect of fractionated total lymphoid irradiation (TLI) on the maturation of B cells was examined in mice. At various times after irradiation of the mice, their spleen cells were tested for the mitogenic responses to dextran sulfate and lipopolysaccharide. In parallel the cells were stained with fluorescent anti-T...

journal_title：European journal of immunology

authors： Zan-Bar I

更新日期：1983-01-01 00:00:00

abstract：:The ligand for the B cell surface antigen CD40 was recently cloned from a murine thymoma cDNA library and shown to be expressed on activated T cells. In this study, we investigate the biological effects of murine recombinant CD40 ligand. The recombinant CD40 ligand expressed on the CV-1/EBNA monkey fibroblast cell lin...

journal_title：European journal of immunology

authors： Maliszewski CR,Grabstein K,Fanslow WC,Armitage R,Spriggs MK,Sato TA

更新日期：1993-05-01 00:00:00

abstract：:The role of mineralocorticoid receptors (MRs) in human T-cell migration is not yet understood. We have recently shown that the MR antagonist spironolactone selectively increases the numbers of circulating naïve and central memory T cells during early sleep, which is the time period in the 24 h cycle hallmarked by pred...

journal_title：European journal of immunology

authors： Besedovsky L,Linz B,Born J,Lange T

更新日期：2014-06-01 00:00:00

abstract：:Reciprocal expression of CD45RA and CD45RO in human CD4+ T cells defines populations understood to be naive cells (CD45RA+CD45RO-) and memory cells (CD45RA-CD45RO+). We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright a...

journal_title：European journal of immunology

authors： Horgan KJ,Tanaka Y,Luce GE,van Seventer GA,Nutman TB,Shaw S

更新日期：1994-05-01 00:00:00

abstract：:The molecular mechanism of the interleukin (IL) 2-induced differentiation of human B cells has been investigated. The experimental results show that Staphylococcus aureus Cowan strain I (SAC) activation alone induces IL6 secretion from B cells. When B cells were activated by SAC, there was an increased transcription o...

journal_title：European journal of immunology

authors： Xia X,Lee HK,Clark SC,Choi YS

更新日期：1989-12-01 00:00:00

abstract：:Naturally activated T lymphocytes present in normal mouse spleen were studied for direct reactivity to interleukin 2 (IL 2) and for binding of anti-IL 2 receptor (IL 2R) antibodies or radiolabeled IL 2. The majority of large-sized splenic T lymphocytes are IL 2R-; thus, at the most one third of large L3T4+ T cells and...

journal_title：European journal of immunology

authors： Bandeira A,Larsson EL,Forni L,Pereira P,Coutinho A

更新日期：1987-07-01 00:00:00

abstract：:Transgenic mice in which mouse interleukin (IL)-7 cDNA is expressed under the control of the mouse major histocompatibility complex (MHC) class II (E alpha) promoter develop a lymphoproliferative disease characterized by the early polyclonal expansion of T cells followed in many cases by the development of lymphomas o...

journal_title：European journal of immunology

authors： Mertsching E,Grawunder U,Meyer V,Rolink T,Ceredig R

更新日期：1996-01-01 00:00:00

abstract：:Glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE) is a synthetic adjuvant TLR4 agonist that promotes potent poly-functional T(H)1 responses. Different TLR4 agonists may preferentially signal via MyD88 or TIR-domain-containing adapter inducing IFN-beta (TRIF) to exert adjuvant effects; however, the contribution of...

journal_title：European journal of immunology

authors： Orr MT,Duthie MS,Windish HP,Lucas EA,Guderian JA,Hudson TE,Shaverdian N,O'Donnell J,Desbien AL,Reed SG,Coler RN

更新日期：2013-09-01 00:00:00

abstract：:The costimulatory receptor OX40 is expressed on activated T cells and regulates T-cell responses. Here, we show the efficacy and mechanism of action of an OX40 blocking antibody using the chronic house dust mite (HDM) mouse model of lung inflammation and in vitro HDM stimulation of cells from HDM allergic human donors...

journal_title：European journal of immunology

authors： Burrows KE,Dumont C,Thompson CL,Catley MC,Dixon KL,Marshall D

更新日期：2015-04-01 00:00:00

abstract：:Th17 cells are defined by their capacity to produce IL-17, and are important mediators of inflammation and autoimmunity. Human Th17 cells express high levels of the retinoic acid-related orphan receptor variant 2 (RORC2), but it is currently unclear whether expression of this transcription factor alone is sufficient t...

journal_title：European journal of immunology

authors： Crome SQ,Wang AY,Kang CY,Levings MK

更新日期：2009-06-01 00:00:00

abstract：:Two out of five murine IgG3 anti-trinitrophenyl (TNP) monoclonal antibodies (mAb) obtained either by immunization with TNP-keyhole limpet hemocyanin (KLH) (CB1, CB5, CB6 and 4H10) or with dinitrophenyl-lipopolysaccharide (9A6), exhibited anti-IgG rheumatoid factor (RF) activity (CB6 and 4H10). The anti-IgG activity of...

journal_title：European journal of immunology

authors： Reininger L,Spertini F,Shibata T,Jaton JC,Izui S

更新日期：1989-11-01 00:00:00

abstract：:Large-scale extravasation of lymphocytes takes place in vivo under physiological conditions in lymph nodes at very specialized vascular segments called high endothelial venules (HEV). When circulating lymphocytes leave the blood, they first bind to endothelial cells of HEV (HE cells) and subsequently enter lymph nodes...

journal_title：European journal of immunology

authors： Ise Y,Yamaguchi K,Sato K,Yamamura Y,Kitamura F,Tamatani T,Miyasaka M

更新日期：1988-08-01 00:00:00

abstract：:To determine the molecular mechanisms of T cell stimulation by staphylococcal enterotoxin A (SEA), we examined the expression of T cell receptor (TcR) V beta on the T cells from four strains of mice stimulated in vitro with SEA, using flow cytometric analysis for the number of T cells bearing V beta 3, V beta 6, V bet...

journal_title：European journal of immunology

authors： Takimoto H,Yoshikai Y,Kishihara K,Matsuzaki G,Kuga H,Otani T,Nomoto K

更新日期：1990-03-01 00:00:00

abstract：:Human peripheral blood T lymphocytes are stimulated to grow and divide by lectins such as concanavalin A (Con A) and Phaseolus vulgaris phytohemagglutinin (PHA), as well as a few anti-T cell monoclonal antibodies. The latter antibodies recognize the T3 antigen. It has been suggested previously that PHA and Con A media...

journal_title：European journal of immunology

authors： Kanellopoulos JM,De Petris S,Leca G,Crumpton MJ

更新日期：1985-05-01 00:00:00

abstract：:The transcription factor Hhex (hematopoietically expressed homeobox gene) is critical for development of multiple lymphoid lineages beyond the common lymphoid progenitor. In addition, Hhex regulates hematopoietic stem cell (HSC) self-renewal, emergency hematopoiesis, and acute myeloid leukemia initiation and maintenan...

journal_title：European journal of immunology

authors： Jackson JT,O'Donnell K,Light A,Goh W,Huntington ND,Tarlinton DM,McCormack MP

更新日期：2020-07-01 00:00:00

abstract：:F1----parental bone marrow chimeras between CBA and B10 mice were used to show that even after 1 year follicular dendritic cells (FDC), also termed dendritic reticular cells, are not derived from bone marrow stem cells. However clusters of cells wrapped in the dendritic processes of FDC, isolated by enzyme digestion o...

journal_title：European journal of immunology

authors： Humphrey JH,Grennan D,Sundaram V

更新日期：1984-09-01 00:00:00

abstract：:Memory T cells can now be defined with various monoclonal antibodies but little is known about the functional properties of these cells as compared to virgin T cells. We have studied Ca2+ mobilization and proliferation of memory and virgin cells in both the CD4 and CD8 subsets in response to phytohemagglutin-in. Using...

journal_title：European journal of immunology

authors： Schlunck T,Schraut W,Riethmüller G,Ziegler-Heitbrock HW

更新日期：1990-09-01 00:00:00

abstract：:The lymphoid cell composition of milky spots was analyzed in unprimed mice before and after i.p. immunization with sheep red blood cells. Milky spots contained surface immunoglobulin-positive B lymphocytes, and T cells of the helper and cytotoxic phenotype. After secondary antigen challenge the number of lymphocytes i...

journal_title：European journal of immunology

authors： Dux K,Rouse RV,Kyewski B

更新日期：1986-08-01 00:00:00

abstract：:Cytokines are the main agents known to regulate Th1 / Th2 commitment, where they may operate through paracrine activity within clusters of T cells gathered around dendritic cells (DC). An in vitro system is used here to test this possibility, using clusters around DC composed of naive TCR-transgenic ovalbumin peptide ...

journal_title：European journal of immunology

authors： Schuhbauer DM,Mitchison NA,Mueller B

更新日期：2000-05-01 00:00:00

abstract：:Effects of carrageenan (CAR) treatment on the response of interferon (IFN) production in vivo and in vitro after stimulation with an IFN-gamma inducer, staphylococcal enterotoxin A (SEA), was investigated. The IFN-gamma production in mice stimulated with SEA was impaired after i.v. administration of a 20 mg/kg dose of...

journal_title：European journal of immunology

authors： Suzuki F,Maeda H,Pollard RB

更新日期：1986-04-01 00:00:00

abstract：:This report describes the study of the expression of an idiotype in the human population which is associated with antibodies to N-acetyl-D-glucosamine (GlcNAc) present in most human sera presumably due to streptococcal infections. The idiotype is identified with antisera and monoclonal antibodies prepared against the ...

journal_title：European journal of immunology

authors： Emmrich F,Greger B,Eichmann K

更新日期：1983-04-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules have been implicated in cell adhesion in two ways. In addition to the well-established role of class II antigens in low-affinity adhesion provided by interactions between class II and CD4, recent data indicated that class II may also induce adhesion between T a...

journal_title：European journal of immunology

authors： Odum N,Ledbetter JA,Martin P,Geraghty D,Tsu T,Hansen JA,Gladstone P

更新日期：1991-09-01 00:00:00

abstract：:Double-negative (DN) thymocyte subsets were examined in mice deficient in the CD3 zeta chain (zeta-/-). The HSA+CD44-CD25- subset was found to be missing, and DN thymocytes seemed to differentiate directly from HSA+CD25+CD44- cells to double-positive (DP) cells. When fetal thymic ontogeny was examined, we found a mark...

journal_title：European journal of immunology

authors： Crompton T,Moore M,MacDonald HR,Malissen B

更新日期：1994-08-01 00:00:00

abstract：:Spontaneous apoptosis in germinal center (GC) B cells can be arrested either by engaging cell surface immunoglobulin (Ig) with immobilized ligand or, more effectively, by treatment with soluble monoclonal antibody (mAb) directed against CD40. The present study examines the intracellular signal transduction pathways th...

journal_title：European journal of immunology

authors： Knox KA,Gordon J

更新日期：1993-10-01 00:00:00

abstract：:Natural killer (NK) cells play an important role in early defense against viral infection. The cytotoxic activity of NK cells is increased by interferon-alpha/beta (IFN-alpha/beta), produced en masse in virally infected cells. However, the mechanism(s) by which IFN-alpha/beta contribute to the NK-cell-mediated antivir...

journal_title：European journal of immunology

authors： Sato K,Hida S,Takayanagi H,Yokochi T,Kayagaki N,Takeda K,Yagita H,Okumura K,Tanaka N,Taniguchi T,Ogasawara K

更新日期：2001-11-01 00:00:00

abstract：:Natural antibodies (Ab) reacting with self antigens have been shown to be present in all individuals. These autoantibodies (auto-Ab) can be either pathogenic or non-pathogenic. Auto-Ab reacting with the alpha-subunit of the high-affinity receptor for IgE (FcepsilonRIalpha) have been implicated in the pathogenesis of a...

journal_title：European journal of immunology

authors： Horn MP,Gerster T,Ochensberger B,Derer T,Kricek F,Jouvin MH,Kinet JP,Tschernig T,Vogel M,Stadler BM,Miescher SM

更新日期：1999-04-01 00:00:00

abstract：:T-cell development is a spatially and temporally regulated process, orchestrated by well-defined contributions of transcription factors and cytokines. Here, we identify the noncoding RNA miR-142 as an additional regulatory layer within murine thymocyte development and proliferation. MiR-142 deficiency impairs the expr...

journal_title：European journal of immunology

authors： Mildner A,Chapnik E,Varol D,Aychek T,Lampl N,Rivkin N,Bringmann A,Paul F,Boura-Halfon S,Hayoun YS,Barnett-Itzhaki Z,Amit I,Hornstein E,Jung S

更新日期：2017-07-01 00:00:00

abstract：:Type I IFN are cytokines which play a central role in host resistance to viral or microbial infections and are important components linking innate and adaptive immunity. We and others have previously demonstrated that the production of IFN-beta by DC following bacterial infections or TLR triggering influences, in an a...

journal_title：European journal of immunology

authors： Remoli ME,Gafa V,Giacomini E,Severa M,Lande R,Coccia EM

更新日期：2007-12-01 00:00:00

abstract：:Antigens in the form of immune complexes are retained on the membranes of follicular dendritic cells (FDC) for long periods of time. To examine how immune complexes reach germinal centers, where FDC are located, we injected mice with anti-2,4-dinitrophenyl (DNP) antibodies complexed to DNP-myoglobin-coated gold partic...

journal_title：European journal of immunology

authors： Heinen E,Braun M,Coulie PG,Van Snick J,Moeremans M,Cormann N,Kinet-Denoël C,Simar LJ

更新日期：1986-02-01 00:00:00

abstract：:Multiple myeloma is a fatal B cell malignancy characterized by the accumulation of plasma cells within the bone marrow. IL-6 is a major survival factor for myeloma cells. Bcl-2 protein family regulates pathways to apoptosis that are activated upon growth factor deprivation. Pro-apoptotic proteins that have only a sing...

journal_title：European journal of immunology

authors： Gomez-Bougie P,Bataille R,Amiot M

更新日期：2004-11-01 00:00:00