Triggering of the alternative pathway of human T cell activation involves members of the T 200 family of glycoproteins.

abstract：:Pre-graft priming of heart allograft recipients with donor strain blood induces tolerance in 100% of adult rats in the congenic LEW.1W to LEW.1A combination. This tolerant state is specific for donor MHC antigens as third-party blood transfusions fail to induce tolerance, and third-party skin grafts are promptly rejec...

journal_title：European journal of immunology

authors： van Denderen B,Pêche H,Gagne K,Usal C,Cuturi MC,Soulillou JP

更新日期：2001-05-01 00:00:00

abstract：:It has been reported that Thy-1+CD3+CD4-CD8- cells as well as Langerhans cells migrate from organ-cultured murine skin into culture medium. We examined whether these Thy-1+ populations of migrating cells were derived from Thy-1+ dendritic epidermal T cells (Thy-1+ DEC) and found that they were Thy-1+CD3+CD4-CD8-gamma/...

journal_title：European journal of immunology

authors： Nakagawa S,Hara M,Seki M,Yagita H,Tagami H,Aiba S

更新日期：1993-07-01 00:00:00

abstract：:Murine Thy-1+, TcR V gamma 3/V delta 1+ dendritic epidermal T cells (DETC) differ from most other T cell subsets by the absence of CD4 and CD8 antigens as well as the lack of CD5 expression. To see whether negativity for those antigens is an intrinsic feature of a given T cell population or if such triple-negative T c...

journal_title：European journal of immunology

authors： Payer E,Kutil R,Stingl G

更新日期：1994-06-01 00:00:00

abstract：:A fusion between the mouse AKR thymoma BW5147 and a culture of homogeneously OX8+ (CD8) rat T lymphoblasts yield interleukin (IL) 2-dependent T cell hybridomas when selected in HAT medium supplemented with IL 2-containing supernatants of concanvalin A-activated cells and dexamethasone. IL 2-independent variants can be...

journal_title：European journal of immunology

authors： Somoza C,Fernández-Ruiz E,Jotterand-Bellomo M,Sanz E,Nabholz M,Silva A

更新日期：1989-07-01 00:00:00

abstract：:A monoclonal antibody (mAb) directed to a human leukocyte 55-kDa cell surface molecule with identical cellular distribution and biochemical properties to the CD4 was able to inhibit T cell proliferation induced either in a mixed lymphocyte culture or by activation with mAb anti-CD3, anti-CD2 or phytohemagglutinin. The...

journal_title：European journal of immunology

authors： Carrera AC,Sanchez-Madrid F,Lopez-Botet M,Bernabeu C,De Landazuri MO

更新日期：1987-02-01 00:00:00

abstract：:In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed. Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of class II gene transcription. We s...

journal_title：European journal of immunology

authors： Sartoris S,Tosi G,De Lerma Barbaro A,Cestari T,Accolla RS

更新日期：1996-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) elicits innate inflammatory responses that can lead to secondary brain injury. To better understand the mechanisms involved in TBI-induced inflammation, we examined the nature of macrophages responding to TBI in mice. In this model, brain macrophages were increased >20-fold the day after i...

journal_title：European journal of immunology

authors： Hsieh CL,Kim CC,Ryba BE,Niemi EC,Bando JK,Locksley RM,Liu J,Nakamura MC,Seaman WE

更新日期：2013-08-01 00:00:00

abstract：:Protein kinase C (PKC) has been implicated in the signaling of a number of cellular responses including activation of T cells. In the present report we have evaluated the effect of increased cAMP levels on PKC activation after stimulation of two distinct receptor systems on normal human T cells. PKC substrate phosphor...

journal_title：European journal of immunology

authors： Friedrich B,Cantrell DA,Gullberg M

更新日期：1989-06-01 00:00:00

abstract：:The functional relevance of CD2-mediated signal transduction in triggering T cell receptor/CD3-independent natural killer cell cytotoxicity was investigated by introducing wild-type CD2 or signaling-deficient CD2 with truncated cytoplasmic region into a murine natural killer-like large granular lymphocyte clone lackin...

journal_title：European journal of immunology

authors： Nakamura T,Takahashi K,Koyanagi M,Yagita H,Okumura K

更新日期：1991-03-01 00:00:00

abstract：:The development of the antibody repertoire in newborn mice is greatly influenced by idiotype network interactions. It has been demonstrated that anti-idiotypic antibodies either directly injected or transferred from the mother may alter the repertoire for life. For an elucidation of the underlying mechanisms we have a...

journal_title：European journal of immunology

authors： Lemke H,Lange H,Berek C

更新日期：1994-12-01 00:00:00

abstract：:The role of mineralocorticoid receptors (MRs) in human T-cell migration is not yet understood. We have recently shown that the MR antagonist spironolactone selectively increases the numbers of circulating naïve and central memory T cells during early sleep, which is the time period in the 24 h cycle hallmarked by pred...

journal_title：European journal of immunology

authors： Besedovsky L,Linz B,Born J,Lange T

更新日期：2014-06-01 00:00:00

abstract：:Tertiary lymphoid organs can form at sites of chronic inflammation. Their presence has been mainly associated with tissue destruction. In transplantation, there is a dynamic immune response as in chronic inflammation. Indeed, the presence of tertiary lymphoid organs has been associated with chronic rejection. In addit...

journal_title：European journal of immunology

authors： Brown K,Sacks SH,Wong W

更新日期：2011-01-01 00:00:00

abstract：:The anti-PC antibodies of BALB/c origin bear predominantly the idiotype characteristic of the phosphorylcholine (PC)-binding T15 idiotype than sera from adult mice, and, unlike the latter, they also contain detectable amounts of anti-T15 antibodies. By 2 weeks of age the anti-T15 antibodies are no longer detectable wh...

journal_title：European journal of immunology

authors： Augustin A,Cosenza H

更新日期：1976-07-01 00:00:00

abstract：:Ly49Q, a type II C-type lectin expressed on mouse plasmacytoid DC (pDC), contains a single carbohydrate recognition domain in its extracellular region and an ITIM in its cytoplasmic domain. We have identified the MHC class I molecule H-2K(b) as a Ly49Q ligand, confirming prior reports. Although H-2K(b) is expressed on...

journal_title：European journal of immunology

authors： Toma-Hirano M,Namiki S,Shibata Y,Ishida K,Arase H,Miyatake S,Arai K,Kamogawa-Schifter Y

更新日期：2009-05-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have revolutionized the search for genetic influences on complex disorders, such as primary biliary cirrhosis (PBC). Recent GWAS have identified many disease-associated genetic variants. These, overall, highlighted the remarkable contribution of key immunological pathways in PBC ...

journal_title：European journal of immunology

authors： Carbone M,Lleo A,Sandford RN,Invernizzi P

更新日期：2014-04-01 00:00:00

abstract：:T cell recognition of self antigens is a key event in the pathogenesis of autoimmune diseases. To date, the initial events that trigger autoreactive T cells are unknown. The "molecular mimicry" hypothesis predicts that during an infection T cells that recognize both a microbial antigen and a related self peptide becom...

journal_title：European journal of immunology

authors： Maier B,Molinger M,Cope AP,Fugger L,Schneider-Mergener J,Sønderstrup G,Kamradt T,Kramer A

更新日期：2000-02-01 00:00:00

abstract：:To study the question when and where self peptides become associated with major histocompatibility complex class II molecules for tolerance induction, we recently developed a system in which the intracellular site(s) of antigen expression could be manipulated using gene cloning techniques. We previously constructed a ...

journal_title：European journal of immunology

authors： Bikoff EK

更新日期：1991-06-01 00:00:00

abstract：:Rabbit antibodies to Atlantic cod (Gadus morhua L.) immunoglobulin were affinity purified and used to screen cDNA libraries from spleen and head kidney mRNA. cDNA clones for both the secretory and membrane-bound heavy (H) chain were isolated, the nucleotide and deduced amino acid sequences of which are reported here. ...

journal_title：European journal of immunology

authors： Bengtén E,Leanderson T,Pilström L

更新日期：1991-12-01 00:00:00

abstract：:Macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19 are members of the CC chemokine subfamily which exert their effects through specific receptors, CCR6 and CCR7, respectively. Previously, we have reported that human neutrophils have the capacity to produce a number of chemokines, including I...

journal_title：European journal of immunology

authors： Scapini P,Laudanna C,Pinardi C,Allavena P,Mantovani A,Sozzani S,Cassatella MA

更新日期：2001-07-01 00:00:00

abstract：:Checkpoint blockade of CTLA-4 results in long-lasting survival benefits in metastatic cancer patients. However, patients treated with CTLA-4 blockade have suffered from immune-related adverse events, most likely due to the breadth of the induced T-cell activation. Here, we investigated the efficacy of a local low-dose...

journal_title：European journal of immunology

authors： van Hooren L,Sandin LC,Moskalev I,Ellmark P,Dimberg A,Black P,Tötterman TH,Mangsbo SM

更新日期：2017-02-01 00:00:00

abstract：:Btk is a member of the Tec family of protein tyrosine kinases expressed in B cells. It is stimulated following cross-linking of the B cell receptor which leads to the autophosphorylation of a specific residue in the SH3 domain, Y223. Previous work using Btk-derived fusion proteins has shown that the Btk SH3 domain bin...

journal_title：European journal of immunology

authors： Morrogh LM,Hinshelwood S,Costello P,Cory GO,Kinnon C

更新日期：1999-07-01 00:00:00

abstract：:The autoimmune regulator (AIRE) promotes "promiscuous" expression of tissue-restricted antigens (TRA) in thymic medullary epithelial cells to facilitate thymic deletion of autoreactive T-cells. Here, we show that AIRE-deficient mice showed an earlier development of myelin oligonucleotide glycoprotein (MOG)-induced exp...

journal_title：European journal of immunology

authors： Ko HJ,Kinkel SA,Hubert FX,Nasa Z,Chan J,Siatskas C,Hirubalan P,Toh BH,Scott HS,Alderuccio F

更新日期：2010-12-01 00:00:00

abstract：:NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 in...

journal_title：European journal of immunology

authors： Campos PC,Gomes MTR,Marinho FAV,Guimarães ES,de Moura Lodi Cruz MGF,Oliveira SC

更新日期：2019-07-01 00:00:00

abstract：:Defined tumor-associated antigens (TAA) are attractive targets for anti-tumor immunotherapy. Here, we describe a novel genome-wide approach to identify multiple TAA from any given tumor. A panel of transplantable thymomas was established from an inbred p53-/- mouse strain. The resulting tumors were examined for gene e...

journal_title：European journal of immunology

authors： Mathiassen S,Lauemøller SL,Ruhwald M,Claesson MH,Buus S

更新日期：2001-04-01 00:00:00

abstract：:Following antigen encounter and subsequent resolution of the immune response, a single naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic and functional properties and gene expression profiles. Single-cell technologies, first and foremost flow cytometry, have revealed the com...

journal_title：European journal of immunology

authors： Mahnke YD,Brodie TM,Sallusto F,Roederer M,Lugli E

更新日期：2013-11-01 00:00:00

abstract：:The pathways leading to activation of mucosal lamina propria (LP) T cells differ from those of peripheral T cells. LP T cells exhibit enhanced IFN-gamma secretion when activated through the CD2 pathway. This study demonstrates CD2 signaling is followed by activation of STAT proteins in both peripheral blood mononuclea...

journal_title：European journal of immunology

authors： Gonsky R,Deem RL,Young HA,Targan SR

更新日期：2003-05-01 00:00:00

abstract：:We have analyzed the T cell receptor (TcR) V alpha and TcR V beta regions in the spontaneous mouse model for insulin-dependent diabetes mellitus, the NOD mouse, and compared it to the regions in the two sister strains, the NON and CTS strains. Based on restriction fragment length polymorphism analysis the TcR V alpha ...

journal_title：European journal of immunology

authors： Lund T,Shaikh S,Hattori M,Makino S

更新日期：1992-03-01 00:00:00

abstract：:Interleukin (IL)-5 is produced by variety of cell types and contributes to both lymphocyte development an eosinophil terminal differentiation in vitro. The coincidence of worm expulsion and eosinophilia in sheep infected with the gastrointestinal nematode Trichostrongylus colubriformis suggest that eosinophils may be ...

journal_title：European journal of immunology

authors： Bao S,McClure SJ,Emery DL,Husband AJ

更新日期：1996-03-01 00:00:00

abstract：:Sand fly saliva contains maxadilan, a peptide that causes vasodilation and modifies the secretion of pro-inflammatory cytokines by macrophages. We show that 1 to 10 microg maxadilan protected BALB/c mice against a lethal dose of LPS. Maxadilan reduced serum levels of TNF-alpha by approximately tenfold, while it caused...

journal_title：European journal of immunology

authors： Bozza M,Soares MB,Bozza PT,Satoskar AR,Diacovo TG,Brombacher F,Titus RG,Shoemaker CB,David JR

更新日期：1998-10-01 00:00:00

abstract：:Human peripheral blood T lymphocytes are stimulated to grow and divide by lectins such as concanavalin A (Con A) and Phaseolus vulgaris phytohemagglutinin (PHA), as well as a few anti-T cell monoclonal antibodies. The latter antibodies recognize the T3 antigen. It has been suggested previously that PHA and Con A media...

journal_title：European journal of immunology

authors： Kanellopoulos JM,De Petris S,Leca G,Crumpton MJ

更新日期：1985-05-01 00:00:00