Expression of new idiotypes following neonatal idiotypic suppression of a dominant clone.

abstract：:While the nasal mucosa is a potentially useful site for human immunization, toxin-based nasal adjuvants are generally unsafe and less effective in humans. Safe mucosal adjuvants that activate protective immunity via mucosal administration are highly dependent on barrier antigen sampling by epithelial and DCs. Here, we...

journal_title：European journal of immunology

authors： Makidon PE,Belyakov IM,Blanco LP,Janczak KW,Landers J,Bielinska AU,Groom JV 2nd,Baker JR Jr

更新日期：2012-08-01 00:00:00

abstract：:Activation of the alternative complement pathway by human B cell lymphoma lines is correlated with the presence of Epstein Barr virus (EBV) in the cell genome. EBV-negative B cell lymphoma lines produce little activation of the alternative pathway as measured either by C3 deposition on the cell surface or C3 conversio...

journal_title：European journal of immunology

authors： McConnell I,Klein G,Lint TF,Lachmann PJ

更新日期：1978-07-01 00:00:00

abstract：:Two cloned murine helper T lymphocyte (HTL) lines were used to investigate the immunoregulatory properties of highly purified interleukin 2 (IL2). The clone, designated J6.19, secretes lymphokines, including IL2, and proliferates when stimulated with ovalbumin in the presence of I-Ak-bearing spleen cells, while the al...

journal_title：European journal of immunology

authors： Otten G,Wilde DB,Prystowsky MB,Olshan JS,Rabin H,Henderson LE,Fitch FW

更新日期：1986-03-01 00:00:00

abstract：:Antigen-specific CD4(+) T cells are central to natural and vaccine-induced immunity. An ongoing antigen-specific T-cell response can, however, influence surrounding T cells with unrelated antigen specificities. We previously observed this bystander effect in healthy human subjects following recall vaccination with tet...

journal_title：European journal of immunology

authors： Di Genova G,Savelyeva N,Suchacki A,Thirdborough SM,Stevenson FK

更新日期：2010-04-01 00:00:00

abstract：:Major advances in preventing, delaying, or curing individual pathologies are responsible for an increasingly long life span in the developed parts of our planet, and indeed reaching eight to nine decades of life is nowadays extremely frequent. However, medical and sanitary advances have not prevented or delayed the un...

journal_title：European journal of immunology

authors： Pinti M,Appay V,Campisi J,Frasca D,Fülöp T,Sauce D,Larbi A,Weinberger B,Cossarizza A

更新日期：2016-10-01 00:00:00

abstract：:Even if omalizumab is broadly used in the treatment of severe, allergic asthma, the immunological effects in long-term treated patients have not been fully elucidated. To this aim, a cohort of 15 allergic asthmatic patients treated with omalizumab for at least three years was compared with 12 allergic asthma patients ...

journal_title：European journal of immunology

authors： Maggi L,Rossettini B,Montaini G,Matucci A,Vultaggio A,Mazzoni A,Palterer B,Parronchi P,Maggi E,Liotta F,Annunziato F,Cosmi L

更新日期：2018-12-01 00:00:00

abstract：:Antigen-presenting cells (APC), including dendritic cells and macrophages, produce a large amount of interferon (IFN)-gamma, a crucial cytokine for the control of infectious diseases. To elucidate the role of IFN-gamma from APC in vivo, we employed cytokine receptor common gamma subunit (gamma c) and recombination-act...

journal_title：European journal of immunology

authors： Suzue K,Asai T,Takeuchi T,Koyasu S

更新日期：2003-10-01 00:00:00

abstract：:Acute inflammatory activation of macrophages by Toll-like and related receptors is characterized by transient activation of MAPK-, NF-κB- and IRF-mediated signaling pathways and expression of pro-inflammatory genes. This activation state is inherently unstable and often transitions into a state of 'tolerance' characte...

journal_title：European journal of immunology

authors： Ivashkiv LB

更新日期：2011-09-01 00:00:00

abstract：:Regulatory T (Treg) cells are a constitutively immunosuppressive subtype of T cells that contribute to the maintenance of immunological self-tolerance and immune homeostasis. However, the molecular mechanisms involved in the regulation of Treg cells remain unclear. In the present study, we identified ubiquitously expr...

journal_title：European journal of immunology

authors： Li W,Wang L,Jiang C,Li H,Zhang K,Xu Y,Hao Q,Li M,Xue X,Qin X,Zhang C,Wang H,Zhang W,Zhang Y

更新日期：2014-02-01 00:00:00

abstract：:A fusion between the mouse AKR thymoma BW5147 and a culture of homogeneously OX8+ (CD8) rat T lymphoblasts yield interleukin (IL) 2-dependent T cell hybridomas when selected in HAT medium supplemented with IL 2-containing supernatants of concanvalin A-activated cells and dexamethasone. IL 2-independent variants can be...

journal_title：European journal of immunology

authors： Somoza C,Fernández-Ruiz E,Jotterand-Bellomo M,Sanz E,Nabholz M,Silva A

更新日期：1989-07-01 00:00:00

abstract：:DNA vaccines induce CTL attack on target tumor epitopes, but tumor elimination in vivo also requires sufficient effector CTL to enter the site, guided by inflammatory chemokines. Many herpesviruses contain genes for chemokine and chemokine receptor-like proteins to protect infected cells from immune attack. To assess ...

journal_title：European journal of immunology

authors： Rice J,de Lima B,Stevenson FK,Stevenson PG

更新日期：2002-12-01 00:00:00

abstract：:The immunosuppressor sanglifehrin A (SfA) is a member of a family of immunophilin cyclophilin A-binding molecules and does not inhibit calcineurin activity. Sanglifehrin A inhibits M-CSF-dependent macrophage proliferation by arresting the G1 phase of the cell cycle but does not affect cell viability. This immunosuppre...

journal_title：European journal of immunology

authors： Sànchez-Tilló E,Wojciechowska M,Comalada M,Farrera C,Lloberas J,Celada A

更新日期：2006-09-01 00:00:00

abstract：:CBA/J mice immunized with thyroglobulin (Tg) develop an experimental autoimmune thyroiditis (EAT) with lymphocytic infiltration of the thyroid glands, autoantibodies to Tg and occurrence of EAT-specific T cells. When these mice were treated for 4 weeks after immunization with 1 mg/week of a monoclonal antibody (mAb) t...

journal_title：European journal of immunology

authors： Tang H,Mignon-Godefroy K,Meroni PL,Garotta G,Charreire J,Nicoletti F

更新日期：1993-01-01 00:00:00

abstract：:IL-6-specific autoantibodies (aAb-IL-6) have been reported in diseased and healthy individuals. We recently established a model for aAb-IL-6 in different mouse strains, based on vaccination with immunogenic IL-6 analogues, in which titers of aAb-IL-6 above 1,000 resulted in an in vivo IL-6 deficiency. Here, we examine...

journal_title：European journal of immunology

authors： Galle P,Svenson M,Bendtzen K,Hansen MB

更新日期：2004-11-01 00:00:00

abstract：:NK cells play important roles in immune surveillance against malignancy and virus-infected cells. NK cell functions are affected in patients infected with HIV-1; however, whether there is direct interaction between NK cells and HIV-1 remains controversial. In this study the expression of CD4, an important receptor for...

journal_title：European journal of immunology

authors： Harada H,Goto Y,Ohno T,Suzu S,Okada S

更新日期：2007-08-01 00:00:00

abstract：:Acute and chronic airway inflammations caused by environmental agents including endotoxin represent an increasing health problem. Local TNF production may contribute to lung dysfunction and inflammation, although pulmonary neutrophil recruitment occurs in the absence of TNF. First, we demonstrate that membrane-bound T...

journal_title：European journal of immunology

authors： Togbe D,Grivennikov SI,Noulin N,Couillin I,Maillet I,Jacobs M,Maret M,Fick L,Nedospasov SA,Quesniaux VF,Schnyder B,Schnyder-Candrian S

更新日期：2007-03-01 00:00:00

abstract：:The mechanisms responsible for major histocompatibility complex (MHC)-linked unresponsiveness are still poorly understood. Here we examine the cellular events that follow when B10. A mice are immunized with cow insulin, an antigen to which they make no apparent immunologic response. Despite the fact that there is no d...

journal_title：European journal of immunology

authors： Abromson-Leeman S,Laning J,Cantor H,Dorf ME

更新日期：1988-01-01 00:00:00

abstract：:Priming mice with a chicken gamma globulin (CGG) carrier protein significantly accelerated the onset of somatic mutation in the V chi Ox1 gene when the mice were subsequently immunized with 2-phenyl-5-oxazolone (phOx) coupled to CGG. The first mutations were already detected 7 days after immunization, while in the tru...

journal_title：European journal of immunology

authors： Källberg E,Gray D,Leanderson T

更新日期：1995-08-01 00:00:00

abstract：:We have characterized the peripheral B cell repertoire in T cell-mediated insulin-dependent diabetes mellitus (IDMM) and in B cell-mediated autoimmune idiopathic thrombocytopenic purpura (AITP). The VH6-containing repertoire in adult patients with IDDM or AITP and healthy control subjects was investigated by PCR ampli...

journal_title：European journal of immunology

authors： Söderström I,van Dijk-Härd I,Feld S,Hillörn V,Holmberg D,Lundkvist I

更新日期：1999-09-01 00:00:00

abstract：:Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum. Recent functional and genetic studies linked DMBT1 to the suppression of LPS-induced TLR4-mediated NF-kappaB activation and to the pathogenesis of Crohn's disease. Here, we aimed at unraveling the mole...

journal_title：European journal of immunology

authors： End C,Bikker F,Renner M,Bergmann G,Lyer S,Blaich S,Hudler M,Helmke B,Gassler N,Autschbach F,Ligtenberg AJ,Benner A,Holmskov U,Schirmacher P,Nieuw Amerongen AV,Rosenstiel P,Sina C,Franke A,Hafner M,Kioschis P,Schre

更新日期：2009-03-01 00:00:00

abstract：:A method for infection of lymphocytes with Moloney(Abelson) murine leukemia virus [M(A)-MuLV] is described. Only lymphoblasts obtained after stimulation of normal spleen cells by the B cell mitogen lipopolysaccharide (LPS) were satisfactory targets for virus-specific, secondary cytotoxic T lymphocytes (CTL), whereas s...

journal_title：European journal of immunology

authors： Stukart MJ,Vos A,Melitef CJ

更新日期：1981-03-01 00:00:00

abstract：:Multinucleated giant cells (MGC), which are a common feature of various pathologic states, were generated in vitro by cytokine-stimulation of human peripheral blood monocytes. As expected, conditioned medium, i.e. the supernatant of concanavalin A-stimulated peripheral blood mononuclear cells, readily caused generatio...

journal_title：European journal of immunology

authors： Möst J,Neumayer HP,Dierich MP

更新日期：1990-08-01 00:00:00

abstract：:IL-12 is an important immunomodulatory cytokine that induces tyrosine phosphorylation and activation of the signal transducer and activator of transcription (STAT)4. IL-12 induces sustained activation and nuclear translocation of STAT4 and this regulatory process is coupled to both tyrosine and serine phosphorylation ...

journal_title：European journal of immunology

authors： Athié-M V,Flotow H,Hilyard KL,Cantrell DA

更新日期：2000-05-01 00:00:00

abstract：:It has been shown previously that three different H-2-associated genes control the resistance to viremia and leukemia in Moloney virus-infected mice: Rmv. 1, mapping to the I-A or less probably K regions; Rmv. 2, mapping to the I-C, S or G regions and Rmv. 3, mapping to the D or T regions. Experiments have been perfo...

journal_title：European journal of immunology

authors： Debré P,Boyer B,Gisselbrecht S,Bismuth A,Lévy JP

更新日期：1980-12-01 00:00:00

abstract：:FTY720 is a novel immunosuppressant that improves the outcomes after solid organ and bone marrow transplantation (BMT) due to the sequestration of T cells into LN. We tested the hypothesis that the sequestration of donor T cells in LN by FTY720 would enhance their interaction with host APC, thus causing a greater degr...

journal_title：European journal of immunology

authors： Hashimoto D,Asakura S,Matsuoka K,Sakoda Y,Koyama M,Aoyama K,Tanimoto M,Teshima T

更新日期：2007-01-01 00:00:00

abstract：:The major leukocyte population in the decidua during the first trimester of pregnancy consists of NK cells that express receptors capable of recognizing MHC class I molecules expressed by placental trophoblast. These include members of the killer immunoglobulin-like receptor (KIR) family, the two-domain KIR (KIR2D), w...

journal_title：European journal of immunology

authors： Male V,Sharkey A,Masters L,Kennedy PR,Farrell LE,Moffett A

更新日期：2011-10-01 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (ALCAM; CD166) is a member of the immunoglobulin gene superfamily (IgSF) which is expressed by activated leukocytes and thymic epithelial cells and is a ligand for the lymphocyte antigen CD6. Herein, we report on the isolation and characterization of cDNA clones encoding mous...

journal_title：European journal of immunology

authors： Bowen MA,Bajorath J,D'Egidio M,Whitney GS,Palmer D,Kobarg J,Starling GC,Siadak AW,Aruffo A

更新日期：1997-06-01 00:00:00

abstract：:Human herpes virus 6B (HHV-6B) is a widespread virus that infects most people early in infancy and establishes a chronic life-long infection with periodic reactivation. CD4 T cells have been implicated in control of HHV-6B, but antigenic targets and functional characteristics of the CD4 T-cell response are poorly unde...

journal_title：European journal of immunology

authors： Becerra-Artiles A,Cruz J,Leszyk JD,Sidney J,Sette A,Shaffer SA,Stern LJ

更新日期：2019-08-01 00:00:00

abstract：:The distribution of the murine receptor for interleukin (IL) 6 was examined on a variety of cells. Binding sites for IL 6 were found on many cell lines including fibroblasts and bone marrow-derived macrophages. The highest density of binding sites was found on B cell hybridomas and plasmacytomas, irrespective of their...

journal_title：European journal of immunology

authors： Coulie PG,Stevens M,Van Snick J

更新日期：1989-11-01 00:00:00

abstract：:Spontaneous cytolytic activity of shark peripheral blood leukocytes is observed only during periods of decreased environmental temperature (less than 23 degrees C). The effector cell is adherent to glass and is phagocytic. Leukocytes tested during warmer periods (26-31 degrees C) exhibit no spontaneous activity; howev...

journal_title：European journal of immunology

authors： Pettey CL,McKinney EC

更新日期：1983-02-01 00:00:00