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A gamma-herpesvirus immune evasion gene allows tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope.

Abstract：

:DNA vaccines induce CTL attack on target tumor epitopes, but tumor elimination in vivo also requires sufficient effector CTL to enter the site, guided by inflammatory chemokines. Many herpesviruses contain genes for chemokine and chemokine receptor-like proteins to protect infected cells from immune attack. To assess if this evasion strategy could protect tumor cells, we used a model where CTL specific for a single epitope were the only effectors. Following DNA vaccination, CTL eliminated tumor cells from a subcutaneous site. However, introducing a viral gene encoding a secreted broad-spectrum chemokine-binding protein (M3) into tumor cells completely blocked CTL attack. Transduced tumor cells also protected neighboring non-transduced tumor. These findings confirm the importance of chemokines for migration of CTL to a non-lymphoid site. They may have relevance for escape of human virus-associated malignancies, and raise the question of whether analogous molecules might contribute to the failure of CTL to eliminate tumors.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Rice J,de Lima B,Stevenson FK,Stevenson PG

doi

10.1002/1521-4141(200212)32:12<3481::AID-IMMU3481>

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

3481-7

issue

12

eissn

0014-2980

issn

1521-4141

journal_volume

32

pub_type

杂志文章

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