Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease.

abstract：:Regulation of the development of thymocytes into mature T cells within the thymus is now known to involve antigen-induced deletion, by apoptosis, of potentially autoreactive thymocytes, and it can be mimicked either by stimulating the T cell receptor (TcR) complex by monoclonal antibody (mAb) or by ionophore-induced e...

journal_title：European journal of immunology

authors： Conroy LA,Jenkinson EJ,Owen JJ,Michell RH

更新日期：1995-07-01 00:00:00

abstract：:BALB/c mice were repeatedly immunized with microgram doses of benzylpenicilloylated Ascaris protein(s) (BPO9Asc) in alum. At different stages of the immune response, BPO21 eicosa-L-lysine or two analogs containing one or two hydrophobic p-oxymethylbenzyl-3 beta-cholestanyl succinate (OSuco) groups were injected. When ...

journal_title：European journal of immunology

authors： Lüscher IF,Weber E,de Weck AL

更新日期：1984-01-01 00:00:00

abstract：:The monoclonal antibody W6/32.1 recognizes a public determinant on the HLA-A, B and C antigens of all tested human haplotypes. Though the antibody does not bind to normal mouse cells of any H-2 haplotype, it does show an unexpected specificity for the T cell leukemia line MBL-2 from a C57BL/6 mouse. It is shown that t...

journal_title：European journal of immunology

authors： Evan GI,Lennox ES,Alderson T,Croft L

更新日期：1983-02-01 00:00:00

abstract：:The glycoprotein CD8 is believed to play an important role in the maturation and function of MHC class I-restricted T lymphocytes. CD8 has been proposed to function as a co-receptor of the TcR to participate in signal transduction, possibly through its cytoplasmic domain that binds to protein tyrosine kinase p56lck. A...

journal_title：European journal of immunology

authors： Fung-Leung WP,Louie MC,Limmer A,Ohashi PS,Ngo K,Chen L,Kawai K,Lacy E,Loh DY,Mak TW

更新日期：1993-11-01 00:00:00

abstract：:In the present study, we sought evidence for a surface nucleosome receptor in the fibroblastic cell line CV-1, and questioned whether anti-double-stranded (ds) DNA and/or anti-histone autoantibodies could recognize and influence the fate of cell surface-bound nucleosomes. 125I-labeled mononucleosomes were shown to bin...

journal_title：European journal of immunology

authors： Koutouzov S,Cabrespines A,Amoura Z,Chabre H,Lotton C,Bach JF

更新日期：1996-02-01 00:00:00

abstract：:Cross-linking of surface Ig receptors (sIg) by mitogenic forms of anti-Ig antibodies (e.g. F(ab')2 fragments of rabbit anti-Ig) causes the rapid, and prolonged breakdown of phosphatidylinositol 4,5-bisphosphate. This response involves an unidentified guanine nucleotide regulatory protein (termed Gp), which couples sIg...

journal_title：European journal of immunology

authors： Rigley KP,Harnett MM,Klaus GG

更新日期：1989-03-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a clonal hematopoietic stem-cell malignancy characterized by the presence of the chimeric BCR-ABL oncoprotein with deregulated tyrosine-kinase (TK) activity. Although conventional T cells are acknowledged as important players in the control of CML, a possible modification of invariant...

journal_title：European journal of immunology

authors： Rossignol A,Levescot A,Jacomet F,Robin A,Basbous S,Giraud C,Roy L,Guilhot F,Turhan AG,Barra A,Herbelin A,Gombert JM

更新日期：2012-07-01 00:00:00

abstract：:MicroRNAs control developmental pathways and effector functions in immune cells. Previous studies have studied the role of microRNAs in natural killer (NK) cells. However, the mouse models of microRNA depletion used were nonNK-specific and only partially depleting, hampering the interpretation of the data obtained. To...

journal_title：European journal of immunology

authors： Degouve S,Tavares A,Viel S,Walzer T,Marçais A

更新日期：2016-08-01 00:00:00

abstract：:The MRC OX-47 monoclonal antibody recognizes a membrane antigen present at low levels on many lymphocytes but whose expression is markedly increased on activation with mitogens. cDNA clones for the OX-47 antigen were isolated from an expression library and the protein sequence deduced. It contains a leader sequence gi...

journal_title：European journal of immunology

authors： Fossum S,Mallett S,Barclay AN

更新日期：1991-03-01 00:00:00

abstract：:Six different cell-mediated lympholysis (CML) combinations were established, four of which generated effector cells against the I-E, and two against the I-A molecule. The cell surface phenotype of effector cells was then determined by depletion of cytotoxic T lymphocyte (CTL) activity with antisera and rabbit compleme...

journal_title：European journal of immunology

authors： Vidovic D,Juretic A,Nagy ZA,Klein J

更新日期：1981-06-01 00:00:00

abstract：:Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg...

journal_title：European journal of immunology

authors： Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ

更新日期：2009-01-01 00:00:00

abstract：:IL-10 plays an important role in the regulation of immune responses. We and others have demonstrated recently that cyclic adenosine monophosphate (cAMP)-elevating substances up-regulate monocytic IL-10 expression in vitro and in vivo. Computer analysis of the IL-10 promoter/enhancer region localized four putative cAMP...

journal_title：European journal of immunology

authors： Platzer C,Fritsch E,Elsner T,Lehmann MH,Volk HD,Prösch S

更新日期：1999-10-01 00:00:00

abstract：:Gout manifests as recurrent episodes of acute joint inflammation and pain due to the deposition of monosodium urate (MSU) crystals within the affected tissue in a process dependent on NLRP3 inflammasome activation. The synthesis, activation, and release of IL-1β are crucial for MSU-induced inflammation. The current st...

journal_title：European journal of immunology

authors： Amaral FA,Bastos LF,Oliveira TH,Dias AC,Oliveira VL,Tavares LD,Costa VV,Galvão I,Soriani FM,Szymkowski DE,Ryffel B,Souza DG,Teixeira MM

更新日期：2016-01-01 00:00:00

abstract：:The multimeric Fc gamma RIIIA (CD16) complex is expressed on the surface of natural killer (NK) cells and is composed of a 50-70-kDa transmembrane glycoprotein Fc gamma receptor (CD16), the T cell receptor (TCR)-zeta chain, and the Fc epsilon RI gamma chain. Cross-linking Fc gamma RIIIA initiates the rapid tyrosine ph...

journal_title：European journal of immunology

authors： Cone JC,Lu Y,Trevillyan JM,Bjorndahl JM,Phillips CA

更新日期：1993-10-01 00:00:00

abstract：:Monoclonal gammopathies (MG) are monoclonal proliferative disorders of B cells at the differentiation stage of Ig production. They can be detected in the serum, either as transient or as persistent homogenous immunoglobulin (H-Ig) components. The exact phenotype, localization, and cell lineage origin of the precursor ...

journal_title：European journal of immunology

authors： van Arkel C,Hopstaken CM,Zurcher C,Bos NA,Kroese FG,Savelkoul HF,Benner R,Radl J

更新日期：1997-09-01 00:00:00

abstract：:A fusion between the mouse AKR thymoma BW5147 and a culture of homogeneously OX8+ (CD8) rat T lymphoblasts yield interleukin (IL) 2-dependent T cell hybridomas when selected in HAT medium supplemented with IL 2-containing supernatants of concanvalin A-activated cells and dexamethasone. IL 2-independent variants can be...

journal_title：European journal of immunology

authors： Somoza C,Fernández-Ruiz E,Jotterand-Bellomo M,Sanz E,Nabholz M,Silva A

更新日期：1989-07-01 00:00:00

abstract：:Listeria monocytogenes induces the formation of inflammasomes and subsequent caspase-1 activation, and the adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is crucial for this response. However, the role of ASC in L. monocytogenes infection in vivo is unclear. In this study, we demonstrate that ...

journal_title：European journal of immunology

authors： Tsuchiya K,Hara H,Fang R,Hernandez-Cuellar E,Sakai S,Daim S,Chen X,Dewamitta SR,Qu H,Mitsuyama M,Kawamura I

更新日期：2014-12-01 00:00:00

abstract：:The approximately 20-kDa heat-labile toxin produced by enterotoxigenic Bacteroides fragilis is known to be associated with the development of enteritis. However, the molecular mechanism involved is not yet fully understood. In this study, we assessed whether B. fragilis enterotoxin (BFT)-induced enteritis is related t...

journal_title：European journal of immunology

authors： Kim JM,Jung HY,Lee JY,Youn J,Lee CH,Kim KH

更新日期：2005-09-01 00:00:00

abstract：:Physical exercise, mental stress, or infusion of beta-adrenergic agonists result in an increase in the number of natural killer (NK) cells in the peripheral circulation. In view of the specific migration pattern of NK cells in vivo, it has been suggested that these cells may be released from the marginating pool in bl...

journal_title：European journal of immunology

authors： Benschop RJ,Oostveen FG,Heijnen CJ,Ballieux RE

更新日期：1993-12-01 00:00:00

abstract：:The MHC-related 1 (MR1) protein is a monomorphic, evolutionarily conserved MHC class I-like molecule, which is necessary for the development and functions of mucosal-associated invariant T (MAIT) cells, a new subset of innate-like lymphocytes. Multiple isoforms of the MR1 gene are naturally transcribed, but only the f...

journal_title：European journal of immunology

authors： Lion J,Debuysscher V,Wlodarczyk A,Hodroge A,Serriari NE,Choteau L,Ouled-haddou H,Plistat M,Lassoued K,Lantz O,Treiner E

更新日期：2013-05-01 00:00:00

abstract：:Constitutive expression of CD25, the IL-2 receptor alpha-chain, defines a distinct population of CD4+ T cells (Treg) with suppressive activity in vitro and in vivo. IL-2 has been implicated in the generation and maintenance of Treg, however, a functional contribution of the IL-2 receptor during suppression is thus far...

journal_title：European journal of immunology

authors： de la Rosa M,Rutz S,Dorninger H,Scheffold A

更新日期：2004-09-01 00:00:00

abstract：:The functional relevance of CD2-mediated signal transduction in triggering T cell receptor/CD3-independent natural killer cell cytotoxicity was investigated by introducing wild-type CD2 or signaling-deficient CD2 with truncated cytoplasmic region into a murine natural killer-like large granular lymphocyte clone lackin...

journal_title：European journal of immunology

authors： Nakamura T,Takahashi K,Koyanagi M,Yagita H,Okumura K

更新日期：1991-03-01 00:00:00

abstract：:Using a model of 2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity (CHS) we found that, as compared with wild-type mice, IL-15 receptor alpha chain (IL-15Ralpha)-deficient mice showed significantly less ear swelling. This decreased response was associated with diminished expression of CCL5/RANTES and CXCL10...

journal_title：European journal of immunology

authors： Chen JP,Liao NS,Lai SL,Hsu L,Mao WY,Ku MC,Liao F

更新日期：2005-03-01 00:00:00

abstract：:In this report we investigated the production and role of interleukin (IL)2 and IL4 in the generation of antigen-specific cytotoxic T cells (CTL). We used as our model the ultraviolet-light-induced epithelial tumor 1591, a highly immunogenic regressor tumor which evokes a strong cell-mediated immune response leading t...

journal_title：European journal of immunology

authors： Horvat B,Loukides JA,Anandan L,Brewer E,Flood PM

更新日期：1991-08-01 00:00:00

abstract：:The number of patients with severe atopic dermatitis (AD) has been on the rise recently. We are therefore urgently in need of a treatment that can suppress Th2 cell-mediated responses in an Ag-specific fashion. Oligodeoxynucleotides (ODN)containing CpG motifs (CpG ODN) have been highlighted as immunomodulators that re...

journal_title：European journal of immunology

authors： Kootiratrakarn T,Fujimura T,Sano K,Okuyama R,Aiba S,Tagami H,Terui T

更新日期：2005-11-01 00:00:00

abstract：:In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed. Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of class II gene transcription. We s...

journal_title：European journal of immunology

authors： Sartoris S,Tosi G,De Lerma Barbaro A,Cestari T,Accolla RS

更新日期：1996-10-01 00:00:00

abstract：:Previous studies have shown that IL-10 inhibits the accessory cell functions required for production of IFN-gamma by T cells and NK cells. Our results show that although IL-10 did not induce the production of IFN-gamma by NK cells, it did enhance the ability of IL-18 to stimulate NK cell production of IFN-gamma. In ad...

journal_title：European journal of immunology

authors： Cai G,Kastelein RA,Hunter CA

更新日期：1999-09-01 00:00:00

abstract：:H-2 gene-dependent nonresponsiveness and responsiveness to H-2-matched male cells can be observed in cytotoxic assays in several mouse strains. H-2 genes of several low responder strains can complement each other in cis or trans position to produce high responders. One of the H-2 gene products functions at the level o...

journal_title：European journal of immunology

authors： von Boehmer H,Fathman CG,Haas W

更新日期：1977-07-01 00:00:00

abstract：:Antigen-induced stimulation of T cells is mediated via the CD3 antigen receptor (Ti) complex and monoclonal antibodies (mAb) reacting with CD3 and Ti result in rapid intracellular Ca2+ mobilization, followed by monocyte-dependent proliferation. Combinations of mAb to CD2, the sheep red blood cell receptor, also mobili...

journal_title：European journal of immunology

authors： O'Flynn K,Knott LJ,Russul-Saib M,Abdul-Gaffar R,Morgan G,Beverley PC,Linch DC

更新日期：1986-05-01 00:00:00

abstract：:Bone marrow (BM) stromal cells are important in the development and maintenance of cells of the immune system. Using single cell RNA sequencing, we here explore the functional and phenotypic heterogeneity of individual transcriptomes of 1167 murine BM mesenchymal stromal cells. These cells exhibit a tremendous heterog...

journal_title：European journal of immunology

authors： Addo RK,Heinrich F,Heinz GA,Schulz D,Sercan-Alp Ö,Lehmann K,Tran CL,Bardua M,Matz M,Löhning M,Hauser AE,Kruglov A,Chang HD,Durek P,Radbruch A,Mashreghi MF

更新日期：2019-09-01 00:00:00