Monoclonal gammopathies in aging mu, kappa-transgenic mice: involvement of the B-1 cell lineage.

abstract：:Stimulation of human peripheral blood lymphocytes via T cell receptor/CD3 complex resulted in a bimodal activation of protein kinase(s) C (PKC). Within 10 min of stimulation PKC-alpha was translocated to, and thus activated in, the plasma membranes of human lymphocytes, followed by a fast dissociation of this isotype ...

journal_title：European journal of immunology

authors： Szamel M,Bartels F,Resch K

更新日期：1993-12-01 00:00:00

abstract：:Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that activate innate immune inflammatory responses, however, mechanism(s) by which SFAs control inflamma...

journal_title：European journal of immunology

authors： Davis FM,denDekker A,Joshi AD,Wolf SJ,Audu C,Melvin WJ,Mangum K,Riordan MO,Kunkel SL,Gallagher KA

更新日期：2020-12-01 00:00:00

abstract：:Co-infection of HCV with HIV has been associated with more rapid progression of HCV-related disease. HCV-specific T-cell immune responses, which are essential for disease control, are attenuated in co-infection with HIV. T-cell exhaustion has recently been implicated in the deficient control of chronic viral infection...

journal_title：European journal of immunology

authors： Vali B,Jones RB,Sakhdari A,Sheth PM,Clayton K,Yue FY,Gyenes G,Wong D,Klein MB,Saeed S,Benko E,Kovacs C,Kaul R,Ostrowski MA

更新日期：2010-09-01 00:00:00

abstract：:Anchor residues in peptides determine the specificity of binding to major histocompatibility complex class I molecules through interactions of their side chains with pockets in the peptide-binding groove. We have compared the kinetics of association of a Sendai virus nucleoprotein-derived peptide (FAPGNYPAL, termed SV...

journal_title：European journal of immunology

authors： Neefjes JJ,Dierx J,Ploegh HL

更新日期：1993-04-01 00:00:00

abstract：:This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. ...

journal_title：European journal of immunology

authors： Hanitsch L,Baumann U,Boztug K,Burkhard-Meier U,Fasshauer M,Habermehl P,Hauck F,Klock G,Liese J,Meyer O,Müller R,Pachlopnik-Schmid J,Pfeiffer-Kascha D,Warnatz K,Wehr C,Wittke K,Niehues T,von Bernuth H

更新日期：2020-10-01 00:00:00

abstract：:Interleukin (IL)-6 transsignaling plays a pivotal role in the shift from neutrophil to monocyte recruitment at the inflammatory site. Release of neutrophil IL-6 receptor-alpha (IL-6Ralpha, CD126) in its soluble form is a key step of IL-6 transsignaling, however, its physiological inducers are poorly known. Here, we ob...

journal_title：European journal of immunology

authors： Marin V,Montero-Julian F,Grès S,Bongrand P,Farnarier C,Kaplanski G

更新日期：2002-10-01 00:00:00

abstract：:Mouse B cells cultured with either phorbol myristate acetate (PMA), or with Ca2+ ionophores enter a transitional activated state, between quiescence (G0) and G1, but do not synthesize DNA. It is shown here that the combination of PMA plus the ionophore ionomycin induces resting B cells to synthesize DNA, but not to se...

journal_title：European journal of immunology

authors： Klaus GG,O'Garra A,Bijsterbosch MK,Holman M

更新日期：1986-01-01 00:00:00

abstract：:Intravenous immunoglobulins (IVIgs) efficiently suppress a variety of autoimmune diseases. Over the past few years several potential mechanisms underlying this antiinflammatory activity have become apparent. Among these, terminal sialic acid residues in the sugar moiety of the immunoglobulin G constant fragment have b...

journal_title：European journal of immunology

authors： Schwab I,Seeling M,Biburger M,Aschermann S,Nitschke L,Nimmerjahn F

更新日期：2012-12-01 00:00:00

abstract：:The heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) has been described as an important autoantigen in rheumatoid arthritis (RA) since it is targeted by autoantibodies, autoreactive T cells, and is aberrantly expressed in synovial cells in patients. To identify hnRNP-A2-specific T-cell epitopes possibly associate...

journal_title：European journal of immunology

authors： Trembleau S,Hoffmann M,Meyer B,Nell V,Radner H,Zauner W,Hammer J,Aichinger G,Fischer G,Smolen J,Steiner G

更新日期：2010-06-01 00:00:00

abstract：:Germinal center (GC) B cells undergo proliferation, somatic hypermutation and isotype switching in the course of differentiation into plasma cells to produce high-affinity antibodies. To understand the molecular mechanism regulating the expansion of memory B cells and the termination of expansion by differentiation in...

journal_title：European journal of immunology

authors： Choe J,Choi YS

更新日期：1998-02-01 00:00:00

abstract：:Mucosal boosting of BCG-immunised individuals with a subunit tuberculosis (TB) vaccine would be highly desirable, considering that the lungs are the principal port of entry for Mycobacterium tuberculosis (MTB) and the site of the primary infection and reactivation. However, the main roadblock for subunit TB vaccine de...

journal_title：European journal of immunology

authors： Stylianou E,Diogo GR,Pepponi I,van Dolleweerd C,Arias MA,Locht C,Rider CC,Sibley L,Cutting SM,Loxley A,Ma JK,Reljic R

更新日期：2014-02-01 00:00:00

abstract：:IL-10 is a potent anti-inflammatory molecule, which regulates TNF-alpha at multiple levels. We investigated whether IL-10 also modulated the activity of the TNF-alpha-converting enzyme (TACE). Using an ex vivo fluorogenic assay we observed that LPS rapidly induced TACE activity in monocytes coinciding with release of ...

journal_title：European journal of immunology

authors： Brennan FM,Green P,Amjadi P,Robertshaw HJ,Alvarez-Iglesias M,Takata M

更新日期：2008-04-01 00:00:00

abstract：:Development of Th1 and Th2 effector lymphocytes is driven primarily by IL-12 or IL-4, but is also influenced by the strength of antigenic stimulation. However, the mechanism by which TCR signaling contributes to T cell polarization remains elusive. We show that in the presence of IL-12 a short TCR stimulation can lead...

journal_title：European journal of immunology

authors： Iezzi G,Scotet E,Scheidegger D,Lanzavecchia A

更新日期：1999-12-01 00:00:00

abstract：:The mechanisms underlying the relatively slow progression of human immunodeficiency virus type 2 (HIV-2) compared with HIV-1 infection are undefined and could be a result of more effective immune responses. We used HIV-2 and HIV-1 IFN-gamma enzyme-linked immunospot assays to evaluate CD8(+) T cell responses in antiret...

journal_title：European journal of immunology

authors： Gillespie GM,Pinheiro S,Sayeid-Al-Jamee M,Alabi A,Kaye S,Sabally S,Sarge-Njie R,Njai H,Joof K,Jaye A,Whittle H,Rowland-Jones S,Dorrell L

更新日期：2005-05-01 00:00:00

abstract：:Synthetic peptides encoding protective pathogen-derived epitopes represent--in principle--an ideal approach to T-cell vaccination. Empirically, however, these strategies have not been successful. In the current study, we profiled the early activation of CD8+ T cells by MHC class I-restricted peptide immunization to be...

journal_title：European journal of immunology

authors： Overstreet MG,Freyberger H,Cockburn IA,Chen YC,Tse SW,Zavala F

更新日期：2010-01-01 00:00:00

abstract：:An association between T-cell lymphopenia and autoimmunity has long been proposed, but it remains to be elucidated whether T-cell lymphopenia affects B-cell responses to autoantigens. Human neonatal thymectomy (Tx) results in a decrease in T-cell numbers and we used this model to study the development of autoreactivit...

journal_title：European journal of immunology

authors： van den Broek T,Madi A,Delemarre EM,Schadenberg AWL,Tesselaar K,Borghans JAM,Nierkens S,Redegeld FA,Otten HG,Rossetti M,Albani S,Sorek R,Cohen IR,Jansen NJG,van Wijk F

更新日期：2017-11-01 00:00:00

abstract：:The physical association of CD5 and the T cell antigen receptor (TcR)/CD3 complex on the surface of intact human lymphocytes was investigated using co-capping experiments and fluorescence resonance energy transfer (FRET) analyses. Antibody-induced capping of CD5 or CD3 and double indirect immunofluorescence labeling r...

journal_title：European journal of immunology

authors： Osman N,Lazarovits AI,Crumpton MJ

更新日期：1993-05-01 00:00:00

abstract：:Twelve continuous rat tissue cultured mast cell (MC) lines were established by prolonged culture of rat peritoneal MC in the absence of added factors or feeder layers. Two of these lines, RCMC1 and RCMC2, have been briefly described previously, seven others are now also described. Both RCMC1 and RCMC2 lack a marker ch...

journal_title：European journal of immunology

authors： Chan BM,Ra CS,Hu WN,McNeill K,Miller HR,Befus D,Kinet JP,Froese A

更新日期：1990-01-01 00:00:00

abstract：:The pathogenesis of the decline of CD4 lymphocyte counts accompanying the typical course of HIV-1 infection is not completely defined and might be related to a differential susceptibility of naive and memory cells to HIV-1 exposure. Here, we examined the effects induced by heat-inactivated HIV-1 virions on these lymph...

journal_title：European journal of immunology

authors： Masci AM,Paz FL,Borriello A,Cassano S,Della Pietra V,Stoiber H,Matarese G,Della Ragione F,Zappacosta S,Racioppi L

更新日期：1999-06-01 00:00:00

abstract：:Radiolabeled protein A from Staphylococcus aureus (SpA) injected i.v. into mice and rabbits forms a soluble [(IgG)2-(SpA)1]2 complex (Mr = 684 000) which is identical in composition to that formed by SpA in vitro with an equivalent amount or an excess of IgG. A soluble rabbit IgG-SpA complex injected into a mice or ra...

journal_title：European journal of immunology

authors： Dima S,Medeşan C,Moţa G,Moraru I,Sjöquist J,Gheţie V

更新日期：1983-08-01 00:00:00

abstract：:A T3 complex-bearing subpopulation was characterized within an in vivo cycling T4-8- early thymocyte compartment which contains cells constitutively expressing interleukin 2 and transferrin receptors. We show differentiation in vitro of both mature subsets of thymocytes (T3+4+8- and T3+4-8+) from the above T4-8- compa...

journal_title：European journal of immunology

authors： De la Hera A,Toribio ML,Marquez C,Marcos MA,Cabrero E,Martinez-A C

更新日期：1986-06-01 00:00:00

abstract：:Large granular lymphocyte clones were prepared from normal human mononuclear cells. Seven clones were studied in detail. All had high cytotoxic activity against the natural killer (NK) cell target K562 and all were T11- and DR-positive but T4- and T8-negative: none released migration inhibitory factor, a characteristi...

journal_title：European journal of immunology

authors： Vyakarnam A,Brenner MK,Reittie JE,Houlker CH,Lachmann PJ

更新日期：1985-06-01 00:00:00

abstract：:Expression of activation markers and proliferative status were measured in peripheral CD4+ and CD8+ T cells of various T cell receptor (TCR)-transgenic mice either before or after intentional antigenic stimulation. In the absence of intentional immunization, CD4+ T cells persisted as resting or partially activated and...

journal_title：European journal of immunology

authors： Bruno L,von Boehmer H,Kirberg J

更新日期：1996-12-01 00:00:00

abstract：:The thymus is the primary organ for T-cell differentiation and maturation. Unlike other major organs, the thymus is highly dynamic, capable of undergoing multiple rounds of almost complete atrophy followed by rapid restoration. The process of thymic atrophy, or involution, results in decreased thymopoiesis and emigrat...

journal_title：European journal of immunology

authors： Dooley J,Liston A

更新日期：2012-05-01 00:00:00

abstract：:Anti-immunoglobulin antibodies (anti-Ig) provoke the rapid breakdown of phosphatidylinositol bisphosphate (PIP2), elevation of cytoplasmic Ca2+ levels ([Ca2+]i) and activation of protein kinase C (PKC) in B lymphocytes. Tumor-promoting phorbol esters, like phorbol myristate acetate, also activate PKC, but inhibit anti...

journal_title：European journal of immunology

authors： Bijsterbosch MK,Klaus GG

更新日期：1987-01-01 00:00:00

abstract：:Alpha-galactosylceramide (alpha-GalCer) activates invariant (i)NKT cells, which in turn stimulate immunocompetent cells. Although activation of iNKT cells appears critical for regulation of immune responses, it remains elusive whether protection against intracellular bacteria can be induced by alpha-GalCer. Here, we s...

journal_title：European journal of immunology

authors： Emoto M,Emoto Y,Yoshizawa I,Kita E,Shimizu T,Hurwitz R,Brinkmann V,Kaufmann SH

更新日期：2010-05-01 00:00:00

abstract：:Surfactant protein A (SP-A) and surfactant protein D (SP-D) are collectins, and both proteins were shown to interact with influenza A virus and alveolar macrophages. However, it is not known whether SP-A and SP-D can serve as opsonins for the phagocytosis of influenza A virus by alveolar macrophages. In the present st...

journal_title：European journal of immunology

authors： Benne CA,Benaissa-Trouw B,van Strijp JA,Kraaijeveld CA,van Iwaarden JF

更新日期：1997-04-01 00:00:00

abstract：:IL-18 was originally described as a cytokine which induced IFN-gamma production by established Th1 cells in an IL-12-independent manner. However, subsequent studies demonstrated that exogenous IL-18 in the absence of IL-12 failed to drive Th1 differentiation of naive cells and induced IFN-gamma from established Th1 ce...

journal_title：European journal of immunology

authors： Chang JT,Segal BM,Nakanishi K,Okamura H,Shevach EM

更新日期：2000-04-01 00:00:00

abstract：:A monoclonal antibody (mAb), 3A35, produced against mouse macrophages (M phi) was found to react against certain activated T cells. This mAb, a rat IgM, resulted from a cell fusion between a mouse plasmacytoma and rat lymphocytes immunized against mouse M phi. It bound more avidly to activated than to resident M phi. ...

journal_title：European journal of immunology

authors： Le Corre R,Gerlier D,Martin A,Le Garrec Y,Corradin G,Bron C,Toujas L

更新日期：1987-03-01 00:00:00

abstract：:Major advances in preventing, delaying, or curing individual pathologies are responsible for an increasingly long life span in the developed parts of our planet, and indeed reaching eight to nine decades of life is nowadays extremely frequent. However, medical and sanitary advances have not prevented or delayed the un...

journal_title：European journal of immunology

authors： Pinti M,Appay V,Campisi J,Frasca D,Fülöp T,Sauce D,Larbi A,Weinberger B,Cossarizza A

更新日期：2016-10-01 00:00:00