Abstract:
:A T3 complex-bearing subpopulation was characterized within an in vivo cycling T4-8- early thymocyte compartment which contains cells constitutively expressing interleukin 2 and transferrin receptors. We show differentiation in vitro of both mature subsets of thymocytes (T3+4+8- and T3+4-8+) from the above T4-8- compartment, their appearance being preceded by cells in a T3+4-8- intermediate stage. Furthermore, those mature thymocytes generated in vitro contain functionally competent cells which use T3, T4 and T8 structures for their cytolytic activity. The finding of T3+4-8- thymocytes in vivo, together with the observation that T3 antigen expression precedes that of T4 or T8 molecules in vitro, shows that T3 (and presumably Ti) is present early in ontogeny, and suggests that T3+4-8- cells constitute an "intermediate" stage relevant to the connection between early precursors and mature thymocytes during T lymphocyte ontogeny.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
De la Hera A,Toribio ML,Marquez C,Marcos MA,Cabrero E,Martinez-A Cdoi
10.1002/eji.1830160611subject
Has Abstractpub_date
1986-06-01 00:00:00pages
653-8issue
6eissn
0014-2980issn
1521-4141journal_volume
16pub_type
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