Reduced 2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity response in IL-15 receptor alpha-deficient mice correlates with diminished CCL5/RANTES and CXCL10/IP-10 expression.

abstract：:Dendritic cells (DC) are extremely proficient inducers of naïve CD4+ T cell activation due to their high expression level of peptide-MHC and an array of accessory molecules involved in cell migration, adhesion and co-signaling, including PD-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). Whether PD-L1 and PD-L2 have a s...

journal_title：European journal of immunology

authors： Kuipers H,Muskens F,Willart M,Hijdra D,van Assema FB,Coyle AJ,Hoogsteden HC,Lambrecht BN

更新日期：2006-09-01 00:00:00

abstract：:The third component of complement C3 has been implied in the stimulation of B lymphocytes to proliferation and maturation for Ig secretion. We have reinvestigated the extent of this activation with either activated or resting murine splenic lymphocytes in serum-substituted cultures. Human C3 was used in either soluble...

journal_title：European journal of immunology

authors： Erdei A,Melchers F,Schulz T,Dierich M

更新日期：1985-02-01 00:00:00

abstract：:Current models of lymphocyte traffic suggest that homing specificities of T cells to tissues such as skin are generated outside the thymus as a result of activation of naive T cells by antigen in lymph nodes. Virgin T cells are thought to home to high endothelial venules in lymph nodes, but are thought to be unable to...

journal_title：European journal of immunology

authors： Washington EA,Kimpton WG,Holder JE,Cahill RN

更新日期：1995-03-01 00:00:00

abstract：:Between 10 and 20% of the peripheral gammadelta T cells express cytoplasmic TCR-beta proteins, but whether such TCR-beta chains can partake in alphabeta T-cell development has never been systematically investigated. Therefore, we reconstituted the T-cell compartment of CD3epsilon-deficient mice with Pax5-TCR-beta defi...

journal_title：European journal of immunology

authors： Bosco N,Engdahl C,Bénard A,Rolink J,Ceredig R,Rolink AG

更新日期：2008-12-01 00:00:00

abstract：:Only activated and effector memory T cells are thought to access non-lymphoid tissues. In contrast, naive T cells are thought to circulate only between the blood, lymph and secondary lymphoid organs. We examined the phenotype of endogenous T cells in various non-lymphoid organs and showed that a subset of cells exhibi...

journal_title：European journal of immunology

authors： Cose S,Brammer C,Khanna KM,Masopust D,Lefrançois L

更新日期：2006-06-01 00:00:00

abstract：:Peptides associated with HLA-B35 commonly have a proline or occasionally a serine residue in the P2 anchor position of the peptide, with a tyrosine at the C terminus. Based on this motif, we identified an octamer epitope from influenza A matrix protein which is presented by HLA-B35. The requirements for MHC binding an...

journal_title：European journal of immunology

authors： Dong T,Boyd D,Rosenberg W,Alp N,Takiguchi M,McMichael A,Rowland-Jones S

更新日期：1996-02-01 00:00:00

abstract：:MICA and MICB (MHC-class-I-related chain A/B) are transmembrane proteins expressed in pathological conditions that are ligands for NKG2D, an activating receptor found on cytotoxic lymphocytes. The recognition on target cells of NKG2D ligands leads to the activation of lysis and cytokine secretion by NK cells and T cel...

journal_title：European journal of immunology

authors： Agüera-González S,Gross CC,Fernández-Messina L,Ashiru O,Esteso G,Hang HC,Reyburn HT,Long EO,Valés-Gómez M

更新日期：2011-12-01 00:00:00

abstract：:Bone morphogenetic proteins (BMP) are multifunctional cytokines that belong to the TGF-beta superfamily. BMP have been shown to regulate haematopoietic stem cells, B lymphopoiesis and early thymocyte differentiation. In the present study we explored the role of BMP-6 in Jurkat TAg cells. BMP-6 rapidly induced phosphor...

journal_title：European journal of immunology

authors： Sivertsen EA,Huse K,Hystad ME,Kersten C,Smeland EB,Myklebust JH

更新日期：2007-10-01 00:00:00

abstract：:The stimulatory as well as the inhibitory capacity of alloantisera has been investigated with respect to rat mast cell functions. Alloantibody against alloantigens coded for by the major histocompatibility (H-1) gene region promoted histamine release from purified LEW mast cells. This process was found to be complemen...

journal_title：European journal of immunology

authors： Mossmann H,Lauer W,Vortisch U,Gunther E,Bazin H,Hammer DK

更新日期：1976-08-01 00:00:00

abstract：:Listeria monocytogenes (LM) is a foodborne Gram-positive intracellular pathogen that can cause listeriosis in humans and animals. Although phagocytes are known to be involved in the response to this infection, the role of neutrophils is not entirely clear. Here, we have demonstrated that soon after LM infection, a lar...

journal_title：European journal of immunology

authors： Wang G,Lin A,Han Q,Zhao H,Tian Z,Zhang J

更新日期：2018-09-01 00:00:00

abstract：:The human T lymphocyte-specific CD2 (T11) molecule, that regulates T cell activation, is capable of mediating increases of intracellular cAMP. Monoclonal antibodies directed to different epitopes of the CD2 molecule which either induce or inhibit T cell proliferation are capable of triggering an increase of cAMP compa...

journal_title：European journal of immunology

authors： Carrera AC,Rincón M,De Landázuri MO,López-Botet M

更新日期：1988-06-01 00:00:00

abstract：:MicroRNA (miRNA) are a class of post-transcriptional regulators of gene expression targeting mRNA for translational repression and/or degradation. We analyzed the expression of 365 miRNA in lymphocytes in relapsing-remitting MS patients, and show the first evidence for distinct miRNA expression profiles in CD4(+), CD8...

journal_title：European journal of immunology

authors： Lindberg RL,Hoffmann F,Mehling M,Kuhle J,Kappos L

更新日期：2010-03-01 00:00:00

abstract：:Immunotherapies that augment antitumor T cells have had recent success for treating patients with cancer. Here we examined whether tumor-specific CD4(+) T cells enhance CD8(+) T-cell adoptive immunotherapy in a lymphopenic environment. Our model employed physiological doses of tyrosinase-related protein 1-specific CD4...

journal_title：European journal of immunology

authors： Church SE,Jensen SM,Antony PA,Restifo NP,Fox BA

更新日期：2014-01-01 00:00:00

abstract：:ME3738 is a new compound that attenuates liver disease in several models of acute and chronic liver inflammation. We used the concanavalin A (Con A) model to elucidate the molecular mechanisms of ME3738 to block liver cell damage. Pretreatment of BALB/c mice with ME3738 prior to Con A injection resulted in a significa...

journal_title：European journal of immunology

authors： Klein C,Wüstefeld T,Heinrich PC,Streetz KL,Manns MP,Trautwein C

更新日期：2003-08-01 00:00:00

abstract：:The BCR plays a central role in B cell development, survival, activation, and differentiation. We have identified the B cell novel protein 1 (BCNP1) as a new regulator of BCR signaling. BCNP1 contains a pleckstrin homology domain, three proline-rich motifs, and a potential SH2 binding site, and is predominantly expres...

journal_title：European journal of immunology

authors： Hong R,Lai N,Ouchida R,Xiong E,Zhou Y,Min Q,Liu J,Tang Y,Hikida M,Tsubata T,Wang Y,Wang JY

更新日期：2019-06-01 00:00:00

abstract：:The 20S proteasome is a protease complex of functional importance for antigen processing. Two of the 14 proteasome subunits, delta and MB1, can be replaced by the major histocompatibility complex (MHC)-encoded and interferon-gamma (IFN-gamma)-inducible subunits LMP2 and LMP7, respectively. LMP2 and LMP7 alter the clea...

journal_title：European journal of immunology

authors： Groettrup M,Kraft R,Kostka S,Standera S,Stohwasser R,Kloetzel PM

更新日期：1996-04-01 00:00:00

abstract：:CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of resting B cells, immunoglobulin (Ig) secretion from B cells cultured with cytokines and cytokine secretion and tumoricidal activity from monocytes. In this report...

journal_title：European journal of immunology

authors： Armitage RJ,Tough TW,Macduff BM,Fanslow WC,Spriggs MK,Ramsdell F,Alderson MR

更新日期：1993-09-01 00:00:00

abstract：:Three molecular forms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1ra type II (IL-1ra3), have no leader sequence, thus ...

journal_title：European journal of immunology

authors： Muzio M,Polentarutti N,Facchetti F,Peri G,Doni A,Sironi M,Transidico P,Salmona M,Introna M,Mantovani A

更新日期：1999-03-01 00:00:00

abstract：:This study was performed as a means to examine the effects of environment and stem cell origin on the molding of T cell receptor gene rearrangements during T cell development. Lethally irradiated adult mice were first reconstituted with (C57BL/6 x DBA/2)F1 stem cells, which derived either from a fetal liver or adult b...

journal_title：European journal of immunology

authors： Larché M,Manzo AR,Hurwitz JL

更新日期：1991-12-01 00:00:00

abstract：:Strains CBA (M523) (= M523) and CBA differ by a mutation which has been mapped genetically into the K region of the H-2 complex. Similarly, strains B 10.D2 (M504 (= M504) and b 10.D2 differ in a mutation which occurred in the D region. The data presented in this study show that mixed lymphocyte culture in M523 anti-CB...

journal_title：European journal of immunology

authors： Geib RW,Klein J

更新日期：1979-02-01 00:00:00

abstract：:Collagen type II-induced arthritis (CIA) is an experimental model of arthritis that has been successfully used to dissect the pathogenesis of human rheumatoid arthritis and to identify potential therapeutic targets. We have used this model to evaluate the role of T cell co-stimulation in both disease development and p...

journal_title：European journal of immunology

authors： Webb LM,Walmsley MJ,Feldmann M

更新日期：1996-10-01 00:00:00

abstract：:The molecular mimicry represented by cross-recognition of determinants shared by unrelated antigens by antibodies or T cells is of broad immunological interest. In this study, we analyzed the cross-recognition by CD4+ T cells of a peptide epitope shared by two mycobacterial proteins of diverse sequence, represented by...

journal_title：European journal of immunology

authors： Harris DP,Vordermeier HM,Singh M,Moreno C,Jurcevic S,Ivanyi J

更新日期：1995-11-01 00:00:00

abstract：:We have shown previously that complement factor H (CFH) and complement factor B (CFB) are constitutively expressed by retinal pigment epithelial cells and their production is regulated by inflammatory cytokines, suggesting that the alternative pathway (AP) of complement activation might play a role in retinal inflamma...

journal_title：European journal of immunology

authors： Chen M,Muckersie E,Luo C,Forrester JV,Xu H

更新日期：2010-10-01 00:00:00

abstract：:Two out of five murine IgG3 anti-trinitrophenyl (TNP) monoclonal antibodies (mAb) obtained either by immunization with TNP-keyhole limpet hemocyanin (KLH) (CB1, CB5, CB6 and 4H10) or with dinitrophenyl-lipopolysaccharide (9A6), exhibited anti-IgG rheumatoid factor (RF) activity (CB6 and 4H10). The anti-IgG activity of...

journal_title：European journal of immunology

authors： Reininger L,Spertini F,Shibata T,Jaton JC,Izui S

更新日期：1989-11-01 00:00:00

abstract：:Injection into mice of a free reactive form of the hapten (4-hydroxy-3,5-dinitrophenyl)acetyl (NNP), induces a state of specific unresponsiveness to the hapten, upon its challenge with thymus-cependent and independent carriers. This unresponsiveness is maintained in vitro. Both induction and expression of the unrespon...

journal_title：European journal of immunology

authors： Gronowicz E,Coutinho A

更新日期：1976-06-01 00:00:00

abstract：:In this study we have examined the role of small numbers of adherent cells in the stimulation of highly purified resting T lymphocytes by cross-linked monoclonal anti-CD3 antibodies (T3). T cells were obtained by 3 cycles of purification, using adherence to plastic surface, nylon wool column separation and rosetting w...

journal_title：European journal of immunology

authors： Heumann D,Vischer TL

更新日期：1987-11-01 00:00:00

abstract：:We investigated here the potential role of Toll-like receptors (TLR) and the adaptor protein MyD88 in innate immunity responses to Cryptococcus neoformans, a pathogenic encapsulated yeast. Peritoneal macrophages from MyD88(-/-) or TLR2(-/-) mice released significantly less TNF-alpha, compared with wild-type controls, ...

journal_title：European journal of immunology

authors： Biondo C,Midiri A,Messina L,Tomasello F,Garufi G,Catania MR,Bombaci M,Beninati C,Teti G,Mancuso G

更新日期：2005-03-01 00:00:00

abstract：:The transcriptional repressor Gfi1 is a nuclear zinc-finger protein that is expressed in T cell precursors in the thymus, but is down-regulated in mature, resting T cells. Gfi1 expression rises transiently to levels seen in thymocytes upon antigenic activation. We show here that lack of Gfi1 causes delayed cell cycle ...

journal_title：European journal of immunology

authors： Pargmann D,Yücel R,Kosan C,Saba I,Klein-Hitpass L,Schimmer S,Heyd F,Dittmer U,Möröy T

更新日期：2007-12-01 00:00:00

abstract：:Regulatory T cells (Treg) are vital in maintaining the homeostasis of immune reactions. In chronic infections, such as schistosomiasis, it remains unclear whether engagement of the TLR family is required to induce Treg activity. Thus, we performed in vivo studies using TLR2-/- mice infected with Schistosoma mansoni an...

journal_title：European journal of immunology

authors： Layland LE,Rad R,Wagner H,da Costa CU

更新日期：2007-08-01 00:00:00

abstract：:In humans and mice, mucosal immune responses are dominated by IgA antibodies and the cytokine TGF-β, suppressing unwanted immune reactions but also targeting Ig class switching to IgA. It had been suggested that eosinophils promote the generation and maintenance of mucosal IgA-expressing plasma cells. Here, we demonst...

journal_title：European journal of immunology

authors： Beller A,Kruglov A,Durek P,von Goetze V,Werner K,Heinz GA,Ninnemann J,Lehmann K,Maier R,Hoffmann U,Riedel R,Heiking K,Zimmermann J,Siegmund B,Mashreghi MF,Radbruch A,Chang HD

更新日期：2020-06-01 00:00:00