Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation.

abstract：:Myeloid dendritic cells (DC) and macrophages evolve from a common precursor. However, factors controlling monocyte differentiation toward DC or macrophages are poorly defined. We report that the surface density of the GM-CSF receptor (GM-CSFR) alpha subunit in human peripheral blood monocytes varies among donors. Alth...

journal_title：European journal of immunology

authors： Conti L,Cardone M,Varano B,Puddu P,Belardelli F,Gessani S

更新日期：2008-03-01 00:00:00

abstract：:CD5 is expressed on T cells and a subset of B cells (B1a). It can attenuate TCR signalling and impair CTL activation and is a therapeutic targetable tumour antigen expressed on leukemic T and B cells. However, the potential therapeutic effect of functionally blocking CD5 to increase T cell anti-tumour activity against...

journal_title：European journal of immunology

authors： Alotaibi F,Rytelewski M,Figueredo R,Zareardalan R,Zhang M,Ferguson PJ,Maleki Vareki S,Najajreh Y,El-Hajjar M,Zheng X,Min WP,Koropatnick J

更新日期：2020-05-01 00:00:00

abstract：:Cell ablation is a valuable complement to mutagenesis for experimentally defining specific cell functions in physiology and pathophysiology in small animal models. One of the most popular ablation strategies involves transgenic expression of a primate diphtheria toxin receptor (DTR) on murine cells that are otherwise ...

journal_title：European journal of immunology

authors： Ruedl C,Jung S

更新日期：2018-07-01 00:00:00

abstract：:Retinoic acid (RA), which is the biologically active form of vitamin A, acts through the nuclear hormone receptor RAR (RA receptor) to induce either gene activation or repression. RA production and its effects have been linked to macrophages, dendritic cells, T and B cells, and iNKT cells in the immune system and play...

journal_title：European journal of immunology

authors： Nagy L

更新日期：2012-07-01 00:00:00

abstract：:Intravenous immunoglobulin G (IVIg) therapy is widely used to treat autoimmune and inflammatory diseases. Recent evidence suggests that in mice, splenic resident cells might be important for the anti-inflammatory activity of IVIg in a model of serum transfer arthritis. Splenectomized human immunothrombocytopenia (ITP)...

journal_title：European journal of immunology

authors： Schwab I,Biburger M,Krönke G,Schett G,Nimmerjahn F

更新日期：2012-04-01 00:00:00

abstract：:During the chronic phase of infection with the parasite Trypanosoma cruzi, mice develop inflammatory lesions in the heart and skeletal muscles, as well as in peripheral nerves and the liver. We demonstrated the presence, in the blood of chronically infected mice, of L3T4+ T cells able to transfer a specific T. cruzi d...

journal_title：European journal of immunology

authors： Hontebeyrie-Joskowicz M,Said G,Milon G,Marchal G,Eisen H

更新日期：1987-07-01 00:00:00

abstract：:CD4+CD25(hi)CD127(lo/-) regulatory T cells (Treg) have been implicated in the resolution of asthma-associated inflammation while the opposite role of CD4+ invariant NKT (iNKT) cells has been the subject of recent investigations. Studies here focused on mechanisms of interaction between CD4+ iNKT cells and Treg to furt...

journal_title：European journal of immunology

authors： Nguyen KD,Vanichsarn C,Nadeau KC

更新日期：2008-07-01 00:00:00

abstract：:A study was made of the ability of the superantigen staphylococcal enterotoxin B (SEB) to induce relapses of experimental allergic encephalomyelitis (EAE) in SJL mice that had partially or completely recovered from acute EAE. We find that a single injection of 0.05 mg SEB i.v. induces mild relapses in 50% of such mice...

journal_title：European journal of immunology

authors： Crisi GM,Santambrogio L,Hochwald GM,Smith SR,Carlino JA,Thorbecke GJ

更新日期：1995-11-01 00:00:00

abstract：:NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 in...

journal_title：European journal of immunology

authors： Campos PC,Gomes MTR,Marinho FAV,Guimarães ES,de Moura Lodi Cruz MGF,Oliveira SC

更新日期：2019-07-01 00:00:00

abstract：:Vaccination of mice with irradiated Schistosoma mansoni larvae confers high levels of immunity which is mediated by Th1-type lymphocytes. To investigate a possible role for IL-12 in the induction of protection, we have compared the immune response of IL-12 p40-deficient (KO) mice and their C57BL/6 (WT) counterparts fo...

journal_title：European journal of immunology

authors： Anderson S,Shires VL,Wilson RA,Mountford AP

更新日期：1998-09-01 00:00:00

abstract：:Immunodominant T cell epitopes from the autoantigen human cartilage glycoprotein 39 have previously been mapped in the context of HLA-DR*0401 and *0402, using mice expressing HLA-DR4 transgenes. We measured the dissociation rates of these epitopes from soluble recombinant DR*0401 and DR*0402 to assess the relationship...

journal_title：European journal of immunology

authors： Hall FC,Rabinowitz JD,Busch R,Visconti KC,Belmares M,Patil NS,Cope AP,Patel S,McConnell HM,Mellins ED,Sonderstrup G

更新日期：2002-03-01 00:00:00

abstract：:LeIF, a gene homologue of the eukaryotic initiation factor 4A was first described as a leishmanial antigen that induced a Th1-type T cell response in peripheral blood mononuclear cells (PBMC) from leishmaniasis patients. Moreover, the interferon (IFN)-gamma production by PBMC was found to be interleukin (IL)-12 depend...

journal_title：European journal of immunology

authors： Probst P,Skeiky YA,Steeves M,Gervassi A,Grabstein KH,Reed SG

更新日期：1997-10-01 00:00:00

abstract：:The deposition of immune complexes, followed by activation of complement and/or Fc receptors and generation of chemoattractants, is the most common feature of human glomerulonephritis. Recently we have shown that primary cultured human glomerular mesangial cells (HMC), which are normally negative for IgG Fc receptors,...

journal_title：European journal of immunology

authors： Uciechowski P,Schwarz M,Gessner JE,Schmidt RE,Resch K,Radeke HH

更新日期：1998-09-01 00:00:00

abstract：:The interaction of polymorphonuclear leukocytes (PMN) with the vascular endothelium and their subsequent extravasation to the tissues is a key step during different physiological and pathological processes. In certain of these pathologies the oxygen tension becomes very low, leading to reduced cellular oxidative statu...

journal_title：European journal of immunology

authors： Montoya MC,Luscinskas FW,del Pozo MA,Aragonés J,de Landázuri MO

更新日期：1997-08-01 00:00:00

abstract：:Two subpopulations of human T lymphocytes expressing different antigen receptors, alpha/beta and gamma/delta, emigrate into inflamed tissues in distinctive patterns. We compared the transmigration of alpha/beta and gamma/delta T cells to C-C and C-X-C chemokines using an in vitro transendothelial chemotaxis assay. The...

journal_title：European journal of immunology

authors： Roth SJ,Diacovo TG,Brenner MB,Rosat JP,Buccola J,Morita CT,Springer TA

更新日期：1998-01-01 00:00:00

abstract：:Mature T cells first appear in the thymus of the mouse a few days before birth, about 7-8 days after the thymus was colonized by stem cells. These mature cells are exported to the peripheral lymphoid organs beginning at about the time of birth, but because the number is very small at this stage, little is known about ...

journal_title：European journal of immunology

authors： Kelly KA,Scollay R

更新日期：1992-02-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) suppresses T cell responses by its action in catabolising tryptophan. It is important in maintenance of immune privilege in the placenta. We investigated the activity of IDO in the cornea, following corneal transplantation and the effect of IDO over-expression in donor corneal endothe...

journal_title：European journal of immunology

authors： Beutelspacher SC,Pillai R,Watson MP,Tan PH,Tsang J,McClure MO,George AJ,Larkin DF

更新日期：2006-03-01 00:00:00

abstract：:The mechanisms responsible for major histocompatibility complex (MHC)-linked unresponsiveness are still poorly understood. Here we examine the cellular events that follow when B10. A mice are immunized with cow insulin, an antigen to which they make no apparent immunologic response. Despite the fact that there is no d...

journal_title：European journal of immunology

authors： Abromson-Leeman S,Laning J,Cantor H,Dorf ME

更新日期：1988-01-01 00:00:00

abstract：:We have analyzed the relationship between the signaling pathways coupled to surface immunoglobulin and interleukin (IL)-4 receptors in human B cells from the patterns of expression of a panel of phorbol ester-inducible early response genes (ERG) activated by anti-IgM and IL-4 stimulation in vitro. Anti-IgM stimulation...

journal_title：European journal of immunology

authors： Murphy JJ,Norton JD

更新日期：1993-11-01 00:00:00

abstract：:The inflammatory cytokine IL-17 plays a critical role in immunity to infection and is involved in the inflammatory pathology associated with certain autoimmune diseases, such as psoriasis and rheumatoid arthritis. While CD4(+) and CD8(+) T cells are important sources of this cytokine, recent evidence has suggested tha...

journal_title：European journal of immunology

authors： Sutton CE,Mielke LA,Mills KH

更新日期：2012-09-01 00:00:00

abstract：:B cells get help in the antibody response by presenting antigen to helper T (Th) cells. Upon antigen recognition, T cells produce lymphokines that act as growth and differentiation factors for B cells, but resting B cells require additional helper signals that depend on cell contact with an activated Th cell. Like lym...

journal_title：European journal of immunology

authors： Kawakami K,Parker DC

更新日期：1992-01-01 00:00:00

abstract：:The present study was designed to elucidate the role of Valpha14(+) NKT cells in the host defense against pulmonary infection with Streptococcus pneumoniae using Jalpha281 gene-disrupted mice (Jalpha281KO mice) that lacked this lymphocyte subset. In these mice, pneumococcal infection was severely exacerbated, as shown...

journal_title：European journal of immunology

authors： Kawakami K,Yamamoto N,Kinjo Y,Miyagi K,Nakasone C,Uezu K,Kinjo T,Nakayama T,Taniguchi M,Saito A

更新日期：2003-12-01 00:00:00

abstract：:An anti-T cell receptor (TcR) monoclonal antibody (mAb), LC4, directed against a human leukemic T cell line, SUP-T13, caused DNA fragmentation ("apoptosis") and cell death upon binding to this cell line. Cross-linking of receptor molecules was necessary for this effect since F(ab')2, but not Fab', fragments of LC4 cou...

journal_title：European journal of immunology

authors： Takahashi S,Maecker HT,Levy R

更新日期：1989-10-01 00:00:00

abstract：:A method is described for radiolabeling polyanionic macromolecules by the formation of an electrostatic complex with a radioiodinated tyramine conjugated DEAE-dextran. Data is presented on the use of this technique for the detection and quantitation of immunospecific binding of polynitrophenylated proteins, deoxyribon...

journal_title：European journal of immunology

authors： Little JR,Blanke TJ,Little KD

更新日期：1976-06-01 00:00:00

abstract：:The number of patients with severe atopic dermatitis (AD) has been on the rise recently. We are therefore urgently in need of a treatment that can suppress Th2 cell-mediated responses in an Ag-specific fashion. Oligodeoxynucleotides (ODN)containing CpG motifs (CpG ODN) have been highlighted as immunomodulators that re...

journal_title：European journal of immunology

authors： Kootiratrakarn T,Fujimura T,Sano K,Okuyama R,Aiba S,Tagami H,Terui T

更新日期：2005-11-01 00:00:00

abstract：:Despite accounting for only a minor fraction of all cells in Hodgkin's lymphoma tissue, the Hodgkin and Reed-Sternberg (HRS) cells represent the malignant tumor cell clone in Hodgkin's disease (HD). By far the most abundant cell type in the tumor tissue are CD4+ T cells. Some of them intimately associate with HRS cell...

journal_title：European journal of immunology

authors： Roers A,Montesinos-Rongen M,Hansmann ML,Rajewsky K,Küppers R

更新日期：1998-08-01 00:00:00

abstract：:Vaccinia virus (VV)-encoded MHC class I Kd molecules which differ by a single amino acid change from glutamine (Kdw, wild type) to histidine (Kdm, mutant) at position 114 located in the floor of the peptide binding groove were compared in terms of peptide binding and cytotoxic T (Tc) cell recognition. Most anti-viral ...

journal_title：European journal of immunology

authors： Müllbacher A,Lobigs M,Yewdell JW,Bennink JR,Tha Hla R,Blanden RV

更新日期：1999-04-01 00:00:00

abstract：:Bispecific antibodies binding to the TCR/CD3 complex and to a tumor-associated surface molecule can be used to target cytotoxic T lymphocytes against tumor cells. We reasoned that high-affinity binding to CD3 may reduce the efficiency of T cell stimulation and target the bispecific reagent to T cells rather than to tu...

journal_title：European journal of immunology

authors： Bortoletto N,Scotet E,Myamoto Y,D'Oro U,Lanzavecchia A

更新日期：2002-11-01 00:00:00

abstract：:In humans and in BALB/c mice, immune responses to the hormone insulin use evolutionarily related VHV (human) and VHIX (murine) gene families. To determine if these structural relationships include regulatory elements, BALB/c mice were pretreated with autologous immunoglobulin G (IgG) monoclonal antibodies (mAb) that r...

journal_title：European journal of immunology

authors： Thomas JW

更新日期：1992-09-01 00:00:00

abstract：:The interaction of KB-V1, a multidrug resistant (MDR) variant of the KB-3-1 human oral carcinoma, with human complement was investigated. KB-V1 cells were found to be more sensitive than KB-3-1 cells to complement-mediated lysis. Detailed analysis of the capacity of KB cells to activate human complement demonstrated t...

journal_title：European journal of immunology

authors： Bomstein Y,Fishelson Z

更新日期：1997-09-01 00:00:00