L3T4+ T cells able to mediate parasite-specific delayed-type hypersensitivity play a role in the pathology of experimental Chagas' disease.

Abstract:

:During the chronic phase of infection with the parasite Trypanosoma cruzi, mice develop inflammatory lesions in the heart and skeletal muscles, as well as in peripheral nerves and the liver. We demonstrated the presence, in the blood of chronically infected mice, of L3T4+ T cells able to transfer a specific T. cruzi delayed-type hypersensitivity (DTH) reaction. Transfer of the chronic inflammatory lesions was obtained by injecting Lyt-2+-depleted lymphocytes from either lymph node or blood of infected mice. T cell lines were established from the chronically infected mice by culturing peripheral blood lymphocytes or lymph node cells with either T. cruzi extracts (TC) or mouse peripheral nerve extracts (PN). Those cell lines that presented an L3T4+ phenotype were also able to specifically transfer a local DTH reaction to naive recipients. Examination of the antigen specificities of these TDTH lines revealed three types: those that mediated a DTH reaction to TC, those that responded to both TC and PN and those that provoked a DTH response when injected with subinflammatory doses of an irrelevant antigen. Some of the lines, when injected into the sciatic nerve of naive recipients, provoked demyelination of the type observed in chronically infected animals. These results suggest that T. cruzi and the host nervous system share common epitopes that can be recognized by TDTH cells.

journal_name

Eur J Immunol

authors

Hontebeyrie-Joskowicz M,Said G,Milon G,Marchal G,Eisen H

doi

10.1002/eji.1830170720

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

1027-33

issue

7

eissn

0014-2980

issn

1521-4141

journal_volume

17

pub_type

杂志文章
  • NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity.

    abstract::The NKG2D receptor is expressed by human NK, gammadelta T and alpha/beta T lymphocytes and its engagement results in the stimulation of effector cells. We evaluated the role of NKG2D receptor in anti-colorectal cancer (CRC) immune response. The cell surface expression of stress-inducible NKG2D ligands MICA/B (MHC clas...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200323909

    authors: Maccalli C,Pende D,Castelli C,Mingari MC,Robbins PF,Parmiani G

    更新日期:2003-07-01 00:00:00

  • Age- and strain-dependent polymorphism in IgE antibody against the phosphorylcholine hapten.

    abstract::The magnitude of the IgE antibody response against the phosphorylcholine (PC) hapten and the rate of age-related change of IgE formation is polymorphic in the three long-lived and six relatively short-lived strains of mice studied. Long-lived mice showed an early increase, followed by a decline in the levels of anti-P...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830160621

    authors: Gerber V,Ponnappan U,Heusser CH,Blaser K,Cinader B

    更新日期:1986-06-01 00:00:00

  • Fine specificity of the H-2 linked immune response gene for the gallinaceous lysozymes.

    abstract::An immune response (Ir) gene is described which controls the ability of mice to respond to seven very closely related gallinaceous egg white lysozymes (GEL). This Ir-GEL gene locus is linked to the major histocompatibility locus of the mouse and operates at the level of the T cell. Responsiveness to the nonimmunogenic...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830050506

    authors: Hill SW,Sercarz EE

    更新日期:1975-05-01 00:00:00

  • The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity.

    abstract::The mer receptor tyrosine kinase mediates phagocytosis of apoptotic cells and modulates cytokine production; it is also required for prevention of systemic autoimmune disease. Using a mer-specific antibody, we have confirmed the presence of mer on macrophages and now report its expression on NK cells, NKT cells, and d...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200324076

    authors: Behrens EM,Gadue P,Gong SY,Garrett S,Stein PL,Cohen PL

    更新日期:2003-08-01 00:00:00

  • Human papillomavirus entry into NK cells requires CD16 expression and triggers cytotoxic activity and cytokine secretion.

    abstract::Human papillomavirus (HPV) infections account for more than 50% of infection-linked cancers in women worldwide. The immune system controls, at least partially, viral infection and around 90% of HPV-infected women clear the virus within two years. However, it remains unclear which immune cells are implicated in this pr...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201141693

    authors: Renoux VM,Bisig B,Langers I,Dortu E,Clémenceau B,Thiry M,Deroanne C,Colige A,Boniver J,Delvenne P,Jacobs N

    更新日期:2011-11-01 00:00:00

  • DTR-mediated conditional cell ablation-Progress and challenges.

    abstract::Cell ablation is a valuable complement to mutagenesis for experimentally defining specific cell functions in physiology and pathophysiology in small animal models. One of the most popular ablation strategies involves transgenic expression of a primate diphtheria toxin receptor (DTR) on murine cells that are otherwise ...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章

    doi:10.1002/eji.201847527

    authors: Ruedl C,Jung S

    更新日期:2018-07-01 00:00:00

  • Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity.

    abstract::MS and EAE are T cell-driven autoimmune diseases of the CNS where IL-17-producing Th17 cells promote damage and are pathogenic. Conversely, tolerogenic DCs induce Treg cells and suppress Th17 cells. Chloroquine (CQ) suppresses EAE through the modulation of DCs by unknown mechanisms. Here, we show that STAT 1 is necess...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201747362

    authors: Thome R,Bonfanti AP,Rasouli J,Mari ER,Zhang GX,Rostami A,Verinaud L

    更新日期:2018-07-01 00:00:00

  • Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes.

    abstract::Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognat...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/1521-4141(200204)32:4<945::AID-IMMU945>3.0

    authors: Czarneski J,Berguer P,Bekinschtein P,Kim DC,Hakimpour P,Wagner N,Nepomnaschy I,Piazzon I,Ross SR

    更新日期:2002-04-01 00:00:00

  • Antigen-independent binding of IgG dimers to C 1 q as studied by sedimentation equilibrium, complement fixation and electron microscopy.

    abstract::Rabbit anti-SII pneumococcal polysaccharide IgG antibody was cross-linked by dithiobis (succinimidyl propionate). The IgG dimers were visualized by electronmicroscopy and resembled two Y-shaped structures connected in random orientations. The three arms of the Y's were of equal length. The six globular domains of the ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830100709

    authors: Tschopp J,Villiger W,Lustig A,Jaton JC,Engel J

    更新日期:1980-07-01 00:00:00

  • Distribution of perforin-containing cells in normal and pregnant mice.

    abstract::Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells elaborate a cytolytic protein named perforin or cytolysin. It was widely held that, in vivo, high quantities of perforin are not present in resting lymphocytes and are usually produced only by activated lymphocytes found under pathological conditions. Until n...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830230907

    authors: Zheng LM,Ojcius DM,Young JD

    更新日期:1993-09-01 00:00:00

  • IgE secretion is attenuated by an inhibitor of proteolytic processing of CD23 (Fc epsilonRII).

    abstract::CD23, the low-affinity IgE receptor, is up-regulated on interleukin (IL)-4-stimulated B cells and monocytes, with a concomitant increase in the release of soluble fragments of CD23 (sCD23) into the medium by proteolytic processing of the surface-bound intact CD23. The effect of inhibition of the processing of CD23 on ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830271221

    authors: Christie G,Barton A,Bolognese B,Buckle DR,Cook RM,Hansbury MJ,Harper GP,Marshall LA,McCord ME,Moulder K,Murdock PR,Seal SM,Spackman VM,Weston BJ,Mayer RJ

    更新日期:1997-12-01 00:00:00

  • IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.

    abstract::Mast cells are important cellular constituents of epithelial-mesenchymal interactions, densely located at sites of microbial entry into the host where they are continuously exposed to products from commensals. In order to avoid excessive activation and the associated pathology, mast cell responses to TLR agonists must...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201242786

    authors: Sandig H,Jobbings CE,Roldan NG,Whittingham-Dowd JK,Orinska Z,Takeuchi O,Akira S,Bulfone-Paus S

    更新日期:2013-04-01 00:00:00

  • The mechanism of synergistic complement-mediated lysis of rat red cells by monoclonal IgG antibodies.

    abstract::The mechanism of synergistic complement-mediated lysis of rat red cells was investigated using rat monoclonal antibodies against class I RT1Aa antigens. The increased lytic activity when using two antibodies simultaneously is due to the increase in the number of activated C1 molecules on the cell surface and this resu...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830130806

    authors: Hughes-Jones NC,Gorick BD,Howard JC

    更新日期:1983-08-01 00:00:00

  • MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airways.

    abstract::Th2 lymphocytes deliver essential signals for induction of asthmatic airway inflammation. We previously found that airway antigen challenge induces recruitment of Gr-1(+) neutrophils prior to the recruitment of Th2 cells. We examined, therefore, whether Gr-1(+) cells contribute to the development of Th2-dependent airw...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200838985

    authors: Jung YW,Zindl CL,Lai JF,Weaver CT,Chaplin DD

    更新日期:2009-08-01 00:00:00

  • CD28 co-stimulation is intact and contributes to prolonged ex vivo survival of hyporesponsive synovial fluid T cells in rheumatoid arthritis.

    abstract::In rheumatoid arthritis (RA), T cells in the inflamed joint are considered to play a crucial role in the pathogenesis. However, despite the fact that synovial T cells have an activated memory phenotype, they are functionally suppressed upon combined CD3 and CD28 stimulation. Here, we analyzed the contribution of both ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-4141(199805)28:05<1554::AID-IMM

    authors: Maurice MM,van der Voort EA,Leow A,Levarht N,Breedveld FC,Verweij CL

    更新日期:1998-05-01 00:00:00

  • Delayed-type hypersensitivity induced in immunodeficient mice with syngeneic modified self antigens: a suggestive model of autoimmune response.

    abstract::Previous studies suggested that trinitrophenyl (TNP)-modified syngeneic red cells induced humoral autoimmune response in mice with defective T cell function but not in normal mice. The ability of modified self antigen to induce autoimmune response in immunodeficient mice was further explored using the delayed-type hyp...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830121112

    authors: Tarcic N,Naor D

    更新日期:1982-11-01 00:00:00

  • Stress protein (hsp73)-mediated, TAP-independent processing of endogenous, truncated SV40 large T antigen for Db-restricted peptide presentation.

    abstract::Transporter associated with antigen processing (TAP)-competent and TAP-deficient cell lines were transfected with expression plasmids encoding either the wild-type (wt) large tumor antigen (T-Ag) of SV40, or a truncated cytoplasmic variant (cT-Ag) of this viral protein. Stable expression of comparable levels of both f...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830270828

    authors: Schirmbeck R,Böhm W,Reimann J

    更新日期:1997-08-01 00:00:00

  • Fc gamma RII-dependent sensitisation of natural interferon-producing cells for viral infection and interferon-alpha responses.

    abstract::Natural interferon-producing cells (NIPC), also called plasmacytoid dendritic cells, are the most potent producers of IFN-alpha in response to viral and bacterial components, serving an important function in innate immune defences. The present work demonstrates that NIPC responsiveness can be primed by immunisation, i...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200525998

    authors: Balmelli C,Vincent IE,Rau H,Guzylack-Piriou L,McCullough K,Summerfield A

    更新日期:2005-08-01 00:00:00

  • Direct exosome stimulation of peripheral human T cells detected by ELISPOT.

    abstract::Exosomes from APC are nano-vesicles that can induce antigen-specific T cell responses and are presently explored as therapeutic tools in different clinical settings. Investigations of the capacity of exosomes to stimulate T cells in vitro have mostly been performed on T cell hybridomas, clones or lines. Whether exosom...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200535615

    authors: Admyre C,Johansson SM,Paulie S,Gabrielsson S

    更新日期:2006-07-01 00:00:00

  • CD45RB expression defines two interconvertible subsets of human CD4+ T cells with memory function.

    abstract::Reciprocal expression of CD45RA and CD45RO in human CD4+ T cells defines populations understood to be naive cells (CD45RA+CD45RO-) and memory cells (CD45RA-CD45RO+). We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright a...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830240536

    authors: Horgan KJ,Tanaka Y,Luce GE,van Seventer GA,Nutman TB,Shaw S

    更新日期:1994-05-01 00:00:00

  • Hepatic dendritic cell subsets in the mouse.

    abstract::The CD11c(+) cell population in the non-parenchymal cell population of the mouse liver contains dendritic cells (DC), NK cells, B cells and T cells. In the hepatic CD11c(+) DC population from immunocompetent or immunodeficient [recombinase-activating gene-1 (RAG1)(-/-)] C57BL/6 mice (rigorously depleted of T cells, B ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200324336

    authors: Jomantaite I,Dikopoulos N,Kröger A,Leithäuser F,Hauser H,Schirmbeck R,Reimann J

    更新日期:2004-02-01 00:00:00

  • Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules.

    abstract::The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent activator of invariant natural killer T (iNKT) cells and has been shown to be an effective agent against cancer, infections and autoimmune diseases. The effectiveness of alpha-GalCer and its alkyl chain analogues depends on efficient loading and presen...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200737518

    authors: Denkberg G,Stronge VS,Zahavi E,Pittoni P,Oren R,Shepherd D,Salio M,McCarthy C,Illarionov PA,van der Merwe A,Besra GS,Dellabona P,Casorati G,Cerundolo V,Reiter Y

    更新日期:2008-03-01 00:00:00

  • CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human γδ peripheral blood lymphocytes.

    abstract::Human Vγ9Vδ2 T cells are potent anti-tumor lymphocytes that specifically respond to pyrophosphate (phospho-) antigens, which constitute the basis of current γδ T-cell-based immunotherapy strategies. Despite a clear involvement of the TCR, the costimulation requirements of Vγ9Vδ2 T cells remain ill-defined. Here, we sh...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201040905

    authors: DeBarros A,Chaves-Ferreira M,d'Orey F,Ribot JC,Silva-Santos B

    更新日期:2011-01-01 00:00:00

  • LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation.

    abstract::The T cell-dependent differentiation and function of B lymphocytes are tightly regulated by TNF ligands (L) and receptors interactions, such as CD40/CD40L, CD27/CD70 and CD134/CD314L. The LIGHT/HVEM system [homologous to lymphotoxin, inducible expression, competing for GpD of herpes virus, that binds to the herpes vir...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200425598

    authors: Duhen T,Pasero C,Mallet F,Barbarat B,Olive D,Costello RT

    更新日期:2004-12-01 00:00:00

  • Complement alternative pathway activation and control on membranes of human lymphoid B cell lines.

    abstract::Membrane regulatory molecules normally prevent complement activation by autologous cells, therefore we compared the membrane control system of human lymphoid cell lines which activate or not human complement through the alternative pathway (AP). Membrane expression of decay-accelerating factor (DAF), membrane cofactor...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830201218

    authors: Caudwell V,Porteu F,Calender A,Pangburn MK,Halbwachs-Mecarelli L

    更新日期:1990-12-01 00:00:00

  • Cholera toxin increases intracellular pH in B lymphoma cells and decreases their antigen-presenting ability.

    abstract::Cholera toxin (CT) can function as a potent adjuvant in the mucosal immune response. However, we have found that treatment of A20-HL murine B lymphoma cells with CT severely inhibits the presentation of ovalbumin (OVA) to cells of the T cell clone 42-6A specific for OVA(323-339)/I-Ad, whereas it does not affect the pr...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-4141(199905)29:05<1561::AID-IMM

    authors: Tanaka Y,Nakano H,Ishikawa F,Yoshida M,Gyotoku Y,Kakiuchi T

    更新日期:1999-05-01 00:00:00

  • Sequences of the mouse F protein alleles and identification of a T cell epitope.

    abstract::F protein is found predominantly in the liver and is of unknown function. The protein has been of interest to immunologists in the areas of self tolerance and the immunogenetics of the anti-F protein response. In the mouse there are two alleles (F1 and F2), and although mice are completely tolerant to the self form of...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830210521

    authors: Schofield JP,Vijayakumar RK,Oliveira DB

    更新日期:1991-05-01 00:00:00

  • Functional half-life of virgin and primed B lymphocytes.

    abstract::The functional half-life, a measure of the persistence of lymphocytes in an antigen-free environment, has been estimated and found to be about 7 days for virgin 2,4,6-trinitrophenyl (TNP)-reactive mouse B cells, and 2--3 times longer for TNP-primed B cells. Using allotype-congenic mice, lymph node cells were transferr...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830060908

    authors: Elson CJ,Jablonska KF,Taylor RB

    更新日期:1976-09-01 00:00:00

  • T cell clones with normal or defective O-galactosylation from a patient with permanent mixed-field polyagglutinability.

    abstract::To delineate the extent of O-galactosyltransferase deficiency within the lymphoid lineage, monoclonal antibody specific for the Thomsen-Friedenreich (TF) antigen (Gal beta 1----3GalNAc alpha 1-O-Ser/Thr) and its precursor the Tn antigen (GalNAc alpha 1-O-Ser/Thr) were applied to the flow cytometric analysis of periphe...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830220724

    authors: Thurnher M,Clausen H,Fierz W,Lanzavecchia A,Berger EG

    更新日期:1992-07-01 00:00:00

  • Soluble anti-mu monoclonal antibodies prime resting B cells to secrete immunoglobulins in response to interleukins-4 and -5.

    abstract::Soluble anti-immunoglobulin (Ig) antibodies have been generally found to inhibit Ig secretion in B cells, via largely unknown mechanisms. To investigate this phenomenon further a two-step culture system was used in which B cells are primed for 24-72 h with various soluble monoclonal or polyclonal anti-Ig antibodies: a...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830220629

    authors: Phillips C,Klaus GG

    更新日期:1992-06-01 00:00:00