An HLA-B35-restricted epitope modified at an anchor residue results in an antagonist peptide.


:Peptides associated with HLA-B35 commonly have a proline or occasionally a serine residue in the P2 anchor position of the peptide, with a tyrosine at the C terminus. Based on this motif, we identified an octamer epitope from influenza A matrix protein which is presented by HLA-B35. The requirements for MHC binding and T cell receptor contact have been analyzed using analogs of this peptide with substitutions at positions 1, 2, 4, 7 and 8. The natural epitope contains a serine residue at P2 of the peptide. Substitution of this residue with proline (the favored amino acid in this position in B35-associated peptides) considerably enhances binding to HLA-B35 in the T2-B35 cell line, but the peptide is not recognized by the majority of CTL clones and can antagonize recognition of the index peptide. This suggests that a conservative substitution at the P2 anchor position results in a conformational change in the peptide-MHC surface exposed to the T cell receptor.


Eur J Immunol


Dong T,Boyd D,Rosenberg W,Alp N,Takiguchi M,McMichael A,Rowland-Jones S




Has Abstract


1996-02-01 00:00:00












  • Fulfilling the dream: tolerogenic dendritic cells to treat multiple sclerosis.

    abstract::Autoimmune diseases including multiple sclerosis (MS) are the result of an imbalanced immune tolerance network. Dendritic cells (DCs) are key players in both initiating immunity (immunogenic DCs) and regulating immune responses (tolerogenic DCs = tolDCs) and are potential targets for the treatment of MS. While the imm...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章


    authors: Gross CC,Jonuleit H,Wiendl H

    更新日期:2012-03-01 00:00:00

  • The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them.

    abstract::F1----parental bone marrow chimeras between CBA and B10 mice were used to show that even after 1 year follicular dendritic cells (FDC), also termed dendritic reticular cells, are not derived from bone marrow stem cells. However clusters of cells wrapped in the dendritic processes of FDC, isolated by enzyme digestion o...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Humphrey JH,Grennan D,Sundaram V

    更新日期:1984-09-01 00:00:00

  • Identification of human cytotoxic ILC3s.

    abstract::Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cytotoxic CD127+ CD94- , ILC1s, ILC2s, ILC3s, and LTi cells. Here, we identify a previously unrecognized subset within the CD127+ ILC population, characterized by the expression of the cytotoxic marker CD94. These CD94+ I...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Krabbendam L,Heesters BA,Kradolfer CMA,Spits H,Bernink JH

    更新日期:2020-12-09 00:00:00

  • Mini-review CD4 T cells are required for CD8 T cell memory generation.

    abstract::Whereas the role of CD4 T cells in B cell memory generation is well established and unequivocal, the role that CD4 T cells play in CD8 responses was until recently far more elusive and controversial. A series of recent reports, however, have re-assessed the role of CD4 help on CD8 responses and have given rise to surp...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Bourgeois C,Tanchot C

    更新日期:2003-12-01 00:00:00

  • Polyreactive autoantibodies to negatively charged epitopes following Trypanosoma cruzi infection.

    abstract::During the course of many human autoimmune diseases, antibodies which recognize negatively charged epitopes on self antigens are detected. Trypanosoma cruzi, an intracellular protozoan parasite capable of infecting a wide variety of vertebrates, is the cause of Chagas disease in humans. Infection with the parasite fre...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Kahn S,Kahn M,Eisen H

    更新日期:1992-12-01 00:00:00

  • Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice.

    abstract::Mucosa-associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating the activation of nuclear factor κB (NF-κB) signaling through both its adaptor and proteolytic function. Malt1 is also a target of its own protease activity and this self-cleavage further contributes to NF-κB activity. Until now, t...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Baens M,Stirparo R,Lampi Y,Verbeke D,Vandepoel R,Cools J,Marynen P,de Bock CE,Bornschein S

    更新日期:2018-10-01 00:00:00

  • Fasciola hepatica tegumental antigens induce anergic-like T cells via dendritic cells in a mannose receptor-dependent manner.

    abstract::FoxP3(+) Treg cells and anergic T cells are the two regulatory phenotypes of T-cell responses associated with helminth infection. Here, we examine the T-cell responses in mice during Fasciola hepatica infection, and to its tegumental coat antigens (FhTeg) that are shed from the fluke every 2-3 h. FhTeg comprises a ric...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Aldridge A,O'Neill SM

    更新日期:2016-05-01 00:00:00

  • The lymphocyte surface antigen CD38 acts as a nicotinamide adenine dinucleotide glycohydrolase in human T lymphocytes.

    abstract::The extracellular domain of the lymphocyte surface antigen CD38 has been recently shown to share a high sequence homology with a nicotinamide adenine dinucleotide (NAD+)-specific hydrolyzing enzyme cloned from the ovotestis of the gastropod Aplysia (E. States, D.J., Walseth, T.F., Lee, H. C., Trends Biochem. Sci. 1992...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Gelman L,Deterre P,Gouy H,Boumsell L,Debré P,Bismuth G

    更新日期:1993-12-01 00:00:00

  • gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes.

    abstract::Under physiological conditions, activation of CD4+ T cells by major histocompatibility complex (MHC)antigen complexes requires engagement of both the T cell receptor and the CD4 molecule. However, CD4 ligands binding to the CD4 molecule has also been shown to inhibit T cell proliferation and interleukin (IL)-2 product...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Jabado N,Pallier A,Jauliac S,Fischer A,Hivroz C

    更新日期:1997-02-01 00:00:00

  • Heterogeneity of rat encephalitogenic T cells elicited by variants of the myelin basic protein (68-86) peptide.

    abstract::By immunizing Lewis rats with myelin basic protein (MBP) peptide variants derived from the major encephalitogenic epitope of guinea pig (MBP(68-88) and then isolating encephalitogenic T cells from these animals, we demonstrated that the variant peptides do not elicit the same encephalitogenic T cell subsets as those i...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Sun D,Coleclough C,Hu XZ

    更新日期:1995-06-01 00:00:00

  • Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregions.

    abstract::Differential screening of a subtracted cDNA library led to the detection of two distinct but homologous mouse cDNA, called CTLA-2 alpha and CTLA-2 beta. The corresponding transcripts have a tissue distribution restricted to T lymphocytes, where they are inducible upon activation, and to mast cells. The open-frame regi...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Denizot F,Brunet JF,Roustan P,Harper K,Suzan M,Luciani MF,Mattei MG,Golstein P

    更新日期:1989-04-01 00:00:00

  • The relation of idiotype expression to isotype and allotype in the anti-p-azobenzenearsonate response.

    abstract::The distribution of idiotype-positive plaques in mice of various strains injected with T-independent (TI) and T-dependent conjugates of p-azobenzenearsonate (Ars) has been investigated. With maturation of the responses there is a progressive loss of dominance of the major cross-reactive idiotype (CRI) in A/J and C.AL-...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Henry C,Lucas A

    更新日期:1982-03-01 00:00:00

  • High diversity of the immune repertoire in humanized NOD.SCID.gamma c-/- mice.

    abstract::The diversity of the human immune repertoire and how it relates to a functional immune response has not yet been studied in detail in humanized NOD.SCID.gammac(-/-) immunodeficient mice. Here, we used a multiplex PCR on genomic DNA to quantify the combinatorial diversity of all possible V-J rearrangements at the TCR-b...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Marodon G,Desjardins D,Mercey L,Baillou C,Parent P,Manuel M,Caux C,Bellier B,Pasqual N,Klatzmann D

    更新日期:2009-08-01 00:00:00

  • The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells.

    abstract::Th17 cells are defined by their capacity to produce IL-17, and are important mediators of inflammation and autoimmunity. Human Th17 cells express high levels of the retinoic acid-related orphan receptor variant 2 (RORC2), but it is currently unclear whether expression of this transcription factor alone is sufficient t...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Crome SQ,Wang AY,Kang CY,Levings MK

    更新日期:2009-06-01 00:00:00

  • CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses.

    abstract::The magnitude and quality of T cell responses generated when Ag is targeted to receptors on DC is influenced by both the specific receptor targeted and its distribution among DC subsets. Here we examine the targeting of the model Ag OVA to potential DC targets, including CD11c, CD205, MHC class II, CD40, TLR2 and Fcga...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Castro FV,Tutt AL,White AL,Teeling JL,James S,French RR,Glennie MJ

    更新日期:2008-08-01 00:00:00

  • Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity.

    abstract::Mast cells are widely distributed in tissues, particularly near surfaces exposed to the environment. Mast cells can be activated to secrete diverse mediators and cytokines by IgE and specific Ag and many other stimuli, including products derived from either pathogens or the host during innate immune responses. Althoug...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Galli SJ,Tsai M

    更新日期:2010-07-01 00:00:00

  • A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice.

    abstract::Interleukin-12 family cytokines have emerged as critical regulators of immunity with some members (IL-12, IL-23) associated with disease pathogenesis while others (IL-27, IL-35) mitigate autoimmune diseases. Each IL-12 family member is comprised of an α and a β chain, and chain-sharing is a key feature. Although four ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Wang X,Wei Y,Xiao H,Liu X,Zhang Y,Han G,Chen G,Hou C,Ma N,Shen B,Li Y,Egwuagu CE,Wang R

    更新日期:2016-06-01 00:00:00

  • Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability.

    abstract::Antimicrobial peptides human beta-defensins (hBD) are mainly produced by epithelia of several organs including skin, and participate in innate immunity by killing invading pathogens. Besides their microbicidal activities, hBD activate several inflammatory and immune cells. Since hBD are generated by tissues where mast...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Chen X,Niyonsaba F,Ushio H,Hara M,Yokoi H,Matsumoto K,Saito H,Nagaoka I,Ikeda S,Okumura K,Ogawa H

    更新日期:2007-02-01 00:00:00

  • Liposomes as immunological adjuvants in eliciting antibodies specific to the synthetic polypeptide poly(LTyr, LGlu)-poly(DLAla)--(LLys) with high frequency of site-associated idiotypic determinants.

    abstract::The antibody response to the synthetic polypeptide, poly(LTyr, LGlu)-poly(DLAla)--poly(LLys), [(T,G)-A--L], injected entrapped in liposomes which served as adjuvant has been analyzed. The liposomes used were composed of phosphatidylcholine, cholesterol, dicetylphosphate and DL alpha-tocopherol (molar ratios as 4:3:0.1...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Lifshitz R,Gitler C,Mozes E

    更新日期:1981-05-01 00:00:00

  • Macrophage colony-stimulating factor gene transfer into tumor cells induces macrophage infiltration but not tumor suppression.

    abstract::In order to analyze the effect of a high local concentration of macrophage colony-stimulating factor (M-CSF; CSF-1) on tumor growth, the plasmacytoma cell line J558L was transfected with the human M-CSF gene and injected into syngeneic BALB/c mice. In contrast to the parental tumors, M-CSF transfectants were heavily i...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Dorsch M,Hock H,Kunzendorf U,Diamantstein T,Blankenstein T

    更新日期:1993-01-01 00:00:00

  • Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4⁺ effector memory T cells.

    abstract::Graft-versus-host disease (GVHD) caused by donor T cells attacking recipient tissues is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (alloSCT). Studies have shown that effector memory T (T(EM) ) cells do not cause GVHD but are capable of immune functions post-tr...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Anderson BE,Tang AL,Wang Y,Froicu M,Rothstein D,McNiff JM,Jain D,Demetris AJ,Farber DL,Shlomchik WD,Shlomchik MJ

    更新日期:2011-09-01 00:00:00

  • T90/44 (9.3 antigen). A cell surface molecule with a function in human T cell activation.

    abstract::T90/44 is a cell surface antigen which is present on human T cells of the helper and cytotoxic subsets and which binds the 9.3 monoclonal antibody (9.3 mAb). It is expressed in the form of 90-kDa disulfide-bonded dimers of a 44-kDa polypeptide and of free 44-kDa subunits. The function of T90/44 was investigated in a s...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Lesslauer W,Koning F,Ottenhoff T,Giphart M,Goulmy E,van Rood JJ

    更新日期:1986-10-01 00:00:00

  • A pseudosymmetric cell adhesion regulatory domain in the beta7 tail of the integrin alpha4beta7 that interacts with focal adhesion kinase and src.

    abstract::The beta7 integrins alpha4beta7 and alphaEbeta7 play key roles in forming the gut-associated lymphoid tissue, and contribute to chronic inflammation. The alpha4beta7 integrin-mediated adhesion of activated lymphocytes is largely due to a transient increase in avidity from ligand-induced clustering of alpha4beta7 at th...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Krissansen GW,Singh J,Kanwar RK,Chan YC,Leung E,Lehnert KB,Kanwar JR,Yang Y

    更新日期:2006-08-01 00:00:00

  • Expression of new idiotypes following neonatal idiotypic suppression of a dominant clone.

    abstract::The anti-PC antibodies of BALB/c origin bear predominantly the idiotype characteristic of the phosphorylcholine (PC)-binding T15 idiotype than sera from adult mice, and, unlike the latter, they also contain detectable amounts of anti-T15 antibodies. By 2 weeks of age the anti-T15 antibodies are no longer detectable wh...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Augustin A,Cosenza H

    更新日期:1976-07-01 00:00:00

  • CD2 physically associates with CD5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains.

    abstract::T lymphocytes can be activated and induced to proliferate through stimulation of the CD2 glycoprotein with functional combinations of CD2 antibodies. However, this mechanism of signal transduction via CD2 is still not fully understood. We have investigated which molecules on the T cell surface preferentially associate...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Castro MA,Tavares PA,Almeida MS,Nunes RJ,Wright MD,Mason D,Moreira A,Carmo AM

    更新日期:2002-05-01 00:00:00

  • Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages.

    abstract::Recent evidence suggests a role for phosphatidylinositol (PI) 3-kinase in various inflammatory responses. In this study, the consequences of LPS-induced PI 3-kinase activation on cytokine and chemokine expression and the intracellular mechanisms of inflammatory activation were examined in mouse macrophages. LPS stimul...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ojaniemi M,Glumoff V,Harju K,Liljeroos M,Vuori K,Hallman M

    更新日期:2003-03-01 00:00:00

  • Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells.

    abstract::T cell recognition of self antigens is a key event in the pathogenesis of autoimmune diseases. To date, the initial events that trigger autoreactive T cells are unknown. The "molecular mimicry" hypothesis predicts that during an infection T cells that recognize both a microbial antigen and a related self peptide becom...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Maier B,Molinger M,Cope AP,Fugger L,Schneider-Mergener J,Sønderstrup G,Kamradt T,Kramer A

    更新日期:2000-02-01 00:00:00

  • Immunization through dermal delivery of protein-encoding DNA: a role for migratory dendritic cells.

    abstract::The early mechanisms by which DNA-dependent immunization occurs remain poorly understood. We determined whether intradermal injection of a cytomegalovirus (CMV) promoter-driven plasmid encoding hen egg lysozyme (pCMV:HEL) induced sensitization against the encoded protein, and whether cutaneous dendritic cells (DC) wer...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Bouloc A,Walker P,Grivel JC,Vogel JC,Katz SI

    更新日期:1999-02-01 00:00:00

  • Transendothelial chemotaxis of human alpha/beta and gamma/delta T lymphocytes to chemokines.

    abstract::Two subpopulations of human T lymphocytes expressing different antigen receptors, alpha/beta and gamma/delta, emigrate into inflamed tissues in distinctive patterns. We compared the transmigration of alpha/beta and gamma/delta T cells to C-C and C-X-C chemokines using an in vitro transendothelial chemotaxis assay. The...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Roth SJ,Diacovo TG,Brenner MB,Rosat JP,Buccola J,Morita CT,Springer TA

    更新日期:1998-01-01 00:00:00

  • Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2.

    abstract::Collagen type II-induced arthritis (CIA) is an experimental model of arthritis that has been successfully used to dissect the pathogenesis of human rheumatoid arthritis and to identify potential therapeutic targets. We have used this model to evaluate the role of T cell co-stimulation in both disease development and p...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Webb LM,Walmsley MJ,Feldmann M

    更新日期:1996-10-01 00:00:00