An HLA-B35-restricted epitope modified at an anchor residue results in an antagonist peptide.


:Peptides associated with HLA-B35 commonly have a proline or occasionally a serine residue in the P2 anchor position of the peptide, with a tyrosine at the C terminus. Based on this motif, we identified an octamer epitope from influenza A matrix protein which is presented by HLA-B35. The requirements for MHC binding and T cell receptor contact have been analyzed using analogs of this peptide with substitutions at positions 1, 2, 4, 7 and 8. The natural epitope contains a serine residue at P2 of the peptide. Substitution of this residue with proline (the favored amino acid in this position in B35-associated peptides) considerably enhances binding to HLA-B35 in the T2-B35 cell line, but the peptide is not recognized by the majority of CTL clones and can antagonize recognition of the index peptide. This suggests that a conservative substitution at the P2 anchor position results in a conformational change in the peptide-MHC surface exposed to the T cell receptor.


Eur J Immunol


Dong T,Boyd D,Rosenberg W,Alp N,Takiguchi M,McMichael A,Rowland-Jones S




Has Abstract


1996-02-01 00:00:00












  • Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guérin-infected dendritic cells.

    abstract::In the lung, dendritic cells (DC) are key antigen-presenting cells capable of triggering specific cellular responses to inhaled pathogens, and thus, they may be important in the initiation of an early response to mycobacterial infections. The ability of DC to enhance antigen presentation to naive T cells within the lu...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Demangel C,Bean AG,Martin E,Feng CG,Kamath AT,Britton WJ

    更新日期:1999-06-01 00:00:00

  • Epitope-specific regulation of the T cell repertoire: carrier recognition in association with I-E or I-A does not influence the restriction of hapten-specific T cells.

    abstract::The T cell repertoire of BALB/c mice contains clones capable of recognizing p-azobenzenearsonate (ABA)-tyrosine (Tyr) in association with both I-A and I-E-encoded class II molecules. Immunization of BALB/c animals with ABA-GAT (terpolymer of L-Glu60-L-Ala30-L-Tyr10) or ABA-GLT (terpolymer of L-Glu51-L-Lys34-L-Tyr15) i...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Trannoy E,Regnier D,Campbell H,Seman M

    更新日期:1985-12-01 00:00:00

  • Physiology of murine B lymphocytes. I. Life-spans of anti-mu and haptenated Ficoll (thymus-independent antigen)-reactive B cells.

    abstract::We have evaluated the life-span of B lymphocytes by measuring the functional reactivity of normal B cells upon transfer into xid mice, which do not respond to anti-mu, fluoresceinated-Ficoll (FL-Ficoll) and 2,4,6-trinitrophenyl aminoethylcarbamylmethyl Ficoll (TNP-Ficoll). After 4 days of transfer only 30-40% of anti-...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Udhayakumar V,Goud SN,Subbarao B

    更新日期:1988-10-01 00:00:00

  • On the significance of CD8 alpha alpha expression for T cell memory.

    abstract::Longitudinal studies on the kinetics of viral antigen specific CD8 T cell responses have led to a model whereby a relatively small subset of the primary effector CD8 T cells expanding after the first week of acute viral infection initiate a program of cell survival and differentiation into long lived memory T cells. T...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章


    authors: Romero P,Cerottini JC,Luescher I

    更新日期:2005-11-01 00:00:00

  • IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1.

    abstract::Intravenous immunoglobulin G (IVIg) therapy is widely used to treat autoimmune and inflammatory diseases. Recent evidence suggests that in mice, splenic resident cells might be important for the anti-inflammatory activity of IVIg in a model of serum transfer arthritis. Splenectomized human immunothrombocytopenia (ITP)...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Schwab I,Biburger M,Krönke G,Schett G,Nimmerjahn F

    更新日期:2012-04-01 00:00:00

  • Roles of CCAAT/enhancer-binding protein in transcriptional regulation of the human IL-5 gene.

    abstract::Interleukin-5 (IL-5) plays a critical role in the pathogenesis of eosinophil-associated allergic disorders, such as asthma. IL-5 may also play a major role in the development of eosinophilia-associated lymphoproliferative disorders caused by human T lymphotropic virus type I (HTLV-I). In this study, we have investigat...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Li-Weber M,Giaisi M,Krammer PH

    更新日期:2001-12-01 00:00:00

  • The blind-spot of regulatory T cells.

    abstract::CD4+ CD25+ Foxp3+ regulatory T cells (Treg) are natural suppressors of autoimmunity but they can also dampen the effective clearance of infectious organisms. These cells have the potential to be exploited to prevent transplant rejection and to treat autoimmune disease. A paper in this issue of the European Journal of ...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章,评审


    authors: Graça L,Silva-Santos B,Coutinho A

    更新日期:2006-04-01 00:00:00

  • Establishment of mouse thymic nurse cell clones from a spontaneous BALB/c thymic tumor.

    abstract::This is the first report on the establishment of the readily identifiable and functioning thymic nurse cell (TNC) clones from the mouse thymus. In the course of the culture of an epithelial cell line using a medium with a low concentration of Ca2+ from the spontaneous BALB/c thymic tumor, lymphocytes as well as thymic...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Itoh T,Doi H,Chin S,Nishimura T,Kasahara S

    更新日期:1988-05-01 00:00:00

  • Induction of interleukin-2 transcription by the hamster polyomavirus middle T antigen: a role for Fyn in T cell signal transduction.

    abstract::The transforming protein of mouse polyomavirus, the mouse middle T antigen (MomT), and its counterpart in the hamster polyomavirus, the hamster middle T antigen (HamT), interact with a number of cellular proteins. Among these are members of the Src family of tyrosine kinases, the phosphatidylinositol 3-kinase, the ser...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Brizuela L,Ulug ET,Jones MA,Courtneidge SA

    更新日期:1995-02-01 00:00:00

  • The nature of active and passive thyroglobulin binding lymphoid cells in Obese strain (OS) chickens.

    abstract::Thyroglobulin-binding lymphoid cells were identified in the spleen of Obese strain (DS) chickens by their capacity to form rosettes with thyroglobulin-coated chicken red blood cells. The nature of these cells was studied in inhibition experiments using turkey anti-chicken bursa or thymus cell sera and rabbit antisera ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Richter E,Wick G,Schauenstein K

    更新日期:1975-08-01 00:00:00

  • Interactions between membrane IgM and the cytoskeleton involve the cytoplasmic domain of the immunoglobulin receptor.

    abstract::Cross-linking induced interactions between the membrane form of immunoglobulin (mIg) and the cytoskeletal matrix have been described by several groups. To date, the function of mIgM association with the cytoskeleton is not yet understood. Delineation of the molecular basis of these interactions will be instrumental in...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Park JY,Jongstra-Bilen J

    更新日期:1997-11-01 00:00:00

  • Human monoclonal anti-DNA antibodies react as lymphocytotoxic antibodies.

    abstract::Two out of 25 monoclonal anti-DNA autoantibodies that were produced by human-human hybridoma were found to have lymphocytotoxic activity. The antibodies reacted with normal B and T lymphocytes at cold (4 degrees C) as well as at warm (37 degrees C) temperatures. The lymphocytotoxic activity of the monoclonal anti-DNA ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Shoenfeld Y,Zamir R,Joshua H,Lavie G,Pinkhas J

    更新日期:1985-10-01 00:00:00

  • CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses.

    abstract::The magnitude and quality of T cell responses generated when Ag is targeted to receptors on DC is influenced by both the specific receptor targeted and its distribution among DC subsets. Here we examine the targeting of the model Ag OVA to potential DC targets, including CD11c, CD205, MHC class II, CD40, TLR2 and Fcga...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Castro FV,Tutt AL,White AL,Teeling JL,James S,French RR,Glennie MJ

    更新日期:2008-08-01 00:00:00

  • The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them.

    abstract::F1----parental bone marrow chimeras between CBA and B10 mice were used to show that even after 1 year follicular dendritic cells (FDC), also termed dendritic reticular cells, are not derived from bone marrow stem cells. However clusters of cells wrapped in the dendritic processes of FDC, isolated by enzyme digestion o...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Humphrey JH,Grennan D,Sundaram V

    更新日期:1984-09-01 00:00:00

  • Evidence for the stochastic acquisition of cytokine profile by CD4+ T cells activated in a T helper type 2-like response in vivo.

    abstract::The diversity of cytokine production patterns displayed by T cells activated in vivo was investigated by analyzing short-term antigen-specific CD4+ T cell clones and single CD4+ T cells derived from draining lymph nodes of mice undergoing a T helper 2 (Th2)-like response to keyhole limpet hemocyanin (KLH). On average,...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Kelso A,Groves P,Troutt AB,Francis K

    更新日期:1995-05-01 00:00:00

  • Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody.

    abstract::The properties of human lymphocyte fractions isolated either by sheep red cell(E) rosetting or by fluorescence-activated cell sorting after staining with UCHT1 monoclonal anti-T cell antibody have been compared. Two populations of E+ cells with very different phenotype and function have been identified. E+/UCHT1+ cell...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Beverley PC,Callard RE

    更新日期:1981-04-01 00:00:00

  • Surface receptors identify mouse NK1.1+ T cell subsets distinguished by function and T cell receptor type.

    abstract::Natural killer T (NKT) lymphocytes rapidly produce several cytokines, including IL-4 and IFN-gamma, upon activation, and act as regulatory cells at an early interphase of innate and adaptive immune responses. They have been implicated as important elements in diverse immune responses including the regulation of autoim...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Stenström M,Sköld M,Ericsson A,Beaudoin L,Sidobre S,Kronenberg M,Lehuen A,Cardell S

    更新日期:2004-01-01 00:00:00

  • High antigen concentration inhibits T cell proliferation but not interleukin 2 production: examination of limiting dilution microcultures and T cell clones.

    abstract::The effect of high antigen dose on the activation of cytochrome c peptide-primed lymph node cells was determined in several strains of mice by a limiting dilution analysis. It was found that proliferation of cytochrome c peptide-specific T cells was completely inhibited at high antigen concentration in C57BL/6 but onl...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ceredig R,Corradin G

    更新日期:1986-01-01 00:00:00

  • Allelic exclusion of membrane but not secreted immunoglobulin in a mature B cell line.

    abstract::Although many B lymphocytes contain two completely rearranged immunoglobulin (Ig) heavy (H) chain genes, only one of the alleles specifies a protein product. This phenomenon is termed allelic exclusion and is controlled in part by the membrane portion of Ig H chains. We have identified a mature B cell line derived fro...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Picarella D,Serunian LA,Rosenberg N

    更新日期:1991-01-01 00:00:00

  • Cyclosporin A inhibits the delayed-type hypersensitivity reaction: impaired production of early pro-inflammatory mediator(s).

    abstract::The effect of cyclosporin A (CsA) on the delayed-type hypersensitivity (DTH) elicited in mice by sheep red blood cells was investigated. Evidence is presented that a single injection of CsA adversely affects the inflammatory reaction. Sensitized T lymphocytes initiate the DTH reaction by their recruiting activity on p...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Shidani B,Milon G,Marchal G,Truffa-Bachi P

    更新日期:1984-04-01 00:00:00

  • IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-gamma when combined with IL-18.

    abstract::Previous studies have shown that IL-10 inhibits the accessory cell functions required for production of IFN-gamma by T cells and NK cells. Our results show that although IL-10 did not induce the production of IFN-gamma by NK cells, it did enhance the ability of IL-18 to stimulate NK cell production of IFN-gamma. In ad...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Cai G,Kastelein RA,Hunter CA

    更新日期:1999-09-01 00:00:00

  • Presence of CD8 alpha-CD8 beta-positive TcR gamma/delta thymocytes in the fetal murine thymus and their in vitro expansion with interleukin-7.

    abstract::Several groups have described that a low percentage of in vitro cultured T cell receptor (TcR) gamma/delta cells express CD8. Contrary to TcR alpha/beta cells, however, CD8 on these TcR gamma/delta cells was shown to be a CD8 alpha homodimer. We describe here that addition of interleukin-7 (IL-7) to a short-term in vi...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Leclercq G,De Smedt M,Plum J

    更新日期:1992-09-01 00:00:00

  • The mechanism of synergistic complement-mediated lysis of rat red cells by monoclonal IgG antibodies.

    abstract::The mechanism of synergistic complement-mediated lysis of rat red cells was investigated using rat monoclonal antibodies against class I RT1Aa antigens. The increased lytic activity when using two antibodies simultaneously is due to the increase in the number of activated C1 molecules on the cell surface and this resu...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Hughes-Jones NC,Gorick BD,Howard JC

    更新日期:1983-08-01 00:00:00

  • Inhibition of proliferation and differentiation during early T cell development by anti-transferrin receptor antibody.

    abstract::Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake. Cycling thymocytes, which have the CD4-8-3-, CD4-8+3-, or CD4+8+3- phenotypes, also express CD71. The importance of CD71-mediated iron uptake for proliferation and maturation of thymocytes was s...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Brekelmans P,van Soest P,Leenen PJ,van Ewijk W

    更新日期:1994-11-01 00:00:00

  • Rapid activation of ornithine decarboxylase by mitogenic (but not by nonmitogenic) ligands in human T lymphocytes.

    abstract::The T cell mitogens, concanavalin A and the monoclonal antibody OKT3, cause a rapid activation of ornithine decarboxylase (ODC) activity in human T lymphocytes, maximal within 10 min of mitogen addition. Nonmitogenic ligands to T cell surface structures do not induce ODC. The enzyme induction is dependent upon an inta...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Scott IG,Pösö H,Akerman KE,Andersson LC

    更新日期:1985-08-01 00:00:00

  • Lymph node stromal cells strongly influence immune response suppression.

    abstract::Many pathogens are initially encountered in the gut, where the decision is made to mount an immune response or induce tolerance. The mesentric lymph node (mLN) has been shown to be involved in immune response and much more in oral tolerance induction. Furthermore, using an in vivo transplantation model, we showed rece...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Buettner M,Pabst R,Bode U

    更新日期:2011-03-01 00:00:00

  • Interleukin-2 is essential for CD4+CD25+ regulatory T cell function.

    abstract::Constitutive expression of CD25, the IL-2 receptor alpha-chain, defines a distinct population of CD4+ T cells (Treg) with suppressive activity in vitro and in vivo. IL-2 has been implicated in the generation and maintenance of Treg, however, a functional contribution of the IL-2 receptor during suppression is thus far...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: de la Rosa M,Rutz S,Dorninger H,Scheffold A

    更新日期:2004-09-01 00:00:00

  • FcγRI (CD64): an identity card for intestinal macrophages.

    abstract::Macrophages are becoming increasingly recognized as key cellular players in intestinal immune homeostasis. However, differentiating between macrophages and dendritic cells (DCs) is often difficult, and finding a specific phenotypic signature for intestinal macrophage identification has remained elusive. In this issue ...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章


    authors: De Calisto J,Villablanca EJ,Mora JR

    更新日期:2012-12-01 00:00:00

  • The aryl hydrocarbon receptor modulates the function of human CD56bright NK cells.

    abstract::Human natural killer (NK) cells are divided into two subsets: CD56bright and CD56dim NK cells, which differ in maturation, function and distribution. Mechanisms regulating NK cell functions are not completely understood. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, that binds to a variet...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Moreno-Nieves UY,Mundy DC,Shin JH,Tam K,Sunwoo JB

    更新日期:2018-05-01 00:00:00

  • CD4+CD25+ T cells as immunoregulatory T cells in vitro.

    abstract::We have further characterized the in vitro phenotype and function of anergic and suppressive CD4(+)25(+) T cells. Following TCR ligation, DO.11.10 CD4(+)25(+) T cells suppress the activation of OT-1 CD8(+)25(-) T cells in an antigen nonspecific manner. Although suppression was seen when using a mixture of APC from bot...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Chai JG,Tsang JY,Lechler R,Simpson E,Dyson J,Scott D

    更新日期:2002-08-01 00:00:00