Environmental and allele-specific influences on T cell receptor gene rearrangement: skewed alpha, delta, and gamma gene rearrangement patterns in chimeric mice.

abstract：:Crosslinking of Fc γ receptor II B (FcγRIIB) and the BCR by immune complexes (IC) can downregulate antigen-specific B-cell responses. Accordingly, FcγRIIB deficiencies have been associated with B-cell hyperactivity in patients with systemic lupus erythematosus and mouse models of lupus. However, we have previously sho...

journal_title：European journal of immunology

authors： Avalos AM,Uccellini MB,Lenert P,Viglianti GA,Marshak-Rothstein A

更新日期：2010-10-01 00:00:00

abstract：:Considering the role of interleukin-8 (IL-8) in a large number of acute and chronic inflammatory diseases, the regulation of IL-8-mediated biological responses is important. Alpha-melanocyte-stimulating hormone (alpha-MSH), a tridecapeptide, inhibits most forms of inflammation by an unknown mechanism. In the present s...

journal_title：European journal of immunology

authors： Manna SK,Sarkar A,Sreenivasan Y

更新日期：2006-03-01 00:00:00

abstract：:The costimulatory receptor OX40 is expressed on activated T cells and regulates T-cell responses. Here, we show the efficacy and mechanism of action of an OX40 blocking antibody using the chronic house dust mite (HDM) mouse model of lung inflammation and in vitro HDM stimulation of cells from HDM allergic human donors...

journal_title：European journal of immunology

authors： Burrows KE,Dumont C,Thompson CL,Catley MC,Dixon KL,Marshall D

更新日期：2015-04-01 00:00:00

abstract：:The pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) have been shown to be primary mediators in the pathogenesis of chronic inflammatory joint diseases. However, the relative contributions of these molecules to the development and progression of disease is not known. In the present study...

journal_title：European journal of immunology

authors： Probert L,Plows D,Kontogeorgos G,Kollias G

更新日期：1995-06-01 00:00:00

abstract：:The host protective immune response to blood stage malaria infection was studied using Plasmodium chabaudi chabaudi (P.chabaudi) in NIH mice. It has been shown previously that CD4+ cells are critically required for protection against erythrocytic infection. Mice lacking a functional CD4+ cell compartment suffer unremi...

journal_title：European journal of immunology

authors： Taylor-Robinson AW,Phillips RS

更新日期：1994-01-01 00:00:00

abstract：:Secretion of proinflammatory mediators by activated macrophages plays an important role in the immune response to Trypanosoma cruzi. We have previously reported that AgC10, a glycosylphosphatidylinositol-anchored mucin from T. cruzi, inhibits TNF secretion by activated macrophages (de Diego, J., Punzon, C., Duarte, M....

journal_title：European journal of immunology

authors： Alcaide P,Fresno M

更新日期：2004-06-01 00:00:00

abstract：:The effect of high antigen dose on the activation of cytochrome c peptide-primed lymph node cells was determined in several strains of mice by a limiting dilution analysis. It was found that proliferation of cytochrome c peptide-specific T cells was completely inhibited at high antigen concentration in C57BL/6 but onl...

journal_title：European journal of immunology

authors： Ceredig R,Corradin G

更新日期：1986-01-01 00:00:00

abstract：:AMD3100 (plerixafor), is a specific CXCR4 antagonist approved by the FDA for mobilizing hematopoietic stem cells from bone marrow to blood for transplantation in cancer. AMD3100 also mobilizes most mature leukocyte subsets to blood; however, their source and trafficking potential have not been fully delineated. Here, ...

journal_title：European journal of immunology

authors： Liu Q,Li Z,Gao JL,Wan W,Ganesan S,McDermott DH,Murphy PM

更新日期：2015-06-01 00:00:00

abstract：:Production of indoleamine 2,3-dioxygenase (IDO) by tumor cells, leading to tryptophan depletion and production of immunosuppressive metabolites, may facilitate immune tolerance of cancer. IDO gene is also expressed in dendritic cells (DC) upon maturation induced by lipopolysaccarides or IFN. We investigated IDO gene e...

journal_title：European journal of immunology

authors： Weber WP,Feder-Mengus C,Chiarugi A,Rosenthal R,Reschner A,Schumacher R,Zajac P,Misteli H,Frey DM,Oertli D,Heberer M,Spagnoli GC

更新日期：2006-02-01 00:00:00

abstract：:The fine specificity of murine B 10.A/SgSn (B 10.A) T cells reactive with hen egg-white lysozyme (HEL) has been studied through the use of reduced, carboxymethylated HEL, a set of peptides encompassing the entire molecule, and a set of variant lysozymes from other species. Cells were taken from the lymph nodes drainin...

journal_title：European journal of immunology

authors： Maizels RM,Clarke JA,Harvey MA,Miller A,Sercarz EE

更新日期：1980-07-01 00:00:00

abstract：:Cellular metabolism is dynamically regulated in NK cells and strongly influences their responses. Metabolic dysfunction is linked to defective NK cell responses in diseases such as obesity and cancer. The transcription factors, sterol regulatory element binding protein (SREBP) and cMyc, are crucial for controlling NK ...

journal_title：European journal of immunology

authors： O'Brien KL,Assmann N,O'Connor E,Keane C,Walls J,Choi C,Oefner PJ,Gardiner CM,Dettmer K,Finlay DK

更新日期：2020-09-18 00:00:00

abstract：:The proteins p40 (Mr = 40 000), p32 (Mr = 32 000), p28 (Mr = 28 000), p20 (Mr = 20 000) and p10 (Mr = 10 000) are described which occur in noncovalent association with the polymorphic alpha, beta heterodimer of class II antigens. They were investigated with respect to their molecular characteristics and their mutual s...

journal_title：European journal of immunology

authors： Zecher R,Ballhausen W,Reske K,Linder D,Schlüter M,Stirm S

更新日期：1984-06-01 00:00:00

abstract：:Low zone tolerance (LZT) to contact allergens is induced by epicutaneous exposure to haptens in subsensitizing doses resulting in an inhibition of contact hypersensitivity (CHS), which, in contrast, occurs after sensitization with immunogenic doses of allergens. Performing the protocol of tolerance induction resulted ...

journal_title：European journal of immunology

authors： Seidel-Guyenot W,Alt R,Perschon S,Knop J,Steinbrink K

更新日期：2004-11-01 00:00:00

abstract：:Dendritic cells (DC) play an essential role in the induction of primary immune responses; however, very little information is available on cytokine production by DC. Here we determined the cytokine gene expression profile of two immortalized DC clones, CB1 and D2SC/1, both generated from mouse spleen but differing in ...

journal_title：European journal of immunology

authors： Granucci F,Girolomoni G,Lutz MB,Foti M,Marconi G,Gnocchi P,Nolli L,Ricciardi-Castagnoli P

更新日期：1994-10-01 00:00:00

abstract：:A mouse T cell hybrid specific for pigeon cytochrome c in the context of I-Ek responds by secreting interleukin 2 when co-cultured with the native antigen and the B cell lymphoma, LK-35.2, or naive splenic B cells as antigen-presenting cells (APC). Cytochromes c and their corresponding C-terminal fragments which are n...

journal_title：European journal of immunology

authors： Lakey EK,Margoliash E,Flouret G,Pierce SK

更新日期：1986-07-01 00:00:00

abstract：:Following immunization with a complex antigen, a B cell internalizes this antigen through an interaction between its surface immunoglobulins and an epitope of the antigen. Enzymatic processing of the antigen frees one or more short peptide determinants (TD) which bind to class II molecules of the B cell. If the comple...

journal_title：European journal of immunology

authors： Sarobe P,Lasarte JJ,Golvano J,Gullón A,Civeira MP,Prieto J,Borrás-Cuesta F

更新日期：1991-06-01 00:00:00

abstract：:T cell-depleted B cells from a patient with LFA-1 deficiency were tested in costimulation assays for responsiveness to recombinant human IL4 (BSF-1) and purified low molecular weight B cell growth factor (BCGFlow). In both cases the response of LFA-1-deficient B cells was comparable with normal controls. Monoclonal an...

journal_title：European journal of immunology

authors： Shields JG,Smith SH,Strobel S,Levinsky RJ,Defrance T,De Vries J,Banchereau J,Callard RE

更新日期：1988-02-01 00:00:00

abstract：:In intestine, neutrophils are recruited in response to bacterial infiltration and their anti-cellular activities contribute to inflammatory bowel diseases. In contrast, little is known regarding the recruitment of MPhi to the intestinal epithelium. Extracellular adenosine and uridine 5'-triphosphate (ATP and UTP) can ...

journal_title：European journal of immunology

authors： Langlois C,Gendron FP

更新日期：2009-10-01 00:00:00

abstract：:Tuberculosis (TB) is one of the world's most pernicious diseases mainly due to immune evasion strategies displayed by its causative agent Mycobacterium tuberculosis (Mtb). Blood monocytes (Mos) represent an important source of DCs during chronic infections; consequently, the alteration of their differentiation constit...

journal_title：European journal of immunology

authors： Balboa L,Romero MM,Laborde E,Sabio Y García CA,Basile JI,Schierloh P,Yokobori N,Musella RM,Castagnino J,de la Barrera S,Sasiain MC,Alemán M

更新日期：2013-02-01 00:00:00

abstract：:Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimul...

journal_title：European journal of immunology

authors： Sander B,Cardell S,Möller G,Möller E

更新日期：1991-08-01 00:00:00

abstract：:Mice of strain MRL/Mp-lpr/lpr develop resistance against tolerance induction with aggregate-freed rabbit gamma-globulin as early as 6 weeks of age and show very complete resistance when they are 10 weeks old; congenic mice MRL-Mp+/+ of 6 and 10 weeks can be rendered tolerant. By reconstitution experiments, it was show...

journal_title：European journal of immunology

authors： Amagai T,Cinader B

更新日期：1981-11-01 00:00:00

abstract：:The delivery of T-cell help to B cells is antigen-specific, MHC-restricted, and CD40L (CD154) dependent. It has been thought that when a T cell recognizes an antigen-presenting B cell, CD40L expressed on the T-cell surface engages with CD40 on the surface of B cells as long as the cells remain conjugated. By adding fl...

journal_title：European journal of immunology

authors： Gardell JL,Parker DC

更新日期：2017-01-01 00:00:00

abstract：:Between 10 and 20% of the peripheral gammadelta T cells express cytoplasmic TCR-beta proteins, but whether such TCR-beta chains can partake in alphabeta T-cell development has never been systematically investigated. Therefore, we reconstituted the T-cell compartment of CD3epsilon-deficient mice with Pax5-TCR-beta defi...

journal_title：European journal of immunology

authors： Bosco N,Engdahl C,Bénard A,Rolink J,Ceredig R,Rolink AG

更新日期：2008-12-01 00:00:00

abstract：:Immunodominant T cell epitopes from the autoantigen human cartilage glycoprotein 39 have previously been mapped in the context of HLA-DR*0401 and *0402, using mice expressing HLA-DR4 transgenes. We measured the dissociation rates of these epitopes from soluble recombinant DR*0401 and DR*0402 to assess the relationship...

journal_title：European journal of immunology

authors： Hall FC,Rabinowitz JD,Busch R,Visconti KC,Belmares M,Patil NS,Cope AP,Patel S,McConnell HM,Mellins ED,Sonderstrup G

更新日期：2002-03-01 00:00:00

abstract：:The potential of synthetic peptides as vaccines is restricted by their frequent lack of immunogenicity. As with haptens, coupling to a carrier protein is usually required to provide T cell help to anti-peptide antibody-producing B cells. In spite of their short length, a few natural or synthetic peptides are immunogen...

journal_title：European journal of immunology

authors： Borras-Cuesta F,Petit-Camurdan A,Fedon Y

更新日期：1987-08-01 00:00:00

abstract：:Using a model of 2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity (CHS) we found that, as compared with wild-type mice, IL-15 receptor alpha chain (IL-15Ralpha)-deficient mice showed significantly less ear swelling. This decreased response was associated with diminished expression of CCL5/RANTES and CXCL10...

journal_title：European journal of immunology

authors： Chen JP,Liao NS,Lai SL,Hsu L,Mao WY,Ku MC,Liao F

更新日期：2005-03-01 00:00:00

abstract：:The role of T cell differentiation antigens in antigen-specific and nonspecific cytotoxicity by human cytotoxic T lymphocyte (CTL) clones was investigated. In contrast to other reports, several monoclonal antibodies (mAb) against the T3 antigen only marginally blocked antigen-specific cytotoxicity at high concentratio...

journal_title：European journal of immunology

authors： Schrezenmeier H,Kurrle R,Wagner H,Fleischer B

更新日期：1985-10-01 00:00:00

abstract：:Levamisole, an anti-anergic chemotherapeutic agent, is shown to depress the azathioprine sensitivity of rosette-forming cells (RFC) in the spleen of normal mice, and to restore the azathioprine sensitivity of RFC in the spleen of adult thymectomized mice. Using the fully active dose of 1.25 mg/kg i.v., the restoration...

journal_title：European journal of immunology

authors： van Ginckel RF,Hoebeke J

更新日期：1976-04-01 00:00:00

abstract：:A previously designed isotopic in vivo method for measuring delayed hypersensitivity was used with nonantigenic (or weakly antigenic) phlogogenic substances. A strong reaction was observed in some circumstances, witnessing the fact that the method has a specific and a nonspecific component. The reaction is drastically...

journal_title：European journal of immunology

authors： Sabolović D,Oth D,Bujadoux M

更新日期：1976-06-01 00:00:00

abstract：:Nonhematopoietic stromal cells contribute to the organization and homeostasis of secondary lymphoid organs by producing cytokines and chemokines. The development and maintenance of these stromal cells are thought to be regulated by innate immune cells. Indeed, we recently showed that signal regulatory protein α (SIRPα...

journal_title：European journal of immunology

authors： Komori S,Saito Y,Respatika D,Nishimura T,Kotani T,Murata Y,Matozaki T

更新日期：2019-09-01 00:00:00