A third interferon-gamma-induced subunit exchange in the 20S proteasome.

Abstract:

:The 20S proteasome is a protease complex of functional importance for antigen processing. Two of the 14 proteasome subunits, delta and MB1, can be replaced by the major histocompatibility complex (MHC)-encoded and interferon-gamma (IFN-gamma)-inducible subunits LMP2 and LMP7, respectively. LMP2 and LMP7 alter the cleavage site specificity of the 20S proteasome and are required for the efficient generation of T cell epitopes from a number of viral proteins and for optimal MHC class I cell surface expression. We compared the 20S proteasome subunit pattern from IFN-gamma-induced and non-induced mouse fibroblasts on two-dimensional gels and identified a third subunit exchange by microsequencing: the non-MHC-encoded subunit MECL-1 is induced by IFN-gamma and replaces a sofar barely characterized beta subunit designated 'MC14'. In analogy to LMP2 and LMP7, MECL-1 may be functional in MHC class I-restricted antigen presentation.

journal_name

Eur J Immunol

authors

Groettrup M,Kraft R,Kostka S,Standera S,Stohwasser R,Kloetzel PM

doi

10.1002/eji.1830260421

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

863-9

issue

4

eissn

0014-2980

issn

1521-4141

journal_volume

26

pub_type

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