A third interferon-gamma-induced subunit exchange in the 20S proteasome.


:The 20S proteasome is a protease complex of functional importance for antigen processing. Two of the 14 proteasome subunits, delta and MB1, can be replaced by the major histocompatibility complex (MHC)-encoded and interferon-gamma (IFN-gamma)-inducible subunits LMP2 and LMP7, respectively. LMP2 and LMP7 alter the cleavage site specificity of the 20S proteasome and are required for the efficient generation of T cell epitopes from a number of viral proteins and for optimal MHC class I cell surface expression. We compared the 20S proteasome subunit pattern from IFN-gamma-induced and non-induced mouse fibroblasts on two-dimensional gels and identified a third subunit exchange by microsequencing: the non-MHC-encoded subunit MECL-1 is induced by IFN-gamma and replaces a sofar barely characterized beta subunit designated 'MC14'. In analogy to LMP2 and LMP7, MECL-1 may be functional in MHC class I-restricted antigen presentation.


Eur J Immunol


Groettrup M,Kraft R,Kostka S,Standera S,Stohwasser R,Kloetzel PM




Has Abstract


1996-04-01 00:00:00












  • The soluble isoform of CTLA-4 as a regulator of T-cell responses.

    abstract::CTLA-4 is a crucial immune regulator that mediates both negative costimulation signals to T cells, and regulatory T (Treg)-cell extrinsic control of effector responses. Here we present evidence supporting a novel mechanism for this extrinsic suppression, executed by the alternatively spliced soluble CTLA-4 isoform (sC...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ward FJ,Dahal LN,Wijesekera SK,Abdul-Jawad SK,Kaewarpai T,Xu H,Vickers MA,Barker RN

    更新日期:2013-05-01 00:00:00

  • Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function.

    abstract::Mutations in PTEN-induced kinase 1 (PINK1), a serine/threonine kinase linked to familial early-onset Parkinsonism, compromise mitochondrial integrity and metabolism and impair AKT signaling. As the activation of a naïve T cell requires an AKT-dependent reorganization of a cell's metabolic machinery, we sought to deter...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ellis GI,Zhi L,Akundi R,Büeler H,Marti F

    更新日期:2013-12-01 00:00:00

  • Harnessing proteases for T regulatory cell immunotherapy.

    abstract::The immune system is tightly regulated by a subset of T cells defined as regulatory T cells (Tregs). Tregs maintain immune homeostasis by restraining unwarranted immune cell activation and effector function. Here, we discuss an important but underappreciated role of proteases in controlling Treg function. Proteases re...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Amarnath S,Brown ML

    更新日期:2020-06-01 00:00:00

  • Induction of CD3 delta epsilon omega by phorbol 12-myristate 13-acetate.

    abstract::The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain. Treatment of the human leukemic T cell line Jurkat with PMA increased the synthesis of the Ti alpha, CD3 gamma and CG3 zeta...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Vangsted A,Neisig A,Wallin H,Zeuthen J,Geisler C

    更新日期:1993-06-01 00:00:00

  • CD40 ligand is a T cell growth factor.

    abstract::CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of resting B cells, immunoglobulin (Ig) secretion from B cells cultured with cytokines and cytokine secretion and tumoricidal activity from monocytes. In this report...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Armitage RJ,Tough TW,Macduff BM,Fanslow WC,Spriggs MK,Ramsdell F,Alderson MR

    更新日期:1993-09-01 00:00:00

  • 5'-Ectonucleotidase/CD73 expression on lymph-circulating lymphocytes and lymphatic endothelial cells offers new paths to explore barrier function.

    abstract::5'-Nucleotidase/CD73 is a key enzyme in the regulation of purinergic signaling, hydrolyzing extracellular AMP to produce adenosine, which is critical in the blood vascular system and in immunosuppression. CD73 is expressed by both blood endothelial cells and lymphatic endothelial cells. Although the role of CD73 on bl...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章


    authors: Sidibé A,Imhof BA

    更新日期:2015-02-01 00:00:00

  • Developmentally regulated expression of P-glycoprotein (multidrug resistance) activity in mouse thymocytes.

    abstract::P-glycoprotein (P-gly) is the transmembrane efflux pump responsible for multidrug resistance in tumor cells. The activity of P-gly in mature peripheral lymphocytes is lineage specific, with CD8+ T cells and natural killer (NK) cells expressing high levels as compared to CD4+ T cells and B cells. We have now investigat...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: MacDonald HR,Bommhardt U,Cerottini JC

    更新日期:1995-05-01 00:00:00

  • Specific microbiota enhances intestinal IgA levels by inducing TGF-β in T follicular helper cells of Peyer's patches in mice.

    abstract::In humans and mice, mucosal immune responses are dominated by IgA antibodies and the cytokine TGF-β, suppressing unwanted immune reactions but also targeting Ig class switching to IgA. It had been suggested that eosinophils promote the generation and maintenance of mucosal IgA-expressing plasma cells. Here, we demonst...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Beller A,Kruglov A,Durek P,von Goetze V,Werner K,Heinz GA,Ninnemann J,Lehmann K,Maier R,Hoffmann U,Riedel R,Heiking K,Zimmermann J,Siegmund B,Mashreghi MF,Radbruch A,Chang HD

    更新日期:2020-06-01 00:00:00

  • A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules.

    abstract::The heat shock protein (HSP) Hsp90 is known to chaperone cytosolic peptides for MHC class I (MHCI)-restricted antigen presentation to T lymphocytes. We now demonstrate a role for Hsp90 activity in presentation of antigens on MHCII. Treatment of mouse antigen-presenting cells (APC) with the pharmacological Hsp90 inhibi...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Rajagopal D,Bal V,Mayor S,George A,Rath S

    更新日期:2006-04-01 00:00:00

  • Evidence for distinct epitopes on human IgG with T cell proliferative and suppressor function.

    abstract::The Fc or pFc' fragments of the human IgG were demonstrated to exert different effects on murine T lymphocyte subsets. Thus, murine lymph node (LN) T cells were specifically induced to proliferate in vitro to pFc' after priming in vivo. This proliferation could be inhibited, either by depleting the responding LN popul...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Baxevanis CN,Ioannides CD,Reclos GJ,Papamichail M

    更新日期:1986-08-01 00:00:00

  • One cause for the apparent inability of human T cell clones to function as professional superantigen-presenting cells is autoactivation.

    abstract::Human T cell clones (TCC) are antigen-presenting cells (APC) able to present peptides and superantigens (SAg) and to process and present intact proteins. TCC express major histocompatibility complex (MHC) class II antigens and molecules involved in the accessory signal delivery, such as B7.1 and B7.2/B70. Notwithstand...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Nisini R,Fattorossi A,Ferlini C,D'Amelio R

    更新日期:1996-04-01 00:00:00

  • Physiology of murine B lymphocytes. I. Life-spans of anti-mu and haptenated Ficoll (thymus-independent antigen)-reactive B cells.

    abstract::We have evaluated the life-span of B lymphocytes by measuring the functional reactivity of normal B cells upon transfer into xid mice, which do not respond to anti-mu, fluoresceinated-Ficoll (FL-Ficoll) and 2,4,6-trinitrophenyl aminoethylcarbamylmethyl Ficoll (TNP-Ficoll). After 4 days of transfer only 30-40% of anti-...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Udhayakumar V,Goud SN,Subbarao B

    更新日期:1988-10-01 00:00:00

  • Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells.

    abstract::To identify environmental stimuli that induce dendritic cell (DC) maturation, we exposed human monocyte-derived immature DC to apoptotic or necrotic cells and measured the levels of expression of costimulatory molecules and cytokine production. While most necrotic or apoptotic cells did not have any effect, some induc...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Salio M,Cerundolo V,Lanzavecchia A

    更新日期:2000-02-01 00:00:00

  • Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells.

    abstract::Cytokine-induced memory-like (CIML) NK cells are endowed with the capacity to mediate enhanced effector functions upon cytokine or activating receptor restimulation for several weeks following short-term preactivation with IL-12, IL-15, and IL-18. Promising results from a first-in-human clinical trial highlighted the ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Ghofrani J,Lucar O,Dugan H,Reeves RK,Jost S

    更新日期:2019-08-01 00:00:00

  • Helminth-induced regulation of T-cell transfer colitis requires intact and regulated T cell Stat6 signaling in mice.

    abstract::Infection with parasitic worms (helminths) alters host immune responses and can inhibit pathogenic inflammation. Helminth infection promotes a strong Th2 and T regulatory response while suppressing Th1 and Th17 function. Th2 responses are largely dependent on transcriptional programs directed by Stat6-signaling. We ex...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Metwali A,Winckler S,Urban JF Jr,Kaplan MH,Ince MN,Elliott DE

    更新日期:2020-10-16 00:00:00

  • Serological analysis of antigen-specific helper factors specific for poly-L(Tyr, Glu)-poly-DLAla--poly-LLys [(T, G)-A--L] and L Glu60-LAla30-LTyr10 (GAT).

    abstract::In vitro prepared antigen-specific helper factors reactive to the synthetic polypeptide antigens poly-L(Tyr, Glu)-poly-DLAla--poly-LLys [(T, G)-A--L] or LGlu60-LAla30-LTyr10 (GAT) and bearing Ia determinants were analyzed serologically to determine the nature of the Ia determinants they expressed. I subregion-specific...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Howie S,Parish CR,David CS,McKenzie IF,Maurer PH,Feldmann M

    更新日期:1979-07-01 00:00:00

  • The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci.

    abstract::An approach to the preparation of antigen-specific human monoclonal antibodies focuses on mice transgenic for human immunoglobulin gene miniloci; the V gene segments in these miniloci undergo productive rearrangement to yield mouse B cells expressing human immunoglobulin (Ig) chains. The general usefulness of this str...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Wagner SD,Popov AV,Davies SL,Xian J,Neuberger MS,Brüggemann M

    更新日期:1994-11-01 00:00:00

  • Leptin: nourishment for the immune system.

    abstract::Leptin, a protein produced by adipocytes, exerts several functions, including modulation of the immune response. A report in this issue of the European Journal of Immunology describes for the first time the effect of either leptin receptor deficiency or blockade on murine dendritic cell (DC) maturation, survival and f...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审


    authors: Fantuzzi G

    更新日期:2006-12-01 00:00:00

  • Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC).

    abstract::Signal transducer and activator of transcription 3 (STAT3) triggered production of Th-17 cytokines mediates protective immunity against fungi. Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to fungal (Candida) infections, a hallmark of chronic mucocutaneous candidiasis (CMC...

    journal_title:European journal of immunology

    pub_type: 临床试验,杂志文章


    authors: Zheng J,van de Veerdonk FL,Crossland KL,Smeekens SP,Chan CM,Al Shehri T,Abinun M,Gennery AR,Mann J,Lendrem DW,Netea MG,Rowan AD,Lilic D

    更新日期:2015-10-01 00:00:00

  • Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

    abstract::Mice with homologous disruption of the gene coding for either the p35 subunit or the p40 subunit of interleukin-12 (IL-12) and derived from a strain genetically resistant to infection with Leishmania major have been used to study further the role of this cytokine in resistance to infection and the differentiation of f...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Mattner F,Magram J,Ferrante J,Launois P,Di Padova K,Behin R,Gately MK,Louis JA,Alber G

    更新日期:1996-07-01 00:00:00

  • The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells.

    abstract::We have proposed earlier that the poor capacity of the lipocalin allergen Bos d 2 to stimulate highly allergic subjects' peripheral blood mononuclear cells could be ascribed to endogenous lipocalins and could be related to the allergenic potential of the molecule. Here, we have characterized the proliferative and cyto...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Kinnunen T,Buhot C,Närvänen A,Rytkönen-Nissinen M,Saarelainen S,Pouvelle-Moratille S,Rautiainen J,Taivainen A,Maillère B,Mäntyjärvi R,Virtanen T

    更新日期:2003-06-01 00:00:00

  • Phenotypic and functional analysis of B lymphopoiesis in interleukin-7-transgenic mice: expansion of pro/pre-B cell number and persistence of B lymphocyte development in lymph nodes and spleen.

    abstract::Transgenic mice in which mouse interleukin (IL)-7 cDNA is expressed under the control of the mouse major histocompatibility complex (MHC) class II (E alpha) promoter develop a lymphoproliferative disease characterized by the early polyclonal expansion of T cells followed in many cases by the development of lymphomas o...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Mertsching E,Grawunder U,Meyer V,Rolink T,Ceredig R

    更新日期:1996-01-01 00:00:00

  • WC1+ gammadelta T cell memory population is induced by killed bacterial vaccine.

    abstract::Limited studies have addressed the ability of gammadelta T cells to become memory populations. We previously demonstrated that WC1.1(+) gammadelta T cells from ruminants vaccinated with killed Leptospira borgpetersenii proliferate and produce IFN-gamma in recall responses. Here we show that this response is dependent ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Blumerman SL,Herzig CT,Baldwin CL

    更新日期:2007-05-01 00:00:00

  • The effect of pregnancy on the uterine NK cell KIR repertoire.

    abstract::The major leukocyte population in the decidua during the first trimester of pregnancy consists of NK cells that express receptors capable of recognizing MHC class I molecules expressed by placental trophoblast. These include members of the killer immunoglobulin-like receptor (KIR) family, the two-domain KIR (KIR2D), w...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Male V,Sharkey A,Masters L,Kennedy PR,Farrell LE,Moffett A

    更新日期:2011-10-01 00:00:00

  • Anti-inflammatory effects of high-dose IgG on TNF-α-activated human coronary artery endothelial cells.

    abstract::High-dose infusion of IgG (IVIG) is used to treat autoimmune and inflammatory diseases, including Kawasaki disease (KD). Although the immunomodulatory effects of IVIG on blood cells such as macrophages have been well studied, its effects on tissue cells remain unclear. Here, we show that high-dose IgG specifically and...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Matsuda A,Morita H,Unno H,Saito H,Matsumoto K,Hirao Y,Munechika K,Abe J

    更新日期:2012-08-01 00:00:00

  • H-2 gene complementation in cytotoxic T cell responses of female against male cells.

    abstract::H-2 gene-dependent nonresponsiveness and responsiveness to H-2-matched male cells can be observed in cytotoxic assays in several mouse strains. H-2 genes of several low responder strains can complement each other in cis or trans position to produce high responders. One of the H-2 gene products functions at the level o...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: von Boehmer H,Fathman CG,Haas W

    更新日期:1977-07-01 00:00:00

  • Demonstration of the stability of the membrane phenotype of T helper cells after priming and boosting with a hapten-carrier conjugate.

    abstract::Evidence is presented that the phenotype of the rat T helper cells is stable after priming and boosting with a hapten-carrier conjugate and that the phenotype is W3/25+, MRC OX-22-, MRC OX-8-. Data are also presented that demonstrate the presence of doubly marked, W3/25+, MRC OX-8+, cells in the spleens of rats primed...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Spickett GP,Mason DW

    更新日期:1983-09-01 00:00:00

  • Human cytotoxic T cell structures associated with expression of cytolysis. I. Analysis at the clonal cell level of the cytolysis-inhibiting effect of 7 monoclonal antibodies.

    abstract::Monoclonal antibodies (mAb) derived from BALB/c mice immunized with human anti-HLA-A2 cloned cytotoxic T lymphocytes (CTL) were screened for their ability to block, in the absence of complement, the cytolytic activity of the immunizing CTL clone. Eight cytolysis-inhibiting mAb have been derived. One of these was direc...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Malissen B,Rebai N,Liabeuf A,Mawas C

    更新日期:1982-09-01 00:00:00

  • Influence of adenosine deaminase inhibition on the phosphoinositide turnover in the initial stages of human T cell activation.

    abstract::An experimental model of adenosine deaminase deficiency was established on the human T cell line Jurkat by using 2'-deoxycoformycin, a strong specific inhibitor of the enzyme. When deoxyadenosine was added to the inhibited cells, the nucleotide profile was modified reproducing that found in lymphocytes from adenosine ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Buc HA,Moncion A,Hamet M,Houllier AM,Thuilier L,Perignon JL

    更新日期:1990-03-01 00:00:00

  • An inhibitor of cytotoxic functions produced by CD8+CD57+ T lymphocytes from patients suffering from AIDS and immunosuppressed bone marrow recipients.

    abstract::An inhibitor of the cytotoxic functions (ICF) mediated by human immunodeficiency virus (HIV)- or HLA-specific cytotoxic T lymphocytes, natural killer and lymphokine-activated killer (LAK) cells is secreted by CD8+CD57+ T lymphocytes, a subset expanded during infection with HIV and after bone marrow transplantation. We...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Sadat-Sowti B,Debré P,Mollet L,Quint L,Hadida F,Leblond V,Bismuth G,Autran B

    更新日期:1994-11-01 00:00:00