Single-cell dynamics of mast cell-CD4+ CD25+ regulatory T cell interactions.

abstract：:We investigated the efficacy of a combination of anti-CD80 and CD86 (CD80 + 86) monoclonal antibodies (mAb), anti-interleukin (IL)-12 mAb, or both, for prophylaxis in a mouse acute graft-versus-host-disease (GVHD) model. The treatment with a combination of anti-CD80 + 86 mAb efficiently reduced the lethality of GVHD, ...

journal_title：European journal of immunology

authors： Saito K,Yagita H,Hashimoto H,Okumura K,Azuma M

更新日期：1996-12-01 00:00:00

abstract：:The interaction of CD40 ligand (CD40L) on activated T cells with CD40 on B cells, monocytes and dendritic cells is essential for humoral immunity and for up-regulation of antigen-presenting cell (APC) functions, as a result of signaling through CD40. There are also some indications that after interaction with CD40, CD...

journal_title：European journal of immunology

authors： Peng X,Kasran A,Warmerdam PA,de Boer M,Ceuppens JL

更新日期：1996-07-01 00:00:00

abstract：:This is the first report on the establishment of the readily identifiable and functioning thymic nurse cell (TNC) clones from the mouse thymus. In the course of the culture of an epithelial cell line using a medium with a low concentration of Ca2+ from the spontaneous BALB/c thymic tumor, lymphocytes as well as thymic...

journal_title：European journal of immunology

authors： Itoh T,Doi H,Chin S,Nishimura T,Kasahara S

更新日期：1988-05-01 00:00:00

abstract：:Reciprocal expression of CD45RA and CD45RO in human CD4+ T cells defines populations understood to be naive cells (CD45RA+CD45RO-) and memory cells (CD45RA-CD45RO+). We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright a...

journal_title：European journal of immunology

authors： Horgan KJ,Tanaka Y,Luce GE,van Seventer GA,Nutman TB,Shaw S

更新日期：1994-05-01 00:00:00

abstract：:Splenic T cells were primed, after removal of alloreactive cells, to beef insulin on allogeneic antigen-presenting cells (APC). The fine specificity of in vitro secondary response was tested in combinations H-2b (responder) T cell-H-2k (nonresponder) APC, and vice versa, using separated chains of beef and pork insulin...

journal_title：European journal of immunology

authors： Ishii N,Klein J,Nagy ZA

更新日期：1983-08-01 00:00:00

abstract：:A detailed restriction map of a 430-kb contig comprising the single Ckappa, the 5 Jkappa and the adjoining 22 Vkappa gene segments is presented. The first 12 Vkappa genes following the JkappaCkappa region belong to the Vkappa21 family, the subsequent ones to the closely related families Vkappa8 and Vkappal 9/ 28. Prev...

journal_title：European journal of immunology

authors： Kirschbaum T,Pourrajabi S,Zocher I,Schwendinger J,Heim V,Röschenthaler F,Kirschbaum V,Zachau HG

更新日期：1998-05-01 00:00:00

abstract：:The B cell line 721.174 has lost the ability to present intracellular antigens to major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTL). This phenotype results from a homozygous deletion in the MHC that includes the peptide transporter genes TAP1 and TAP2, and the proteasome subunits ...

journal_title：European journal of immunology

authors： Cerundolo V,Kelly A,Elliott T,Trowsdale J,Townsend A

更新日期：1995-02-01 00:00:00

abstract：:The invariant chain (Ii) is a chaperone that regulates assembly and transport of class II MHC molecules. In the absence of the lysosomal protease cathepsin S (CatS), degradation of Ii is impaired and an Ii remnant that extends from the N terminus to about residue 110 accumulates in class II MHC-positive endosomal comp...

journal_title：European journal of immunology

authors： Boes M,van der Wel N,Peperzak V,Kim YM,Peters PJ,Ploegh H

更新日期：2005-09-01 00:00:00

abstract：:Using a new mAb, 2F1, we characterize a mouse natural killer (NK) cell antigen termed 'killer cell lectin-like receptor G1' (KLRG1; formerly mouse MAFA or 2F1-Ag). KLRG1 is expressed on 30-60% of murine NK cells, and a small fraction of T cells, and is composed of a homodimer of glycosylated 30-38-kDa subunits. Striki...

journal_title：European journal of immunology

authors： Corral L,Hanke T,Vance RE,Cado D,Raulet DH

更新日期：2000-03-01 00:00:00

abstract：:B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. fo...

journal_title：European journal of immunology

authors： Ceredig R,Rolink AG,Melchers F,Andersson J

更新日期：2000-03-01 00:00:00

abstract：:Human adherent monocytes were incubated with interferon (IFN) preparations, then washed and stimulated with endotoxins. The interleukin (IL1) activity in the supernatants of IFN-treated monocyte cultures was found to be increased as compared to control (not pretreated) cultures. This phenomenon was observed whether al...

journal_title：European journal of immunology

authors： Arenzana-Seisdedos F,Virelizier JL

更新日期：1983-06-01 00:00:00

abstract：:The interaction of polymorphonuclear leukocytes (PMN) with the vascular endothelium and their subsequent extravasation to the tissues is a key step during different physiological and pathological processes. In certain of these pathologies the oxygen tension becomes very low, leading to reduced cellular oxidative statu...

journal_title：European journal of immunology

authors： Montoya MC,Luscinskas FW,del Pozo MA,Aragonés J,de Landázuri MO

更新日期：1997-08-01 00:00:00

abstract：:In the past 15 years, it became clear that the symbiotic microbiota has an important impact on the development and regulation of the immune system. Consequently, it is incorrect to interpret a phenotype solely as a direct result of the genotype, without considering the impact of the microbiota. In fact, ignorance of t...

journal_title：European journal of immunology

authors： Eberl G,Vieira P

更新日期：2020-06-01 00:00:00

abstract：:The BCR plays a central role in B cell development, survival, activation, and differentiation. We have identified the B cell novel protein 1 (BCNP1) as a new regulator of BCR signaling. BCNP1 contains a pleckstrin homology domain, three proline-rich motifs, and a potential SH2 binding site, and is predominantly expres...

journal_title：European journal of immunology

authors： Hong R,Lai N,Ouchida R,Xiong E,Zhou Y,Min Q,Liu J,Tang Y,Hikida M,Tsubata T,Wang Y,Wang JY

更新日期：2019-06-01 00:00:00

abstract：:The involvement of Lyt-2+ T cells in the immunological control of cutaneous leishmaniasis was assessed by studying the course of the disease in mice in which the number of these cells was reduced by treatment with anti-Lyt-2 monoclonal antibody (mAb). Administration of anti-Lyt-2 mAb exacerbated Leishmania major-induc...

journal_title：European journal of immunology

authors： Titus RG,Milon G,Marchal G,Vassalli P,Cerottini JC,Louis JA

更新日期：1987-10-01 00:00:00

abstract：:In this study we have investigated the specificity of bioassays in which interleukin (IL) 1 and/or IL 6 are active. The thymocyte assay cannot be used to discriminate between IL 1 and IL 6; both monokines are active in this assay. Moreover the detection limit for both IL 1 and IL 6 is around 100 pg/ml. IL 6 activity c...

journal_title：European journal of immunology

authors： Helle M,Boeije L,Aarden LA

更新日期：1988-10-01 00:00:00

abstract：:The beta7 integrins alpha4beta7 and alphaEbeta7 play key roles in forming the gut-associated lymphoid tissue, and contribute to chronic inflammation. The alpha4beta7 integrin-mediated adhesion of activated lymphocytes is largely due to a transient increase in avidity from ligand-induced clustering of alpha4beta7 at th...

journal_title：European journal of immunology

authors： Krissansen GW,Singh J,Kanwar RK,Chan YC,Leung E,Lehnert KB,Kanwar JR,Yang Y

更新日期：2006-08-01 00:00:00

abstract：:Sequential development of antibody titer, functional avidity, helper and suppressor activities were investigated in rhesus monkeys. These were immunized with a single dose of 0.1 microgram to 10 mg of a streptococcal protein antigen (SA) in aluminium hydroxide. The IgG antibody titers followed the classical pattern fi...

journal_title：European journal of immunology

authors： Lehner T,Caldwell J,Avery J

更新日期：1984-09-01 00:00:00

abstract：:A study was made of the ability of the superantigen staphylococcal enterotoxin B (SEB) to induce relapses of experimental allergic encephalomyelitis (EAE) in SJL mice that had partially or completely recovered from acute EAE. We find that a single injection of 0.05 mg SEB i.v. induces mild relapses in 50% of such mice...

journal_title：European journal of immunology

authors： Crisi GM,Santambrogio L,Hochwald GM,Smith SR,Carlino JA,Thorbecke GJ

更新日期：1995-11-01 00:00:00

abstract：:The variable region nucleotide sequences of seven (five IgM and two IgG) anti-histone monoclonal antibodies from a single MRL/Mp-lpr/lpr mouse have been determined. These antibodies are not clonally related and used diverse V, D and J genes. However, six of the seven antibodies have VH segments encoded by genes from t...

journal_title：European journal of immunology

authors： Monestier M

更新日期：1991-07-01 00:00:00

abstract：:Interferon regulatory factor-1 (IRF-1) is a transcription factor regulating the expression of several cytokines. Using IRF-1 knockout (KO) mice, the role of IRF-1 in the production and activity of IL-18 was evaluated. Administration of IL-12 or concanavalin A significantly increased levels of circulating IL-18 in wild...

journal_title：European journal of immunology

authors： Fantuzzi G,Reed D,Qi M,Scully S,Dinarello CA,Senaldi G

更新日期：2001-02-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) plays an important role in the immune response by modulating the complex interactions between leukocytes and tissue cells under inflammatory conditions. PGE(2) may possibly influence pro-inflammatory effects of chemokines and chemokine receptors that are among the main regulators of directi...

journal_title：European journal of immunology

authors： Panzer U,Uguccioni M

更新日期：2004-12-01 00:00:00

abstract：:Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg...

journal_title：European journal of immunology

authors： Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ

更新日期：2009-01-01 00:00:00

abstract：:Treg subsets play a role in sustaining peripheral tolerance, are characterized by markers such as forkhead winged-helix transcription factor (FOXP3) and CD25, and produce suppressive cytokines, such as IL-10 and TGF-β. Glucocorticoid-induced TNF receptor family-related (GITR) protein has been suggested to regulate Tre...

journal_title：European journal of immunology

authors： Bianchini R,Bistoni O,Alunno A,Petrillo MG,Ronchetti S,Sportoletti P,Bocci EB,Nocentini G,Gerli R,Riccardi C

更新日期：2011-08-01 00:00:00

abstract：:Peptides presented by MHC class I molecules are mostly derived from proteins synthesized by the antigen-presenting cell itself, while peptides presented by MHC class II molecules are predominantly from materials acquired by endocytosis. External antigens can also be presented by MHC class I molecules in a process refe...

journal_title：European journal of immunology

authors： Hari A,Ganguly A,Mu L,Davis SP,Stenner MD,Lam R,Munro F,Namet I,Alghamdi E,Fürstenhaupt T,Dong W,Detampel P,Shen LJ,Amrein MW,Yates RM,Shi Y

更新日期：2015-02-01 00:00:00

abstract：:Type I IFN play a very important role in immunity against viral infections. Murine type I IFN belongs to a multigene family including 14 IFN-alpha subtypes but the biological functions of IFN-alpha subtypes in retroviral infections are unknown. We have used the Friend retrovirus model to determine the anti-viral effec...

journal_title：European journal of immunology

authors： Gerlach N,Gibbert K,Alter C,Nair S,Zelinskyy G,James CM,Dittmer U

更新日期：2009-01-01 00:00:00

abstract：:A conditionally immortalized dendritic cell line was established from bone marrow of mice transgenic for a thermolabile mutant of the SV40 large T antigen under the control of the class I Kb promoter. At the permissive temperature of 33 degrees-37 degrees C, the line divides in the absence of granulocyte/macrophage co...

journal_title：European journal of immunology

authors： Volkmann A,Neefjes J,Stockinger B

更新日期：1996-11-01 00:00:00

abstract：:A major feature of the immature immune system in the newborn is its inability to produce significant levels of immunoglobulins other than IgM in response to antigens. It has recently been demonstrated that interaction of the CD40 molecule on B cells with the CD40 ligand (CD40L) on activated T cells is pivotal for immu...

journal_title：European journal of immunology

authors： Brugnoni D,Airò P,Graf D,Marconi M,Lebowitz M,Plebani A,Giliani S,Malacarne F,Cattaneo R,Ugazio AG

更新日期：1994-08-01 00:00:00

abstract：:Fas is a cell surface molecule that is expressed on a wide array of cell types and triggers apoptosis. While in most situations Fas ligation activates programmed cell death, on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex. This incongruity suggests that Fas may eli...

journal_title：European journal of immunology

authors： Wilson DJ,Fortner KA,Lynch DH,Mattingly RR,Macara IG,Posada JA,Budd RC

更新日期：1996-05-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma ), a member of the nuclear receptor superfamily, has recently been described as a modulator of macrophage functions and as an inhibitor of T cell proliferation. Here, we investigated the role of PPARgamma in dendritic cells (DC), the most potent antigen-prese...

journal_title：European journal of immunology

authors： Gosset P,Charbonnier AS,Delerive P,Fontaine J,Staels B,Pestel J,Tonnel AB,Trottein F

更新日期：2001-10-01 00:00:00