The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation.

abstract：:We have constructed four different deletion mutants of a chimeric mouse-human IgG3 anti-(4-hydroxy-3-nitrophenyl)acetyl/(5-iodo-4 hydroxy-3 nitrophenyl) acetyl (NP/NIP) antibody lacking one or more of the four exons coding for the hinge region. The mutant variants all retained intact hinge region epitopes since they a...

journal_title：European journal of immunology

authors： Sandlie I,Aase A,Westby C,Michaelsen TE

更新日期：1989-09-01 00:00:00

abstract：:The human T lymphocyte-specific CD2 (T11) molecule, that regulates T cell activation, is capable of mediating increases of intracellular cAMP. Monoclonal antibodies directed to different epitopes of the CD2 molecule which either induce or inhibit T cell proliferation are capable of triggering an increase of cAMP compa...

journal_title：European journal of immunology

authors： Carrera AC,Rincón M,De Landázuri MO,López-Botet M

更新日期：1988-06-01 00:00:00

abstract：:Influenza matrix peptide 58-66 is shown to be the optimal nonamer for binding to HLA-A2 and presentation to cytotoxic T lymphocytes (CTL). If titered out to 2 x 10(-10) - 4 x 10(-10) M in CTL-mediated lysis assays and to 3 x 10(-9) M in an HLA-A2 assembly-stabilization assay in cell lysates. The peptide was shown to m...

journal_title：European journal of immunology

authors： Morrison J,Elvin J,Latron F,Gotch F,Moots R,Strominger JL,McMichael A

更新日期：1992-04-01 00:00:00

abstract：:During mammalian pregnancy, one or more semiallogeneic fetuses gestate in direct contact with the maternal circulation and uterine tissue. However, a damaging maternal immune response is not normally provoked. We studied two possible mechanisms for this maternal-fetal tolerance, alone and in combination. First, we dir...

journal_title：European journal of immunology

authors： Rogers AM,Boime I,Connolly J,Cook JR,Russell JH

更新日期：1998-11-01 00:00:00

abstract：:The responses of resting human B lymphocytes to a variety of activation signals were studied. Human tonsillar B lymphocytes were separated according to size by countercurrent elutriation. The small B lymphocytes were then stimulated in vitro with various concentrations of anti-mu antibody in the presence or absence of...

journal_title：European journal of immunology

authors： Kehrl JH,Muraguchi A,Fauci AS

更新日期：1984-02-01 00:00:00

abstract：:Bcl-3 is an atypical member of the IκB family. Bcl-3 functions as a cofactor of p50/NF-κB1 or p52/NF-κB2 homodimers in nuclei, where it modulates NF-κB-regulated transcription in a context-dependent way. Bcl-3 has tumorigenic potential, is critical in host defense of pathogens, and has been reported to ameliorate or e...

journal_title：European journal of immunology

authors： Tassi I,Rikhi N,Claudio E,Wang H,Tang W,Ha HL,Saret S,Kaplan DH,Siebenlist U

更新日期：2015-04-01 00:00:00

abstract：:IL-15 induces proliferation, inhibits apoptosis and increases IL-4 production in murine mast cells. There is evidence that these activities are mediated via the uncharacterised receptor, IL-15R-X, rather than the classical three-chain IL-15 receptor. Effects of IL-15 on important aspects of mast cell biology, such as ...

journal_title：European journal of immunology

authors： Jackson NE,Wang HW,Tedla N,McNeil HP,Geczy CL,Collins A,Grimm MC,Hampartzoumian T,Hunt JE

更新日期：2005-08-01 00:00:00

abstract：:Reactive nitrogen intermediates (RNI), like nitric oxide (NO) and peroxynitrite, have antiviral effects against certain viruses. Hantaviruses, like other members of the Bunyaviridae family, have previously not been shown to be sensitive to RNI. In this study, we compared the effects of NO and peroxynitrite on hantavir...

journal_title：European journal of immunology

authors： Klingström J,Akerström S,Hardestam J,Stoltz M,Simon M,Falk KI,Mirazimi A,Rottenberg M,Lundkvist A

更新日期：2006-10-01 00:00:00

abstract：:B cells and regulatory T (Treg) cells can both facilitate remission from experimental auto immune encephalomyelitis (EAE), a disease of the central nervous system (CNS) used as a model for multiple sclerosis (MS). Considering that B-cell-depletion therapy (BCDT) is used to treat MS patients, we asked whether Treg-cell...

journal_title：European journal of immunology

authors： Hoehlig K,Shen P,Lampropoulou V,Roch T,Malissen B,O'Connor R,Ries S,Hilgenberg E,Anderton SM,Fillatreau S

更新日期：2012-05-01 00:00:00

abstract：:Abnormal cytokine production can contribute in many instances to the development of pathology. Our study focuses on the regulation of interleukin (IL)-6 production in vitro in brain-specific endothelial cells (BEC) under physiological conditions and in a model of human T leukemia virus-1 (HTLV-1) infection. IL-6 produ...

journal_title：European journal of immunology

authors： Rott O,Tontsch U,Fleischer B,Cash E

更新日期：1993-08-01 00:00:00

abstract：:In this study, we have analyzed the in vivo dynamics of the interaction between polyclonal Foxp3(+) Treg cells, effector T (Teff) cells, and DCs in order to further our understanding of the mechanisms of Treg cell-mediated suppression. Cotransfer of polyclonal activated Treg cells into healthy mice attenuated the ind...

journal_title：European journal of immunology

authors： Davidson TS,Shevach EM

更新日期：2011-10-01 00:00:00

abstract：:A recombinant Plasmodium vivax circumsporozoite (CS) protein (rPvCS-1) has been investigated as a possible malaria sporozoite vaccine candidate. Experiments were carried out to determine whether sporozoite-specific memory cells develop in Swiss Webster mice immunized with rPvCS-1. Challenge of rPvCS-1-immunized mice w...

journal_title：European journal of immunology

authors： Nardin EH,Barr PJ,Gibson HL,Collins WE,Nussenzweig RS,Nussenzweig V

更新日期：1987-12-01 00:00:00

abstract：:X-linked agammaglobulinemia (XLA) is a primary immunodeficiency of the B-cell compartment caused by a defective gene encoding for the tyrosine kinase (btk) essential for B cell differentiation. Affected males undergo recurrent pyogenic infections and deficient immunoglobulin production. Peripheral blood T cells from 6...

journal_title：European journal of immunology

authors： Amedei A,Romagnani C,Benagiano M,Azzurri A,Fomia F,Torrente F,Plebani A,D'Elios MM,Del Prete G

更新日期：2001-06-01 00:00:00

abstract：:To investigate the role of membrane lymphotoxin (LT)alpha1 / beta2 and its LTbeta receptor (LTbetaR) in the protective immune response to Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection, we have used a soluble fusion molecule (LTbetaR-IgG1). LTbetaR-Ig treatment interferes with granuloma formation mainly ...

journal_title：European journal of immunology

authors： Lucas R,Tacchini-Cottier F,Guler R,Vesin D,Jemelin S,Olleros ML,Marchal G,Browning JL,Vassalli P,Garcia I

更新日期：1999-12-01 00:00:00

abstract：:The T cell-dependent differentiation and function of B lymphocytes are tightly regulated by TNF ligands (L) and receptors interactions, such as CD40/CD40L, CD27/CD70 and CD134/CD314L. The LIGHT/HVEM system [homologous to lymphotoxin, inducible expression, competing for GpD of herpes virus, that binds to the herpes vir...

journal_title：European journal of immunology

authors： Duhen T,Pasero C,Mallet F,Barbarat B,Olive D,Costello RT

更新日期：2004-12-01 00:00:00

abstract：:Mitochondria are master regulators of metabolism. Mitochondria generate ATP by oxidative phosphorylation using pyruvate (derived from glucose and glycolysis) and fatty acids (FAs), both of which are oxidized in the Krebs cycle, as fuel sources. Mitochondria are also an important source of reactive oxygen species (ROS)...

journal_title：European journal of immunology

authors： Mills EL,O'Neill LA

更新日期：2016-01-01 00:00:00

abstract：:Strains CBA (M523) (= M523) and CBA differ by a mutation which has been mapped genetically into the K region of the H-2 complex. Similarly, strains B 10.D2 (M504 (= M504) and b 10.D2 differ in a mutation which occurred in the D region. The data presented in this study show that mixed lymphocyte culture in M523 anti-CB...

journal_title：European journal of immunology

authors： Geib RW,Klein J

更新日期：1979-02-01 00:00:00

abstract：:From human precursor B cells which had both immunoglobulin (Ig) heavy (H) chain loci in germ-line configuration, various IgH chain germ-line transcripts were isolated and sequenced. These transcripts were shown to contain sequences derived from the JH region, the IgH chain enhancer element or the Ig switch region. A n...

journal_title：European journal of immunology

authors： Thompson A,Timmers E,Schuurman RK,Hendriks RW

更新日期：1995-01-01 00:00:00

abstract：:The HIV-1 Tat protein plays a critical role in the pathogenesis of HIV and has been considered as a candidate vaccine antigen. In an effort to design a non-invasive vaccination strategy against HIV-1 that stimulates the induction of systemic and mucosal immune responses, we studied the transcutaneous delivery of a syn...

journal_title：European journal of immunology

authors： Partidos CD,Moreau E,Chaloin O,Tunis M,Briand JP,Desgranges C,Muller S

更新日期：2004-12-01 00:00:00

abstract：:The TNF member LIGHT also known as TL4 or TNFSF14) can play a major role in cancer control via its two receptors; it induces tumor cell death through lymphotoxin-beta receptor (LT-betaR) and ligation to the herpes virus entry mediator (HVEM) amplifies the immune response. By studying the effect of LIGHT in the transcr...

journal_title：European journal of immunology

authors： Pasero C,Barbarat B,Just-Landi S,Bernard A,Aurran-Schleinitz T,Rey J,Eldering E,Truneh A,Costello RT,Olive D

更新日期：2009-09-01 00:00:00

abstract：:Peptides presented by MHC class I molecules are mostly derived from proteins synthesized by the antigen-presenting cell itself, while peptides presented by MHC class II molecules are predominantly from materials acquired by endocytosis. External antigens can also be presented by MHC class I molecules in a process refe...

journal_title：European journal of immunology

authors： Hari A,Ganguly A,Mu L,Davis SP,Stenner MD,Lam R,Munro F,Namet I,Alghamdi E,Fürstenhaupt T,Dong W,Detampel P,Shen LJ,Amrein MW,Yates RM,Shi Y

更新日期：2015-02-01 00:00:00

abstract：:The murine intestinal epithelium contains a heterogeneous population of intraepithelial leukocytes (IEL) most of which are granulated, Thy-1-CD5-CD8+. In order to assess the lineage relationship of this subgroup of IEL to peripheral T cells, we examined IEL in mice with the severe combined immunodeficiency (scid/scid)...

journal_title：European journal of immunology

authors： Croitoru K,Stead RH,Bienenstock J,Fulop G,Harnish DG,Shultz LD,Jeffery PK,Ernst PB

更新日期：1990-03-01 00:00:00

abstract：:A T3 complex-bearing subpopulation was characterized within an in vivo cycling T4-8- early thymocyte compartment which contains cells constitutively expressing interleukin 2 and transferrin receptors. We show differentiation in vitro of both mature subsets of thymocytes (T3+4+8- and T3+4-8+) from the above T4-8- compa...

journal_title：European journal of immunology

authors： De la Hera A,Toribio ML,Marquez C,Marcos MA,Cabrero E,Martinez-A C

更新日期：1986-06-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class II region is assumed to influence autoimmune diseases such as rheumatoid arthritis. In the mouse, the H-2q haplotype is associated with susceptibility to collagen-induced arthritis, while the H-2p haplotype is not. The class II A molecules of these haplotypes differ by ...

journal_title：European journal of immunology

authors： Brunsberg U,Gustafsson K,Jansson L,Michaëlsson E,Ahrlund-Richter L,Pettersson S,Mattsson R,Holmdahl R

更新日期：1994-07-01 00:00:00

abstract：:DNase II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. Macrophages in DNase II-deficient mice accumulate undigested DNA and constitutively produce IFN-beta as well as TNF-alpha. The IFN-beta causes severe anemia in the DNase II(-/-) embryos, which die...

journal_title：European journal of immunology

authors： Okabe Y,Kawane K,Nagata S

更新日期：2008-11-01 00:00:00

abstract：:About one hundred immunologists recently met in Capo Caccia, Sardinia, for the first of three events that will comprise the EMBO Conference Series, organised by the ENII, on Molecular and Cellular Mechanisms of Immune Regulation. The 2007 Conference focused on how immunity is shaped in healthy and diseased tissues. ...

journal_title：European journal of immunology

authors： Borst J,Ricciardi-Castagnoli P

更新日期：2007-08-01 00:00:00

abstract：:The murine monoclonal antibody F23.1 reacts with an allotypic determinant on the beta chain of the T cell receptor expressed by approximately 20% of T helper and cytotoxic T lymphocytes of most common mouse strains. This IgG2a antibody, either in soluble form or covalently coupled to Sepharose beads, can activate rest...

journal_title：European journal of immunology

authors： Staerz UD,Bevan MJ

更新日期：1986-03-01 00:00:00

abstract：:Peptide ligands presented by MHC class I molecules are generated in a cascade of proteolytic events starting with the proteasome in the cytosol and frequently terminating with trimming aminopeptidases in the endoplasmic reticulum. Several cytosolic proteases can carry out intermediate proteolytic steps between these s...

journal_title：European journal of immunology

authors： Endert Pv

更新日期：2008-03-01 00:00:00

abstract：:We have examined the influence of listeriolysin O (LLO), the hemolysin secreted by the pathogenic bacterium Listeria monocytogenes, on major histocompatibility complex class II-dependent T cell activation. Stimulation of T cells by native antigens but not by peptides is inhibited upon pretreatment of antigen-presentin...

journal_title：European journal of immunology

authors： Darji A,Stockinger B,Wehland J,Chakraborty T,Weiss S

更新日期：1997-07-01 00:00:00

abstract：:In a search for proteins involved in signal transduction through the T cell receptor (TcR/CD3 complex), a recently developed highly efficient method for labeling of nucleotide binding proteins in permeabilized cells was applied. Here, we report that human CD3-gamma could be labeled by periodate-oxidized [alpha-32P] GT...

journal_title：European journal of immunology

authors： Peter ME,Wileman T,Terhorst C

更新日期：1993-02-01 00:00:00