Abstract:
:About one hundred immunologists recently met in Capo Caccia, Sardinia, for the first of three events that will comprise the EMBO Conference Series, organised by the ENII, on Molecular and Cellular Mechanisms of Immune Regulation. The 2007 Conference focused on how immunity is shaped in healthy and diseased tissues.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Borst J,Ricciardi-Castagnoli Pdoi
10.1002/eji.200790031subject
Has Abstractpub_date
2007-08-01 00:00:00pages
2055-8issue
8eissn
0014-2980issn
1521-4141journal_volume
37pub_type
杂志文章abstract::Regulatory T cells (Treg) provide protection from autoimmune disease, graft-versus-host disease, transplant rejection and overwhelming tissue destruction during infections. Conversely, high Treg numbers enable cancer cells to evade the host immune response. Thus, Treg are seen as an important tool to manipulate the im...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.200636459
更新日期:2006-11-01 00:00:00
abstract::Intravenous immunoglobulin G (IVIg) therapy is widely used to treat autoimmune and inflammatory diseases. Recent evidence suggests that in mice, splenic resident cells might be important for the anti-inflammatory activity of IVIg in a model of serum transfer arthritis. Splenectomized human immunothrombocytopenia (ITP)...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142260
更新日期:2012-04-01 00:00:00
abstract::To investigate the role of TCR-pMHC interaction in regulating lung CD8 tissue-resident T cell (TR ) differentiation, polyclonal responses were compared against NP366-374 /Db and PA224-233 /Db , two immunodominant epitopes that arise during influenza A infection in mice. Memory niches distinct from iBALTs develop withi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201747174
更新日期:2018-01-01 00:00:00
abstract::Staphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is associated with intense pain and permanent articular damage, neutrop...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201747198
更新日期:2018-03-01 00:00:00
abstract::Two major histocompatibility complex (MHC) class I-reactive T cell clones derived from H-2b mice, generated against the allogeneic Ld molecule, were found to recognize the H-2b class II mutant Abm12 molecule as well. In addition, these clones also recognize the class II A(s) molecule, and display a class II-dependent ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230823
更新日期:1993-08-01 00:00:00
abstract::Major histocompatibility complex (MHC) class II-associated antigen presentation is mainly linked to processing of exogenous antigens upon cellular uptake by endocytosis, but has also been observed for endogenously synthesized antigens. We have studied the MHC class II-associated presentation of the endogenously synthe...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251230
更新日期:1995-12-01 00:00:00
abstract::PKCε is implicated in T cell activation and proliferation and is overexpressed in CD4+ -T cells from patients with autoimmune Hashimoto's thyroiditis. Although this might induce the suspicion that PKCε takes part in autoimmunity, its role in the molecular pathophysiology of immune-mediated disorders is still largely u...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201747102
更新日期:2018-04-01 00:00:00
abstract::Vaccine efficacy largely depends upon DC targeting and activation. The most potent TLR soluble ligands induce diffuse DC activation, which may be associated with marked pro-inflammatory responses and possibly adverse effects. This raises the concern that effective vaccine adjuvants may similarly rely on widespread DC ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200737889
更新日期:2008-05-01 00:00:00
abstract::The capacity of human peripheral blood lymphocytes (PBL) to bind antigen-IgG antibody (EA(IgG)) and antigen-IgM antibody (EA(IgM)) complexes was investigated using a rosette technique with ox erythrocytes coated with rabbit IgG or IgM antibody. It was found that while EA(IgG)-rosette-forming cells (RFC) were detected ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830050812
更新日期:1975-08-01 00:00:00
abstract::Impaired control of chronic pathogen replication may be associated to alterations of NK-cell function. Whether mechanisms underlying this dysfunction involve perturbations of differentiating NK cells is still unknown. We studied an "in vitro" model of differentiation from CD34(+)Lin(-) precursors growing only myelomon...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200838532
更新日期:2009-01-01 00:00:00
abstract::A monoclonal antibody, B20.1, was generated by fusing spleen cells from a Lou rat immunized with a soluble alpha/beta T cell receptor (TcR; V alpha 2/V beta 2) to mouse myeloma cells. Analysis of a panel of V alpha 2 mRNA-expressing T cell lines, hybridomas and transfectants revealed that the B20.1 antibody was specif...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220217
更新日期:1992-02-01 00:00:00
abstract::An anti-T cell receptor (TcR) monoclonal antibody (mAb), LC4, directed against a human leukemic T cell line, SUP-T13, caused DNA fragmentation ("apoptosis") and cell death upon binding to this cell line. Cross-linking of receptor molecules was necessary for this effect since F(ab')2, but not Fab', fragments of LC4 cou...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830191023
更新日期:1989-10-01 00:00:00
abstract::Propionibacterium acnes-primed mice develop an IFN-gamma-dependent hypersensitivity towards LPS. Since CD14 plays a key role in LPS-induced cell activation the regulation and function of CD14 in this sensitization process were studied in IFN-gamma R-/- and the respective wild-type (wt) mice. In unprimed mice, CD14 (mR...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200203)32:3<761::AID-IMMU761>3.0
更新日期:2002-03-01 00:00:00
abstract::Human T cells expressing Vgamma9Ndelta2-encoded TCR recognize several nonpeptide phosphoantigens in the absence of major histocompatibility complex restriction. As these cells respond differentially to increasing concentrations of structurally related phosphoantigens, such ligands constitute agonists of different stre...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200105)31:5<1628::AID-IMMU1628>3
更新日期:2001-05-01 00:00:00
abstract::Ly49Q, a type II C-type lectin expressed on mouse plasmacytoid DC (pDC), contains a single carbohydrate recognition domain in its extracellular region and an ITIM in its cytoplasmic domain. We have identified the MHC class I molecule H-2K(b) as a Ly49Q ligand, confirming prior reports. Although H-2K(b) is expressed on...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200838363
更新日期:2009-05-01 00:00:00
abstract::In the homeostasis of the immune system regulatory cells play a major role. Removal of one group of regulatory cells, the CD25(+)CD4(+) T cells, leads to autoimmune manifestations in experimental animal models, and reintroduction of this population prevents disease. This study addresses the role of such regulatory T c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/immu.200390024
更新日期:2003-01-01 00:00:00
abstract::B cells from bursa of Fabricius of newly hatched chickens are able to reconstitute the B cell compartment of chemically bursectomized chickens. The resulting B cell chimerism can be detected with monoclonal antibodies against donor B cell alloantigen. Chimeric chickens accept donor-type skin grafts and are unresponsiv...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190303
更新日期:1989-03-01 00:00:00
abstract::A mouse lymphocyte surface molecule which is selectively expressed by mucosal T cells and detected with the monoclonal antibody (mAb) M290 has provisionally been identified as a beta 7 integrin. Identification was based on close homology of its beta subunit at the N terminus with the recently reported, highly distinct...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830211041
更新日期:1991-10-01 00:00:00
abstract::To study the question when and where self peptides become associated with major histocompatibility complex class II molecules for tolerance induction, we recently developed a system in which the intracellular site(s) of antigen expression could be manipulated using gene cloning techniques. We previously constructed a ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210613
更新日期:1991-06-01 00:00:00
abstract::NK cells display several killer inhibitory receptors (KIR) specific for different alleles of MHC class I molecules. A family of KIR are represented by type I transmembrane proteins belonging to the immunoglobulin superfamily (Ig-SF). Besides cDNA encoding for these KIR, additional cDNA have been identified which encod...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199806)28:06<1980::AID-IMM
更新日期:1998-06-01 00:00:00
abstract::Major advances in preventing, delaying, or curing individual pathologies are responsible for an increasingly long life span in the developed parts of our planet, and indeed reaching eight to nine decades of life is nowadays extremely frequent. However, medical and sanitary advances have not prevented or delayed the un...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201546178
更新日期:2016-10-01 00:00:00
abstract::Radiolabeled protein A from Staphylococcus aureus (SpA) injected i.v. into mice and rabbits forms a soluble [(IgG)2-(SpA)1]2 complex (Mr = 684 000) which is identical in composition to that formed by SpA in vitro with an equivalent amount or an excess of IgG. A soluble rabbit IgG-SpA complex injected into a mice or ra...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830130802
更新日期:1983-08-01 00:00:00
abstract::Leukosialin (CD43) is a major glycoprotein of T lymphocytes which has an extracellular domain of 45 nm in length that is heavily O-glycosylated. Monoclonal antibodies (mAb) to the extracellular domain of human leukosialin induce aggregation of T lymphocytes, monocytes and some cell lines that express leukosialin. The ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830221015
更新日期:1992-10-01 00:00:00
abstract::Inhibition of growth or eradication of experimentally induced tumors has been shown to be accompanied by infiltration of eosinophils and macrophages into the tumor mass. Since macrophages are important mediators of host antitumor activity, the possibility arises that a collaboration may exist between these two cell ty...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250535
更新日期:1995-05-01 00:00:00
abstract::Chronic myeloid leukemia (CML) is a clonal hematopoietic stem-cell malignancy characterized by the presence of the chimeric BCR-ABL oncoprotein with deregulated tyrosine-kinase (TK) activity. Although conventional T cells are acknowledged as important players in the control of CML, a possible modification of invariant...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142043
更新日期:2012-07-01 00:00:00
abstract::CD82, a member of tetraspan family (tetraspanin), is a multifunctional molecule that is involved in cell activation, costimulation, and cell spreading of T cells. Here we show that immobilized anti-CD82 monoclonal antibody (mAb) as well as anti-alpha4beta1 integrin mAb induced tyrosine phosphorylation of pp105/Crk-ass...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200205)32:5<1328::AID-IMMU1328>3
更新日期:2002-05-01 00:00:00
abstract::Despite accounting for only a minor fraction of all cells in Hodgkin's lymphoma tissue, the Hodgkin and Reed-Sternberg (HRS) cells represent the malignant tumor cell clone in Hodgkin's disease (HD). By far the most abundant cell type in the tumor tissue are CD4+ T cells. Some of them intimately associate with HRS cell...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199808)28:08<2424::AID-IMM
更新日期:1998-08-01 00:00:00
abstract::The killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed by memory T cells and NK cells in man and mice. It is frequently used as a cell differentiation marker and members of the cadherin family are ligands for KLRG1. The present study provides new insights into the interaction of mouse KLRG...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200838690
更新日期:2008-12-01 00:00:00
abstract::The T cell mitogens, concanavalin A and the monoclonal antibody OKT3, cause a rapid activation of ornithine decarboxylase (ODC) activity in human T lymphocytes, maximal within 10 min of mitogen addition. Nonmitogenic ligands to T cell surface structures do not induce ODC. The enzyme induction is dependent upon an inta...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150808
更新日期:1985-08-01 00:00:00
abstract::We have further characterized the in vitro phenotype and function of anergic and suppressive CD4(+)25(+) T cells. Following TCR ligation, DO.11.10 CD4(+)25(+) T cells suppress the activation of OT-1 CD8(+)25(-) T cells in an antigen nonspecific manner. Although suppression was seen when using a mixture of APC from bot...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200208)32:8<2365::AID-IMMU2365>3
更新日期:2002-08-01 00:00:00