Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture.

abstract：:Adenosine triphosphate has previously been shown to induce semi-mature human monocyte-derived dendritic cells (DC). These are characterized by the up-regulation of co-stimulatory molecules, the inhibition of IL-12 and the up-regulation of some genes involved in immune tolerance, such as thrombospondin-1 and indoleamin...

journal_title：European journal of immunology

authors： Ben Addi A,Lefort A,Hua X,Libert F,Communi D,Ledent C,Macours P,Tilley SL,Boeynaems JM,Robaye B

更新日期：2008-06-01 00:00:00

abstract：:This study reports on the earliest stages of mononuclear phagocyte differentiation. A crucial question in this developmental process is whether mature macrophage (M phi) heterogeneity is already appointed at the precursor cell level. For this purpose, we produced clonal populations of mononuclear phagocytes from bone ...

journal_title：European journal of immunology

authors： Leenen PJ,Slieker WA,Melis M,Van Ewijk W

更新日期：1990-01-01 00:00:00

abstract：:A method is described for radiolabeling polyanionic macromolecules by the formation of an electrostatic complex with a radioiodinated tyramine conjugated DEAE-dextran. Data is presented on the use of this technique for the detection and quantitation of immunospecific binding of polynitrophenylated proteins, deoxyribon...

journal_title：European journal of immunology

authors： Little JR,Blanke TJ,Little KD

更新日期：1976-06-01 00:00:00

abstract：:The contribution of direct and indirect alloresponses by CD4(+) Th1 and Th2 cells in acute and chronic rejection of allogeneic transplants remains unclear. In the present study, we addressed this question using a transplant model in a single MHC class I-disparate donor-recipient mouse combination. BALB/c-dm2 (dm2) mut...

journal_title：European journal of immunology

authors： Illigens BM,Yamada A,Anosova N,Dong VM,Sayegh MH,Benichou G

更新日期：2009-11-01 00:00:00

abstract：:Among 15 anti-DNA antibody-producing hybridomas derived from a single NZB X NZW F1 mouse, an IgM and an IgG were shown to use the same VH gene of the Q52 family. Using a combination of two primers both consisting of a mixture of oligonucleotides (one complementary to the 5' end of VH segment and one to the 3' end of V...

journal_title：European journal of immunology

authors： Taki S,Hirose S,Kinoshita K,Nishimura H,Shimamura T,Hamuro J,Shirai T

更新日期：1992-04-01 00:00:00

abstract：:Ig class switch recombination (CSR) is dependent upon the expression of activation-induced deaminase and targeted to specific isotypes by germ-line transcript expression and isotype-specific factors. NF-kappaB plays critical roles in multiple aspects of B cell biology and has been implicated in the mechanism of CSR by...

journal_title：European journal of immunology

authors： Wang L,Wuerffel R,Kenter AL

更新日期：2006-12-01 00:00:00

abstract：:The cytokine interleukin 1 (IL 1) plays an important role in the induction of IL 2 secretion and high-affinity IL 2 receptor (IL 2R) expression by T cells. The events that follow binding of IL 1 to IL 1R, however, are still unknown. In this study we describe two variants of the murine thymoma EL4 (5D3 and D6/76) that ...

journal_title：European journal of immunology

authors： Von Hoegen I,Falk W,Kojouharoff G,Krammer PH

更新日期：1989-02-01 00:00:00

abstract：:To investigate the role of interferon-gamma (IFN-gamma) in experimental autoimmune thyroidits (EAT), H-2k mice with a disrupted IFN-gamma receptor (IFN-gamma R) gene were immunized with porcine thyroglobulin (pTg). We observed that EAT occurred on day 19 and remitted on day 35 in IFN-gamma R-deficient (IFN-gamma R(0/0...

journal_title：European journal of immunology

authors： Alimi E,Huang S,Brazillet MP,Charreire J

更新日期：1998-01-01 00:00:00

abstract：:We identified the presence in the Aleutian skate, Bathyraja aleutica, of two classes of immunoglobulins (Ig), a high molecular weight Ig analogous to mammalian IgM and a low molecular weight Ig, similarly to the spiny rasp skate, Raja kenojei, (Kobayashi, K. et al., Mol. Immunol. 1984. 21: 397), using an immunological...

journal_title：European journal of immunology

authors： Kobayashi K,Tomonaga S,Teshima K,Kajii T

更新日期：1985-09-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognat...

journal_title：European journal of immunology

authors： Czarneski J,Berguer P,Bekinschtein P,Kim DC,Hakimpour P,Wagner N,Nepomnaschy I,Piazzon I,Ross SR

更新日期：2002-04-01 00:00:00

abstract：:NK cells can kill transformed, infected and stressed cells while most normal cells are spared. NK cells are activated by various endogenous self-ligands, some of which are actually expressed by normal cells. Thus, NK cells are inherently self-reactive and consequently, potentially auto-aggressive. How these cells are ...

journal_title：European journal of immunology

authors： Held W

更新日期：2008-11-01 00:00:00

abstract：:Despite accounting for only a minor fraction of all cells in Hodgkin's lymphoma tissue, the Hodgkin and Reed-Sternberg (HRS) cells represent the malignant tumor cell clone in Hodgkin's disease (HD). By far the most abundant cell type in the tumor tissue are CD4+ T cells. Some of them intimately associate with HRS cell...

journal_title：European journal of immunology

authors： Roers A,Montesinos-Rongen M,Hansmann ML,Rajewsky K,Küppers R

更新日期：1998-08-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis, an experimental murine model for multiple sclerosis, is induced by stimulation of myelin-specific T lymphocytes. Myelin oligodendrocyte glycoprotein (MOG), a minor component of myelin proteins, is a potent autoantigen which contributes extensively to the anti-myelin response....

journal_title：European journal of immunology

authors： Fazilleau N,Delarasse C,Sweenie CH,Anderton SM,Fillatreau S,Lemonnier FA,Pham-Dinh D,Kanellopoulos JM

更新日期：2006-03-01 00:00:00

abstract：:Antigen-presenting cells (APC), including dendritic cells and macrophages, produce a large amount of interferon (IFN)-gamma, a crucial cytokine for the control of infectious diseases. To elucidate the role of IFN-gamma from APC in vivo, we employed cytokine receptor common gamma subunit (gamma c) and recombination-act...

journal_title：European journal of immunology

authors： Suzue K,Asai T,Takeuchi T,Koyasu S

更新日期：2003-10-01 00:00:00

abstract：:Diacylglycerol kinases (DGKs) play important roles in restraining diacylglycerol (DAG)-mediated signaling. Within the DGK family, the ζ isoform appears to be the most important isoform in T cells for controlling their development and function. DGKζ has been demonstrated to regulate T cell maturation, activation, anerg...

journal_title：European journal of immunology

authors： Xie D,Zhang S,Chen P,Deng W,Pan Y,Xie J,Wang J,Liao B,Sleasman JW,Zhong XP

更新日期：2020-11-01 00:00:00

abstract：:The stimulatory as well as the inhibitory capacity of alloantisera has been investigated with respect to rat mast cell functions. Alloantibody against alloantigens coded for by the major histocompatibility (H-1) gene region promoted histamine release from purified LEW mast cells. This process was found to be complemen...

journal_title：European journal of immunology

authors： Mossmann H,Lauer W,Vortisch U,Gunther E,Bazin H,Hammer DK

更新日期：1976-08-01 00:00:00

abstract：:In this work the suppressive activity of splenic T cells from young and aged BALB/c mice infected with Trypanosoma cruzi were compared and correlated with the development of autoimmune myocarditis. The T cells from young adult BALB/c mice with acute T. cruzi infection exhibit suppressor activity when added to full all...

journal_title：European journal of immunology

authors： Cardillo F,Falcão RP,Rossi MA,Mengel J

更新日期：1993-10-01 00:00:00

abstract：:Toll-like receptors (TLR) 7 and 8 are closely related members of the TLR family of pathogen-associated molecular pattern recognition receptors and have an important function in activation of innate immune responses upon viral infection. TLR7 can be activated selectively by the guanosine analogue loxoribine, whereas th...

journal_title：European journal of immunology

authors： Jurk M,Kritzler A,Schulte B,Tluk S,Schetter C,Krieg AM,Vollmer J

更新日期：2006-07-01 00:00:00

abstract：:Bone morphogenetic proteins (BMP) are multifunctional cytokines that belong to the TGF-beta superfamily. BMP have been shown to regulate haematopoietic stem cells, B lymphopoiesis and early thymocyte differentiation. In the present study we explored the role of BMP-6 in Jurkat TAg cells. BMP-6 rapidly induced phosphor...

journal_title：European journal of immunology

authors： Sivertsen EA,Huse K,Hystad ME,Kersten C,Smeland EB,Myklebust JH

更新日期：2007-10-01 00:00:00

abstract：:MICA and MICB (MHC-class-I-related chain A/B) are transmembrane proteins expressed in pathological conditions that are ligands for NKG2D, an activating receptor found on cytotoxic lymphocytes. The recognition on target cells of NKG2D ligands leads to the activation of lysis and cytokine secretion by NK cells and T cel...

journal_title：European journal of immunology

authors： Agüera-González S,Gross CC,Fernández-Messina L,Ashiru O,Esteso G,Hang HC,Reyburn HT,Long EO,Valés-Gómez M

更新日期：2011-12-01 00:00:00

abstract：:The binding of antigen to the multicomponent T cell antigen receptor (TcR)-CD3 complex leads to the activation of several signal transduction pathways which result in T lymphocyte proliferation and lymphokine secretion by molecular mechanisms and catalytic molecules as yet poorly defined. One of the earliest events th...

journal_title：European journal of immunology

authors： Gassmann M,Guttinger M,Amrein KE,Burn P

更新日期：1992-01-01 00:00:00

abstract：:Programmed cell death (PCD) is involved in the physiological regulation of lymphocyte turnover, as well in the antigen-driven selection of T and B cells. Here it is shown that the immunomodulator linomide (quinoline-3-carboxamide) inhibits the apoptotic decay of peripheral T lymphocytes in response to three different ...

journal_title：European journal of immunology

authors： Gonzalo JA,González-García A,Kalland T,Hedlung G,Martínez C,Kroemer G

更新日期：1994-01-01 00:00:00

abstract：:In this report, we provide new evidence of a crosstalk between T cell activation and adhesion processes through a functional cytokeleton. We show that CD82 signaling induces long-lasting adhesion, spreading and development of membrane extensions, involving actin polymerization. Addition of various co-stimuli (phorbol ...

journal_title：European journal of immunology

authors： Lagaudrière-Gesbert C,Lebel-Binay S,Hubeau C,Fradelizi D,Conjeaud H

更新日期：1998-12-01 00:00:00

abstract：:The distribution of the murine receptor for interleukin (IL) 6 was examined on a variety of cells. Binding sites for IL 6 were found on many cell lines including fibroblasts and bone marrow-derived macrophages. The highest density of binding sites was found on B cell hybridomas and plasmacytomas, irrespective of their...

journal_title：European journal of immunology

authors： Coulie PG,Stevens M,Van Snick J

更新日期：1989-11-01 00:00:00

abstract：:Dendritic cells (DC) are extremely proficient inducers of naïve CD4+ T cell activation due to their high expression level of peptide-MHC and an array of accessory molecules involved in cell migration, adhesion and co-signaling, including PD-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). Whether PD-L1 and PD-L2 have a s...

journal_title：European journal of immunology

authors： Kuipers H,Muskens F,Willart M,Hijdra D,van Assema FB,Coyle AJ,Hoogsteden HC,Lambrecht BN

更新日期：2006-09-01 00:00:00

abstract：:Ptak and Askenase showed that both alphabeta and gammadelta cells are required for transfer of contact sensitivity (CS). This study confirms that day 4 immune cells depleted of gammadelta cells fail to transfer CS to trinitrochlorobenzene (TNP-Cl) systemically and demonstrates that administration of anti-gammadelta mo...

journal_title：European journal of immunology

authors： Dieli F,Asherson GL,Sireci G,Dominici R,Gervasi F,Vendetti S,Colizzi V,Salerno A

更新日期：1997-01-01 00:00:00

abstract：:T and B cells continually migrate around the body by recirculating between blood and lymph via lymphoid tissues. This is an important way of fostering the cell-cell interactions required for the initiation of an immune response. Data from previous studies of T and B cell recirculation, based on relatively complex appr...

journal_title：European journal of immunology

authors： Reynolds JD,Chin W,Shmoorkoff J

更新日期：1988-06-01 00:00:00

abstract：:Interleukin-12 (IL-12) has been shown to be produced by monocytes by the ligation of CD40. In the present experiments, IL-12 is shown to be produced by murine spleen antigen-presenting cells (APC) by interaction with T helper 1 (Th1) clones through CD40-CD40 ligand (CD40L) interaction, but not with Th2 clones. The IL-...

journal_title：European journal of immunology

authors： Hino A,Nariuchi H

更新日期：1996-03-01 00:00:00

abstract：:The surface expression of given HLA class I alleles protects target cells from lysis mediated by natural killer (NK) clones specific for these (or related) alleles. We could define two groups of NK clones specifically recognizing either Cw4 and related C alleles ("group 1") or Cw3 and related C alleles ("group 2"), re...

journal_title：European journal of immunology

authors： Ciccone E,Pende D,Vitale M,Nanni L,Di Donato C,Bottino C,Morelli L,Viale O,Amoroso A,Moretta A

更新日期：1994-04-01 00:00:00

abstract：:Macrophage scavenger receptors are trimeric integral membrane glycoproteins which have been implicated in various macrophage functions including uptake of oxidized lipoprotein and the serum-dependent, divalent cation-independent adhesion of macrophages to tissue culture-treated plastic. In this study we have used a re...

journal_title：European journal of immunology

authors： Hughes DA,Fraser IP,Gordon S

更新日期：1995-02-01 00:00:00