Abstract:
:In this work the suppressive activity of splenic T cells from young and aged BALB/c mice infected with Trypanosoma cruzi were compared and correlated with the development of autoimmune myocarditis. The T cells from young adult BALB/c mice with acute T. cruzi infection exhibit suppressor activity when added to full allogeneic or Mls-disparate mixed lymphocyte cultures. This suppression could not be reverted by exogenous interleukin (IL)-2 and was not directly dependent on the presence of IL-4, IL-10 or transforming growth factor-beta. Further characterization of the T cell lineage responsible for the suppressor activity by in vitro and/or in vivo depletion with monoclonal antibody to alpha beta or gamma delta T cell receptor revealed that splenic gamma delta T cells function as suppressor lymphocytes in young T. cruzi-infected mice. In addition, these young adult BALB/c mice do not develop autoimmune myocarditis and showed a low incidence of syngeneic heart graft rejection in the early chronic phase of the infection. In contrast, T cells from acutely infected aged BALB/c mice lacked demonstrable T suppressor activity. Furthermore, these mice developed a severe autoimmune myocarditis as early as 2 months after the onset of the infection, when the majority of them reject syngeneic heart grafts. These findings suggest that a gamma delta T cell-mediated suppressor mechanism may operate in the avoidance of the breaking of tissue-specific tolerance during the acute infection. Moreover, such a mechanism is likely related to the immune system chronobiology.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Cardillo F,Falcão RP,Rossi MA,Mengel Jdoi
10.1002/eji.1830231033subject
Has Abstractpub_date
1993-10-01 00:00:00pages
2597-605issue
10eissn
0014-2980issn
1521-4141journal_volume
23pub_type
杂志文章abstract::To detect possible differences in immunogenicity between tumors induced in T cell-deficient mice and phenotypically normal congenic mice, 16 sarcomas, 8 having developed in nude BALB/c mice and 8 having developed in congenic normal (nu/+) mice, were transplanted to normal BALB/c recipients and the rates of rejection o...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260827
更新日期:1996-08-01 00:00:00
abstract::It is well accepted that Th17 cells are a highly plastic cell subset that can be easily directed toward the Th1 phenotype in vitro and also in vivo during inflammation. However, there is an ongoing debate regarding the reverse plasticity (conversion from Th1 to Th17). We show here that ectopic ROR-γt expression can re...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201847677
更新日期:2019-01-01 00:00:00
abstract::The functional relevance of CD2-mediated signal transduction in triggering T cell receptor/CD3-independent natural killer cell cytotoxicity was investigated by introducing wild-type CD2 or signaling-deficient CD2 with truncated cytoplasmic region into a murine natural killer-like large granular lymphocyte clone lackin...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210345
更新日期:1991-03-01 00:00:00
abstract::Dendritic cells (DC) play the dual task of initiating cellular immunity against potentially harmful foreign antigens (Ag), while maintaining immunological tolerance to self-Ag and environmental Ag. As an approach to induce Ag-specific suppression, we and others introduced CD95 ligand (L) cDNA into DC. The resulting "k...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200204)32:4<1035::AID-IMMU1035>3
更新日期:2002-04-01 00:00:00
abstract::Human T cell clones expressing the T cell receptor (TcR) gamma/delta were isolated from peripheral blood lymphocytes of two unrelated donors. The TcR gamma/delta+ clones derived from one of these donors were all of the Ti gamma A+, delta-TCS1-, BB3+ phenotype indicating the exclusive use of the V gamma 9 and V delta 3...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830191120
更新日期:1989-11-01 00:00:00
abstract::The heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) has been described as an important autoantigen in rheumatoid arthritis (RA) since it is targeted by autoantibodies, autoreactive T cells, and is aberrantly expressed in synovial cells in patients. To identify hnRNP-A2-specific T-cell epitopes possibly associate...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200939482
更新日期:2010-06-01 00:00:00
abstract::The expression of IgG Fc receptor (FcR) molecules was examined on Ly-1+ B cells and B cells tumors. FcR molecules were found on a representative Ly-1+ B cell lymphoma of the pre-B and as well as of the mature cell B phenotypes. The expression of the FcR did not change on these cells during their differentiation to B c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830170621
更新日期:1987-06-01 00:00:00
abstract::Tumor-associated macrophages (TAMs) are key components of the tumor macroenvironment. Cancer- and host cell-derived signals generally drive the functions of TAMs towards an M2-like polarized, tumor-propelling mode; however, when appropriately re-educated. TAMs also have the potential to elicit tumor destructive reacti...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201141894
更新日期:2011-09-01 00:00:00
abstract::Induction of the glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids plays a role in their antiinflammatory action, whereas GILZ expression is reduced under inflammatory conditions. The mechanisms regulating GILZ expression during inflammation, however, have not yet been characterized. Here, we investigate...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142081
更新日期:2012-05-01 00:00:00
abstract::The early-life immune environment has been implicated as a modulator of acute lymphoblastic leukemia (ALL) development in children, with infection being associated with significant changes in ALL risk. Furthermore, polymorphisms in several cytokine genes, including IL-10 and IFN-γ, are associated with leukemia develop...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201646806
更新日期:2017-05-01 00:00:00
abstract::The entry of neutrophils into inflamed tissues is initiated by cell rolling on the blood vessel wall followed by arrest and transendothelial migration. Rolling is mediated by the selectins, while the two subsequent steps require activated beta 2-integrins. We have investigated whether the binding of P-selectin to mous...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199802)28:02<433::AID-IMMU
更新日期:1998-02-01 00:00:00
abstract::Tetanus toxin has been a valuable model antigen to study the MHC class II-restricted antigen processing pathway and is also frequently used to provide T helper determinants in vaccine formulations. To date most basic studies on the processing of this antigen have utilized human T and B cell clones. As a first step tow...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200202)32:2<530::AID-IMMU530>3.0
更新日期:2002-02-01 00:00:00
abstract::The magnitude of the IgE antibody response against the phosphorylcholine (PC) hapten and the rate of age-related change of IgE formation is polymorphic in the three long-lived and six relatively short-lived strains of mice studied. Long-lived mice showed an early increase, followed by a decline in the levels of anti-P...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160621
更新日期:1986-06-01 00:00:00
abstract::Nonhematopoietic stromal cells contribute to the organization and homeostasis of secondary lymphoid organs by producing cytokines and chemokines. The development and maintenance of these stromal cells are thought to be regulated by innate immune cells. Indeed, we recently showed that signal regulatory protein α (SIRPα...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948103
更新日期:2019-09-01 00:00:00
abstract::Two major histocompatibility complex (MHC) class I-reactive T cell clones derived from H-2b mice, generated against the allogeneic Ld molecule, were found to recognize the H-2b class II mutant Abm12 molecule as well. In addition, these clones also recognize the class II A(s) molecule, and display a class II-dependent ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230823
更新日期:1993-08-01 00:00:00
abstract::The present experiments address functional antibody diversity and clonal distribution in murine available repertoires. IgM-containing supernatants were prepared by unbiased, polyclonal stimulation of resting splenic B cells from C57BL/6 mice, to ensure similar numbers of responding clones/culture and equivalent growth...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199804)28:04<1204::AID-IMM
更新日期:1998-04-01 00:00:00
abstract::CD30 is a costimulatory molecule of the TNF receptor superfamily, expressed on activated T and B cells. Previously, we have shown in a murine asthma model the crucial role of CD30 signaling for the development of this Th2-cell-mediated disease. In the present study, we investigated the role of CD30 in the maintenance ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200839004
更新日期:2009-07-01 00:00:00
abstract::CD23, the low-affinity IgE receptor, is up-regulated on interleukin (IL)-4-stimulated B cells and monocytes, with a concomitant increase in the release of soluble fragments of CD23 (sCD23) into the medium by proteolytic processing of the surface-bound intact CD23. The effect of inhibition of the processing of CD23 on ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830271221
更新日期:1997-12-01 00:00:00
abstract::FoxP3(+) Treg cells and anergic T cells are the two regulatory phenotypes of T-cell responses associated with helminth infection. Here, we examine the T-cell responses in mice during Fasciola hepatica infection, and to its tegumental coat antigens (FhTeg) that are shed from the fluke every 2-3 h. FhTeg comprises a ric...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201545905
更新日期:2016-05-01 00:00:00
abstract::The lectin leucoagglutinin has been used to induce reactivity to interleukin 2 (IL2) in unseparated spleen cells and in highly purified Lyt-2+ lymph node T cells. Recombinant human IL2 and various other IL2-containing preparations, including concanavalin A-induced spleen cell supernatant, were compared for their capac...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150405
更新日期:1985-04-01 00:00:00
abstract::MHC class II molecules present peptides, derived largely from exogenous antigens, to CD4+ T cells. Complex-generation occurs mainly in the specialized late endosomal MHC class II-rich compartment (MIIC) vesicles of antigen-presenting cells (APC). Dendritic cells (DC) have been reported to store intact antigen in MIIC ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200211)32:11<3246::AID-IMMU3246>
更新日期:2002-11-01 00:00:00
abstract::The elevated interleukin (IL)-4 and IgE production in Schistosoma mansoni infection seems to be induced essentially by the egg stage of the parasite. The underlying mechanism, however, is not known. Since basophils from human peripheral blood can produce IL-4, we asked, whether soluble S. mansoni egg antigens (SEA) wo...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260528
更新日期:1996-05-01 00:00:00
abstract::Allogeneic bone marrow transplantation in the neonate is an effective way of inducing permanent tolerance to donor tissue. To do the same in the immunocompetent adult requires immunosuppression to counter host-versus-graft alloreactivity. Conditioning with monoclonal antibodies (mAb) to CD4 and CD8 has been sufficient...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830221111
更新日期:1992-11-01 00:00:00
abstract::The autoimmune regulator (AIRE) promotes "promiscuous" expression of tissue-restricted antigens (TRA) in thymic medullary epithelial cells to facilitate thymic deletion of autoreactive T-cells. Here, we show that AIRE-deficient mice showed an earlier development of myelin oligonucleotide glycoprotein (MOG)-induced exp...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040679
更新日期:2010-12-01 00:00:00
abstract::AMD3100 (plerixafor), is a specific CXCR4 antagonist approved by the FDA for mobilizing hematopoietic stem cells from bone marrow to blood for transplantation in cancer. AMD3100 also mobilizes most mature leukocyte subsets to blood; however, their source and trafficking potential have not been fully delineated. Here, ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201445245
更新日期:2015-06-01 00:00:00
abstract::Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200838734
更新日期:2009-01-01 00:00:00
abstract::Human Vgamma9Vdelta2 T cells contribute to immunity against intracellular pathogens and recognize nonpeptidic antigens, such as the mycobacterial phosphoantigen TUBAg. HIV infection is associated with a polyclonal decrease of peripheral Vgamma9Vdelta2 T cells and we previously reported that the remaining cells show a ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199901)29:01<90::AID-IMMU9
更新日期:1999-01-01 00:00:00
abstract::Current models of lymphocyte traffic suggest that homing specificities of T cells to tissues such as skin are generated outside the thymus as a result of activation of naive T cells by antigen in lymph nodes. Virgin T cells are thought to home to high endothelial venules in lymph nodes, but are thought to be unable to...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250314
更新日期:1995-03-01 00:00:00
abstract::The NLRP3 inflammasome is a molecular complex that translates signals from pathogens and tissue damage into inflammatory responses, and plays crucial roles in numerous neurological diseases. Activation of the NLRP3 inflammasome leads to caspase-1 dependent cleavage of pro-IL-1β to form mature IL-1β. By acting on the P...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201848013
更新日期:2020-02-01 00:00:00
abstract::Transporter associated with antigen processing (TAP)-competent and TAP-deficient cell lines were transfected with expression plasmids encoding either the wild-type (wt) large tumor antigen (T-Ag) of SV40, or a truncated cytoplasmic variant (cT-Ag) of this viral protein. Stable expression of comparable levels of both f...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270828
更新日期:1997-08-01 00:00:00