Fasciola hepatica tegumental antigens induce anergic-like T cells via dendritic cells in a mannose receptor-dependent manner.

abstract：:The immune and endocrine systems ensure two vital functions in the body. The immune system protects us from lethal pathogens, whereas the endocrine system ensures proper metabolic function of peripheral organs by regulating systemic homeostasis. These two systems were long thought to operate independently. The immune ...

journal_title：European journal of immunology

authors： Wensveen FM,Šestan M,Turk Wensveen T,Polić B

更新日期：2019-07-01 00:00:00

abstract：:Changes in endothelial permeability are crucial in the pathogenesis of many diseases. Adenosine is one of the endogenous mediators controlling endothelial permeability under normal conditions, and an endothelial cell surface enzyme CD73 is a key regulator of adenosine production. Here we report that IFN-beta is a nove...

journal_title：European journal of immunology

authors： Kiss J,Yegutkin GG,Koskinen K,Savunen T,Jalkanen S,Salmi M

更新日期：2007-12-01 00:00:00

abstract：:MS is a multifactorial disease in which a series of genetic and non-genetic, environmental factors plays a role in its etiology. In particular, HLA class II alleles, mainly HLADRB1*15:01 (HLA-DR15), increase the risk for this disease. Out of several environmental factors, and with regard to infections, EBV remains to ...

journal_title：European journal of immunology

authors： Olsson T

更新日期：2020-12-22 00:00:00

abstract：:T-cell development is a spatially and temporally regulated process, orchestrated by well-defined contributions of transcription factors and cytokines. Here, we identify the noncoding RNA miR-142 as an additional regulatory layer within murine thymocyte development and proliferation. MiR-142 deficiency impairs the expr...

journal_title：European journal of immunology

authors： Mildner A,Chapnik E,Varol D,Aychek T,Lampl N,Rivkin N,Bringmann A,Paul F,Boura-Halfon S,Hayoun YS,Barnett-Itzhaki Z,Amit I,Hornstein E,Jung S

更新日期：2017-07-01 00:00:00

abstract：:The liver and activation-regulated chemokine (LARC), also termed MIP-3alpha and Exodus, is a novel human CC chemokine with a selective chemotactic activity for lymphocytes and dendritic cells. Here we describe genomic and cDNA clones encoding the murine orthologue of LARC (mLARC). The gene consists of four exons and t...

journal_title：European journal of immunology

authors： Tanaka Y,Imai T,Baba M,Ishikawa I,Uehira M,Nomiyama H,Yoshie O

更新日期：1999-02-01 00:00:00

abstract：:Leptin, a protein produced by adipocytes, exerts several functions, including modulation of the immune response. A report in this issue of the European Journal of Immunology describes for the first time the effect of either leptin receptor deficiency or blockade on murine dendritic cell (DC) maturation, survival and f...

journal_title：European journal of immunology

authors： Fantuzzi G

更新日期：2006-12-01 00:00:00

abstract：:The infiltration and activation of monocytes is a hallmark of chronic inflammation, including that associated with a variety of disease states such as rheumatoid arthritis, atherosclerosis, and various autoimmune conditions. Recently, a family of small molecular mass proteins has been described which appear to have in...

journal_title：European journal of immunology

authors： Schall TJ,Simpson NJ,Mak JY

更新日期：1992-06-01 00:00:00

abstract：:The interaction between activated T cells and eosinophils has been proposed to play an important role in the pathogenesis of allergic diseases. T cell-derived cytokines such as interleukin-5 and granulocyte/macrophage colony-stimulating factor inhibit eosinophil apoptosis and may therefore contribute to the developmen...

journal_title：European journal of immunology

authors： Hebestreit H,Yousefi S,Balatti I,Weber M,Crameri R,Simon D,Hartung K,Schapowal A,Blaser K,Simon HU

更新日期：1996-08-01 00:00:00

abstract：:Leishmania-induced macrophage (Mphi) dysfunctions have been correlated with altered signaling events. Recent findings from our laboratory suggest that modulation of host protein tyrosine phosphatase (PTP) following Leishmania infection could lead to these Mphi defects. To address this issue, Mphi PTP activity and IFN-...

journal_title：European journal of immunology

authors： Blanchette J,Racette N,Faure R,Siminovitch KA,Olivier M

更新日期：1999-11-01 00:00:00

abstract：:The active role of chemokines in the central nervous system (CNS) during the pathogenesis of experimental autoimmune encephalomyelitis (EAE) has been clearly established. In this study the expression pattern of several chemokines and cytokines was elucidated using reverse transcription-PCR and immunohistochemistry in ...

journal_title：European journal of immunology

authors： Nygårdas PT,Määttä JA,Hinkkanen AE

更新日期：2000-07-01 00:00:00

abstract：:Peptide ligands presented by MHC class I molecules are generated in a cascade of proteolytic events starting with the proteasome in the cytosol and frequently terminating with trimming aminopeptidases in the endoplasmic reticulum. Several cytosolic proteases can carry out intermediate proteolytic steps between these s...

journal_title：European journal of immunology

authors： Endert Pv

更新日期：2008-03-01 00:00:00

abstract：:The pathways of human anti-pig T cell xenorecognition have been investigated. Freshly isolated porcine alveolar lavage (AL) cells induced primary proliferative responses by human peripheral and cord blood mononuclear cells which were inhibited by anti-HLA-DR antibody (indirect xenorecognition). Following over-night cu...

journal_title：European journal of immunology

authors： Dorling A,Lombardi G,Binns R,Lechler RI

更新日期：1996-06-01 00:00:00

abstract：:The IgG2a(b) heavy chain allopeptide determinant gamma2a(b) 436-451 (Kabat numbering) presented by the major histocompatibility complex (MHC) class II molecule I-Ad is recognized by T cells which cross-react with a corneal self antigen and with the UL6 protein of the herpes simplex virus which induce autoimmune kerati...

journal_title：European journal of immunology

authors： Bartnes K,Leon F,Briand JP,Travers PJ,Hannestad K

更新日期：1999-01-01 00:00:00

abstract：:Macrophage-chemotactic factor (MChF)-producing T cell hybridomas were established. These hybridomas produced MChF upon the specific antigenic stimulation with phosphorylcholine (PC)-conjugated protein in the presence of I-Ed-positive antigen-presenting cells. The hybridomas also secreted MChF after co-culture with con...

journal_title：European journal of immunology

authors： Harita S,Sugimura K,Watanabe T

更新日期：1984-08-01 00:00:00

abstract：:The expression of the Pit-1/GHF-1 transcription factor (hereafter Pit-1), which controls the expression of growth hormone (GH) and prolactin (PRL) in the pituitary gland, has been documented in human and rat hemopoietic and lymphoid tissues and cell lines. Pit-1 mRNA was detected by in situ hybridization in about 1% o...

journal_title：European journal of immunology

authors： Delhase M,Vergani P,Malur A,Hooghe-Peters EL,Hooghe RJ

更新日期：1993-04-01 00:00:00

abstract：:Dendritic cells (DC) are extremely proficient inducers of naïve CD4+ T cell activation due to their high expression level of peptide-MHC and an array of accessory molecules involved in cell migration, adhesion and co-signaling, including PD-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). Whether PD-L1 and PD-L2 have a s...

journal_title：European journal of immunology

authors： Kuipers H,Muskens F,Willart M,Hijdra D,van Assema FB,Coyle AJ,Hoogsteden HC,Lambrecht BN

更新日期：2006-09-01 00:00:00

abstract：:It is well accepted that Th17 cells are a highly plastic cell subset that can be easily directed toward the Th1 phenotype in vitro and also in vivo during inflammation. However, there is an ongoing debate regarding the reverse plasticity (conversion from Th1 to Th17). We show here that ectopic ROR-γt expression can re...

journal_title：European journal of immunology

authors： Mazzoni A,Maggi L,Siracusa F,Ramazzotti M,Rossi MC,Santarlasci V,Montaini G,Capone M,Rossettini B,De Palma R,Kruglov A,Chang HD,Cimaz R,Maggi E,Romagnani S,Liotta F,Cosmi L,Annunziato F

更新日期：2019-01-01 00:00:00

abstract：:This study was performed as a means to examine the effects of environment and stem cell origin on the molding of T cell receptor gene rearrangements during T cell development. Lethally irradiated adult mice were first reconstituted with (C57BL/6 x DBA/2)F1 stem cells, which derived either from a fetal liver or adult b...

journal_title：European journal of immunology

authors： Larché M,Manzo AR,Hurwitz JL

更新日期：1991-12-01 00:00:00

abstract：:Lymphocyte infiltration to pancreatic islets is associated to chemoattraction, as are other inflammatory autoimmune processes. We examined whether development of insulitis and diabetes depends on chemoattraction of lymphocytes via the CCR5 chemokine receptor. In non-obese diabetic (NOD) mice, a substantial fraction of...

journal_title：European journal of immunology

authors： Carvalho-Pinto C,García MI,Gómez L,Ballesteros A,Zaballos A,Flores JM,Mellado M,Rodríguez-Frade JM,Balomenos D,Martínez-A C

更新日期：2004-02-01 00:00:00

abstract：:The C-terminal fragment of merozoite surface protein-1 (MSP-1) of the mouse malaria parasite Plasmodium chabaudi chabaudi (AS) stimulates a weak CD4 T cell response when compared to the response to a more structurally simple region of the molecule. The tertiary structure of the C-terminal region of MSP-1 is maintained...

journal_title：European journal of immunology

authors： Quin SJ,Seixas EM,Cross CA,Berg M,Lindo V,Stockinger B,Langhorne J

更新日期：2001-01-01 00:00:00

abstract：:The mechanisms responsible for major histocompatibility complex (MHC)-linked unresponsiveness are still poorly understood. Here we examine the cellular events that follow when B10. A mice are immunized with cow insulin, an antigen to which they make no apparent immunologic response. Despite the fact that there is no d...

journal_title：European journal of immunology

authors： Abromson-Leeman S,Laning J,Cantor H,Dorf ME

更新日期：1988-01-01 00:00:00

abstract：:Dermal and mucosal lymphocyte infiltrates in patients with lichen ruber planus and chronic graft-vs.-host disease exhibited reactivity with anti-fibronectin antibodies. This reactivity was associated with the lymphocytes and localized pericellularly. In contrast, biopsy areas outside lymphocyte accumulations were rela...

journal_title：European journal of immunology

authors： Sundqvist KG,Wanger L,Heimdahl A,Lönnqvist B,Hauzenberger D

更新日期：1991-02-01 00:00:00

abstract：:The human promyelocytic U937 cells express detectable levels of MHC class II (MHC-II) molecules. Treatment with 12-o--tetradecanoyl phorbol 13-acetate (TPA), inducing macrophage-like differentiation, produces a dramatic decrease of MHC-II expression as result of down-modulation of the activation of immune response gen...

journal_title：European journal of immunology

authors： De Lerma Barbaro A,Procopio FA,Mortara L,Tosi G,Accolla RS

更新日期：2005-02-01 00:00:00

abstract：:We have utilized the sensitive polymerase chain reaction (PCR) to determine whether cytotoxic T lymphocyte (CTL) hybridomas generated from peritoneal exudate lymphocytes (PEL) and mixed lymphocyte cultures (MLC) express transcripts for perforin and the cytotoxic cell proteinases CCP1 to CCP5. We could readily detect l...

journal_title：European journal of immunology

authors： Helgason CD,Prendergast JA,Berke G,Bleackley RC

更新日期：1992-12-01 00:00:00

abstract：:The migration of immunocytes within the extracellular matrix (ECM) is influenced by the activation state of the incoming cell and its responses to the presence of chemokines and cytokines. We studied the regulatory role of TGF-beta1 on T cell homing to secondary lymphatic organs, such as the spleen, and chemotaxis wit...

journal_title：European journal of immunology

authors： Franitza S,Kollet O,Brill A,Vaday GG,Petit I,Lapidot T,Alon R,Lider O

更新日期：2002-01-01 00:00:00

abstract：:The magnitude of the output of lymphocytes from Peyer's patches (PP), the morphology of the lymphocytes and their route of exit from PP has been examined in sheep. An extracorporeal perfusion system was used to selectively label a 3-4 m length of the terminal ileum of lambs at 6-10 weeks of age (the mesenteric lymph n...

journal_title：European journal of immunology

authors： Reynolds JD,Pabst R

更新日期：1984-01-01 00:00:00

abstract：:Two out of 25 monoclonal anti-DNA autoantibodies that were produced by human-human hybridoma were found to have lymphocytotoxic activity. The antibodies reacted with normal B and T lymphocytes at cold (4 degrees C) as well as at warm (37 degrees C) temperatures. The lymphocytotoxic activity of the monoclonal anti-DNA ...

journal_title：European journal of immunology

authors： Shoenfeld Y,Zamir R,Joshua H,Lavie G,Pinkhas J

更新日期：1985-10-01 00:00:00

abstract：:We and others have demonstrated that adipose tissue is a reservoir for HIV. Evaluation of the mechanisms responsible for viral persistence may lead to ways of reducing these reservoirs. Here, we evaluated the immune characteristics of adipose tissue in HIV-infected patients receiving antiretroviral therapy (ART) and i...

journal_title：European journal of immunology

authors： Damouche A,Pourcher G,Pourcher V,Benoist S,Busson E,Lataillade JJ,Le Van M,Lazure T,Adam J,Favier B,Vaslin B,Müller-Trutwin M,Lambotte O,Bourgeois C

更新日期：2017-12-01 00:00:00

abstract：:HLA-A2.1-binding peptides (n = 38) were screened for immunogenicity with human peripheral blood mononuclear cells in cytotoxic T lymphocyte (CTL) induction experiments in vitro and with splenocytes from HLA-A2.1/Kb transgenic mice following immunization in vivo. These data were compiled and analyzed to determine the l...

journal_title：European journal of immunology

authors： Wentworth PA,Vitiello A,Sidney J,Keogh E,Chesnut RW,Grey H,Sette A

更新日期：1996-01-01 00:00:00

abstract：:Natural killer (NK) cells play an important role in early defense against viral infection. The cytotoxic activity of NK cells is increased by interferon-alpha/beta (IFN-alpha/beta), produced en masse in virally infected cells. However, the mechanism(s) by which IFN-alpha/beta contribute to the NK-cell-mediated antivir...

journal_title：European journal of immunology

authors： Sato K,Hida S,Takayanagi H,Yokochi T,Kayagaki N,Takeda K,Yagita H,Okumura K,Tanaka N,Taniguchi T,Ogasawara K

更新日期：2001-11-01 00:00:00