当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-γ+ and FOXP3+ T cells with potent suppressive function.

Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-γ+ and FOXP3+ T cells with potent suppressive function.

Abstract：

:Accumulating evidence suggests that Th17 cells and Tregs may exhibit development plasticity and that CD4(+) Tregs can differentiate into IL-17-producing T cells; however, whether Th17 cells can reciprocally convert into Tregs has not been described. In this study, we generated Th17 clones from tumor-infiltrating T lymphocytes (TILs). We showed that Th17 clones generated from TILs can differentiate into IFN-γ-producing and FOXP3(+) cells after in vitro stimulation with OKT3 and allogeneic peripheral blood mononuclear cells. We further demonstrated that T-cell receptor (TCR) engagement was responsible for this conversion, and that this differentiation was due to the epigenetic modification and reprogramming of gene expression profiles, including lineage-specific transcriptional factor and cytokine genes. In addition to expressing IFN-γ and FOXP3, we showed that these differentiated Th17 clones mediated potent suppressive function after repetitive stimulation with OKT3, suggesting that these Th17 clones had differentiated into functional Tregs. We further demonstrated that the Th17-derived Tregs, unlike naturally occurring CD4(+) CD25(+) Tregs, did not reconvert back into Th17 cells even under Th17-biasing cytokine conditions. These results provide the critical evidence that human tumor-infiltrating Th17 cells can differentiate into Tregs and indicate a substantial developmental plasticity of Th17 cells.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Ye J,Su X,Hsueh EC,Zhang Y,Koenig JM,Hoft DF,Peng G

doi

10.1002/eji.201040682

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

936-51

issue

4

eissn

0014-2980

issn

1521-4141

journal_volume

41

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Cholera toxin increases intracellular pH in B lymphoma cells and decreases their antigen-presenting ability.

    abstract：:Cholera toxin (CT) can function as a potent adjuvant in the mucosal immune response. However, we have found that treatment of A20-HL murine B lymphoma cells with CT severely inhibits the presentation of ovalbumin (OVA) to cells of the T cell clone 42-6A specific for OVA(323-339)/I-Ad, whereas it does not affect the pr...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199905)29:05<1561::AID-IMM

    authors： Tanaka Y,Nakano H,Ishikawa F,Yoshida M,Gyotoku Y,Kakiuchi T

    更新日期：1999-05-01 00:00:00

  • Mice deficient for the type II topoisomerase-like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching.

    abstract：:Somatic hypermutation in B cells undergoing T cell dependent immune responses generates high affinity antibodies that provide protective immunity. B cells also switch from the expression of immunoglobulin (Ig) M and IgD to that of other Ig classes through somatic DNA recombination. Recent work has implicated DNA stran...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200202)32:2<316::AID-IMMU316>3.0

    authors： Klein U,Esposito G,Baudat F,Keeney S,Jasin M

    更新日期：2002-02-01 00:00:00

  • Cyclophilin A is required for M-CSF-dependent macrophage proliferation.

    abstract：:The immunosuppressor sanglifehrin A (SfA) is a member of a family of immunophilin cyclophilin A-binding molecules and does not inhibit calcineurin activity. Sanglifehrin A inhibits M-CSF-dependent macrophage proliferation by arresting the G1 phase of the cell cycle but does not affect cell viability. This immunosuppre...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200535270

    authors： Sànchez-Tilló E,Wojciechowska M,Comalada M,Farrera C,Lloberas J,Celada A

    更新日期：2006-09-01 00:00:00

  • IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis.

    abstract：:Glomerular crescent formation characterizes severe glomerulonephritis (GN). Evidence suggests that crescent formation results from a delayed-type hypersensitivity-like Th1 response. As IL-12 directs Th1 responses, we tested the hypothesis that IL-12 is important in crescentic GN. Neutralization of IL-12 attenuated cre...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199901)29:01<1::AID-IMMU1>

    authors： Kitching AR,Tipping PG,Holdsworth SR

    更新日期：1999-01-01 00:00:00

  • Tyrosine kinase triggering in thymocytes undergoing positive selection.

    abstract：:Developing T cells undergo distinct selection processes that determine the T cell receptor (TcR) repertoire. One of these processes is positive selection. Positive selection involves the differentiation to mature T cells of thymocytes bearing TcR capable of recognizing antigens in the context of self-major histocompat...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830220917

    authors： Carrera AC,Baker C,Roberts TM,Pardoll DM

    更新日期：1992-09-01 00:00:00

  • Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules.

    abstract：:Lipid antigens are presented to T cells by the non-polymorphic MHC class I-related CD1 molecules. Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident chaperone that has been shown to lipidate the group 2 CD1 molecule CD1d and thus to regulate its function. We now report that MTP al...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200738102

    authors： Kaser A,Hava DL,Dougan SK,Chen Z,Zeissig S,Brenner MB,Blumberg RS

    更新日期：2008-08-01 00:00:00

  • Immune depression in trypanosome-infected mice. III. suppressor cells.

    abstract：:Spleen cells from trypanosome-infected mice strongly suppressed lymphocyte stimulation induced in normal spleen cell populations by lipopolysaccharide, concanavalin A or allogeneic (H-2-different) stimulator cells. This suppression was not H-2-restricted, as responses of spleen lymphocytes both allogeneic and syngenei...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830090306

    authors： Pearson TW,Roelants GE,Pinder M,Lundin LB,Mayor-Withey KS

    更新日期：1979-03-01 00:00:00

  • Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection.

    abstract：:To investigate negative selection events during intrathymic ontogeny, we established T cell receptor (TCR)-transgenic mice [N15tg/RAG-2-/- (H-2b)] expressing a single TCR specific for vesicular stomatitis virus nuclear octapeptide N52-59 (VSV8) in the context of the major histocompatibility complex (MHC) class I molec...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270923

    authors： Ghendler Y,Hussey RE,Witte T,Mizoguchi E,Clayton LK,Bhan AK,Koyasu S,Chang HC,Reinherz EL

    更新日期：1997-09-01 00:00:00

  • A novel human HER2-derived peptide homologous to the mouse K(d)-restricted tumor rejection antigen can induce HLA-A24-restricted cytotoxic T lymphocytes in ovarian cancer patients and healthy individuals.

    abstract：:A mouse HER2-derived peptide, HER2p63 (A) (TYLPANASL), can induce K(d)-restricted mouse cytotoxic T lymphocytes (CTL) and also function as a tumor rejection antigen in an in vivo assay. Since the anchor motif of mouse K(d) for peptide binding has much similarity to that of human HLA-A2402, we asked if human HER2p63 (T...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200011)30:11<3338::AID-IMMU3338>

    authors： Okugawa T,Ikuta Y,Takahashi Y,Obata H,Tanida K,Watanabe M,Imai S,Furugen R,Nagata Y,Toyoda N,Shiku H

    更新日期：2000-11-01 00:00:00

  • Differences in the cell binding affinity of a cross-reactive monoclonal anti-Ia alloantibody in mice of different H-2 haplotypes.

    abstract：:The analysis of an Ia specificity was performed in several H-2 haplotypes by evaluating the affinity of the binding to mouse spleen cells of a monoclonal anti-Ia alloantibody. We used the monoclonal antibody 10-2.16 (Oi et al., Curr. Top. Microbiol. Immunol. 1978. 81: 115.) which recognizes on I-A gene products a publ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830110912

    authors： Birnbaum D,Kourilsky FM

    更新日期：1981-09-01 00:00:00

  • Major histocompatibility complex class I presentation of exogenous soluble tumor antigen fused to the B-fragment of Shiga toxin.

    abstract：:Targeting exogenous antigen into the MHC class I-restricted presentation pathway is a prerequisite for the induction of cytotoxic T lymphocytes (CTL) which have been shown to represent an important component of the protective and therapeutic immune response to viral infections and tumors. In this study, we produced re...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199809)28:09<2726::AID-IMM

    authors： Lee RS,Tartour E,van der Bruggen P,Vantomme V,Joyeux I,Goud B,Fridman WH,Johannes L

    更新日期：1998-09-01 00:00:00

  • Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.

    abstract：:We report here the identification and characterization of murine CCX-CKR, a high affinity receptor for the murine beta-chemokines SLC/mCCL21, MIP-3beta/mCCL19 and TECK/mCCL25. Unlike most other chemokine receptors, CCX-CKR is unable to mediate Ca(2+) fluxes upon ligand binding when expressed in HEK293 cells. Murine CC...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3

    authors： Townson JR,Nibbs RJ

    更新日期：2002-05-01 00:00:00

  • The cytoplasmic domain of rat NKR-P1 receptor interacts with the N-terminal domain of p56(lck) via cysteine residues.

    abstract：:NKR-P1 is a type II transmembrane protein which acts as an activation receptor on natural killer (NK) cells. The cytoplasmic domains of the CD4, CD8 and 4-1BB receptors contain the sequence Cys-X-Cys-Pro which is directly involved in coupling to another pair of cysteines in the N-terminal domain of the src family tyro...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270111

    authors： Campbell KS,Giorda R

    更新日期：1997-01-01 00:00:00

  • Existence of a small population of IL-2R beta hi TCRint cells in SCG and MRL-lpr/lpr mice which produce normal Fas mRNA and Fas molecules from the lpr gene.

    abstract：:Mice carrying the lpr gene, SCG and MRL-lpr/lpr mice, were used to characterize the phenotype and lpr gene of abnormally proliferating T cells in these mice. A major population which expanded in these mice were T cells expressing intermediate (int) levels of T cell receptor (TCR) (and CD3) and the phenotype of interle...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260702

    authors： Yamagiwa S,Kuwano Y,Hasegawa K,Sato K,Ohtsuka K,Iiai T,Tomiyama K,Watanabe H,Sugahara S,Seki S,Asakura H,Abo T

    更新日期：1996-07-01 00:00:00

  • High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function.

    abstract：:To investigate the effect of HIV-specific CD8(+) T cells on viral plasma load and disease progression, we enumerated HLA-A2-, B8- and B57-restricted CD8(+) T cells directed against several HIV epitopes in a total of 54 patients by the use of tetrameric HLA-peptide complexes. In patients with high CD4(+) T cell numbers...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200103)31:3<677::aid-immu677>3.0

    authors： Kostense S,Ogg GS,Manting EH,Gillespie G,Joling J,Vandenberghe K,Veenhof EZ,van Baarle D,Jurriaans S,Klein MR,Miedema F

    更新日期：2001-03-01 00:00:00

  • R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T cell clonal anergy.

    abstract：:R24 is a monoclonal antibody directed against the cell surface ganglioside GD3. It can detect GD3 on the surface of a subset of T lymphocytes and can stimulate proliferation and secretion of cytokines in vitro. In the present report, we examined the effects of the R24 antibody upon antigen-specific T cell response, em...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260928

    authors： Boussiotis VA,Pardo NA,Collins H,Houghton A,Ritz J,Nadler LM,Soiffer RJ

    更新日期：1996-09-01 00:00:00

  • Opposite effects of the synthetic immunomodulator, muramyl dipeptide, on rejection of mouse skin allografts.

    abstract：:The influence of muramyl dipeptide (N-acetylmuramyl-L-alanyl-D-isoglutamine) on the rejection of mouse skin allografts was investigated. While the 0.1-mg dose administered on days 7, 6, 5 prior to transplantation caused significant prolongation of the graft survival, the 0.5-mg dose administered on days 3, 2, 1 prior ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830131015

    authors： Zídek Z,Capková J,Boubelík M,Masek K

    更新日期：1983-10-01 00:00:00

  • Phenotypic and functional analysis of B lymphopoiesis in interleukin-7-transgenic mice: expansion of pro/pre-B cell number and persistence of B lymphocyte development in lymph nodes and spleen.

    abstract：:Transgenic mice in which mouse interleukin (IL)-7 cDNA is expressed under the control of the mouse major histocompatibility complex (MHC) class II (E alpha) promoter develop a lymphoproliferative disease characterized by the early polyclonal expansion of T cells followed in many cases by the development of lymphomas o...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260105

    authors： Mertsching E,Grawunder U,Meyer V,Rolink T,Ceredig R

    更新日期：1996-01-01 00:00:00

  • Differential responses to interleukin 2 define functionally distinct subsets of human natural killer cells.

    abstract：:Human natural killer (NK) cells can be subdivided into two populations based on the density of cell surface CD56 antigen. The great majority (approximately 90%) of NK cells express CD56 at low levels (the CD56dim phenotype), whereas a small NK cell subset (approximately 10%) exhibits approximately fivefold greater den...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830220102

    authors： Baume DM,Robertson MJ,Levine H,Manley TJ,Schow PW,Ritz J

    更新日期：1992-01-01 00:00:00

  • Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice.

    abstract：:The transfer of maternal antibodies to the offspring and their inhibitory effects on active infant immunization is an important factor hampering the use of certain vaccines, such as measles or respiratory syncytial virus vaccine, in early infancy. The resulting delay in protection by conventional or novel vaccines may...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199812)28:12<4138::AID-IMM

    authors： Siegrist CA,Barrios C,Martinez X,Brandt C,Berney M,Córdova M,Kovarik J,Lambert PH

    更新日期：1998-12-01 00:00:00

  • The mechanism of synergistic complement-mediated lysis of rat red cells by monoclonal IgG antibodies.

    abstract：:The mechanism of synergistic complement-mediated lysis of rat red cells was investigated using rat monoclonal antibodies against class I RT1Aa antigens. The increased lytic activity when using two antibodies simultaneously is due to the increase in the number of activated C1 molecules on the cell surface and this resu...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830130806

    authors： Hughes-Jones NC,Gorick BD,Howard JC

    更新日期：1983-08-01 00:00:00

  • TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells.

    abstract：:We analyzed the functional outcome of the interaction between tumor-associated macrophages (TAMs) and natural killer (NK) cells. TAMs from ascites of ovarian cancer patients displayed an alternatively activated functional phenotype (M2) characterized by a remarkably high frequency and surface density of membrane-bound...

    journal_title：European journal of immunology

    pub_type： 临床试验,杂志文章

    doi：10.1002/eji.201344130

    authors： Bellora F,Castriconi R,Dondero A,Pessino A,Nencioni A,Liggieri G,Moretta L,Mantovani A,Moretta A,Bottino C

    更新日期：2014-06-01 00:00:00

  • Helicobacter pylori polyclonally activates murine CD4(+) T cells in the absence of antigen-presenting cells.

    abstract：:Helicobacter pylori is a Gram-negative bacterium that causes a variety of gastrointestinal diseases, such as duodenal ulcer and gastric carcinoma. The T cell response against H. pylori is thought to contribute to the pathogenesis of these diseases. Here, we show that mouse-adapted H. pylori is able to polyclonally act...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200636676

    authors： Rosenplänter C,Sommer F,Kleemann P,Belkovets A,Schmidt A,Lohoff M

    更新日期：2007-07-01 00:00:00

  • Low CD4(+) T cell responses to the C-terminal region of the malaria merozoite surface protein-1 may be attributed to processing within distinct MHC class II pathways.

    abstract：:The C-terminal fragment of merozoite surface protein-1 (MSP-1) of the mouse malaria parasite Plasmodium chabaudi chabaudi (AS) stimulates a weak CD4 T cell response when compared to the response to a more structurally simple region of the molecule. The tertiary structure of the C-terminal region of MSP-1 is maintained...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200101)31:1<72::aid-immu72&#

    authors： Quin SJ,Seixas EM,Cross CA,Berg M,Lindo V,Stockinger B,Langhorne J

    更新日期：2001-01-01 00:00:00

  • Rapid IgE desensitization is antigen specific and impairs early and late mast cell responses targeting FcεRI internalization.

    abstract：:Rapid IgE desensitization provides temporary tolerization for patients who have presented severe hypersensitivity reactions to food and drugs, protecting them from anaphylaxis, but the underlying mechanisms are still incompletely understood. Thus, here we develop an effective and reproducible in vitro model of rapid I...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201040810

    authors： Sancho-Serra Mdel C,Simarro M,Castells M

    更新日期：2011-04-01 00:00:00

  • Anti-peroxidase antibody-secreting hybrid lines. I. Identification, cloning and cell characterization.

    abstract：:Anti-peroxidase antibody (Ab)-secreting hybrids have been produced by fusion of peroxidase (PO)-immunized mouse lymph node cells and immunoglobulin (Ig)-secreting P3-X63-Ag8 (X63) myeloma cells. Identification of Ab-secreting hybrids can be performed as early as day 5 after cell fusion by the hemolytic plaque assay. I...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830090102

    authors： Zagury D,Phalente L,Bernard J,Hollande E,Buttin G

    更新日期：1979-01-01 00:00:00

  • Negative regulation of autoreactive B cells in transgenic mice expressing a human pathogenic cold agglutinin.

    abstract：:Cold agglutinins (CA) are autoantibodies that bind to erythrocyte carbohydrates at low temperatures and induce complement-mediated cell lysis, thus causing hemolytic anemia. Tolerance mechanisms towards CA-expressing B cells and the factors inducing pathogenic CA production are unknown. In order to develop an animal m...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(2000)30:8<2290::AID-IMMU2290>3.0

    authors： Havouis S,Dumas G,Avé P,Pritsch O,Huerre M,Dighiero G,Pourcel C

    更新日期：2000-08-01 00:00:00

  • Interleukin 2/interleukin 4-independent T helper cell generation during an in vitro antigenic stimulation of mouse spleen cells in the presence of cyclosporin A.

    abstract：:Cyclosporin A (CsA), an immunosuppressive drug which completely suppresses the humoral response to thymus-dependent antigens, does not affect the generation of T helper (Th) cells during an in vitro stimulation of murine spleen cells with sheep red blood cells. The appearance of Th cells depends on time and their deve...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830210304

    authors： Motta I,Colle JH,Shidani B,Truffa-Bachi P

    更新日期：1991-03-01 00:00:00

  • Induction of interferon-gamma production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation.

    abstract：:IFN-gamma produced by CD4+ T helper 1 (Th1) cells promotes protection against intracellular pathogens. Antigen activation of Th1 cells is an important mode of IFN-gamma induction, but here we analyze a second, antigen-nonspecific pathway capable of inducing full IFN-gamma transcription. IL-12 or IL-18 alone do not ind...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199902)29:02<548::AID-IMMU

    authors： Yang J,Murphy TL,Ouyang W,Murphy KM

    更新日期：1999-02-01 00:00:00

  • The MRC OX-47 antigen is a member of the immunoglobulin superfamily with an unusual transmembrane sequence.

    abstract：:The MRC OX-47 monoclonal antibody recognizes a membrane antigen present at low levels on many lymphocytes but whose expression is markedly increased on activation with mitogens. cDNA clones for the OX-47 antigen were isolated from an expression library and the protein sequence deduced. It contains a leader sequence gi...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830210320

    authors： Fossum S,Mallett S,Barclay AN

    更新日期：1991-03-01 00:00:00