Abstract:
:Prostaglandins (PG) are important modulators of immune and inflammatory responses. We recently demonstrated that the production of PGD(2) by the helminthic parasite Schistosoma mansoni inhibits the migration of epidermal Langerhans cells (LC) to the draining lymph nodes (DLN). Here, we identify the responsible parasite enzyme as being a 28-kDa glutathione-S-transferase (termed Sm28GST). Intradermal injection of Sm28GST in wild-type (WT), but not in D prostanoid receptor (DP) 1-deficient mice abrogates the departure of LC from the epidermis after TNF-alpha or FITC treatment. During infection, DP1 deficiency restores LC migration, but does not enhance the rate of T cell proliferation in the skin DLN. However, relative to WT mice, DLN cells from DP1-deficient infected mice produce dramatically less IFN-gamma and IL-10, but equal amount of IL-4. Interestingly, infected DP1-deficient mice develop a more Th2-biased humoral immune response, a significantly reduced parasitemia and a decreased egg-induced inflammatory response in the liver and intestines. Taken together, we propose that DP1 activation by the Sm28GST-derived PGD(2) could represent a strategy for the schistosome to evade host immune defenses. We also suggest that DP1 is important in the Th1/Th2 balance of the immune response and in inflammatory reactions during infection.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Hervé M,Angeli V,Pinzar E,Wintjens R,Faveeuw C,Narumiya S,Capron A,Urade Y,Capron M,Riveau G,Trottein Fdoi
10.1002/eji.200324143keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
2764-72issue
10eissn
0014-2980issn
1521-4141journal_volume
33pub_type
杂志文章abstract::An effective immune response against the intracellular pathogen Mycobacterium tuberculosis is strictly dependent on T cell activation. Although this protective response mainly depends on local release of pro-inflammatory cytokines by Th1 CD4(+) T cells, contribution of Vgamma9 / Vdelta2 T lymphocytes to immune protect...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(200005)30:5<1512::AID-IMMU
更新日期:2000-05-01 00:00:00
abstract::Adoptive lymphocyte transfers between Iga, Igb and Igd allotype-congenic mouse strains revealed host barriers against the production of certain donor allotypes. First, as recipients of Igb cells, Iga and Igd mice permitted the production of donor Ig-4b but not that of Ig-1 b. The apparent mediators of this Ig-1 b barr...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830080805
更新日期:1978-08-01 00:00:00
abstract::CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of resting B cells, immunoglobulin (Ig) secretion from B cells cultured with cytokines and cytokine secretion and tumoricidal activity from monocytes. In this report...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230941
更新日期:1993-09-01 00:00:00
abstract::To further define DNA immunization as a model for anti-DNA production, we investigated the cellular requirements for this response in mice immunized with single-stranded DNA from E. coli. The anti-DNA responses of genetically immune-deficient mice and congenic controls were measured by ELISA after immunization with E....
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200825
更新日期:1990-08-01 00:00:00
abstract::The surface expression of given HLA class I alleles protects target cells from lysis mediated by natural killer (NK) clones specific for these (or related) alleles. We could define two groups of NK clones specifically recognizing either Cw4 and related C alleles ("group 1") or Cw3 and related C alleles ("group 2"), re...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830240434
更新日期:1994-04-01 00:00:00
abstract::Tumor-specific helper T cell activity was detected in the spleens of tumor-bearing mice using a sensitive, simple and reproducible in vitro assay based on those previously described for soluble hapten-carrier antigens. Helper activity disappears when the tumor is large. This is coincident with the appearance of two di...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830120809
更新日期:1982-08-01 00:00:00
abstract::Mouse bone marrow cells differentiate in culture in the presence of L cell-conditioned medium to macrophages (M phi). Proliferation, release of plasminogen activator, expression of transglutaminase, random motility and response to a standard preparation of purified M phi migration inhibitory factor (MIF) was recorded ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830141008
更新日期:1984-10-01 00:00:00
abstract::Th2 lymphocytes deliver essential signals for induction of asthmatic airway inflammation. We previously found that airway antigen challenge induces recruitment of Gr-1(+) neutrophils prior to the recruitment of Th2 cells. We examined, therefore, whether Gr-1(+) cells contribute to the development of Th2-dependent airw...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200838985
更新日期:2009-08-01 00:00:00
abstract::Current concepts of activation of the alternative pathway of complement (APC) focus on the central role of an amplification mechanism triggered by C3b which is covalently bound to the surfact of activating substances. Using sulfated polyanions as model substances, an efficient fluid-phase activation of complement is d...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830110405
更新日期:1981-04-01 00:00:00
abstract::A previously designed isotopic in vivo method for measuring delayed hypersensitivity was used with nonantigenic (or weakly antigenic) phlogogenic substances. A strong reaction was observed in some circumstances, witnessing the fact that the method has a specific and a nonspecific component. The reaction is drastically...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830060606
更新日期:1976-06-01 00:00:00
abstract::Large-scale extravasation of lymphocytes takes place in vivo under physiological conditions in lymph nodes at very specialized vascular segments called high endothelial venules (HEV). When circulating lymphocytes leave the blood, they first bind to endothelial cells of HEV (HE cells) and subsequently enter lymph nodes...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830180814
更新日期:1988-08-01 00:00:00
abstract::CD30 is a costimulatory molecule of the TNF receptor superfamily, expressed on activated T and B cells. Previously, we have shown in a murine asthma model the crucial role of CD30 signaling for the development of this Th2-cell-mediated disease. In the present study, we investigated the role of CD30 in the maintenance ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200839004
更新日期:2009-07-01 00:00:00
abstract::The ganglioside GD3 has been described as a membrane component of human T cells which is involved in T cell growth. In the present study the activating function of GD3 for human CD4+ and CD8+ T cells was analyzed by five different monoclonal antibodies (mAb) directed against the GD3 molecule. Three mAb U5, Z21 and R24...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830240530
更新日期:1994-05-01 00:00:00
abstract::NK cells are innate lymphocytes crucial for surveillance against pathogens and tumors. Although the basic mechanisms through which NK cells operate have been established, many questions are still unresolved. Are all NK cells equal or can we identify subsets with distinct developmental origin and function? How do NK ce...
journal_title:European journal of immunology
pub_type:
doi:10.1002/eji.200838883
更新日期:2008-11-01 00:00:00
abstract::Human plasmacytoid dendritic cells (PDC) are believed to link innate and adaptive immunity by producing type I interferon (IFN-I) and triggering adaptive T cell-mediated immunity. However, it remains elusive to which degree both PDC functions are linked. Here we show that CMV antigen targeted to PDC using a CD303 (blo...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200737552
更新日期:2008-07-01 00:00:00
abstract::Induction of cytolytic activity of peripheral blood mononuclear cells towards target cells was studied by preparing bispecific F(ab')2 which was composed of two Fab' fragments, one of which was derived from anti-CD3 monoclonal antibody and the other from anti-tumor monoclonal antibody. After reduction of the interchan...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190814
更新日期:1989-08-01 00:00:00
abstract::CD22 is a B lymphocyte-specific membrane protein that functions as an adhesion molecule via its interactions with a subset of alpha 2-6-linked sialic acid-containing glycoproteins. Engagement of CD22 with a monoclonal antibody (HB22.23) that blocks the binding of CD22 to its ligands results in rapid CD22 tyrosine phos...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260610
更新日期:1996-06-01 00:00:00
abstract::Thymocytes of T cell receptor transgenic mice with nonselecting and RAG-2 -/- backgrounds were developmentally arrested at the CD4+CD8+ stage before positive selection. These thymocytes underwent lineage commitment upon transient stimulation with a combination of ionomycin, a calcium ionophore, and phorbol 12-myristat...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260918
更新日期:1996-09-01 00:00:00
abstract::The TORC1 pathway is necessary for ribosomal biogenesis and initiation of protein translation. Furthermore, the differentiation of Th1 and Th17 cells requires TORC1 activity. To investigate the role of the TORC1 pathway in the differentiation of Th1 and/or Th17 cells in more detail, we compared the differentiation cap...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201445422
更新日期:2016-01-01 00:00:00
abstract::In the present study, interleukin 1 (IL 1)-containing media from different sources, namely a murine macrophage cell line (P388D1), rabbit peritoneal macrophages, and human peripheral blood mononuclear cells, were compared for their effect on thymocyte proliferation and on collagenase and PGE2 secretion by chondrocytes...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830140603
更新日期:1984-06-01 00:00:00
abstract::Previous studies from our laboratory have shown that prolonged exposure of mouse macrophages to IFN-beta interferes with their subsequent ability to become activated for tumor cell killing. Data reported here show that such inhibition is due to reduced production of NO, resulting from decreased transcription of the ge...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200006)30:6<1551::AID-IMMU1551>3
更新日期:2000-06-01 00:00:00
abstract::The number of patients with severe atopic dermatitis (AD) has been on the rise recently. We are therefore urgently in need of a treatment that can suppress Th2 cell-mediated responses in an Ag-specific fashion. Oligodeoxynucleotides (ODN)containing CpG motifs (CpG ODN) have been highlighted as immunomodulators that re...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200526274
更新日期:2005-11-01 00:00:00
abstract::IL-7 is a major regulator of lymphocyte homeostasis; however, little is known about the mechanisms that regulate IL-7 production. To study Il7 gene regulation in vivo, we generated a novel IL-7-reporter mouse, which allows the non-invasive quantification of Il7 gene activity in live mice and, additionally, the simulta...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040441
更新日期:2010-09-01 00:00:00
abstract::In man, B cell maturation factors obtained from T cells or T cell lines have been shown to induce antibody formation in mitogen or anti-immunoglobulin activated B cells, and in some continuous B cell lines, but the relationships between these factors and B cell differentiation factors in antigen-specific antibody resp...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150111
更新日期:1985-01-01 00:00:00
abstract::The human immunodeficiency virus type 1 (HIV-1) induces a strong cytotoxic T lymphocyte (CTL) response in humans following infection. HIV-specific CTL can be detected directly in the blood and lungs of infected patients, and can be expanded in vitro by stimulation with autologous HIV-infected lymphoblasts. Furthermore...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190904
更新日期:1989-09-01 00:00:00
abstract::Cold agglutinins (CA) are autoantibodies that bind to erythrocyte carbohydrates at low temperatures and induce complement-mediated cell lysis, thus causing hemolytic anemia. Tolerance mechanisms towards CA-expressing B cells and the factors inducing pathogenic CA production are unknown. In order to develop an animal m...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(2000)30:8<2290::AID-IMMU2290>3.0
更新日期:2000-08-01 00:00:00
abstract::NK cells offer a first line of defense against viruses and are considered beneficial to the host during infection. Nevertheless, little is understood regarding the phenotype and function of NK cells in the lung during influenza virus infection. We found that the frequency of NK cells in mouse lung increased during inf...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201242620
更新日期:2013-04-01 00:00:00
abstract::Longitudinal studies on the kinetics of viral antigen specific CD8 T cell responses have led to a model whereby a relatively small subset of the primary effector CD8 T cells expanding after the first week of acute viral infection initiate a program of cell survival and differentiation into long lived memory T cells. T...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.200535516
更新日期:2005-11-01 00:00:00
abstract::Anti-HLA alloantisera inhibit mixed lymphocyte responses in which normal lymphocytes are used as stimulator cells. These same antisera are unable to inhibit lymphocyte proliferative responses stimulated by lymphoblastoid cells from cultured lymphoid cell lines. They also fail to inhibit either the generation of cytoto...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830060402
更新日期:1976-04-01 00:00:00
abstract::A cDNA encoding the human beta Fc gamma receptor II (FcRII) was isolated from a placental cDNA library. Analysis of the predicted amino acid sequence indicates that this receptor is synthesized with a 42-amino acid leader sequence. The mature protein consists of 249 amino acids. The leader sequence and the cytoplasmic...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200624
更新日期:1990-06-01 00:00:00