The soluble isoform of CTLA-4 as a regulator of T-cell responses.

abstract：:Synthetic peptides encoding protective pathogen-derived epitopes represent--in principle--an ideal approach to T-cell vaccination. Empirically, however, these strategies have not been successful. In the current study, we profiled the early activation of CD8+ T cells by MHC class I-restricted peptide immunization to be...

journal_title：European journal of immunology

authors： Overstreet MG,Freyberger H,Cockburn IA,Chen YC,Tse SW,Zavala F

更新日期：2010-01-01 00:00:00

abstract：:IL-22 is an IFN-IL-10 cytokine family member, which is produced by activated Th1 and NK cells and acts primarily on epithelial cells. Here we demonstrate that IL-22, in contrast to its relative IFN-gamma, regulates the expression of only a few genes in keratinocytes. This is due to varied signal transduction. Gene exp...

journal_title：European journal of immunology

authors： Wolk K,Witte E,Wallace E,Döcke WD,Kunz S,Asadullah K,Volk HD,Sterry W,Sabat R

更新日期：2006-05-01 00:00:00

abstract：:Natural killer (NK) cell activity can be stimulated by different surface receptors. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating human NK cell cytotoxicity and cytokine production. Here we show that stimulation of human NK cells by anti...

journal_title：European journal of immunology

authors： Sandusky MM,Messmer B,Watzl C

更新日期：2006-12-01 00:00:00

abstract：:Macrophage scavenger receptors are trimeric integral membrane glycoproteins which have been implicated in various macrophage functions including uptake of oxidized lipoprotein and the serum-dependent, divalent cation-independent adhesion of macrophages to tissue culture-treated plastic. In this study we have used a re...

journal_title：European journal of immunology

authors： Hughes DA,Fraser IP,Gordon S

更新日期：1995-02-01 00:00:00

abstract：:Btk is a member of the Tec family of protein tyrosine kinases expressed in B cells. It is stimulated following cross-linking of the B cell receptor which leads to the autophosphorylation of a specific residue in the SH3 domain, Y223. Previous work using Btk-derived fusion proteins has shown that the Btk SH3 domain bin...

journal_title：European journal of immunology

authors： Morrogh LM,Hinshelwood S,Costello P,Cory GO,Kinnon C

更新日期：1999-07-01 00:00:00

abstract：:Soluble TRAIL (sTRAIL) can be produced by myeloid-derived cells to kill cancer cells. Whether this mechanism is used by T cells, and if so, how sTRAIL production is regulated, remains unclear. Our previous studies showed that ex vivo expanded human γδ T cells express TRAIL and NK receptor group 2 (R2), member D (NKG2D...

journal_title：European journal of immunology

authors： Dokouhaki P,Schuh NW,Joe B,Allen CA,Der SD,Tsao MS,Zhang L

更新日期：2013-12-01 00:00:00

abstract：:Tapasin is a 48-kDa endoplasmic reticulum (ER)-resident glycoprotein that binds to the transporter associated with antigen processing (TAP) and mediates an interaction between TAP and newly synthesized MHC class I molecules. It is also essential for the proper antigen presenting function of HLA-A*0101 (HLA-A1), HLA-A*...

journal_title：European journal of immunology

authors： Lewis JW,Sewell A,Price D,Elliott T

更新日期：1998-10-01 00:00:00

abstract：:The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent activator of invariant natural killer T (iNKT) cells and has been shown to be an effective agent against cancer, infections and autoimmune diseases. The effectiveness of alpha-GalCer and its alkyl chain analogues depends on efficient loading and presen...

journal_title：European journal of immunology

authors： Denkberg G,Stronge VS,Zahavi E,Pittoni P,Oren R,Shepherd D,Salio M,McCarthy C,Illarionov PA,van der Merwe A,Besra GS,Dellabona P,Casorati G,Cerundolo V,Reiter Y

更新日期：2008-03-01 00:00:00

abstract：:Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® syst...

journal_title：European journal of immunology

authors： Mommert M,Perret M,Hockin M,Viel S,Belot A,Richard JC,Mezidi M,Fassier JB,Javouhey E,ANTOINE Study Group.,COVID-SER Study Group.,COVID-HCL Study Group.,Hemmert A,Mallet F,Trouillet-Assant S,Brengel-Pesce K

更新日期：2020-12-12 00:00:00

abstract：:After incorporation of 14C-labeled amino acids and/or of [3H]fucose during in vitro culture of the Thy-1.1-bearing, Fc receptor-positive T lymphoma, L-5187-Y, attempts were made to purify the Fc binding structure(s). Following solubilization of a crude membrane pellet using sodium deoxycholate, the 110 000 x g superna...

journal_title：European journal of immunology

authors： Frade R,Kourilsky FM

更新日期：1977-09-01 00:00:00

abstract：:T-cell destiny during thymic selection depends on the affinity of the TCR for autologous peptide ligands presented in the context of MHC molecules. This is a delicately balanced process; robust binding leads to negative selection, yet some affinity for the antigen complex is required for positive selection. All TCRs o...

journal_title：European journal of immunology

authors： Aleksic M,Liddy N,Molloy PE,Pumphrey N,Vuidepot A,Chang KM,Jakobsen BK

更新日期：2012-12-01 00:00:00

abstract：:CD25+ FOXP3+CD4+ T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high-level expression of FOXP3 (FOXP3high) is sufficient to confer suppressive activity to normal non-Treg. Here, we showed for the first time that vascular...

journal_title：European journal of immunology

authors： Suzuki H,Onishi H,Wada J,Yamasaki A,Tanaka H,Nakano K,Morisaki T,Katano M

更新日期：2010-01-01 00:00:00

abstract：:DNA vaccination is an efficient way to induce CD8+ T cell memory, but it is still unclear to what extent such memory responses afford protection in vivo. To study this, we induced CD8+ memory responses directed towards defined viral epitopes, using DNA vaccines encoding immunodominant MHC class I-restricted epitopes o...

journal_title：European journal of immunology

authors： Bartholdy C,Stryhn A,Hansen NJ,Buus S,Thomsen AR

更新日期：2003-07-01 00:00:00

abstract：:Two subpopulations of human T lymphocytes expressing different antigen receptors, alpha/beta and gamma/delta, emigrate into inflamed tissues in distinctive patterns. We compared the transmigration of alpha/beta and gamma/delta T cells to C-C and C-X-C chemokines using an in vitro transendothelial chemotaxis assay. The...

journal_title：European journal of immunology

authors： Roth SJ,Diacovo TG,Brenner MB,Rosat JP,Buccola J,Morita CT,Springer TA

更新日期：1998-01-01 00:00:00

abstract：:Human cytomegalovirus (CMV) infection can be life threatening in the immune compromised and is associated with congenital defects and / or mental retardation in the neonate. The demonstrated association between CMV infection and rheumatoid factor (RF) raised the possibility of an induction of an autoimmune response up...

journal_title：European journal of immunology

authors： Curtis HA,Singh T,Newkirk MM

更新日期：1999-11-01 00:00:00

abstract：:In this study, after immunization with NK cells from a KIR2DS5(+) donor and screening on cell transfectants expressing different members of the killer immunoglobulin-like receptor (KIR) family, we generated a mAb, DF200, reacting with several KIR2D receptors including KIR2DL1/L2/L3, KIR2DS1/S2 and KIR2DS5. By the anal...

journal_title：European journal of immunology

authors： Della Chiesa M,Romeo E,Falco M,Balsamo M,Augugliaro R,Moretta L,Bottino C,Moretta A,Vitale M

更新日期：2008-08-01 00:00:00

abstract：:Interleukin (IL)-7 and IL-2 are important lymphoproliferative cytokines which both use the gamma c chain as part of their respective receptors. To learn more of their signaling mechanisms a comparison was made of the patterns of intracellular tyrosine phosphorylated proteins induced by these cytokines in the murine T ...

journal_title：European journal of immunology

authors： Crawley JB,Willcocks J,Foxwell BM

更新日期：1996-11-01 00:00:00

abstract：:The nature of Ig receptors carried by lipopolysaccharide (LPS)-stimulated mouse spleen B cells was analyzed by surface iodination, direct antiserum precipitation and polyacrylamide gel electrophoresis. LPS activation led to a rapid decrease of surface IgD to 20 % and 80 % of the original level on days three and five o...

journal_title：European journal of immunology

authors： Bourgois A,Kitajima K,Hunter IR,Askonas BA

更新日期：1977-03-01 00:00:00

abstract：:Elucidating the signaling events that promote T-cell tolerance versus activation provides important insights for manipulating immunity in vivo. Previous studies have suggested that the absence of PKCtheta results in the induction of anergy and that the balance between the induction of the transcription factors NFAT, A...

journal_title：European journal of immunology

authors： Deenick EK,Po L,Chapatte L,Murakami K,Lu YC,Elford AR,Saibil SD,Ruland J,Gerondakis S,Mak TW,Ohashi PS

更新日期：2010-03-01 00:00:00

abstract：:Human plasmacytoid dendritic cells (PDC) are believed to link innate and adaptive immunity by producing type I interferon (IFN-I) and triggering adaptive T cell-mediated immunity. However, it remains elusive to which degree both PDC functions are linked. Here we show that CMV antigen targeted to PDC using a CD303 (blo...

journal_title：European journal of immunology

authors： Jaehn PS,Zaenker KS,Schmitz J,Dzionek A

更新日期：2008-07-01 00:00:00

abstract：:Recognition of foreign DNA by cytosolic innate immune receptors triggers the production of IFN-beta. However, it is unclear whether different types of DNA ligands are recognized by similar receptors and whether the resulting response is distinct from the endosomal TLR response. To address these questions, we compared ...

journal_title：European journal of immunology

authors： Karayel E,Bürckstümmer T,Bilban M,Dürnberger G,Weitzer S,Martinez J,Superti-Furga G

更新日期：2009-07-01 00:00:00

abstract：:This Viewpoint series provides authoritative and detailed outlines of exciting areas of DC research. Some of the subjects that frequently come up include development of DC; distribution of DC in lymphoid and non-lymphoid tissues such as skin, intestine and lung; different forms or subsets of DC; and the role of DC in ...

journal_title：European journal of immunology

authors： Steinman RM

更新日期：2010-08-01 00:00:00

abstract：:Transporter associated with antigen processing (TAP)-competent and TAP-deficient cell lines were transfected with expression plasmids encoding either the wild-type (wt) large tumor antigen (T-Ag) of SV40, or a truncated cytoplasmic variant (cT-Ag) of this viral protein. Stable expression of comparable levels of both f...

journal_title：European journal of immunology

authors： Schirmbeck R,Böhm W,Reimann J

更新日期：1997-08-01 00:00:00

abstract：:Pairs of monoclonal antibodies (mAb) defining epitopes T 11.1 and T 11.2 on the CD 2 molecule are mitogenic for purified human T cells in the presence of a submitogenic dose of 12-O-tetradecanoylphorbol 13-acetate (TPA). Anti-CD 28 mAb can substitute for the action of TPA in the anti-CD 2-induced proliferative respons...

journal_title：European journal of immunology

authors： Pierrès A,Lopez M,Cerdan C,Nunes J,Olive D,Mawas C

更新日期：1988-05-01 00:00:00

abstract：:The murine T cell clone D10.G4.1 can be induced to proliferate by monoclonal antibodies (mAb) to the T cell receptor (TcR) or to Thy-1 molecules. When cells were stimulated by anti-TcR mAb, a group of 4 proteins (19-25 kDa) was specifically phosphorylated. This effect was completely mimicked by the Ca2+ ionophore A231...

journal_title：European journal of immunology

authors： Peyron JF,Pont S,Pierres M,Fehlmann M

更新日期：1988-07-01 00:00:00

abstract：:As we approach the centenary of Elie Metchnikoff's Nobel Prize (1908), it is opportune to reflect upon the history of macrophage immunobiology, take stock of current knowledge and anticipate questions for the future. Starting from his appreciation of phagocytosis as an important determinant of host defence against inf...

journal_title：European journal of immunology

authors： Gordon S

更新日期：2007-11-01 00:00:00

abstract：:Mutations in TNFRSF1A encoding TNF receptor 1 (TNFR1) cause the autosomal dominant TNF receptor-associated periodic syndrome (TRAPS): a systemic autoinflammatory disorder. Misfolding, intracellular aggregation, and ligand-independent signaling by mutant TNFR1 are central to disease pathophysiology. Our aim was to unde...

journal_title：European journal of immunology

authors： Negm OH,Mannsperger HA,McDermott EM,Drewe E,Powell RJ,Todd I,Fairclough LC,Tighe PJ

更新日期：2014-07-01 00:00:00

abstract：:Immunoglobulin (Ig) production by lipopolysaccharide (LPS)-stimulated cells in the presence of various combinations of interleukin (IL)2, IL4 and IL5 was examined. IgG1, IgM and IgE secretion was studied using a 3T3-fibroblast filler cell-supported B cell culture system, either at low cell density to support maximal I...

journal_title：European journal of immunology

authors： McHeyzer-Williams MG

更新日期：1989-11-01 00:00:00

abstract：:Lymphocyte infiltration to pancreatic islets is associated to chemoattraction, as are other inflammatory autoimmune processes. We examined whether development of insulitis and diabetes depends on chemoattraction of lymphocytes via the CCR5 chemokine receptor. In non-obese diabetic (NOD) mice, a substantial fraction of...

journal_title：European journal of immunology

authors： Carvalho-Pinto C,García MI,Gómez L,Ballesteros A,Zaballos A,Flores JM,Mellado M,Rodríguez-Frade JM,Balomenos D,Martínez-A C

更新日期：2004-02-01 00:00:00

abstract：:Targeting exogenous antigen into the MHC class I-restricted presentation pathway is a prerequisite for the induction of cytotoxic T lymphocytes (CTL) which have been shown to represent an important component of the protective and therapeutic immune response to viral infections and tumors. In this study, we produced re...

journal_title：European journal of immunology

authors： Lee RS,Tartour E,van der Bruggen P,Vantomme V,Joyeux I,Goud B,Fridman WH,Johannes L

更新日期：1998-09-01 00:00:00