Abstract:
:Myeloid-derived suppressor cells (MDSC) play an important role in the cellular network regulating immune responses in cancer, chronic infectious diseases, autoimmunity, and in other pathological conditions. Morphological, phenotypic and functional heterogeneity is a hallmark of MDSC. This heterogeneity demonstrates the plasticity of this immune suppressive myeloid compartment, and shows how various tumors and infectious agents can have similar biological effects on myeloid cells despite the differences in the factors that they produce to influence the immune system; however, such a heterogeneity creates ambiguity in the definition of MDSC as well as confusion regarding the origin and fate of these cells. In this review, we will discuss recent findings that help to better clarify these issues and to determine the place of MDSC within the myeloid cell lineage.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Youn JI,Gabrilovich DIdoi
10.1002/eji.201040895subject
Has Abstractpub_date
2010-11-01 00:00:00pages
2969-75issue
11eissn
0014-2980issn
1521-4141journal_volume
40pub_type
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