Abstract:
:Amount and affinity of anti-beta-D-galactosidase-activating antibodies (AAb) were studied in two lines of mice obtained by selective breeding for antibody response to heterologous erythrocytes. These lines, referred to as high (H) and low (L) lines, differ also in their responses to many antigens. Concerning AAb amounts, the maximal titer in H mice is higher than in L mice. However, the AAb levels in H mice decreased with increasing immunizing doses and became lower than in L mice for the highest dose. This fact can be explained in terms of intramolecular competition or suppression. Whereas the usual maturation pattern was observed in H mice, no AAb of high affinity were found in L mice, even after a minimal immunizing dose. At any dose tested, no maturation of AAb occurred until three months after immunization. This deficiency may be ascribed to B lymphocyte or macrophage modifications. A correlation between the deficiency of high-affinity AAb in L mice and their genetically induced low antibody responsiveness cannot be proved.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Conway de Macario E,Heumann AM,Macario AJ,Biozzi Gdoi
10.1002/eji.1830090312subject
Has Abstractpub_date
1979-03-01 00:00:00pages
231-6issue
3eissn
0014-2980issn
1521-4141journal_volume
9pub_type
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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abstract::Reciprocal expression of CD45RA and CD45RO in human CD4+ T cells defines populations understood to be naive cells (CD45RA+CD45RO-) and memory cells (CD45RA-CD45RO+). We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright a...
journal_title:European journal of immunology
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更新日期:1994-05-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
abstract::Maintenance of peripheral tolerance and inactivation of autoreactive T cells is based on a delicate balance between pro-inflammatory and protective cytokines that is poorly understood. We have here addressed how the local expression of the inflammatory cytokine TNF-alpha can impair peripheral tolerance and lead to aut...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200323328
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830180814
更新日期:1988-08-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830141011
更新日期:1984-10-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200323698
更新日期:2003-06-01 00:00:00
abstract::It is widely believed that IL-4 exerts its influence by profiling the immune response during priming and expansion of immune cells, and thereby modulates the outcome of chronic inflammation. In the present investigation, collagen antibody-induced arthritis (CAIA) was used to delineate the role of IL-4 in a T cell-inde...
journal_title:European journal of immunology
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journal_title:European journal of immunology
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更新日期:1998-04-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1997-05-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1982-11-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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更新日期:1979-02-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1985-07-01 00:00:00
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journal_title:European journal of immunology
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更新日期:1997-09-01 00:00:00
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