The effect of TGF-beta1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells.

abstract：:Human papillomavirus (HPV) infections account for more than 50% of infection-linked cancers in women worldwide. The immune system controls, at least partially, viral infection and around 90% of HPV-infected women clear the virus within two years. However, it remains unclear which immune cells are implicated in this pr...

journal_title：European journal of immunology

authors： Renoux VM,Bisig B,Langers I,Dortu E,Clémenceau B,Thiry M,Deroanne C,Colige A,Boniver J,Delvenne P,Jacobs N

更新日期：2011-11-01 00:00:00

abstract：:Dermal and mucosal lymphocyte infiltrates in patients with lichen ruber planus and chronic graft-vs.-host disease exhibited reactivity with anti-fibronectin antibodies. This reactivity was associated with the lymphocytes and localized pericellularly. In contrast, biopsy areas outside lymphocyte accumulations were rela...

journal_title：European journal of immunology

authors： Sundqvist KG,Wanger L,Heimdahl A,Lönnqvist B,Hauzenberger D

更新日期：1991-02-01 00:00:00

abstract：:The squirrel monkey Saimiri sciureus is one of the World Health Organization recommended experimental models of Plasmodium falciparum blood stage infection. Anti-malaria antibodies developed by this host after a drug-controlled infection play an important part in the acquired protection against the P. falciparum blood...

journal_title：European journal of immunology

authors： Groux H,Perraut R,Garraud O,Poingt JP,Gysin J

更新日期：1990-10-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) play an important role in the cellular network regulating immune responses in cancer, chronic infectious diseases, autoimmunity, and in other pathological conditions. Morphological, phenotypic and functional heterogeneity is a hallmark of MDSC. This heterogeneity demonstrates th...

journal_title：European journal of immunology

authors： Youn JI,Gabrilovich DI

更新日期：2010-11-01 00:00:00

abstract：:The human type I interferon (IFN) receptor was characterized by ligand blotting. In this method, plasmalemma proteins or detergent-lysed whole-cell extracts from human Burkitt lymphoma cell lines were separated on polyacrylamide gels and subsequently transferred onto nitrocellulose sheets. Probing the blots with 3 x 1...

journal_title：European journal of immunology

authors： Schwabe M,Princler GL,Faltynek CR

更新日期：1988-12-01 00:00:00

abstract：:Synthetic peptides encoding protective pathogen-derived epitopes represent--in principle--an ideal approach to T-cell vaccination. Empirically, however, these strategies have not been successful. In the current study, we profiled the early activation of CD8+ T cells by MHC class I-restricted peptide immunization to be...

journal_title：European journal of immunology

authors： Overstreet MG,Freyberger H,Cockburn IA,Chen YC,Tse SW,Zavala F

更新日期：2010-01-01 00:00:00

abstract：:Immunization leads to the generation of both antibody-forming cells (AFC) and memory B cells which are thought to arise in germinal centers within lymphoid follicles. The findings that the precursors to memory B cells reside in the J11Dlo subpopulation of the spleens in non-immune mice and that this subpopulation is d...

journal_title：European journal of immunology

authors： Linton PJ,Lo D,Lai L,Thorbecke GJ,Klinman NR

更新日期：1992-05-01 00:00:00

abstract：:The development of preventive or therapeutic recombinant vaccines and the generation of serodiagnostic assays for infectious diseases depend essentially on the availability of molecularly defined antigens. A major bottleneck for the identification of suitable target antigens for many pathogens is the isolation of suff...

journal_title：European journal of immunology

authors： Sahin U,Türeci O,Graf C,Meyer RG,Lennerz V,Britten CM,Dumrese C,Scandella E,Wölfel T,Ludewig B

更新日期：2006-04-01 00:00:00

abstract：:High BDCA3 expression is associated with a specific human IFN-λ-producing dendritic cell (DC) subset. However, BDCA3 has also been detected on other DC subsets. Thus far, development and function of BDCA3 expression on DCs remains poorly understood. Human Langerhans cells (LCs) and interstitial DCs (intDCs) can be gen...

journal_title：European journal of immunology

authors： van der Aa E,van de Laar L,Janssen HL,van Montfoort N,Woltman AM

更新日期：2015-05-01 00:00:00

abstract：:B cell-activating factor belonging to the TNF family (BAFF) and its receptor BAFF-R play critical roles in the maturation and survival of conventional peripheral B cells. However, they appeared to be dispensable for the generation and maintenance of CD5(+) B-1 cells as BAFF(-/-) and BAFF-R(-/-) mice have normal B-1 ce...

journal_title：European journal of immunology

authors： Ng LG,Ng CH,Woehl B,Sutherland AP,Huo J,Xu S,Mackay F,Lam KP

更新日期：2006-07-01 00:00:00

abstract：:Vaccinia virus (VV)-encoded MHC class I Kd molecules which differ by a single amino acid change from glutamine (Kdw, wild type) to histidine (Kdm, mutant) at position 114 located in the floor of the peptide binding groove were compared in terms of peptide binding and cytotoxic T (Tc) cell recognition. Most anti-viral ...

journal_title：European journal of immunology

authors： Müllbacher A,Lobigs M,Yewdell JW,Bennink JR,Tha Hla R,Blanden RV

更新日期：1999-04-01 00:00:00

abstract：:From human precursor B cells which had both immunoglobulin (Ig) heavy (H) chain loci in germ-line configuration, various IgH chain germ-line transcripts were isolated and sequenced. These transcripts were shown to contain sequences derived from the JH region, the IgH chain enhancer element or the Ig switch region. A n...

journal_title：European journal of immunology

authors： Thompson A,Timmers E,Schuurman RK,Hendriks RW

更新日期：1995-01-01 00:00:00

abstract：:The multimeric Fc gamma RIIIA (CD16) complex is expressed on the surface of natural killer (NK) cells and is composed of a 50-70-kDa transmembrane glycoprotein Fc gamma receptor (CD16), the T cell receptor (TCR)-zeta chain, and the Fc epsilon RI gamma chain. Cross-linking Fc gamma RIIIA initiates the rapid tyrosine ph...

journal_title：European journal of immunology

authors： Cone JC,Lu Y,Trevillyan JM,Bjorndahl JM,Phillips CA

更新日期：1993-10-01 00:00:00

abstract：:F1----parental bone marrow chimeras between CBA and B10 mice were used to show that even after 1 year follicular dendritic cells (FDC), also termed dendritic reticular cells, are not derived from bone marrow stem cells. However clusters of cells wrapped in the dendritic processes of FDC, isolated by enzyme digestion o...

journal_title：European journal of immunology

authors： Humphrey JH,Grennan D,Sundaram V

更新日期：1984-09-01 00:00:00

abstract：:Cytokines elicited by superantigens have been suggested to play a central role in severe systemic clinical manifestations of gram-positive sepsis. Here we provide evidence for a potent inflammatory cytokine response in acute invasive group A streptococcal infections, and show a direct correlation between the magnitude...

journal_title：European journal of immunology

authors： Norrby-Teglund A,Chatellier S,Low DE,McGeer A,Green K,Kotb M

更新日期：2000-11-01 00:00:00

abstract：:IL-12 and IL-4, respectively, dominate Th1 versus Th2 polarization. Additionally IL-4 can inhibit IL-12 p40 production in DC. Here we show that macrophages respond to bacterial CpG-DNA with IL-12 p40 production in an IL-4-sensitive manner. Analysis of the molecular mechanism of this inhibition shows that IL-4 acts by ...

journal_title：European journal of immunology

authors： Seegmüller I,Häcker H,Wagner H

更新日期：2003-02-01 00:00:00

abstract：:We tested the effect of interferon (IFN)-alpha on the specific anti-2,4,6-trinitrophenyl (TNP) response induced by TNP-conjugated polyacrylamide beads in cultures of purified human B cells. IFN-alpha alone had no effect. Interleukin 2 (IL2) alone had a restorative effect which could be considerably (10X) enhanced by I...

journal_title：European journal of immunology

authors： Delfraissy JF,Wallon C,Galanaud P

更新日期：1988-09-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a membrane glycoprotein first identified on rat mucosal type mast cells (line RBL-2H3) and known to inhibit the Fc epsilon RI-mediated secretory response. In its extracellular domain, an amino acid stretch homologous to the carbohydrate binding domain of calcium-depe...

journal_title：European journal of immunology

authors： Binsack R,Pecht I

更新日期：1997-10-01 00:00:00

abstract：:A method for infection of lymphocytes with Moloney(Abelson) murine leukemia virus [M(A)-MuLV] is described. Only lymphoblasts obtained after stimulation of normal spleen cells by the B cell mitogen lipopolysaccharide (LPS) were satisfactory targets for virus-specific, secondary cytotoxic T lymphocytes (CTL), whereas s...

journal_title：European journal of immunology

authors： Stukart MJ,Vos A,Melitef CJ

更新日期：1981-03-01 00:00:00

abstract：:The development of the antibody repertoire in newborn mice is greatly influenced by idiotype network interactions. It has been demonstrated that anti-idiotypic antibodies either directly injected or transferred from the mother may alter the repertoire for life. For an elucidation of the underlying mechanisms we have a...

journal_title：European journal of immunology

authors： Lemke H,Lange H,Berek C

更新日期：1994-12-01 00:00:00

abstract：:Tertiary lymphoid organs can form at sites of chronic inflammation. Their presence has been mainly associated with tissue destruction. In transplantation, there is a dynamic immune response as in chronic inflammation. Indeed, the presence of tertiary lymphoid organs has been associated with chronic rejection. In addit...

journal_title：European journal of immunology

authors： Brown K,Sacks SH,Wong W

更新日期：2011-01-01 00:00:00

abstract：:The CD38 antigen displays restricted functional associations with surface molecules involved in immune system and complement. Capping of the CD38 molecule in normal or neoplastic T cells is followed by rapid and specific co-modulation of the CD3-T cell receptor (TcR) complex. In normal and tumor cells of B lineage, CD...

journal_title：European journal of immunology

authors： Funaro A,De Monte LB,Dianzani U,Forni M,Malavasi F

更新日期：1993-10-01 00:00:00

abstract：:Activation pathways inducing the expression of the interferon (IFN)-gamma gene in a cytotoxic T lymphocyte (CTL) clone were studied for their effects on transcription and on mRNA stability. IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein ...

journal_title：European journal of immunology

authors： Kaldy P,Schmitt-Verhulst AM

更新日期：1995-04-01 00:00:00

abstract：:The cell surface expression and biosynthesis of Langerhans cells (LC)-derived major histocompatibility complex (MHC) class II molecules from epidermal cells (EC) prepared freshly and cultured for up to 3 days was investigated. Based on the constitutive expression of MHC class II determinants by LC, a panning and magne...

journal_title：European journal of immunology

authors： Becker D,Reske-Kunz AB,Knop J,Reske K

更新日期：1991-05-01 00:00:00

abstract：:The liver and activation-regulated chemokine (LARC), also termed MIP-3alpha and Exodus, is a novel human CC chemokine with a selective chemotactic activity for lymphocytes and dendritic cells. Here we describe genomic and cDNA clones encoding the murine orthologue of LARC (mLARC). The gene consists of four exons and t...

journal_title：European journal of immunology

authors： Tanaka Y,Imai T,Baba M,Ishikawa I,Uehira M,Nomiyama H,Yoshie O

更新日期：1999-02-01 00:00:00

abstract：:The simultaneous detection of Ig and theta on the surface of mouse lymphocytes permits the detection of four cell types (Ig-theta-, Ig-theta+, Ig+theta-, and Ig+theta+) which also have distinct electrophoretic profiles. All types are present in variable proportions in all lymphoid organs studied. Results obtained in c...

journal_title：European journal of immunology

authors： Roelants GE,Loor F,von Boehmer H,Sprent J,Hägg LB,Mayor KS,Rydén A

更新日期：1975-02-01 00:00:00

abstract：:The encephalitogenic peptide pMOG 35-55 from the myelin oligodendrocyte glycoprotein was used to induce experimental autoimmune encephalomyelitis (EAE) in H-2b mice with the interleukin-6 (IL-6) gene intact or disrupted. The IL-6+/+ mice developed a chronic form of EAE ascending paralysis, whereas the IL-6-/- mice wer...

journal_title：European journal of immunology

authors： Mendel I,Katz A,Kozak N,Ben-Nun A,Revel M

更新日期：1998-05-01 00:00:00

abstract：:Site-directed mutagenesis of a recombinant Fc hinge fragment has recently been used to localize the site of the mouse IgG1 (mIgG1) molecule that is involved in the intestinal transfer of recombinant Fc hinge fragments in neonatal mice. This site encompasses Ile-253, His-310, Gln-311, His-433 and Asn-434, localized at ...

journal_title：European journal of immunology

authors： Medesan C,Radu C,Kim JK,Ghetie V,Ward ES

更新日期：1996-10-01 00:00:00

abstract：:Alpha4-mediated signaling is involved in a variety of functions in mammalian cells. To determine whether this is true for immunocompetent cells, we generated mutant (Lck-alpha4-) mice in which the alpha4 gene was deleted in a T cell-specific manner using the Cre/loxP system. These mice showed impaired early T cell dev...

journal_title：European journal of immunology

authors： Hua DR,Inui S,Yamashita T,Maeda K,Takagi K,Takeda J,Sakaguchi N

更新日期：2003-07-01 00:00:00

abstract：:It is widely believed that DC, but not macrophages, prime naïve T cells in vivo. Here, we investigated the ability of CD68-expressing cells (commonly defined as macrophages) in priming autoreactive T cells and initiating collagen-induced arthritis (CIA) in the mouse. For this purpose, a transgenic mouse was developed ...

journal_title：European journal of immunology

authors： Pizzolla A,Gelderman KA,Hultqvist M,Vestberg M,Gustafsson K,Mattsson R,Holmdahl R

更新日期：2011-02-01 00:00:00