Abstract:
:Rabbit kappa light (L) chain allotypes are controlled by the allelic genes b4, b5, b6, b9 and a recently described allele b4v. The product of the b4v gene differs from that of b4 by at least two amino acid substitutions in the constant region. A serologic distinction between the b4 and b4v allotyes has now been detected by a radioimmune assay using one of six anti-b4 sera tested. The distinction was enhanced by fractionation of this antiserum on an immunoadsorbent containing cottontail rabbit IgG. IgG with L chains of the b4v type are deficient in their ability to inhibit binding of b4 IgG to the antibody preparation. L chains isolated from b4 and b4v IgG samples could not be distinguished by this assay indicating that interaction with an H chain is required for expression of the L chain determinants that differentiate b4 from b4v.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Smith LJ,Sogh JA,Kindt TJ,Mandy WJdoi
10.1002/eji.1830090107keywords:
subject
Has Abstractpub_date
1979-01-01 00:00:00pages
27-31issue
1eissn
0014-2980issn
1521-4141journal_volume
9pub_type
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