MicroRNA-142 controls thymocyte proliferation.

abstract：:The tendency of isolated germinal center (GC) B cells to undergo apoptosis was suppressed by recombinant cell-bound CD40 ligand (CD40L): after 2 days at 37 degrees C, > 80% of cells remained viable in the presence of CD40L as compared to < 1% in control cultures. CD40L sustained a high rate of DNA synthesis in GC cell...

journal_title：European journal of immunology

authors： Holder MJ,Wang H,Milner AE,Casamayor M,Armitage R,Spriggs MK,Fanslow WC,MacLennan IC,Gregory CD,Gordon J

更新日期：1993-09-01 00:00:00

abstract：:The entry of neutrophils into inflamed tissues is initiated by cell rolling on the blood vessel wall followed by arrest and transendothelial migration. Rolling is mediated by the selectins, while the two subsequent steps require activated beta 2-integrins. We have investigated whether the binding of P-selectin to mous...

journal_title：European journal of immunology

authors： Blanks JE,Moll T,Eytner R,Vestweber D

更新日期：1998-02-01 00:00:00

abstract：:The proteins p40 (Mr = 40 000), p32 (Mr = 32 000), p28 (Mr = 28 000), p20 (Mr = 20 000) and p10 (Mr = 10 000) are described which occur in noncovalent association with the polymorphic alpha, beta heterodimer of class II antigens. They were investigated with respect to their molecular characteristics and their mutual s...

journal_title：European journal of immunology

authors： Zecher R,Ballhausen W,Reske K,Linder D,Schlüter M,Stirm S

更新日期：1984-06-01 00:00:00

abstract：:Psoriasis is an inflammatory disease of the skin affecting 2-3% of the population, characterized by a thickening of the epidermis and immune infiltrates throughout the dermis and epidermis, causing skin lesions that can seriously affect quality of life. The study of psoriasis has historically been hampered by the lack...

journal_title：European journal of immunology

authors： Flutter B,Nestle FO

更新日期：2013-12-01 00:00:00

abstract：:During their development, B and T lymphocytes are thought to undergo several cycles of chromatin remodeling at their antigen receptor loci that serve to regulate access of a common V(D)J recombinase to particular gene segments. We used germ-line transcription and susceptibility to DNasel as markers to examine tissue a...

journal_title：European journal of immunology

authors： Haines BB,Brodeur PH

更新日期：1998-12-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I and II products are specialized to present antigens via different intracellular processing routes. Peptides originating from proteins in the cytoplasm can gain access to class I peptide-binding grooves, most likely in the rough endoplasmic reticulum. Peptides from protein...

journal_title：European journal of immunology

authors： Zaghouani H,Kuzu Y,Kuzu H,Brumeanu TD,Swiggard WJ,Steinman RM,Bona CA

更新日期：1993-11-01 00:00:00

abstract：:Previous studies from our laboratory have shown that prolonged exposure of mouse macrophages to IFN-beta interferes with their subsequent ability to become activated for tumor cell killing. Data reported here show that such inhibition is due to reduced production of NO, resulting from decreased transcription of the ge...

journal_title：European journal of immunology

authors： Gao JJ,Filla MB,Lorsbach RB,Pace JL,Crespo A,Russell SW,Murphy WJ

更新日期：2000-06-01 00:00:00

abstract：:Induction of optimal HIV-1-specific T-cell responses, which can contribute to controlling viral infection in vivo, depends on antigen processing and presentation processes occurring in DCs. Opsonization can influence the routing of antigen processing and pathways used for presentation. We studied antigen proteolysis a...

journal_title：European journal of immunology

authors： Tjomsland V,Ellegård R,Burgener A,Mogk K,Che KF,Westmacott G,Hinkula J,Lifson JD,Larsson M

更新日期：2013-06-01 00:00:00

abstract：:Cholera toxin (CT) can function as a potent adjuvant in the mucosal immune response. However, we have found that treatment of A20-HL murine B lymphoma cells with CT severely inhibits the presentation of ovalbumin (OVA) to cells of the T cell clone 42-6A specific for OVA(323-339)/I-Ad, whereas it does not affect the pr...

journal_title：European journal of immunology

authors： Tanaka Y,Nakano H,Ishikawa F,Yoshida M,Gyotoku Y,Kakiuchi T

更新日期：1999-05-01 00:00:00

abstract：:Exosomes from APC are nano-vesicles that can induce antigen-specific T cell responses and are presently explored as therapeutic tools in different clinical settings. Investigations of the capacity of exosomes to stimulate T cells in vitro have mostly been performed on T cell hybridomas, clones or lines. Whether exosom...

journal_title：European journal of immunology

authors： Admyre C,Johansson SM,Paulie S,Gabrielsson S

更新日期：2006-07-01 00:00:00

abstract：:Cross-linking of surface immunoglobulin (sIg) by antibodies against IgM, IgG and IgD activates B cells and in some circumstances can induce cell proliferation. We studied the potential link between anti-Ig-induced changes in the cytosolic free Ca2+ concentration ([Ca2+]i), inositol phosphate production and the ability...

journal_title：European journal of immunology

authors： Roifman CM,Mills GB,Stewart D,Cheung RK,Grinstein S,Gelfand EW

更新日期：1987-12-01 00:00:00

abstract：:Spleen cells from BALB/c mice were fused with the nonsecreting myeloma line X63.Ag8.6.5.3 seven days after immunization with NP-CG (4-hydroxy-3-nitrophenyl) acetyl-chicken gamma-globulin. The hybrid cell lines obtained were analyzed for heavy and light chain distribution, fine specificity, and idiotype. The majority o...

journal_title：European journal of immunology

authors： White-Scharf ME,Imanishi-Kari T

更新日期：1981-11-01 00:00:00

abstract：:The molecular mechanisms leading to anti-double-stranded (ds) DNA antibody production in systemic lupus erythematosus (SLE) are poorly understood. We describe here the immunoglobulin variable region genes of six human hybridomas secreting IgG anti-dsDNA antibodies derived from three SLE patients. The monoclonal IgG an...

journal_title：European journal of immunology

authors： Winkler TH,Fehr H,Kalden JR

更新日期：1992-07-01 00:00:00

abstract：:We have fractionated human tonsillar B cells on the basis of CD5 expression and determined the nucleotide sequences of immunoglobin light chain variable (V) regions encoded by the single member of the V chi 4 gene family in both CD5+ and CD5- populations. The majority of cDNA from both CD5+ and CD5- B cells population...

journal_title：European journal of immunology

authors： Ebeling SB,Schutte ME,Logtenberg T

更新日期：1993-06-01 00:00:00

abstract：:Upon transplantation of T cells from a CD28 superagonist (CD28-SA) treated donor into an irradiated allogeneic host, the CD28-SA-induced activation and expansion of Treg cells inhibits acute graft versus host disease (aGvHD), while not abrogating the desired graft versus tumor effect. Human peripheral blood CD4(+) T c...

journal_title：European journal of immunology

authors： Beyersdorf N,Werner S,Wolf N,Hünig T,Kerkau T

更新日期：2015-07-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoreactive T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these cells in its immunopathogenesis. This subset uses an invariant TC...

journal_title：European journal of immunology

authors： Sireci G,Russo D,Dieli F,Porcelli SA,Taniguchi M,La Manna MP,Di Liberto D,Scarpa F,Salerno A

更新日期：2007-02-01 00:00:00

abstract：:Mouse B cells cultured with either phorbol myristate acetate (PMA), or with Ca2+ ionophores enter a transitional activated state, between quiescence (G0) and G1, but do not synthesize DNA. It is shown here that the combination of PMA plus the ionophore ionomycin induces resting B cells to synthesize DNA, but not to se...

journal_title：European journal of immunology

authors： Klaus GG,O'Garra A,Bijsterbosch MK,Holman M

更新日期：1986-01-01 00:00:00

abstract：:The immune and endocrine systems ensure two vital functions in the body. The immune system protects us from lethal pathogens, whereas the endocrine system ensures proper metabolic function of peripheral organs by regulating systemic homeostasis. These two systems were long thought to operate independently. The immune ...

journal_title：European journal of immunology

authors： Wensveen FM,Šestan M,Turk Wensveen T,Polić B

更新日期：2019-07-01 00:00:00

abstract：:Ab-restricted, H-Y-specific T cell clones from C57BL/6 mice were found to use predominantly V beta 6 T cell receptor genes, conferring Mls-1a reactivity. However, the expression of Mls-1a as a self antigen in (DBA/2 x C57BL/6)F1 mice did not turn these mice into nonresponders to H-Y. Instead of V beta 6, they used oth...

journal_title：European journal of immunology

authors： Frangoulis B,Pla M,Rammensee HG

更新日期：1989-03-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is a cytokine which, among other properties, is a principle mediator of inflammation and septic shock. It acts upon target cells by binding to specific cell surface receptors. A10G10 is a murine monoclonal antibody which recognizes human TNF and neutralizes its activity. A rabbit polyclonal...

journal_title：European journal of immunology

authors： Galloway CJ,Madanat MS,Sarr T,Espevik T,Dumas ML,Mitra G,Ranges GE

更新日期：1992-11-01 00:00:00

abstract：:We isolated immunoglobulin (Ig) VH4 genes that were rearranged in the genomic DNA of 160 day human fetal spleen. Productively rearranged VH 4-21 genes were cloned into pRTM1, a human IgM expression vector. This allowed us to generate IgM kappa-expressing transfectomas by co-transfecting each of these constructs with p...

journal_title：European journal of immunology

authors： Parr TB,Johnson TA,Silberstein LE,Kipps TJ

更新日期：1994-12-01 00:00:00

abstract：:Several studies in human patients and in laboratory animals have revealed a correlation between serum interleukin (IL)-6 levels and outcome in clinical sepsis and in related animal models, respectively. In the present study, two monoclonal antibodies were used to investigate the contribution of IL-6 in the lethal acti...

journal_title：European journal of immunology

authors： Libert C,Vink A,Coulie P,Brouckaert P,Everaerdt B,Van Snick J,Fiers W

更新日期：1992-10-01 00:00:00

abstract：:Amount and affinity of anti-beta-D-galactosidase-activating antibodies (AAb) were studied in two lines of mice obtained by selective breeding for antibody response to heterologous erythrocytes. These lines, referred to as high (H) and low (L) lines, differ also in their responses to many antigens. Concerning AAb amoun...

journal_title：European journal of immunology

authors： Conway de Macario E,Heumann AM,Macario AJ,Biozzi G

更新日期：1979-03-01 00:00:00

abstract：:Osteopontin (OPN) and CD44 have been implicated in the development of autoimmune diseases, including arthritis and multiple sclerosis, as well as chronic inflammatory diseases, such as atherosclerosis and colitis. To investigate their roles in autoimmune myocarditis induced by immunization with heart alpha-myosin (MyH...

journal_title：European journal of immunology

authors： Abel B,Kurrer M,Shamshiev A,Marty RR,Eriksson U,Günthert U,Kopf M

更新日期：2006-02-01 00:00:00

abstract：:The Fas antigen (Fas), which is a cell surface protein belonging to the tumor necrosis factor receptor family, mediates apoptosis. To assess the contribution of Fas to the pathogenesis of retrovirus-induced immunodeficiency, we examined the kinetics of Fas expression on the lymphocytes during the course of murine acqu...

journal_title：European journal of immunology

authors： Hiromatsu K,Aoki Y,Makino M,Matsumoto Y,Mizuochi T,Gotoh Y,Nomoto K,Ogasawara J,Nagata S,Yoshikai Y

更新日期：1994-10-01 00:00:00

abstract：:Cells of the innate immune system build immunological memory via epigenetic reprogramming after stimulations with microbial ligands. This functional readjustment allows for enhanced nonspecific inflammatory responses upon secondary challenges, a process termed "trained immunity." The epigenomic blueprint of trained mo...

journal_title：European journal of immunology

authors： Crișan TO,Netea MG,Joosten LA

更新日期：2016-04-01 00:00:00

abstract：:Interleukin (IL)-4-transgenic mice were used as a model system to study the consequences of low levels of IL-4 expression for the expression of other cytokines examined by quantitative polymerase chain reaction (PCR). For this purpose, a plasmid was constructed which contains, in tandem array, 5' and 3' primer sequenc...

journal_title：European journal of immunology

authors： Platzer C,Richter G,Uberla K,Müller W,Blöcker H,Diamantstein T,Blankenstein T

更新日期：1992-05-01 00:00:00

abstract：:CBA/J mice immunized with thyroglobulin (Tg) develop an experimental autoimmune thyroiditis (EAT) with lymphocytic infiltration of the thyroid glands, autoantibodies to Tg and occurrence of EAT-specific T cells. When these mice were treated for 4 weeks after immunization with 1 mg/week of a monoclonal antibody (mAb) t...

journal_title：European journal of immunology

authors： Tang H,Mignon-Godefroy K,Meroni PL,Garotta G,Charreire J,Nicoletti F

更新日期：1993-01-01 00:00:00

abstract：:CD25+ FOXP3+CD4+ T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high-level expression of FOXP3 (FOXP3high) is sufficient to confer suppressive activity to normal non-Treg. Here, we showed for the first time that vascular...

journal_title：European journal of immunology

authors： Suzuki H,Onishi H,Wada J,Yamasaki A,Tanaka H,Nakano K,Morisaki T,Katano M

更新日期：2010-01-01 00:00:00

abstract：:Antigen-specific immunotherapy is an attractive strategy for cancer control. In the context of antiviral vaccines, adenoviral vectors have emerged as a favorable means for immunization. Therefore, we chose a strategy combining use of these vectors with another successful approach, namely linkage of the vaccine antigen...

journal_title：European journal of immunology

authors： Sorensen MR,Holst PJ,Pircher H,Christensen JP,Thomsen AR

更新日期：2009-10-01 00:00:00