Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase chain reaction.

abstract：:LeIF, a gene homologue of the eukaryotic initiation factor 4A was first described as a leishmanial antigen that induced a Th1-type T cell response in peripheral blood mononuclear cells (PBMC) from leishmaniasis patients. Moreover, the interferon (IFN)-gamma production by PBMC was found to be interleukin (IL)-12 depend...

journal_title：European journal of immunology

authors： Probst P,Skeiky YA,Steeves M,Gervassi A,Grabstein KH,Reed SG

更新日期：1997-10-01 00:00:00

abstract：:During mammalian pregnancy, one or more semiallogeneic fetuses gestate in direct contact with the maternal circulation and uterine tissue. However, a damaging maternal immune response is not normally provoked. We studied two possible mechanisms for this maternal-fetal tolerance, alone and in combination. First, we dir...

journal_title：European journal of immunology

authors： Rogers AM,Boime I,Connolly J,Cook JR,Russell JH

更新日期：1998-11-01 00:00:00

abstract：:IL-22 is an IFN-IL-10 cytokine family member, which is produced by activated Th1 and NK cells and acts primarily on epithelial cells. Here we demonstrate that IL-22, in contrast to its relative IFN-gamma, regulates the expression of only a few genes in keratinocytes. This is due to varied signal transduction. Gene exp...

journal_title：European journal of immunology

authors： Wolk K,Witte E,Wallace E,Döcke WD,Kunz S,Asadullah K,Volk HD,Sterry W,Sabat R

更新日期：2006-05-01 00:00:00

abstract：:The immune mechanisms underlying immunization-induced protection of mice from lethal central nervous system (CNS) listeriosis were evaluated by immunohistochemistry, flow cytometry of leukocytes isolated from the brain, reverse transcription-polymerase chain reaction analysis of intracerebral (i.c.) tumor-necrosis fac...

journal_title：European journal of immunology

authors： Schlüter D,Oprisiu SB,Chahoud S,Weiner D,Wiestler OD,Hof H,Deckert-Schlüter M

更新日期：1995-08-01 00:00:00

abstract：:Peptide ligands presented by MHC class I molecules are generated in a cascade of proteolytic events starting with the proteasome in the cytosol and frequently terminating with trimming aminopeptidases in the endoplasmic reticulum. Several cytosolic proteases can carry out intermediate proteolytic steps between these s...

journal_title：European journal of immunology

authors： Endert Pv

更新日期：2008-03-01 00:00:00

abstract：:The repertoire of V regions of alpha/beta+ T cell receptor (TcR) on CD4+ and CD8+ T cells from the peripheral blood of six patients with a novel X-linked combined immunodeficiency was investigated by flow cytometry. The relative frequencies of V region subfamilies V alpha 2a on CD4+ T lymphocytes and V beta 5b and V b...

journal_title：European journal of immunology

authors： Goldman AS,Palkowetz KH,Rudloff HE,Brooks EG,Schmalstieg FC

更新日期：1992-04-01 00:00:00

abstract：:Ikaros is a transcriptional regulator whose function is essential for B cell development. It is expressed in the hematopoietic stem cell (HSC) through the mature B cell stage. Using genetically engineered mice in which the endogenous Ikaros gene is disrupted, it has been shown that a lack of Ikaros leads to a block in...

journal_title：European journal of immunology

authors： Wojcik H,Griffiths E,Staggs S,Hagman J,Winandy S

更新日期：2007-04-01 00:00:00

abstract：:Polyclonal differentiation of unprimed B cells into IgM-producing cells induced by lipopolysaccharide (LPS) or T cell-derived lymphokine B151-TRF2 has been shown to contain a process of I-A-restricted B-B cell interaction, so that the B cell responses are inhibited by monoclonal antibodies (mAb) specific for I-A molec...

journal_title：European journal of immunology

authors： Takahama Y,Ono S,Ishihara K,Muramatsu M,Hamaoka T

更新日期：1989-12-01 00:00:00

abstract：:Natural interferon-producing cells (NIPC), also called plasmacytoid dendritic cells, are the most potent producers of IFN-alpha in response to viral and bacterial components, serving an important function in innate immune defences. The present work demonstrates that NIPC responsiveness can be primed by immunisation, i...

journal_title：European journal of immunology

authors： Balmelli C,Vincent IE,Rau H,Guzylack-Piriou L,McCullough K,Summerfield A

更新日期：2005-08-01 00:00:00

abstract：:A monoclonal antibody, termed 3-2F1, is specific for the rabbit VH al allotypic marker. This antibody appears to recognize a common al determinant since it reacts with all of the a1 immunoglobulin (Ig) that is bound by polyclonal rabbit anti-a1, and completely inhibits the binding of polyclonal anti-a1 to a1 Ig. When ...

journal_title：European journal of immunology

authors： Metzger DW

更新日期：1984-04-01 00:00:00

abstract：:It is well accepted that Th17 cells are a highly plastic cell subset that can be easily directed toward the Th1 phenotype in vitro and also in vivo during inflammation. However, there is an ongoing debate regarding the reverse plasticity (conversion from Th1 to Th17). We show here that ectopic ROR-γt expression can re...

journal_title：European journal of immunology

authors： Mazzoni A,Maggi L,Siracusa F,Ramazzotti M,Rossi MC,Santarlasci V,Montaini G,Capone M,Rossettini B,De Palma R,Kruglov A,Chang HD,Cimaz R,Maggi E,Romagnani S,Liotta F,Cosmi L,Annunziato F

更新日期：2019-01-01 00:00:00

abstract：:Rapid IgE desensitization provides temporary tolerization for patients who have presented severe hypersensitivity reactions to food and drugs, protecting them from anaphylaxis, but the underlying mechanisms are still incompletely understood. Thus, here we develop an effective and reproducible in vitro model of rapid I...

journal_title：European journal of immunology

authors： Sancho-Serra Mdel C,Simarro M,Castells M

更新日期：2011-04-01 00:00:00

abstract：:Here we show that tumor cells (TC) from renal cancers regulate the migratory properties of autologous tumor-infiltrating lymphocytes (TIL), enhancing their ability to invade the extracellular matrix. A similar effect is exerted by human recombinant macrophage chemotactic protein 1 (MCP-1) and IL-8, chemokines known to...

journal_title：European journal of immunology

authors： Ferrero E,Fabbri M,Poggi A,Galati G,Bernasconi S,Zocchi MR

更新日期：1998-08-01 00:00:00

abstract：:Innate immunity directs the adaptive immune response by identifying antigens that are associated with infectious agents. Although some microbial antigens can be recognized by innate immune receptors, most cannot, and these require identification by some other means. The introduction of aldehydes into antigens by glyco...

journal_title：European journal of immunology

authors： Allison ME,Fearon DT

更新日期：2000-10-01 00:00:00

abstract：:Clonal deletion, anergy and suppression have all been considered mechanisms of immunological tolerance. Although adoptive transfer of immunosuppression has been shown to occur in the periphery, particularly for transplantation tolerance, it has proven difficult to characterize this phenomenon further, due to the lack ...

journal_title：European journal of immunology

authors： Teng YT,Gorczynski RM,Iwasaki S,Williams DB,Hozumi N

更新日期：1995-09-01 00:00:00

abstract：:In order to analyze the effect of a high local concentration of macrophage colony-stimulating factor (M-CSF; CSF-1) on tumor growth, the plasmacytoma cell line J558L was transfected with the human M-CSF gene and injected into syngeneic BALB/c mice. In contrast to the parental tumors, M-CSF transfectants were heavily i...

journal_title：European journal of immunology

authors： Dorsch M,Hock H,Kunzendorf U,Diamantstein T,Blankenstein T

更新日期：1993-01-01 00:00:00

abstract：:The human monocyte line, U-937, derived from an individual with histiocytic lymphoma was studied for the expression of surface C3 receptors, after cultivation in the presence of phorbol myristate acetate (PMA) or T lymphocyte-conditioned medium. Receptors were detected by using EAC4b, EAC3b, EC3b, EAC3bi and EAC3d int...

journal_title：European journal of immunology

authors： Gilbert D,Peulve P,Daveau M,Ripoche J,Fontaine M

更新日期：1985-10-01 00:00:00

abstract：:The present study tests whether the specific inhibition of helper T (Th) cell (and T hybridomas) by suppressor T (Ts) cells is a phenotypic trait of Th cells correlating with their acquired specificity for antigen/major histocompatibility complex or a genotypic trait not related to selection of the T cell repertoire f...

journal_title：European journal of immunology

authors： Araneo BA,Dowell T,Bertelsen K

更新日期：1988-04-01 00:00:00

abstract：:The atypical chemokine receptor CXCR7 binds the chemokines CXCL12 and CXCL11. The receptor is widely expressed and was shown to tune CXCR12-induced responses of CXCR4. Here, the function of CXCR7 was examined at late stages of human B-cell maturation, when B cells differentiate into Ab-secreting plasmablasts. We ident...

journal_title：European journal of immunology

authors： Humpert ML,Pinto D,Jarrossay D,Thelen M

更新日期：2014-03-01 00:00:00

abstract：:Pairs of monoclonal antibodies (mAb) defining epitopes T 11.1 and T 11.2 on the CD 2 molecule are mitogenic for purified human T cells in the presence of a submitogenic dose of 12-O-tetradecanoylphorbol 13-acetate (TPA). Anti-CD 28 mAb can substitute for the action of TPA in the anti-CD 2-induced proliferative respons...

journal_title：European journal of immunology

authors： Pierrès A,Lopez M,Cerdan C,Nunes J,Olive D,Mawas C

更新日期：1988-05-01 00:00:00

abstract：:A previously designed isotopic in vivo method for measuring delayed hypersensitivity was used with nonantigenic (or weakly antigenic) phlogogenic substances. A strong reaction was observed in some circumstances, witnessing the fact that the method has a specific and a nonspecific component. The reaction is drastically...

journal_title：European journal of immunology

authors： Sabolović D,Oth D,Bujadoux M

更新日期：1976-06-01 00:00:00

abstract：:The biochemical behavior and peptide binding properties of a soluble form of the human class II DR4Dw4 molecule (PI-DR4Dw4) were compared to DR4Dw4 molecules containing the transmembrane and cytoplasmic domains that were purified both from B and transfected chinese hamster ovary cells. Recombinant and B cell-derived D...

journal_title：European journal of immunology

authors： Buelow R,Paborsky LR,van Schooten WC,Kummerehl TJ,Schreifels R,Marshall K,Mayer J,Rothbard JB

更新日期：1993-01-01 00:00:00

abstract：:Previously we have reported on the production of two sets of human monoclonal antibodies reacting with mouse mammary tumor virus (MMTV) and human mammary tumor virus (HuMTV) cross-reacting antigens. B11 is a monoclonal IgG generated by the human-human hybridoma technique using axillary lymph node of breast cancer pati...

journal_title：European journal of immunology

authors： Smorodinsky NI,Ghendler Y,Bakimer R,Chaitchuk S,Keydar I,Shoenfeld Y

更新日期：1988-11-01 00:00:00

abstract：:Rabbit antibodies to Atlantic cod (Gadus morhua L.) immunoglobulin were affinity purified and used to screen cDNA libraries from spleen and head kidney mRNA. cDNA clones for both the secretory and membrane-bound heavy (H) chain were isolated, the nucleotide and deduced amino acid sequences of which are reported here. ...

journal_title：European journal of immunology

authors： Bengtén E,Leanderson T,Pilström L

更新日期：1991-12-01 00:00:00

abstract：:Previously, we found that co-expression of CD25 and TNFR2 identified the most suppressive subset of mouse Treg. In this study, we report that human peripheral blood (PB) FOXP3(+) cells present in CD25(high), CD25(low) and even CD25(-) subsets of CD4(+) cells expressed high levels of TNFR2. Consequently, TNFR2-expressi...

journal_title：European journal of immunology

authors： Chen X,Subleski JJ,Hamano R,Howard OM,Wiltrout RH,Oppenheim JJ

更新日期：2010-04-01 00:00:00

abstract：:Reactive nitrogen intermediates (RNI), like nitric oxide (NO) and peroxynitrite, have antiviral effects against certain viruses. Hantaviruses, like other members of the Bunyaviridae family, have previously not been shown to be sensitive to RNI. In this study, we compared the effects of NO and peroxynitrite on hantavir...

journal_title：European journal of immunology

authors： Klingström J,Akerström S,Hardestam J,Stoltz M,Simon M,Falk KI,Mirazimi A,Rottenberg M,Lundkvist A

更新日期：2006-10-01 00:00:00

abstract：:The zinc-finger transcription factor GATA3 serves as a master regulator of T-helper-2 (Th2) differentiation by inducing expression of the Th2 cytokines IL-4, IL-5 and IL-13 and by suppressing Th1 development. Here, we investigated how GATA3 affects Th17 differentiation, using transgenic mice with enforced GATA3 expres...

journal_title：European journal of immunology

authors： van Hamburg JP,de Bruijn MJ,Ribeiro de Almeida C,van Zwam M,van Meurs M,de Haas E,Boon L,Samsom JN,Hendriks RW

更新日期：2008-09-01 00:00:00

abstract：:The aim of this study was to investigate the effects of IL-17-producing T cells, including Th17 and Tc17 cells, on acute graft-versus-host disease (aGVHD) in patients who had undergone granulocyte colony-stimulating factor (G-CSF)-mobilised peripheral blood progenitor cell (PBPC) and G-CSF-primed bone marrow (G-BM) tr...

journal_title：European journal of immunology

authors： Zhao XY,Xu LL,Lu SY,Huang XJ

更新日期：2011-02-01 00:00:00

abstract：:An approach to the preparation of antigen-specific human monoclonal antibodies focuses on mice transgenic for human immunoglobulin gene miniloci; the V gene segments in these miniloci undergo productive rearrangement to yield mouse B cells expressing human immunoglobulin (Ig) chains. The general usefulness of this str...

journal_title：European journal of immunology

authors： Wagner SD,Popov AV,Davies SL,Xian J,Neuberger MS,Brüggemann M

更新日期：1994-11-01 00:00:00

abstract：:Interactions between CD8+ T cells and endothelial cells are important in both protective and pathologic immune responses. Endothelial cells regulate the recruitment of CD8+ T cells into tissues, and the activation of CD8+ T cells by antigen presentation and costimulatory signals. PD-L1 and PD-L2 are recently described...

journal_title：European journal of immunology

authors： Rodig N,Ryan T,Allen JA,Pang H,Grabie N,Chernova T,Greenfield EA,Liang SC,Sharpe AH,Lichtman AH,Freeman GJ

更新日期：2003-11-01 00:00:00