Abstract:
:Genetic and environmental factors both influence autoimmune disease occurrence, but the identity and mechanism of action of environmental factors are poorly understood. Here we show that pinworm-infected neonatal but not adult mice, injected with an ovarian self peptide of the zona pellucida protein 3 (pZP3) in water and without adjuvant, develop Th2 responses and severe eosinophilic autoimmune ovarian disease. A strong Th2 memory response is recalled when, as adults, the mice are challenged with a regimen that elicits a strong Th1 response in naive adults. The strong Th2 autoimmune response included high levels of IL-4 and IL-5 production by pZP3-specific T cells, and an IgG1-biased autoantibody response. The Th2 response ended promptly upon pinworm eradication, and partially resurfaced upon re-infection. We conclude that the rodent pinworm is an environmental agent that modifies the neonatal response to a self peptide, resulting in termination of the tolerance state and induction of a strong Th2-associated autoimmune disease and T cell memory.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Agersborg SS,Garza KM,Tung KSdoi
10.1002/1521-4141(200103)31:3<851::aid-immu851>3.0keywords:
subject
Has Abstractpub_date
2001-03-01 00:00:00pages
851-9issue
3eissn
0014-2980issn
1521-4141pii
10.1002/1521-4141(200103)31:3<851::AID-IMMU851>3.0journal_volume
31pub_type
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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