Abstract:
:Good responder (C57/Br/cd) and poor responder (C57BL/10) mice were immunized with mouse thyroid extract in Freund's complete adjuvant. The good responder mice first showed antibody to thyroglobulin on the seventh day while the poor responder animals had slightly lower titers and antibody did not appear until day 12. The first signs of thyroid infiltration appeared on day 4 in the responder strain, and severe lesions were seen between the third and fifth week. In contrast, the poor responder mice showed almost no evidence of infiltration. The macrophage disappearance reaction, a measure of cell-mediated immunity, was similar in the responder and nonresponder strains.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Tomazic V,Rose NRdoi
10.1002/eji.1830070110subject
Has Abstractpub_date
1977-01-01 00:00:00pages
40-3issue
1eissn
0014-2980issn
1521-4141journal_volume
7pub_type
杂志文章abstract::When cytotoxic titrations were made of rabbit anti-mouse brain and anti-Thy-1.2 sera against mouse lymphoid cells in the presence of sodium barbital or xylocaine, it was observed that a proportion of T cells were much more sensitive (50 x) than the remainder. This effect could be detected with ethidium or fluorescein ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830050408
更新日期:1975-04-01 00:00:00
abstract::Human natural killer (NK) cells are divided into two subsets: CD56bright and CD56dim NK cells, which differ in maturation, function and distribution. Mechanisms regulating NK cell functions are not completely understood. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, that binds to a variet...
journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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abstract::The involvement of the CD2 (T11) molecule, an alternative activation pathway for T lymphocytes, in the regulation of tumor necrosis factor (TNF)-alpha/TNF receptor system in human T lymphocytes has been investigated. It has been found that both TNF-alpha synthesis and secretion were induced after incubation of purifie...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830221219
更新日期:1992-12-01 00:00:00
abstract::Durch Pflanzenkrankheiten entstehen weltweit hohe Ernteverluste. Eine der häufigsten Infektionen in der Familie der Kreuzb&luml;tengewächse wird durch den Pilz Plasmodiophora brassicae verursacht. Die Krankheit äußert sich in Form von Wurzeltumoren, den "Kohlherniegallen". Da es auf verseuchten Böden zu hohen Ernteaus...
journal_title:European journal of immunology
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doi:10.1002/(sici)1521-415x(200001)30:1<14::aid-biuz14
更新日期:2000-01-01 00:00:00
abstract::Cytokines are the main agents known to regulate Th1 / Th2 commitment, where they may operate through paracrine activity within clusters of T cells gathered around dendritic cells (DC). An in vitro system is used here to test this possibility, using clusters around DC composed of naive TCR-transgenic ovalbumin peptide ...
journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270413
更新日期:1997-04-01 00:00:00
abstract::In this study, we examined which cell population contributes to IL-5 production by Peyer's patch (PP) cells. Thy1.2(-) fraction of PP cells, but not those of splenocytes, secreted IL-5 in response to IL-2. We found that CD3epsilon(-)IL-2Ralpha(+) cells purified from the Thy1.2(-)B220(-) fraction of PP cells secreted I...
journal_title:European journal of immunology
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abstract::We have utilized the sensitive polymerase chain reaction (PCR) to determine whether cytotoxic T lymphocyte (CTL) hybridomas generated from peritoneal exudate lymphocytes (PEL) and mixed lymphocyte cultures (MLC) express transcripts for perforin and the cytotoxic cell proteinases CCP1 to CCP5. We could readily detect l...
journal_title:European journal of immunology
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doi:10.1002/eji.1830221225
更新日期:1992-12-01 00:00:00
abstract::Radiolabeled protein A from Staphylococcus aureus (SpA) injected i.v. into mice and rabbits forms a soluble [(IgG)2-(SpA)1]2 complex (Mr = 684 000) which is identical in composition to that formed by SpA in vitro with an equivalent amount or an excess of IgG. A soluble rabbit IgG-SpA complex injected into a mice or ra...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830130802
更新日期:1983-08-01 00:00:00
abstract::Lymphocyte proliferation in response to monocytes pulsed with an antigenic extract of Candida albicans was measured in vitro and the effects of modifying major histocompatibility complex (MHC) class II antigen expression at the surface of the antigen-presenting cells was investigated. The study shows that no simple co...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160410
更新日期:1986-04-01 00:00:00
abstract::Crosslinking of Fc γ receptor II B (FcγRIIB) and the BCR by immune complexes (IC) can downregulate antigen-specific B-cell responses. Accordingly, FcγRIIB deficiencies have been associated with B-cell hyperactivity in patients with systemic lupus erythematosus and mouse models of lupus. However, we have previously sho...
journal_title:European journal of immunology
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更新日期:2010-10-01 00:00:00
abstract::We recently constructed IL-15 transgenic (Tg) mice using cDNA encoding a secretable isoform of the IL-15 precursor protein under the control of an MHC class I promoter. The IL-15 Tg mice exhibited resistance against a primary infection with Listeria monocytogenes. The numbers of memory CD8(+) T cells were markedly inc...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200103)31:3<757::aid-immu757>3.0
更新日期:2001-03-01 00:00:00
abstract::Clonal deletion, anergy and suppression have all been considered mechanisms of immunological tolerance. Although adoptive transfer of immunosuppression has been shown to occur in the periphery, particularly for transplantation tolerance, it has proven difficult to characterize this phenomenon further, due to the lack ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250917
更新日期:1995-09-01 00:00:00
abstract::Plasmid cassette-transfer vectors pBHuC chi and pBHuC gamma l have been designed which enable the construction of recombinant baculoviruses directing the co-expression of complete immunoglobulin in insect cells. We describe the application of these vectors for the expression of a human/mouse chimeric monoclonal antibo...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250731
更新日期:1995-07-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201747183
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abstract::Restriction fragment length polymorphism has been compared between the Igh loci of C57BL/6 and MOLF/EI (Mus musculus molossinus) mice utilizing probes which detect the C gamma 2b gene and genes from nine VH-gene families. Distinct restriction site patterns were found for the CH genes and for VH families PC7183, Q52 an...
journal_title:European journal of immunology
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更新日期:1987-09-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 评论,杂志文章
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abstract::IL-15 induces proliferation, inhibits apoptosis and increases IL-4 production in murine mast cells. There is evidence that these activities are mediated via the uncharacterised receptor, IL-15R-X, rather than the classical three-chain IL-15 receptor. Effects of IL-15 on important aspects of mast cell biology, such as ...
journal_title:European journal of immunology
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更新日期:2005-08-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230918
更新日期:1993-09-01 00:00:00
abstract::Th cells can adopt a number of different phenotypes. We performed microarray-assisted mRNA profiling on antigen-stimulated, TCR transgenic murine splenocytes that were cultured in the presence of cytokines. Transcriptome snapshots of Th cells differentiating into Th1 and Th2 phenotypes were obtained at various time po...
journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
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更新日期:1998-04-01 00:00:00
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journal_title:European journal of immunology
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更新日期:2003-02-01 00:00:00
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journal_title:European journal of immunology
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更新日期:1996-07-01 00:00:00
abstract::This Viewpoint series provides authoritative and detailed outlines of exciting areas of DC research. Some of the subjects that frequently come up include development of DC; distribution of DC in lymphoid and non-lymphoid tissues such as skin, intestine and lung; different forms or subsets of DC; and the role of DC in ...
journal_title:European journal of immunology
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doi:10.1002/eji.201040733
更新日期:2010-08-01 00:00:00
abstract::CD4+ alpha beta T cell populations that develop in mice deficient in MHC class II (through 'knockout' of either the Aalpha, or the Abeta chain of the I-A(b) molecule) comprise a major 'single-positive' (SP) CD4+ CD8- subset (60-90%) and a minor 'double-positive' (DP) CD4+ CD8alpha beta+ subset (10-40%). Many DP T cell...
journal_title:European journal of immunology
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更新日期:2004-03-01 00:00:00
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journal_title:European journal of immunology
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更新日期:2006-07-01 00:00:00