Bipotency of thymic epithelial progenitors comes in sequence.

abstract：:CD27, which belongs to the tumor necrosis factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsi...

journal_title：European journal of immunology

authors： Lens SM,Keehnen RM,van Oers MH,van Lier RA,Pals ST,Koopman G

更新日期：1996-05-01 00:00:00

abstract：:E-selectin is a cytokine-inducible membrane glycoprotein capable of mediating adhesion of leukocytes to endothelial cells. It is highly glycosylated, containing 11 sites for N-linked glycosylation. N-Glycosylation of E-selectin was analyzed by endoglycosidase treatment. Analysis of immunoprecipitated E-selectin from h...

journal_title：European journal of immunology

authors： Påhlsson P,Strindhall J,Srinivas U,Lundblad A

更新日期：1995-09-01 00:00:00

abstract：:In previous publications it was shown by avidity measurements, cross-reactivity patterns and genetic analyses, that the tetrapeptide T-T-G-G is the immuno-dominant epitope of the synthetic polypeptide (T, G)-A--L. In the present study this close immunological relationship between the random multichain copolymer (T, G)...

journal_title：European journal of immunology

authors： Cramer M,Schwartz M,Mozes E,Sela M

更新日期：1976-09-01 00:00:00

abstract：:Development of Th1 and Th2 effector lymphocytes is driven primarily by IL-12 or IL-4, but is also influenced by the strength of antigenic stimulation. However, the mechanism by which TCR signaling contributes to T cell polarization remains elusive. We show that in the presence of IL-12 a short TCR stimulation can lead...

journal_title：European journal of immunology

authors： Iezzi G,Scotet E,Scheidegger D,Lanzavecchia A

更新日期：1999-12-01 00:00:00

abstract：:Antigen-free (AGF) and germ-free (GF) mice, although essentially free of serum IgG, maintain normal levels of circulating IgM. Using a quantitative immunoblot assay, we have now analyzed the repertoire of serum IgM from AGF, GF, and specific pathogen-free (SPF) BALB/c mice, on large panels of natural antigens from hom...

journal_title：European journal of immunology

authors： Haury M,Sundblad A,Grandien A,Barreau C,Coutinho A,Nobrega A

更新日期：1997-06-01 00:00:00

abstract：:The second HLA-DR molecules, which are encoded by loci different from HLA-DRB1 are weakly polymorphic. Predominant alleles such as HLA-DRB3*0101, HLA-DRB4*0101 and HLA-DRB5*0101 are therefore interesting targets to define antigenic peptides with major impact for the entire population. Strikingly, they have been poorly...

journal_title：European journal of immunology

authors： Texier C,Pouvelle-Moratille S,Busson M,Charron D,Ménez A,Maillère B

更新日期：2001-06-01 00:00:00

abstract：:The cell surface expression and biosynthesis of Langerhans cells (LC)-derived major histocompatibility complex (MHC) class II molecules from epidermal cells (EC) prepared freshly and cultured for up to 3 days was investigated. Based on the constitutive expression of MHC class II determinants by LC, a panning and magne...

journal_title：European journal of immunology

authors： Becker D,Reske-Kunz AB,Knop J,Reske K

更新日期：1991-05-01 00:00:00

abstract：:The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain. Treatment of the human leukemic T cell line Jurkat with PMA increased the synthesis of the Ti alpha, CD3 gamma and CG3 zeta...

journal_title：European journal of immunology

authors： Vangsted A,Neisig A,Wallin H,Zeuthen J,Geisler C

更新日期：1993-06-01 00:00:00

abstract：:We recently reported that differentiation of CD8(+) T cells from the naïve to the effector state involves the upregulation of glucose-dependent metabolism. Glucose deprivation or inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) selectively inhibited production of IFN-gamma but not of IL-2. To determine a more glob...

journal_title：European journal of immunology

authors： Cham CM,Driessens G,O'Keefe JP,Gajewski TF

更新日期：2008-09-01 00:00:00

abstract：:Single-positive thymocytes are the immediate precursors of peripheral recent thymic emigrants (RTE) which develop into mature peripheral T cells. The functional ability of RTE is unclear but their state of differentiation may be relevant to the development of tolerance to peripheral "self" antigens. Since RTE are diff...

journal_title：European journal of immunology

authors： Charlton B,Meltzer J,Fathman CG

更新日期：1994-07-01 00:00:00

abstract：:Large-scale extravasation of lymphocytes takes place in vivo under physiological conditions in lymph nodes at very specialized vascular segments called high endothelial venules (HEV). When circulating lymphocytes leave the blood, they first bind to endothelial cells of HEV (HE cells) and subsequently enter lymph nodes...

journal_title：European journal of immunology

authors： Ise Y,Yamaguchi K,Sato K,Yamamura Y,Kitamura F,Tamatani T,Miyasaka M

更新日期：1988-08-01 00:00:00

abstract：:CSF1R (colony stimulating factor 1 receptor) is the main receptor for CSF1 and has crucial roles in regulating myelopoeisis. CSF1R can be proteolytically released from the cell surface by ADAM17 (A disintegrin and metalloprotease 17). Here, we identified CSF1R as a major substrate of ADAM17 in an unbiased degradomics ...

journal_title：European journal of immunology

authors： Qing X,Rogers L,Mortha A,Lavin Y,Redecha P,Issuree PD,Maretzky T,Merad M,McIlwain D,Mak TW,Overall CM,Blobel CP,Salmon JE

更新日期：2016-12-01 00:00:00

abstract：:The biological behavior of immune cells is determined by their intrinsic properties and interactions with other cell populations within their microenvironment. Several studies have confirmed the existence of tight spatial interactions between mast cells (MCs) and Tregs in different settings. For instance, we have rece...

journal_title：European journal of immunology

authors： Frossi B,D'Incà F,Crivellato E,Sibilano R,Gri G,Mongillo M,Danelli L,Maggi L,Pucillo CE

更新日期：2011-07-01 00:00:00

abstract：:Several drugs targeting members of the TNF superfamily or TNF receptor superfamily (TNFRSF) are widely used in medicine or are currently being tested in therapeutic trials. However, their mechanism of action remains poorly understood. Here, we explored the effects of TNFRSF co-stimulation on murine Foxp3+ regulatory T...

journal_title：European journal of immunology

authors： Lubrano di Ricco M,Ronin E,Collares D,Divoux J,Grégoire S,Wajant H,Gomes T,Grinberg-Bleyer Y,Baud V,Marodon G,Salomon BL

更新日期：2020-07-01 00:00:00

abstract：:T lymphocytes can be activated and induced to proliferate through stimulation of the CD2 glycoprotein with functional combinations of CD2 antibodies. However, this mechanism of signal transduction via CD2 is still not fully understood. We have investigated which molecules on the T cell surface preferentially associate...

journal_title：European journal of immunology

authors： Castro MA,Tavares PA,Almeida MS,Nunes RJ,Wright MD,Mason D,Moreira A,Carmo AM

更新日期：2002-05-01 00:00:00

abstract：:Local graft-vs.-host reaction (GVHR) was induced in rats by injecting parental cells into young F1 recipients. As a consequence of antigenic stimulation in the course of developing GVHR in the responding lymph nodes, the number of interleukin 2-receptor (IL 2R)-bearing T cells increased from less than 1% up to 10% of ...

journal_title：European journal of immunology

authors： Volk HD,Brocke S,Osawa H,Diamantstein T

更新日期：1986-10-01 00:00:00

abstract：:The lectin leucoagglutinin has been used to induce reactivity to interleukin 2 (IL2) in unseparated spleen cells and in highly purified Lyt-2+ lymph node T cells. Recombinant human IL2 and various other IL2-containing preparations, including concanavalin A-induced spleen cell supernatant, were compared for their capac...

journal_title：European journal of immunology

authors： Vohr HW,Hünig T

更新日期：1985-04-01 00:00:00

abstract：:Large granular lymphocyte clones were prepared from normal human mononuclear cells. Seven clones were studied in detail. All had high cytotoxic activity against the natural killer (NK) cell target K562 and all were T11- and DR-positive but T4- and T8-negative: none released migration inhibitory factor, a characteristi...

journal_title：European journal of immunology

authors： Vyakarnam A,Brenner MK,Reittie JE,Houlker CH,Lachmann PJ

更新日期：1985-06-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells elaborate a cytolytic protein named perforin or cytolysin. It was widely held that, in vivo, high quantities of perforin are not present in resting lymphocytes and are usually produced only by activated lymphocytes found under pathological conditions. Until n...

journal_title：European journal of immunology

authors： Zheng LM,Ojcius DM,Young JD

更新日期：1993-09-01 00:00:00

abstract：:An interferon (IFN)-gamma immunoreactive molecule, localized to small neurons in peripheral sensory ganglia (N-IFN-gamma), has been detected with two mouse monoclonal antibodies (DB1 and DB16) directed against different epitopes of rat IFN-gamma. To define N-IFN-gamma with regard to its protein characteristics and bio...

journal_title：European journal of immunology

authors： Olsson T,Kelic S,Edlund C,Bakhiet M,Höjeberg B,van der Meide PH,Ljungdahl A,Kristensson K

更新日期：1994-02-01 00:00:00

abstract：:To estimate the extent of the TRG gamma variable (V) gene repertoire used in human T cell ontogeny, we have analyzed the variety of V gamma gene rearrangements in a large series of T and non-T acute and chronic leukemias. A limited heterogeneity of rearranged fragments was observed: only 13 types of differently rearra...

journal_title：European journal of immunology

authors： Migone N,Casorati G,Di Celle PF,Lusso P,Foa R,Lefranc MP

更新日期：1988-01-01 00:00:00

abstract：:A cDNA encoding the human beta Fc gamma receptor II (FcRII) was isolated from a placental cDNA library. Analysis of the predicted amino acid sequence indicates that this receptor is synthesized with a 42-amino acid leader sequence. The mature protein consists of 249 amino acids. The leader sequence and the cytoplasmic...

journal_title：European journal of immunology

authors： Engelhardt W,Geerds C,Frey J

更新日期：1990-06-01 00:00:00

abstract：:Normal immunosuppressive protein, prepared from human plasma by DEAE-cellulose chromatography, inhibits DNA synthesis in human cell lines of lymphocytes of both T and B origin. It also inhibits [3H]thymidine incorporation in mouse cell lines. Normal immunosuppressive protein was able to inhibit the proliferation of th...

journal_title：European journal of immunology

authors： Nelken D,Ovadia H,Hanna N

更新日期：1979-02-01 00:00:00

abstract：:Endoglin is an homodimeric membrane antigen with capacity to bind transforming growth factor-beta (TGF-beta) and whose expression is up-regulated on myeloid cells upon differentiation to macrophages. We have isolated full-length cDNA clones from a lambda gt 10 library, prepared from phorbol 12-myristate 13-acetate-dif...

journal_title：European journal of immunology

authors： Bellón T,Corbí A,Lastres P,Calés C,Cebrián M,Vera S,Cheifetz S,Massague J,Letarte M,Bernabéu C

更新日期：1993-09-01 00:00:00

abstract：:IFN-γ-activated keratinocytes are key contributors to the pathogenetic mechanisms leading to type-1 immune-mediated skin disorders. In these epidermal cells, SOCS1 negatively regulates the molecular cascades triggered by IFN-γ by disabling JAK2 phosphorylation through its kinase inhibitory region (KIR). Aimed at poten...

journal_title：European journal of immunology

authors： Madonna S,Scarponi C,Doti N,Carbone T,Cavani A,Scognamiglio PL,Marasco D,Albanesi C

更新日期：2013-07-01 00:00:00

abstract：:Interferon regulatory factor-1 (IRF-1) is a transcription factor regulating the expression of several cytokines. Using IRF-1 knockout (KO) mice, the role of IRF-1 in the production and activity of IL-18 was evaluated. Administration of IL-12 or concanavalin A significantly increased levels of circulating IL-18 in wild...

journal_title：European journal of immunology

authors： Fantuzzi G,Reed D,Qi M,Scully S,Dinarello CA,Senaldi G

更新日期：2001-02-01 00:00:00

abstract：:Cell ablation is a valuable complement to mutagenesis for experimentally defining specific cell functions in physiology and pathophysiology in small animal models. One of the most popular ablation strategies involves transgenic expression of a primate diphtheria toxin receptor (DTR) on murine cells that are otherwise ...

journal_title：European journal of immunology

authors： Ruedl C,Jung S

更新日期：2018-07-01 00:00:00

abstract：:Recently activated peripheral T cells treated with IL-2 for 4 days expressed Fas ligand (FasL)-mediated cytotoxicity. These IL-2-treated T cells had high nuclear expression of SP1 and NFAT, but lacked the Egr-2 and Egr-3 that could be induced by anti-CD3 stimulation and had been implicated in FasL gene activation. A m...

journal_title：European journal of immunology

authors： Xiao S,Matsui K,Fine A,Zhu B,Marshak-Rothstein A,Widom RL,Ju ST

更新日期：1999-11-01 00:00:00

abstract：:Age-associated thymic involution results in a diminished capacity to regenerate T cell populations, although the magnitude of this effect is unknown. In this report, thymic function was studied in aged vs. young adult mice after lethal irradiation and administration of T cell-depleted bone marrow (BM) from young mice....

journal_title：European journal of immunology

authors： Mackall CL,Punt JA,Morgan P,Farr AG,Gress RE

更新日期：1998-06-01 00:00:00

abstract：:Tetanus toxin has been a valuable model antigen to study the MHC class II-restricted antigen processing pathway and is also frequently used to provide T helper determinants in vaccine formulations. To date most basic studies on the processing of this antigen have utilized human T and B cell clones. As a first step tow...

journal_title：European journal of immunology

authors： Antoniou AN,Watts C

更新日期：2002-02-01 00:00:00