Autoregulation of autoantibody synthesis in mercuric chloride nephritis in the Brown Norway rat. II. Presence of antigen-augmentable plaque-forming cells in the spleen is associated with humoral factors behaving as auto-anti-idiotypic antibodies.

abstract：:Expression and function of the fractalkine receptor CX3CR1 by T lymphocyte subpopulations was evaluated in healthy individuals. In CD8(+) T lymphocytes, CX3CR1 was expressed by and functional in both CD45RO(-) and CD45RO(+) cells. In CD4(+) T lymphocytes, CX3CR1 was expressed mainly by CD45RO(+) cells, and almost excl...

journal_title：European journal of immunology

authors： Foussat A,Coulomb-L'Hermine A,Gosling J,Krzysiek R,Durand-Gasselin I,Schall T,Balian A,Richard Y,Galanaud P,Emilie D

更新日期：2000-01-01 00:00:00

abstract：:The human T lymphocyte-specific CD2 (T11) molecule, that regulates T cell activation, is capable of mediating increases of intracellular cAMP. Monoclonal antibodies directed to different epitopes of the CD2 molecule which either induce or inhibit T cell proliferation are capable of triggering an increase of cAMP compa...

journal_title：European journal of immunology

authors： Carrera AC,Rincón M,De Landázuri MO,López-Botet M

更新日期：1988-06-01 00:00:00

abstract：:The approximately 20-kDa heat-labile toxin produced by enterotoxigenic Bacteroides fragilis is known to be associated with the development of enteritis. However, the molecular mechanism involved is not yet fully understood. In this study, we assessed whether B. fragilis enterotoxin (BFT)-induced enteritis is related t...

journal_title：European journal of immunology

authors： Kim JM,Jung HY,Lee JY,Youn J,Lee CH,Kim KH

更新日期：2005-09-01 00:00:00

abstract：:The present study was designed to elucidate the role of Valpha14(+) NKT cells in the host defense against pulmonary infection with Streptococcus pneumoniae using Jalpha281 gene-disrupted mice (Jalpha281KO mice) that lacked this lymphocyte subset. In these mice, pneumococcal infection was severely exacerbated, as shown...

journal_title：European journal of immunology

authors： Kawakami K,Yamamoto N,Kinjo Y,Miyagi K,Nakasone C,Uezu K,Kinjo T,Nakayama T,Taniguchi M,Saito A

更新日期：2003-12-01 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by congenital thrombocytopenia and progressive deterioration of the immune function. Dendritic cells (DC) are key effectors in the induction of specific immunity and are highly specialized in antigen uptake and subsequent migration to draining lymph ...

journal_title：European journal of immunology

authors： Allavena P,Badolato R,Facchetti F,Vermi W,Paganin C,Luini W,Giliani S,Mazza C,Bolzern U,Chiesa I,Notarangelo L,Mantovani A,Sozzani S

更新日期：2001-12-01 00:00:00

abstract：:DNA vaccination is an efficient way to induce CD8+ T cell memory, but it is still unclear to what extent such memory responses afford protection in vivo. To study this, we induced CD8+ memory responses directed towards defined viral epitopes, using DNA vaccines encoding immunodominant MHC class I-restricted epitopes o...

journal_title：European journal of immunology

authors： Bartholdy C,Stryhn A,Hansen NJ,Buus S,Thomsen AR

更新日期：2003-07-01 00:00:00

abstract：:NKp46 is a novel triggering receptor expressed by all human NK cells that is involved in natural cytotoxicity. In this study we show that the surface density of NKp46 may vary in different NK cells and that a precise correlation exists between the NKp46 phenotype of NK clones and their natural cytotoxicity against HLA...

journal_title：European journal of immunology

authors： Sivori S,Pende D,Bottino C,Marcenaro E,Pessino A,Biassoni R,Moretta L,Moretta A

更新日期：1999-05-01 00:00:00

abstract：:The effect of cyclosporin A (CsA) on the delayed-type hypersensitivity (DTH) elicited in mice by sheep red blood cells was investigated. Evidence is presented that a single injection of CsA adversely affects the inflammatory reaction. Sensitized T lymphocytes initiate the DTH reaction by their recruiting activity on p...

journal_title：European journal of immunology

authors： Shidani B,Milon G,Marchal G,Truffa-Bachi P

更新日期：1984-04-01 00:00:00

abstract：:The biochemical behavior and peptide binding properties of a soluble form of the human class II DR4Dw4 molecule (PI-DR4Dw4) were compared to DR4Dw4 molecules containing the transmembrane and cytoplasmic domains that were purified both from B and transfected chinese hamster ovary cells. Recombinant and B cell-derived D...

journal_title：European journal of immunology

authors： Buelow R,Paborsky LR,van Schooten WC,Kummerehl TJ,Schreifels R,Marshall K,Mayer J,Rothbard JB

更新日期：1993-01-01 00:00:00

abstract：:In this study we have used cells expressing LFA-3 or T11TS, the human and sheep forms of the ligand of CD2, as well as the purified LFA-3 and T11TS molecules themselves to study their effects on T cell activation via the CD2-mediated "alternative pathway". Sheep red blood cells, which bind to CD2 via T11TS in E-rosett...

journal_title：European journal of immunology

authors： Tiefenthaler G,Hünig T,Dustin ML,Springer TA,Meuer SC

更新日期：1987-12-01 00:00:00

abstract：:Bispecific antibodies binding to the TCR/CD3 complex and to a tumor-associated surface molecule can be used to target cytotoxic T lymphocytes against tumor cells. We reasoned that high-affinity binding to CD3 may reduce the efficiency of T cell stimulation and target the bispecific reagent to T cells rather than to tu...

journal_title：European journal of immunology

authors： Bortoletto N,Scotet E,Myamoto Y,D'Oro U,Lanzavecchia A

更新日期：2002-11-01 00:00:00

abstract：:Somatic hypermutation (SH) in B cells undergoing T cell-dependent immune responses generates high-affinity antibodies that provide protective immunity. Most current models of SH postulate the introduction of a nick into the DNA and subsequent replication-independent, error-prone short-patch synthesis by one or more DN...

journal_title：European journal of immunology

authors： Schenten D,Gerlach VL,Guo C,Velasco-Miguel S,Hladik CL,White CL,Friedberg EC,Rajewsky K,Esposito G

更新日期：2002-11-01 00:00:00

abstract：:Leishmaniases are a major international public health problem, and macrophages are crucial for host resistance to this parasite. To determine if phosphatase and tensin homologue deleted on chromosome ten (Pten), a negative regulator of the PI3K pathway, plays a role in macrophage-mediated resistance to Leishmania, we ...

journal_title：European journal of immunology

authors： Kuroda S,Nishio M,Sasaki T,Horie Y,Kawahara K,Sasaki M,Natsui M,Matozaki T,Tezuka H,Ohteki T,Förster I,Mak TW,Nakano T,Suzuki A

更新日期：2008-05-01 00:00:00

abstract：:The transforming protein of mouse polyomavirus, the mouse middle T antigen (MomT), and its counterpart in the hamster polyomavirus, the hamster middle T antigen (HamT), interact with a number of cellular proteins. Among these are members of the Src family of tyrosine kinases, the phosphatidylinositol 3-kinase, the ser...

journal_title：European journal of immunology

authors： Brizuela L,Ulug ET,Jones MA,Courtneidge SA

更新日期：1995-02-01 00:00:00

abstract：:A specialized subpopulation of T lymphocytes is reactive to the MHC class I-like molecule CD1d. It is not clear which cells are the major antigen-presenting cells in vivo in the activation of CD1-restricted immune responses. We have characterized a subset of B lymphocytes expressing six- to eightfold higher levels of ...

journal_title：European journal of immunology

authors： Makowska A,Faizunnessa NN,Anderson P,Midtvedt T,Cardell S

更新日期：1999-10-01 00:00:00

abstract：:Treatment of systemic lupus erythematosus patients with epratuzumab (Emab), a humanized monoclonal antibody targeting CD22, leads to moderately reduced B-cell numbers but does not completely deplete B cells. Emab appears to induce immunomodulation of B cells, but the exact mode of action has not been defined. In the p...

journal_title：European journal of immunology

authors： Özgör L,Brandl C,Shock A,Nitschke L

更新日期：2016-09-01 00:00:00

abstract：:The poxvirus A39R protein is a member of the semaphorin family that binds to Plexin C1, a molecule expressed on neutrophils and dendritic cells (DC). We previously showed that binding of A39R to Plexin C1 induces local rearrangement of the actin cytoskeleton and inhibits integrin-mediated adhesion, leading to cell ret...

journal_title：European journal of immunology

authors： Walzer T,Galibert L,De Smedt T

更新日期：2005-02-01 00:00:00

abstract：:The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model. We found that both the endothelium and epithelium of murine cor...

journal_title：European journal of immunology

authors： Fu H,Khan A,Coe D,Zaher S,Chai JG,Kropf P,Müller I,Larkin DF,George AJ

更新日期：2011-10-01 00:00:00

abstract：:Considering the role of interleukin-8 (IL-8) in a large number of acute and chronic inflammatory diseases, the regulation of IL-8-mediated biological responses is important. Alpha-melanocyte-stimulating hormone (alpha-MSH), a tridecapeptide, inhibits most forms of inflammation by an unknown mechanism. In the present s...

journal_title：European journal of immunology

authors： Manna SK,Sarkar A,Sreenivasan Y

更新日期：2006-03-01 00:00:00

abstract：:Monocyte/macrophage-mediated cytotoxicity requires the generation of activated oxygen radicals, which can be measured by chemiluminescence (CL). To investigate whether natural killer (NK) cell activity required activated oxygen species, both cytotoxicity against K562 target cells and CL were measured in cell populatio...

journal_title：European journal of immunology

authors： Ernst M,Lange A,Flad HD,Havel A,Ennen J,Ulmer AJ

更新日期：1984-07-01 00:00:00

abstract：:A panel of monoclonal antibodies (mAb) specific for the C gamma 2, C gamma 3 or inter C gamma 2/C gamma 3 domain epitopes was tested for inhibition of antibody-dependent cellular cytotoxicity (ADCC) specific for anti-D IgG-coated erythrocytes. Significant inhibition of ADCC was demonstrable for some antibodies having ...

journal_title：European journal of immunology

authors： Sármay G,Jefferis R,Klein E,Benczur M,Gergely J

更新日期：1985-10-01 00:00:00

abstract：:Gammadelta T cells are expanded in human IgA nephropathy and in a rat model of adriamycin (ADR)-induced nephropathy. Despite different diseases and species, these renal gammadelta T cells use a restricted set of gammadelta T cell receptor (TCR) genes. To explore whether this phenomenon of post injury expansion of gamm...

journal_title：European journal of immunology

authors： Wu H,Knight JF,Alexander SI

更新日期：2004-08-01 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE) is an animal model for the human disease, multiple sclerosis. The LEW rat strain is very susceptible to induction of EAE, whereas the closely related, major histocompatibility complex (MHC)-identical, inbred strain LER is resistant. In this report, the two rat strains have...

journal_title：European journal of immunology

authors： Blankenhorn EP,Stranford SA,Smith PD,Hickey WF

更新日期：1991-09-01 00:00:00

abstract：:The diversity of the human immune repertoire and how it relates to a functional immune response has not yet been studied in detail in humanized NOD.SCID.gammac(-/-) immunodeficient mice. Here, we used a multiplex PCR on genomic DNA to quantify the combinatorial diversity of all possible V-J rearrangements at the TCR-b...

journal_title：European journal of immunology

authors： Marodon G,Desjardins D,Mercey L,Baillou C,Parent P,Manuel M,Caux C,Bellier B,Pasqual N,Klatzmann D

更新日期：2009-08-01 00:00:00

abstract：:DNA vaccines induce CTL attack on target tumor epitopes, but tumor elimination in vivo also requires sufficient effector CTL to enter the site, guided by inflammatory chemokines. Many herpesviruses contain genes for chemokine and chemokine receptor-like proteins to protect infected cells from immune attack. To assess ...

journal_title：European journal of immunology

authors： Rice J,de Lima B,Stevenson FK,Stevenson PG

更新日期：2002-12-01 00:00:00

abstract：:Adult, male Lewis rats received a single injection of 5-bromo-2'-deoxyuridine (BrdUrd) i.v. to label proliferating cells in the S phase of the cell cycle. After 1 and 24 h the thymus, bone marrow, blood, spleen, peripheral, cervical and mesenteric lymph nodes as well as Peyer's patches were removed. In cell suspension...

journal_title：European journal of immunology

authors： Westermann J,Ronneberg S,Fritz FJ,Pabst R

更新日期：1989-06-01 00:00:00

abstract：:Accumulating evidence suggests that Th17 cells and Tregs may exhibit development plasticity and that CD4(+) Tregs can differentiate into IL-17-producing T cells; however, whether Th17 cells can reciprocally convert into Tregs has not been described. In this study, we generated Th17 clones from tumor-infiltrating T lym...

journal_title：European journal of immunology

authors： Ye J,Su X,Hsueh EC,Zhang Y,Koenig JM,Hoft DF,Peng G

更新日期：2011-04-01 00:00:00

abstract：:In human T lymphocytes a functional complex is formed between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and a phosphoprotein, pp32, a possible common substrate. Here we demonstrate that the previously described pp32 protein is composed of two distinct molecules (pp29 and pp32) in both r...

journal_title：European journal of immunology

authors： Schraven B,Schirren A,Kirchgessner H,Siebert B,Meuer SC

更新日期：1992-07-01 00:00:00

abstract：:We have investigated the vaccine potential of two peptides derived from the 6-kDa early secretory antigenic target (ESAT)-6 antigen in the mouse model of tuberculosis. The peptides were both strongly immunogenic in B6CBAF1 (H-2b,k) mice and primed recall responses of the same intensity after immunization. However, bot...

journal_title：European journal of immunology

authors： Olsen AW,Hansen PR,Holm A,Andersen P

更新日期：2000-06-01 00:00:00

abstract：:The distribution of idiotype-positive plaques in mice of various strains injected with T-independent (TI) and T-dependent conjugates of p-azobenzenearsonate (Ars) has been investigated. With maturation of the responses there is a progressive loss of dominance of the major cross-reactive idiotype (CRI) in A/J and C.AL-...

journal_title：European journal of immunology

authors： Henry C,Lucas A

更新日期：1982-03-01 00:00:00