Early divergence of Th1 and Th2 transcriptomes involves a small core response and sets of transiently expressed genes.

abstract：:A monoclonal antibody (mAb) directed to a human leukocyte 55-kDa cell surface molecule with identical cellular distribution and biochemical properties to the CD4 was able to inhibit T cell proliferation induced either in a mixed lymphocyte culture or by activation with mAb anti-CD3, anti-CD2 or phytohemagglutinin. The...

journal_title：European journal of immunology

authors： Carrera AC,Sanchez-Madrid F,Lopez-Botet M,Bernabeu C,De Landazuri MO

更新日期：1987-02-01 00:00:00

abstract：:Transgenic CBA (H-2k haplotype) mice expressing the H-2 Kb major histocompatibility complex (MHC) class I gene under control of transcriptional promoter elements from a milk protein gene display high-level H-2 Kb transcription in lactating mammary glands and low-level transcription in skin and thymus of male and virgi...

journal_title：European journal of immunology

authors： Husbands SD,Schönrich G,Arnold B,Chandler PR,Simpson E,Philpott KL,Tomlinson P,O'Reilly L,Cooke A,Mellor AL

更新日期：1992-10-01 00:00:00

abstract：:Activation-induced deaminase (AID) is the master regulator of class switch recombination (CSR) and somatic hypermutation (SHM), but the mechanisms regulating AID function are obscure. The differential pattern of switch plasmid activity in three IgM(+)/AID(+) and two IgG(+)/AID(+) B cell lines prompted an analysis of g...

journal_title：European journal of immunology

authors： Bhattacharya P,Grigera F,Rogozin IB,McCarty T,Morse HC 3rd,Kenter AL

更新日期：2008-01-01 00:00:00

abstract：:Although anti-inflammatory properties of glucocorticoids (GC) are well documented, their activity in allergic diseases is still controversial. Recently, it has been reported that GC can increase, both in vivo and in vitro, the polyclonal production of total IgE. In this study we investigated the effects of GC on the a...

journal_title：European journal of immunology

authors： Akdis CA,Blesken T,Akdis M,Alkan SS,Heusser CH,Blaser K

更新日期：1997-09-01 00:00:00

abstract：:Thymectomy was performed on the urodele amphibian Pleurodeles waltlii Michah. from the 5th to the 20th week of larval development. Thymectomized animals were allografted at 7 months of age. The results obtained are as follows: (1) Pleurodeles thymectomized before 10 weeks always tolerated allografts: (2) Pleurodeles t...

journal_title：European journal of immunology

authors： Fache B,Charlemagne J

更新日期：1975-02-01 00:00:00

abstract：:This article describes the study of the functional relationship between auto-tumor-reactive CD4(+) T cell clones (TCC) and autologous malignant B cells. Four auto-tumor-reactive CD4(+) TCC were derived from tumor-infiltrating T lymphocytes (TIL-T) from a freshly isolated human follicular lymphoma by the following tech...

journal_title：European journal of immunology

authors： Martin I,Bonnefoix T,Roucard C,Perron P,Lajmanovich A,Moine A,Leroux D,Sotto JJ,Garban F

更新日期：1999-10-01 00:00:00

abstract：:Postganglionic sympathetic neurons innervate secondary lymphoid organs and secrete norepinephrine (NE) as the primary neurotransmitter. NE binds and signals through five distinct members of the adrenergic receptor family. In this study, we show elevated expression of the β2-adrenergic receptor (ADRB2) on primary human...

journal_title：European journal of immunology

authors： Estrada LD,Ağaç D,Farrar JD

更新日期：2016-08-01 00:00:00

abstract：:Current models of lymphocyte traffic suggest that homing specificities of T cells to tissues such as skin are generated outside the thymus as a result of activation of naive T cells by antigen in lymph nodes. Virgin T cells are thought to home to high endothelial venules in lymph nodes, but are thought to be unable to...

journal_title：European journal of immunology

authors： Washington EA,Kimpton WG,Holder JE,Cahill RN

更新日期：1995-03-01 00:00:00

abstract：:Autoimmune diseases including multiple sclerosis (MS) are the result of an imbalanced immune tolerance network. Dendritic cells (DCs) are key players in both initiating immunity (immunogenic DCs) and regulating immune responses (tolerogenic DCs = tolDCs) and are potential targets for the treatment of MS. While the imm...

journal_title：European journal of immunology

authors： Gross CC,Jonuleit H,Wiendl H

更新日期：2012-03-01 00:00:00

abstract：:The nonobese diabetic (NOD) mouse is a relevant model for studying human insulin-dependent diabetes mellitus (IDDM). The selective destruction of insulin-secreting cells in this model is subsequent to an autoimmune reaction directed towards the beta cells inside the islets of Langerhans of the pancreas. Given the key ...

journal_title：European journal of immunology

authors： Sempé P,Bédossa P,Richard MF,Villà MC,Bach JF,Boitard C

更新日期：1991-05-01 00:00:00

abstract：:To study the control of immunoglobulin kappa light chain gene rearrangement, we generated transgenic mice carrying a germ-line human kappa minilocus (HK) containing the J kappa-proximal V gene, V kappa IV, the V-J intergenic region, the five J kappa segments and the C kappa gene. This construct includes the intronic, ...

journal_title：European journal of immunology

authors： Cavelier P,Nato F,Coquilleau I,Rolink A,Rougeon F,Goodhardt M

更新日期：1997-07-01 00:00:00

abstract：:Leukocyte adhesion deficiency (LAD) is a recessive autosomal disease characterized by life-threatening recurrent bacterial infections, by defective functions of leukocytes and by deficient membrane expression of leukocyte adhesion glycoproteins. These proteins, LFA-1, Mac-1 and p150,95, are alpha 1/beta 1 heterodimers...

journal_title：European journal of immunology

authors： Dimanche-Boitrel MT,Guyot A,De Saint-Basile G,Fischer A,Griscelli C,Lisowska-Grospierre B

更新日期：1988-10-01 00:00:00

abstract：:Interleukin-12 family cytokines have emerged as critical regulators of immunity with some members (IL-12, IL-23) associated with disease pathogenesis while others (IL-27, IL-35) mitigate autoimmune diseases. Each IL-12 family member is comprised of an α and a β chain, and chain-sharing is a key feature. Although four ...

journal_title：European journal of immunology

authors： Wang X,Wei Y,Xiao H,Liu X,Zhang Y,Han G,Chen G,Hou C,Ma N,Shen B,Li Y,Egwuagu CE,Wang R

更新日期：2016-06-01 00:00:00

abstract：:Antigen stimulation induces specific CD4 T cells to change from a resting phenotype (CD45RC+) to a "memory" phenotype (CD45RC-), an isoform switch that is reversible and regulated by persisting antigen. We show here that CD4 T cells responsible for mediating allograft rejection undergo a similar CD45RC+ to CD45RC- swi...

journal_title：European journal of immunology

authors： Yang CP,Bell EB

更新日期：1999-07-01 00:00:00

abstract：:It has been reported that, following the initial expression of the T cell receptor (TcR) alpha/beta, newly generated thymocytes pass through a developmental window characterized by ineffective coupling between the alpha/beta and CD3 components resulting in resistance to deletion (negative selection). However, we now p...

journal_title：European journal of immunology

authors： Jenkinson EJ,Kingston R,Owen JJ

更新日期：1990-11-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine kinase and is crucial for cellular energy homeostasis. The exact role of AMPK during memory CD8(+) T-cell differentiation, a process that changes from the metabolically active state of effector T cells to one of quiescence in memory cells is...

journal_title：European journal of immunology

authors： Araki K,Ahmed R

更新日期：2013-04-01 00:00:00

abstract：:The crucial role of interleukin (IL)-4 in the induction of murine IgG1 and IgE responses, which are coupled through the process of sequential isotype switching, has been well documented. Whereas IL-4 is obligatory for the induction of IgE responses, it enhances IgG1 responses. In this study, using neutralizing antibod...

journal_title：European journal of immunology

authors： van Ommen R,Vredendaal AE,Savelkoul HF

更新日期：1994-06-01 00:00:00

abstract：:A rapidly-growing, HAT-sensitive cell line LICR-LON-HMy2 has been derived from the ARH-77 human plasma cell leukemia-derived line. It lacks the enzyme hypoxanthine phosphoribosyltransferase (EC 2.4.2.8). Hybrids have been reproducibly made for more than a year and in independent laboratories with lymphocytes from tons...

journal_title：European journal of immunology

authors： Edwards PA,Smith CM,Neville AM,O'Hare MJ

更新日期：1982-08-01 00:00:00

abstract：:The inflammatory cytokine IL-17 plays a critical role in immunity to infection and is involved in the inflammatory pathology associated with certain autoimmune diseases, such as psoriasis and rheumatoid arthritis. While CD4(+) and CD8(+) T cells are important sources of this cytokine, recent evidence has suggested tha...

journal_title：European journal of immunology

authors： Sutton CE,Mielke LA,Mills KH

更新日期：2012-09-01 00:00:00

abstract：:APO-1/Fas (CD95) is a transmembrane receptor that transduces apoptotic signals within various cells including T and B cells. The APO-1 gene was found to be defective in lpr mice. In these mice insertion of a retrotransposon gives rise to transcription of an abnormal mRNA and only a fraction of wild-type APO-1 mRNA. It...

journal_title：European journal of immunology

authors： Mariani SM,Matiba B,Armandola EA,Krammer PH

更新日期：1994-12-01 00:00:00

abstract：:Considering the role of interleukin-8 (IL-8) in a large number of acute and chronic inflammatory diseases, the regulation of IL-8-mediated biological responses is important. Alpha-melanocyte-stimulating hormone (alpha-MSH), a tridecapeptide, inhibits most forms of inflammation by an unknown mechanism. In the present s...

journal_title：European journal of immunology

authors： Manna SK,Sarkar A,Sreenivasan Y

更新日期：2006-03-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) plays an important role in the immune response by modulating the complex interactions between leukocytes and tissue cells under inflammatory conditions. PGE(2) may possibly influence pro-inflammatory effects of chemokines and chemokine receptors that are among the main regulators of directi...

journal_title：European journal of immunology

authors： Panzer U,Uguccioni M

更新日期：2004-12-01 00:00:00

abstract：:Only activated and effector memory T cells are thought to access non-lymphoid tissues. In contrast, naive T cells are thought to circulate only between the blood, lymph and secondary lymphoid organs. We examined the phenotype of endogenous T cells in various non-lymphoid organs and showed that a subset of cells exhibi...

journal_title：European journal of immunology

authors： Cose S,Brammer C,Khanna KM,Masopust D,Lefrançois L

更新日期：2006-06-01 00:00:00

abstract：:We have characterized the peripheral B cell repertoire in T cell-mediated insulin-dependent diabetes mellitus (IDMM) and in B cell-mediated autoimmune idiopathic thrombocytopenic purpura (AITP). The VH6-containing repertoire in adult patients with IDDM or AITP and healthy control subjects was investigated by PCR ampli...

journal_title：European journal of immunology

authors： Söderström I,van Dijk-Härd I,Feld S,Hillörn V,Holmberg D,Lundkvist I

更新日期：1999-09-01 00:00:00

abstract：:MS is a multifactorial disease in which a series of genetic and non-genetic, environmental factors plays a role in its etiology. In particular, HLA class II alleles, mainly HLADRB1*15:01 (HLA-DR15), increase the risk for this disease. Out of several environmental factors, and with regard to infections, EBV remains to ...

journal_title：European journal of immunology

authors： Olsson T

更新日期：2020-12-22 00:00:00

abstract：:Deoxyguanosine (dGuo) has been implicated as the toxic metabolite causing a severe impairment of cellular immunity in children with a genetic deficiency of purine nucleoside phosphorylase (PNP). In peripheral blood T cells of normal donors both the pathway which leads to phosphorylation of dGuo (ultimately resulting i...

journal_title：European journal of immunology

authors： Scharenberg JG,Spaapen LJ,Rijkers GT,Duran M,Staal GE,Zegers BJ

更新日期：1986-04-01 00:00:00

abstract：:Synthetic peptides encoding protective pathogen-derived epitopes represent--in principle--an ideal approach to T-cell vaccination. Empirically, however, these strategies have not been successful. In the current study, we profiled the early activation of CD8+ T cells by MHC class I-restricted peptide immunization to be...

journal_title：European journal of immunology

authors： Overstreet MG,Freyberger H,Cockburn IA,Chen YC,Tse SW,Zavala F

更新日期：2010-01-01 00:00:00

abstract：:Staphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is associated with intense pain and permanent articular damage, neutrop...

journal_title：European journal of immunology

authors： Boff D,Oliveira VLS,Queiroz Junior CM,Silva TA,Allegretti M,Verri WA Jr,Proost P,Teixeira MM,Amaral FA

更新日期：2018-03-01 00:00:00

abstract：:The major histocompatibility complex (MHC)-encoded transporter associated with antigen processing (TAP) delivers cytosolic peptides to the lumen of the endoplasmic reticulum (ER) for presentation by MHC class I molecules. For the rat, it has been demonstrated that TAP polymorphism results in the selection of different...

journal_title：European journal of immunology

authors： Obst R,Armandola EA,Nijenhuis M,Momburg F,Hämmerling GJ

更新日期：1995-08-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) caused by donor T cells attacking recipient tissues is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (alloSCT). Studies have shown that effector memory T (T(EM) ) cells do not cause GVHD but are capable of immune functions post-tr...

journal_title：European journal of immunology

authors： Anderson BE,Tang AL,Wang Y,Froicu M,Rothstein D,McNiff JM,Jain D,Demetris AJ,Farber DL,Shlomchik WD,Shlomchik MJ

更新日期：2011-09-01 00:00:00