A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice.

abstract：:We have fractionated human tonsillar B cells on the basis of CD5 expression and determined the nucleotide sequences of immunoglobin light chain variable (V) regions encoded by the single member of the V chi 4 gene family in both CD5+ and CD5- populations. The majority of cDNA from both CD5+ and CD5- B cells population...

journal_title：European journal of immunology

authors： Ebeling SB,Schutte ME,Logtenberg T

更新日期：1993-06-01 00:00:00

abstract：:IL-23, a proximal regulator of IL-17, may be a major driving force in the induction of autoimmune inflammation. We have used a model of subdiabetogenic treatment with multiple low doses of streptozotocin (MLD-STZ; 4 x 40 mg/kg body weight) in male C57BL/6 mice to study the effect of IL-23 on immune-mediated beta cell ...

journal_title：European journal of immunology

authors： Mensah-Brown EP,Shahin A,Al-Shamisi M,Wei X,Lukic ML

更新日期：2006-01-01 00:00:00

abstract：:Cross-linking of surface immunoglobulin (sIg) by antibodies against IgM, IgG and IgD activates B cells and in some circumstances can induce cell proliferation. We studied the potential link between anti-Ig-induced changes in the cytosolic free Ca2+ concentration ([Ca2+]i), inositol phosphate production and the ability...

journal_title：European journal of immunology

authors： Roifman CM,Mills GB,Stewart D,Cheung RK,Grinstein S,Gelfand EW

更新日期：1987-12-01 00:00:00

abstract：:Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum. Recent functional and genetic studies linked DMBT1 to the suppression of LPS-induced TLR4-mediated NF-kappaB activation and to the pathogenesis of Crohn's disease. Here, we aimed at unraveling the mole...

journal_title：European journal of immunology

authors： End C,Bikker F,Renner M,Bergmann G,Lyer S,Blaich S,Hudler M,Helmke B,Gassler N,Autschbach F,Ligtenberg AJ,Benner A,Holmskov U,Schirmacher P,Nieuw Amerongen AV,Rosenstiel P,Sina C,Franke A,Hafner M,Kioschis P,Schre

更新日期：2009-03-01 00:00:00

abstract：:Immunodominant T cell epitopes from the autoantigen human cartilage glycoprotein 39 have previously been mapped in the context of HLA-DR*0401 and *0402, using mice expressing HLA-DR4 transgenes. We measured the dissociation rates of these epitopes from soluble recombinant DR*0401 and DR*0402 to assess the relationship...

journal_title：European journal of immunology

authors： Hall FC,Rabinowitz JD,Busch R,Visconti KC,Belmares M,Patil NS,Cope AP,Patel S,McConnell HM,Mellins ED,Sonderstrup G

更新日期：2002-03-01 00:00:00

abstract：:Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture after damage. However, a detailed characterization of this family in the thymus is lacking. To better understand the thymic ILC compartment, we have utilized multip...

journal_title：European journal of immunology

authors： Jones R,Cosway EJ,Willis C,White AJ,Jenkinson WE,Fehling HJ,Anderson G,Withers DR

更新日期：2018-09-01 00:00:00

abstract：:The regulation of nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex in primary human T cells has been studied at various times after activation. Only p50 NF-kappa B protein bound the kappa B element of interleukin-2 receptor (IL-2R) alpha chain promoter on resting T cells. However, immedi...

journal_title：European journal of immunology

authors： Pimentel-Muiños FX,Mazana J,Fresno M

更新日期：1995-01-01 00:00:00

abstract：:HIV controllers are a valuable source for the identification of HIV-neutralizing antibodies, as chronic infection over decades allows extensive affinity maturation of antibodies for improved Ag recognition. We analyzed a small cohort of elite controllers (ECs) for HIV-neutralizing antibodies using a panel of standardi...

journal_title：European journal of immunology

authors： Zhou M,Meyer T,Koch S,Koch J,von Briesen H,Benito JM,Soriano V,Haberl A,Bickel M,Dübel S,Hust M,Dietrich U

更新日期：2013-02-01 00:00:00

abstract：:IL-7 is a major regulator of lymphocyte homeostasis; however, little is known about the mechanisms that regulate IL-7 production. To study Il7 gene regulation in vivo, we generated a novel IL-7-reporter mouse, which allows the non-invasive quantification of Il7 gene activity in live mice and, additionally, the simulta...

journal_title：European journal of immunology

authors： Shalapour S,Deiser K,Sercan O,Tuckermann J,Minnich K,Willimsky G,Blankenstein T,Hämmerling GJ,Arnold B,Schüler T

更新日期：2010-09-01 00:00:00

abstract：:Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays an important role in regulating the local inflammatory immune response, but regulatory mechanisms of this cytokine have not been fully elucidated. Here, we demonstrate that IL-10 deficiency renders LPS treatment ineffective in regulating the expression...

journal_title：European journal of immunology

authors： Zhou F,Ciric B,Li H,Yan Y,Li K,Cullimore M,Lauretti E,Gonnella P,Zhang GX,Rostami A

更新日期：2012-06-01 00:00:00

abstract：:Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the sec...

journal_title：European journal of immunology

authors： Müller N,Fischer JC,Yabal M,Haas T,Poeck H,Jost PJ

更新日期：2019-03-01 00:00:00

abstract：:Mutations of forkhead box p3 (FOXP3), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The relevance of other periphe...

journal_title：European journal of immunology

authors： Passerini L,Di Nunzio S,Gregori S,Gambineri E,Cecconi M,Seidel MG,Cazzola G,Perroni L,Tommasini A,Vignola S,Guidi L,Roncarolo MG,Bacchetta R

更新日期：2011-04-01 00:00:00

abstract：:We examined T cell development and T cell repertoire in transgenic mice expressing a single T cell receptor (TCR) alpha chain derived from the H-2Db-lymphocytic choriomeningitis virus (LCMV)-specific cytolytic T lymphocyte (CTL) clone P14. To generate these alpha P14 mice, mice transgenic for the P14 TCR alpha chain w...

journal_title：European journal of immunology

authors： Brändle D,Brduscha-Riem K,Hayday AC,Owen MJ,Hengartner H,Pircher H

更新日期：1995-09-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I molecules present peptides from endogenous proteins. However, in some cases class I-restricted peptides can also derive from exogenous antigens. This MHC class I exogenous presentation could be involved in minor histocompatibility antigen (mHAg)-disparate allograft reject...

journal_title：European journal of immunology

authors： Oukka M,Galou M,Belkaid Y,Tricotet V,Riche N,Reynes M,Kosmatopoulos K

更新日期：1997-12-01 00:00:00

abstract：:The beta7 integrins alpha4beta7 and alphaEbeta7 play key roles in forming the gut-associated lymphoid tissue, and contribute to chronic inflammation. The alpha4beta7 integrin-mediated adhesion of activated lymphocytes is largely due to a transient increase in avidity from ligand-induced clustering of alpha4beta7 at th...

journal_title：European journal of immunology

authors： Krissansen GW,Singh J,Kanwar RK,Chan YC,Leung E,Lehnert KB,Kanwar JR,Yang Y

更新日期：2006-08-01 00:00:00

abstract：:The generation of effective type 1 T helper (Th1)-cell responses is required for immunity against intracellular bacteria. However, some intracellular bacteria require interleukin (IL)-17 to drive Th1-cell immunity and subsequent protective host immunity. Here, in a model of Mycobacterium bovis Bacille Calmette-Guerin ...

journal_title：European journal of immunology

authors： Gopal R,Lin Y,Obermajer N,Slight S,Nuthalapati N,Ahmed M,Kalinski P,Khader SA

更新日期：2012-02-01 00:00:00

abstract：:Immunocompetent adult mice infected with lymphocytic choriomeningitis virus (LCMV) generate a strong antiviral cytotoxic T cell response that clears virus from all organs. Although there is good evidence that immune cytotoxic T lymphocytes (CTL) kill target cells in vitro, in vivo it is debated whether antiviral activ...

journal_title：European journal of immunology

authors： Kyburz D,Speiser DE,Battegay M,Hengartner H,Zinkernagel RM

更新日期：1993-07-01 00:00:00

abstract：:The germ-line V gene segments encoding the subgroups A and G of the BALB/c V kappa 21 family were cloned and assigned to the previously described 30-kb cluster of the V kappa 21 family. Sequence comparison revealed close homology between the two gene segments at the DNA and the predicted amino acid sequence level, ind...

journal_title：European journal of immunology

authors： Alanen A,Weiss S

更新日期：1989-10-01 00:00:00

abstract：:In viral meningitis the inflammatory response involves activated T cells and monocytes which are recruited into the subarachnoid space. To identify the chemotactic signals attracting the cells to the site of infection in the meninges, we measured the levels of two CXC chemokines, interferon-gamma (IFN-gamma) inducible...

journal_title：European journal of immunology

authors： Lahrtz F,Piali L,Nadal D,Pfister HW,Spanaus KS,Baggiolini M,Fontana A

更新日期：1997-10-01 00:00:00

abstract：:A murine monoclonal IgM antibody recognizes an antigen (Mo3e) found on the surface of human peripheral blood monocytes stimulated with phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide and muramyl dipeptide and blocks the monocyte response to migration inhibitory factor (MIF). We utilized Western blot and immu...

journal_title：European journal of immunology

authors： Liu DY,Ree JY,Trochelman RD,Todd RF 3rd

更新日期：1989-04-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are specialized in massive production of type I interferons (IFN) upon viral infections. Activation of IFN regulatory factor (IRF)-7 is critically required for the synthesis of type I IFN in pDC. IRF-7 is highly expressed by resting pDC and translocates into the nucleus to initiate t...

journal_title：European journal of immunology

authors： Danis B,George TC,Goriely S,Dutta B,Renneson J,Gatto L,Fitzgerald-Bocarsly P,Marchant A,Goldman M,Willems F,De Wit D

更新日期：2008-02-01 00:00:00

abstract：:Dendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has shown that diff...

journal_title：European journal of immunology

authors： Redpath SA,Heieis GA,Reynolds LA,Fonseca NM,Kim SS,Perona-Wright G

更新日期：2018-01-01 00:00:00

abstract：:Lymphotoxin (LT)alpha in combination with LTbeta forms membrane-bound heterotrimeric complexes with a crucial function in lymph node (LN) organogenesis and correct morphogenesis of secondary lymphoid tissue. To study the role of membrane LT (mLT) in lymphoid tissue organogenesis we generated an LTbeta-deficient mouse ...

journal_title：European journal of immunology

authors： Wilhelm P,Riminton DS,Ritter U,Lemckert FA,Scheidig C,Hoek R,Sedgwick JD,Körner H

更新日期：2002-07-01 00:00:00

abstract：:An experimental model of adenosine deaminase deficiency was established on the human T cell line Jurkat by using 2'-deoxycoformycin, a strong specific inhibitor of the enzyme. When deoxyadenosine was added to the inhibited cells, the nucleotide profile was modified reproducing that found in lymphocytes from adenosine ...

journal_title：European journal of immunology

authors： Buc HA,Moncion A,Hamet M,Houllier AM,Thuilier L,Perignon JL

更新日期：1990-03-01 00:00:00

abstract：:An important aspect of clinical immunity to malaria is the ability to down-regulate inflammatory responses, once parasitaemia is under control, in order to avoid immune-mediated pathology. The role of classical (CD4(+)CD25(+)CD127(lo/-)FOXP3(+)) Treg in this process, however, remains controversial. Thus, we have chara...

journal_title：European journal of immunology

authors： Finney OC,Nwakanma D,Conway DJ,Walther M,Riley EM

更新日期：2009-05-01 00:00:00

abstract：:This is the first report on the establishment of the readily identifiable and functioning thymic nurse cell (TNC) clones from the mouse thymus. In the course of the culture of an epithelial cell line using a medium with a low concentration of Ca2+ from the spontaneous BALB/c thymic tumor, lymphocytes as well as thymic...

journal_title：European journal of immunology

authors： Itoh T,Doi H,Chin S,Nishimura T,Kasahara S

更新日期：1988-05-01 00:00:00

abstract：:The invariant chain (Ii) binds to newly synthesized major histocompatibility complex (MHC) class II molecules and is targeted to an acidic compartment where it is degraded. To evaluate its role on the conformation and the subcellular distribution of murine MHC class II molecules we have established stable L cell trans...

journal_title：European journal of immunology

authors： Humbert M,Raposo G,Cosson P,Reggio H,Davoust J,Salamero J

更新日期：1993-12-01 00:00:00

abstract：:Injection of M-1 (Cmu), G-1 (Cgamma) heterozygous chickens on the day of hatch with anti-IgM-1 antiserum induced allotype suppression from which chickens recovered over a period of approximately 4 months. The suppression of the serum IgM-1 levels was matched by a decrease in the number of splenic and peripheral blood ...

journal_title：European journal of immunology

authors： Ratcliffe MJ,Ivanyi J

更新日期：1981-04-01 00:00:00

abstract：:An antigen-specific T-T hybridoma was mutagenized with ethylmethane sulfonate and negatively selected by anti-Ly-6 antibody-induced growth inhibition. One of the mutants generated, M4/8, had lost surface expression of a T cell receptor (TcR) V beta 8 epitope detected on the surface of the parental cell line. However, ...

journal_title：European journal of immunology

authors： Reno TA,Ley S,Sugiyama E,Cantagrel A,Blumberg R,Bonventre J,Terhorst C,Yeh ET

更新日期：1990-07-01 00:00:00

abstract：:The killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed by memory T cells and NK cells in man and mice. It is frequently used as a cell differentiation marker and members of the cadherin family are ligands for KLRG1. The present study provides new insights into the interaction of mouse KLRG...

journal_title：European journal of immunology

authors： Rosshart S,Hofmann M,Schweier O,Pfaff AK,Yoshimoto K,Takeuchi T,Molnar E,Schamel WW,Pircher H

更新日期：2008-12-01 00:00:00