XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.

Abstract:

:Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent.

journal_name

Eur J Immunol

authors

Müller N,Fischer JC,Yabal M,Haas T,Poeck H,Jost PJ

doi

10.1002/eji.201847818

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

504-507

issue

3

eissn

0014-2980

issn

1521-4141

journal_volume

49

pub_type

信件
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