Abstract:
:We have fractionated human tonsillar B cells on the basis of CD5 expression and determined the nucleotide sequences of immunoglobin light chain variable (V) regions encoded by the single member of the V chi 4 gene family in both CD5+ and CD5- populations. The majority of cDNA from both CD5+ and CD5- B cells populations harbored somatic mutations. Thus, human tonsillar CD5+ B cells, unlike their murine counterparts, are capable of activating their somatic hypermutation mechanism, resulting in the accumulation of somatic mutation in the VL regions.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Ebeling SB,Schutte ME,Logtenberg Tdoi
10.1002/eji.1830230636subject
Has Abstractpub_date
1993-06-01 00:00:00pages
1405-8issue
6eissn
0014-2980issn
1521-4141journal_volume
23pub_type
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