Most anti-human CD3 monoclonal antibodies are directed to the CD3 epsilon subunit.

abstract：:The molecular mechanism of the interleukin (IL) 2-induced differentiation of human B cells has been investigated. The experimental results show that Staphylococcus aureus Cowan strain I (SAC) activation alone induces IL6 secretion from B cells. When B cells were activated by SAC, there was an increased transcription o...

journal_title：European journal of immunology

authors： Xia X,Lee HK,Clark SC,Choi YS

更新日期：1989-12-01 00:00:00

abstract：:Despite accounting for only a minor fraction of all cells in Hodgkin's lymphoma tissue, the Hodgkin and Reed-Sternberg (HRS) cells represent the malignant tumor cell clone in Hodgkin's disease (HD). By far the most abundant cell type in the tumor tissue are CD4+ T cells. Some of them intimately associate with HRS cell...

journal_title：European journal of immunology

authors： Roers A,Montesinos-Rongen M,Hansmann ML,Rajewsky K,Küppers R

更新日期：1998-08-01 00:00:00

abstract：:The interaction of CD40 ligand (CD40L) on activated T cells with CD40 on B cells, monocytes and dendritic cells is essential for humoral immunity and for up-regulation of antigen-presenting cell (APC) functions, as a result of signaling through CD40. There are also some indications that after interaction with CD40, CD...

journal_title：European journal of immunology

authors： Peng X,Kasran A,Warmerdam PA,de Boer M,Ceuppens JL

更新日期：1996-07-01 00:00:00

abstract：:The contribution of specific antibodies (Ab) to successful clearance of Pneumocystis carinii from host pulmonary tissues has received increasing attention. Sera collected from diseased recombinase-activating gene (RAG)-1(-/-), TCRbetaxdelta(-/-), TCRbeta(-/-) and Abeta(-/-) mutants as well as from aerogenic parasite-e...

journal_title：European journal of immunology

authors： Hanano R,Kaufmann SH

更新日期：1999-08-01 00:00:00

abstract：:CD4 T cells play a central role as helper cells in adaptive immunity. Presentation of exogenous antigens in MHC class II by professional antigen-presenting cells is a crucial step in induction of specific CD4 T cells in adaptive immune responses. For efficient induction of immunity against intracellular threats such a...

journal_title：European journal of immunology

authors： Kremer AN,Zonneveld MI,Kremer AE,van der Meijden ED,Falkenburg JHF,Wauben MHM,Nolte-'t Hoen ENM,Griffioen M

更新日期：2018-10-01 00:00:00

abstract：:We have studied the kinetics of the antigen induced response of naive and memory CD8 T cells expressing a transgenic T cell receptor (TCR) specific for the glycoprotein peptide amino acid 33-41 (GP33) of the lymphocytic choriomeningitis virus (LCMV). Memory T cells were generated in vivo by adoptive transfer of LCMV T...

journal_title：European journal of immunology

authors： Zimmermann C,Prévost-Blondel A,Blaser C,Pircher H

更新日期：1999-01-01 00:00:00

abstract：:The cell surface molecule CD44, thought to be a cell surface receptor for hyaluronic acid, is expressed by thymocytes and peripheral T cells. Following T cell activation with mitogens or antigens, surface expression of CD44 increases. This increase in CD44 cell surface expression has been used as a means of identifyin...

journal_title：European journal of immunology

authors： Haegel H,Ceredig R

更新日期：1991-06-01 00:00:00

abstract：:Leptin, a protein produced by adipocytes, exerts several functions, including modulation of the immune response. A report in this issue of the European Journal of Immunology describes for the first time the effect of either leptin receptor deficiency or blockade on murine dendritic cell (DC) maturation, survival and f...

journal_title：European journal of immunology

authors： Fantuzzi G

更新日期：2006-12-01 00:00:00

abstract：:Staphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is associated with intense pain and permanent articular damage, neutrop...

journal_title：European journal of immunology

authors： Boff D,Oliveira VLS,Queiroz Junior CM,Silva TA,Allegretti M,Verri WA Jr,Proost P,Teixeira MM,Amaral FA

更新日期：2018-03-01 00:00:00

abstract：:Dendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has shown that diff...

journal_title：European journal of immunology

authors： Redpath SA,Heieis GA,Reynolds LA,Fonseca NM,Kim SS,Perona-Wright G

更新日期：2018-01-01 00:00:00

abstract：:Secretion of proinflammatory mediators by activated macrophages plays an important role in the immune response to Trypanosoma cruzi. We have previously reported that AgC10, a glycosylphosphatidylinositol-anchored mucin from T. cruzi, inhibits TNF secretion by activated macrophages (de Diego, J., Punzon, C., Duarte, M....

journal_title：European journal of immunology

authors： Alcaide P,Fresno M

更新日期：2004-06-01 00:00:00

abstract：:Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg...

journal_title：European journal of immunology

authors： Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ

更新日期：2009-01-01 00:00:00

abstract：:FTY720 is a novel immunosuppressant that improves the outcomes after solid organ and bone marrow transplantation (BMT) due to the sequestration of T cells into LN. We tested the hypothesis that the sequestration of donor T cells in LN by FTY720 would enhance their interaction with host APC, thus causing a greater degr...

journal_title：European journal of immunology

authors： Hashimoto D,Asakura S,Matsuoka K,Sakoda Y,Koyama M,Aoyama K,Tanimoto M,Teshima T

更新日期：2007-01-01 00:00:00

abstract：:The genetic control of in vitro primary syngeneic sensitization on monolayers of thyroid epithelial cells was investigated both at the level of the responder lymphocytes and that of stimulator thyroid epithelial cells using congenic resistant strains of mice. It clearly appears that similar to the in vivo model of exp...

journal_title：European journal of immunology

authors： Salamero J,Charreire J

更新日期：1983-11-01 00:00:00

abstract：:Diacylglycerol kinases (DGKs) play important roles in restraining diacylglycerol (DAG)-mediated signaling. Within the DGK family, the ζ isoform appears to be the most important isoform in T cells for controlling their development and function. DGKζ has been demonstrated to regulate T cell maturation, activation, anerg...

journal_title：European journal of immunology

authors： Xie D,Zhang S,Chen P,Deng W,Pan Y,Xie J,Wang J,Liao B,Sleasman JW,Zhong XP

更新日期：2020-11-01 00:00:00

abstract：:A cDNA coding for the human interleukin 1 receptor antagonist protein (IL 1Ra) was used to clone the corresponding murine cDNA. The nucleotide sequence of the open reading frame coding for the processed form of mIL 1Ra predicted a 152-residue protein that was 77% identical to human IL 1Ra. The cellular and tissue dist...

journal_title：European journal of immunology

authors： Shuck ME,Eessalu TE,Tracey DE,Bienkowski MJ

更新日期：1991-11-01 00:00:00

abstract：:Stromal elements are major components of lymphoid tissues contributing to both tissue architecture and function. In this study we report on the phenotype and function of fibroblast-like stromal cells obtained from human spleen. These cells express high levels of CD44 and ICAM-1 and moderate levels of VLA-4, VCAM, CD40...

journal_title：European journal of immunology

authors： Skibinski G,Skibinska A,Stewart GD,James K

更新日期：1998-12-01 00:00:00

abstract：:Upon transplantation of T cells from a CD28 superagonist (CD28-SA) treated donor into an irradiated allogeneic host, the CD28-SA-induced activation and expansion of Treg cells inhibits acute graft versus host disease (aGvHD), while not abrogating the desired graft versus tumor effect. Human peripheral blood CD4(+) T c...

journal_title：European journal of immunology

authors： Beyersdorf N,Werner S,Wolf N,Hünig T,Kerkau T

更新日期：2015-07-01 00:00:00

abstract：:A monoclonal antibody (12-15) reactive with the mouse CD2 was used to study the expression of the antigen in different lymphoid cell subsets. By two-color immunofluorescence using B or T cell-specific reagents and cell sorting in combination with biochemical analysis we provide evidence that the CD2 antigen is present...

journal_title：European journal of immunology

authors： Altevogt P,Michaelis M,Kyewski B

更新日期：1989-08-01 00:00:00

abstract：:Hematopoietic development is a delicate balance of cell fate decisions in multipotent cells between self-renewal and differentiation. In multiple developmental systems, the Notch receptors are important factors regulating these processes. Hematopoietic progenitor cells have been shown to express Notch1, and studies wi...

journal_title：European journal of immunology

authors： Jönsson JI,Xiang Z,Pettersson M,Lardelli M,Nilsson G

更新日期：2001-11-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants worldwide. The immunological factors responsible for RSV susceptibility in infants are poorly understood. Here, we used the BALB/c mouse model of neonatal RSV infection to study the mechanisms leading to severe disease upon reexposure to the viru...

journal_title：European journal of immunology

authors： Remot A,Descamps D,Jouneau L,Laubreton D,Dubuquoy C,Bouet S,Lecardonnel J,Rebours E,Petit-Camurdan A,Riffault S

更新日期：2016-04-01 00:00:00

abstract：:The development of preventive or therapeutic recombinant vaccines and the generation of serodiagnostic assays for infectious diseases depend essentially on the availability of molecularly defined antigens. A major bottleneck for the identification of suitable target antigens for many pathogens is the isolation of suff...

journal_title：European journal of immunology

authors： Sahin U,Türeci O,Graf C,Meyer RG,Lennerz V,Britten CM,Dumrese C,Scandella E,Wölfel T,Ludewig B

更新日期：2006-04-01 00:00:00

abstract：:Studies based on either MHC class II-knockout or CD4+ T cell-depleted murine models have demonstrated a critical role for CD4+ T cells in the generation of CD8+ T cell memory. However, it is difficult to extend these findings to immunocompromised humans where a complete loss of CD4+ T cells is rarely observed. Here, w...

journal_title：European journal of immunology

authors： Smith C,Martinez M,Cooper L,Rist M,Zhong J,Khanna R

更新日期：2008-07-01 00:00:00

abstract：:To elucidate the rapid destruction of allogeneic bone marrow (BM) grafts in nonsensitized rats we have assessed: (a) the 21-h tissue localization of 51Cr-labeled allogeneic vs. syngeneic BM cells, (b) the ability of allogeneic BM cells to proliferate in the BM or irradiated recipients, (c) the survival of allogeneic v...

journal_title：European journal of immunology

authors： Rolstad B,Benestad HB

更新日期：1984-09-01 00:00:00

abstract：:Eight isogeneic anti-idiotypic hybridomas were raised against BALB/c myeloma protein MOPC 104E and one against J558. Both myelomas react specifically with the alpha(1----3) glucosidic linkage of dextran B1355 fraction S (Dex). Six anti-MOPC 104E proteins were IgG1, one was IgG2b and one IgM. The anti-J558 protein was ...

journal_title：European journal of immunology

authors： Wilke J,Weiler E

更新日期：1987-02-01 00:00:00

abstract：:Syntaxin 11 (STX11) controls vesicular trafficking and is a key player in exocytosis. Since Stx11 mutations are causally associated with a familial hemophagocytic lymphohistio-cytosis, we wanted to clarify whether STX11 is functionally important for key immune cell populations. This was studied in primary cells obtain...

journal_title：European journal of immunology

authors： D'Orlando O,Zhao F,Kasper B,Orinska Z,Müller J,Hermans-Borgmeyer I,Griffiths GM,Zur Stadt U,Bulfone-Paus S

更新日期：2013-01-01 00:00:00

abstract：:MHC class I molecules are important components of immune surveillance. There are no available methods to directly visualize and determine the quantity and distribution of MHC/peptide complexes on individual cells or to detect such complexes on antigen-presenting cells in tissues. MHC-restricted recombinant antibodies ...

journal_title：European journal of immunology

authors： Epel M,Carmi I,Soueid-Baumgarten S,Oh S,Bera T,Pastan I,Berzofsky J,Reiter Y

更新日期：2008-06-01 00:00:00

abstract：:Immunotherapies that augment antitumor T cells have had recent success for treating patients with cancer. Here we examined whether tumor-specific CD4(+) T cells enhance CD8(+) T-cell adoptive immunotherapy in a lymphopenic environment. Our model employed physiological doses of tyrosinase-related protein 1-specific CD4...

journal_title：European journal of immunology

authors： Church SE,Jensen SM,Antony PA,Restifo NP,Fox BA

更新日期：2014-01-01 00:00:00

abstract：:A large fraction of glycosylphosphatidylinositol (GPI)-anchored proteins and Src-like kinases are confined to glycolipid-enriched membrane (GEM) microdomains. The particular membrane topology of GPI-anchored proteins has led to the postulation of the existence of integral membrane proteins linking extracellular stimul...

journal_title：European journal of immunology

authors： Millán J,Alonso MA

更新日期：1998-11-01 00:00:00

abstract：:The thymic medulla is composed of distinct epithelial cell subsets, defined in this report by the reactivity of two novel antibodies, 95 and 29, raised against mouse thymic epithelial cell lines. These antibodies were used to probe the development of medulla in wild-type or mutant thymuses. In CD3 epsilon-deficient mi...

journal_title：European journal of immunology

authors： Naspetti M,Aurrand-Lions M,DeKoning J,Malissen M,Galland F,Lo D,Naquet P

更新日期：1997-06-01 00:00:00