当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Major histocompatibility complex class I presentation of exogenously acquired minor alloantigens initiates skin allograft rejection.

Major histocompatibility complex class I presentation of exogenously acquired minor alloantigens initiates skin allograft rejection.

Abstract：

:Major histocompatibility complex (MHC) class I molecules present peptides from endogenous proteins. However, in some cases class I-restricted peptides can also derive from exogenous antigens. This MHC class I exogenous presentation could be involved in minor histocompatibility antigen (mHAg)-disparate allograft rejection when donor alloantigens are not expressed in graft antigen-presenting cells (APC) that initiate the rejection mechanism. Here we addressed this question by using a skin graft experimental model where donors (H-2b or H-2d Tg beta-gal mice) expressed the mHAg like beta-galactosidase (beta-gal) in keratinocytes but not in Langerhans' cells (LC) which have an APC function. Rejection of Tg beta-gal skin by a beta-gal-specific CD8 cytotoxic T lymphocyte (CTL) effector mechanism should require presentation by donor and/or recipient LC of MHC class I-restricted peptides of exogenous beta-gal shed by keratinocytes. Indeed, our results showed that 1) H-2b Tg beta-gal skin was rejected by H-2bxs and H-2bxd recipients; 2) rejection was mediated by beta-gal-specific CD8+ CTL effectors; and 3) H-2bxd mice having rejected H-2b Tg beta-gal skin generated beta-gal-specific CTL restricted by H-2b and H-2d class I molecules and rejected subsequently grafted H-2d Tg beta-gal skin in an accelerated fashion, demonstrating that recipient LC have presented exogenous beta-gal-derived MHC class I epitopes. These results lead to the conclusion that MHC class I exogenous presentation of donor mHAg can initiate allograft rejection.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Oukka M,Galou M,Belkaid Y,Tricotet V,Riche N,Reynes M,Kosmatopoulos K

doi

10.1002/eji.1830271251

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

3499-506

issue

12

eissn

0014-2980

issn

1521-4141

journal_volume

27

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Complement opsonization of HIV-1 results in a different intracellular processing pattern and enhanced MHC class I presentation by dendritic cells.

    abstract：:Induction of optimal HIV-1-specific T-cell responses, which can contribute to controlling viral infection in vivo, depends on antigen processing and presentation processes occurring in DCs. Opsonization can influence the routing of antigen processing and pathways used for presentation. We studied antigen proteolysis a...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201242935

    authors： Tjomsland V,Ellegård R,Burgener A,Mogk K,Che KF,Westmacott G,Hinkula J,Lifson JD,Larsson M

    更新日期：2013-06-01 00:00:00

  • Immunochemical and biochemical study of a human Fcmu-like fragment (mu-chain disease).

    abstract：:An abnormal protein, from a petient with mu-chain disease has been studied: protein BUR. It is devoid of the F (ab'')2 mu fragment; molecular weight determinations and immunological data identify the protein as a F(c) 5 mu fragment. Similarly, carbohydrate determinations and proteolysis experiments relate it to a Fcmu...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830050306

    authors： Lebreton JP,Ropartz C,Rousseaus J,Roussel P,Dautrevaus M,Biserte G

    更新日期：1975-03-01 00:00:00

  • Effects of murine leukemia viruses on the function of dendritic cells.

    abstract：:In asymptomatic human immunodeficiency virus-1 infection T cells respond normally to allogeneic dendritic cells (DC), but DC show reduced stimulatory capacity. By contrast in HTLV-1 infection no significant changes in allogeneic stimulation were seen but DC-stimulated activity of autologous T cells. In seeking animal ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830231131

    authors： Gabrilovich DI,Roberts MS,Harvey JJ,Botcherby M,Bedford PA,Knight SC

    更新日期：1993-11-01 00:00:00

  • Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8+ T cells.

    abstract：:Signaling via the IL-7 receptor complex (IL-7Ralpha/CD127 and IL-2Rgamma/CD132) is required for T-cell development and survival. Decreased CD127 expression has been associated with persistent viral infections (e.g. HIV, HCV) and cancer. Many IL-2Rgamma-sharing (gammaC) cytokines decrease CD127 expression on CD4+ and C...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200940093

    authors： Crawley AM,Vranjkovic A,Young C,Angel JB

    更新日期：2010-05-01 00:00:00

  • Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity.

    abstract：:Although alterations in CD3-associated signal-transducing molecules in tumor-infiltrating T cells of patients with advanced cancer have been previously described, the mechanism behind these changes is not known. We demonstrate that macrophages isolated from metastatic lymph nodes of patients with malignant melanoma do...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260620

    authors： Kono K,Salazar-Onfray F,Petersson M,Hansson J,Masucci G,Wasserman K,Nakazawa T,Anderson P,Kiessling R

    更新日期：1996-06-01 00:00:00

  • Fine specificity of the H-2 linked immune response gene for the gallinaceous lysozymes.

    abstract：:An immune response (Ir) gene is described which controls the ability of mice to respond to seven very closely related gallinaceous egg white lysozymes (GEL). This Ir-GEL gene locus is linked to the major histocompatibility locus of the mouse and operates at the level of the T cell. Responsiveness to the nonimmunogenic...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830050506

    authors： Hill SW,Sercarz EE

    更新日期：1975-05-01 00:00:00

  • Anti-insulin and regulatory anti-idiotypic antibodies use the same germ-line VHIX gene.

    abstract：:In humans and in BALB/c mice, immune responses to the hormone insulin use evolutionarily related VHV (human) and VHIX (murine) gene families. To determine if these structural relationships include regulatory elements, BALB/c mice were pretreated with autologous immunoglobulin G (IgG) monoclonal antibodies (mAb) that r...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830220938

    authors： Thomas JW

    更新日期：1992-09-01 00:00:00

  • IFN-γ protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection.

    abstract：:Listeria monocytogenes (LM) is a foodborne Gram-positive intracellular pathogen that can cause listeriosis in humans and animals. Although phagocytes are known to be involved in the response to this infection, the role of neutrophils is not entirely clear. Here, we have demonstrated that soon after LM infection, a lar...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201847491

    authors： Wang G,Lin A,Han Q,Zhao H,Tian Z,Zhang J

    更新日期：2018-09-01 00:00:00

  • A new method of radioiodine labeling of polyanionic macromolecules for radioimmunoassay.

    abstract：:A method is described for radiolabeling polyanionic macromolecules by the formation of an electrostatic complex with a radioiodinated tyramine conjugated DEAE-dextran. Data is presented on the use of this technique for the detection and quantitation of immunospecific binding of polynitrophenylated proteins, deoxyribon...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830050604

    authors： Little JR,Blanke TJ,Little KD

    更新日期：1976-06-01 00:00:00

  • Inhibition of proliferation and differentiation during early T cell development by anti-transferrin receptor antibody.

    abstract：:Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake. Cycling thymocytes, which have the CD4-8-3-, CD4-8+3-, or CD4+8+3- phenotypes, also express CD71. The importance of CD71-mediated iron uptake for proliferation and maturation of thymocytes was s...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830241147

    authors： Brekelmans P,van Soest P,Leenen PJ,van Ewijk W

    更新日期：1994-11-01 00:00:00

  • Immunoregulatory role of Jalpha281 T cells in aged mice developing lupus-like nephritis.

    abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoreactive T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these cells in its immunopathogenesis. This subset uses an invariant TC...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200636695

    authors： Sireci G,Russo D,Dieli F,Porcelli SA,Taniguchi M,La Manna MP,Di Liberto D,Scarpa F,Salerno A

    更新日期：2007-02-01 00:00:00

  • TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules.

    abstract：:The migration of immunocytes within the extracellular matrix (ECM) is influenced by the activation state of the incoming cell and its responses to the presence of chemokines and cytokines. We studied the regulatory role of TGF-beta1 on T cell homing to secondary lymphatic organs, such as the spleen, and chemotaxis wit...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200201)32:1<193::AID-IMMU193>3.0

    authors： Franitza S,Kollet O,Brill A,Vaday GG,Petit I,Lapidot T,Alon R,Lider O

    更新日期：2002-01-01 00:00:00

  • In vivo tumor cell rejection induced by NK cell inhibitory receptor blockade: maintained tolerance to normal cells even in the presence of IL-2.

    abstract：:Missing-self-reactivity can be mimicked by blocking self-specific inhibitory receptors on NK cells, leading to increased rejection of syngeneic tumor cells. Using a mouse model, we investigated whether Ab-mediated blocking of inhibitory receptors, to a degree where NK cells rejected syngeneic tumor cells, would still ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200939755

    authors： Vahlne G,Lindholm K,Meier A,Wickström S,Lakshmikanth T,Brennan F,Wilken M,Nielsen R,Romagné F,Wagtmann NR,Kärre K,Johansson MH

    更新日期：2010-03-01 00:00:00

  • Defective T-cell receptor-induced apoptosis of T cells and rejection of transplanted immunogenic tumors in p53(-/-) mice.

    abstract：:Mice lacking the tumor suppressor gene p53 spontaneously develop T-cell lymphomas at a high rate, suggesting that in these mice lymphomas arise due to defective apoptosis mechanisms in T cells mediated by p53. However, a role of p53 in regulation of T-cell responses or apoptosis has been poorly defined. TCR-mediated s...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200939736

    authors： Singh N,Huang L,Qin H

    更新日期：2010-02-01 00:00:00

  • In vivo induction of gamma/delta T cells with highly potent and selective anti-tumor cytotoxicity.

    abstract：:High frequencies of CD5+TcR alpha/beta- T cells were induced in the peritoneal cavity of rats immunized with syngeneic W439 lymphoma cells. These TcR alpha/beta- cells expressed TcR delta mRNA as analyzed by the polymerase chain reaction technique. The delta + (TcR gamma/delta +) T cells were of the CD2+, CD3+, CD4-, ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830211122

    authors： Ericsson PO,Hansson J,Widegren B,Dohlsten M,Sjögren HO,Hedlund G

    更新日期：1991-11-01 00:00:00

  • Differential T cell receptor-mediated signaling in naive and memory CD4 T cells.

    abstract：:Naive and memory CD4 T cells differ in cell surface phenotype, function, activation requirements, and modes of regulation. To investigate the molecular bases for the dichotomies between naive and memory CD4 T cells and to understand how the T cell receptor (TCR) directs diverse functional outcomes, we investigated pro...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270838

    authors： Farber DL,Acuto O,Bottomly K

    更新日期：1997-08-01 00:00:00

  • IFN-α-producing PDCA-1+ Siglec-H- B cells mediate innate immune defense by activating NK cells.

    abstract：:B cells have multiple functions in adaptive immunity, including antibody production, antigen presentation and regulation of T-cell responses. Recent evidences indicate that B cells have more subsets than previously thought and may have non-classical functions, such as involvement in innate immunity and immune regulati...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201040840

    authors： Bao Y,Han Y,Chen Z,Xu S,Cao X

    更新日期：2011-03-01 00:00:00

  • Regulation of thymocyte proliferative response by macrophage-derived prostaglandin E2 and interleukin 1.

    abstract：:The antagonistic effects of macrophage (M phi)-derived interleukin 1 (IL 1) and prostaglandin E2 (PGE2) on thymocyte proliferation were uncoupled and studied. Elimination of PGE2 from the culture medium of prostaglandin E2-stimulated M phi was achieved by dialysis of the media or by indomethacin treatment of the M phi...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830150109

    authors： Hayari Y,Kukulansky T,Globerson A

    更新日期：1985-01-01 00:00:00

  • Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.

    abstract：:Immunity to tumor differentiation antigens, such as melanoma antigen recognized by T cells 1 (MART-1), has been comprehensively studied. Intriguingly, CD8(+) T cells specific for the MART-1(26(27)-35) epitope in the context of HLA-A0201 are about 100 times more abundant compared with T cells specific for other tumor-a...

    journal_title：European journal of immunology

    pub_type： 临床试验,杂志文章

    doi：10.1002/eji.201444499

    authors： Pinto S,Sommermeyer D,Michel C,Wilde S,Schendel D,Uckert W,Blankenstein T,Kyewski B

    更新日期：2014-09-01 00:00:00

  • The in vitro immune response to a T-independent antigen. I. The effect of macrophages and 2-mercaptoethanol.

    abstract：:The in vitro immune response of murine spleen cells to the T cell-independent antigen, 2,4-dinitrophenyl-beta-alanyl-glycyl-glycyl-N(2-aminoethyl)carbamyl-methylated Ficoll (DAGG-Ficoll), requires the presence of macrophages, or 24-hr culture supernates from peritoneal cells. Complete reconstitution of the response by...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830081105

    authors： Nordin AA

    更新日期：1978-11-01 00:00:00

  • Activation and proliferation signals in mouse B cells. VIII. Induction of DNA synthesis in B cells by a combination of calcium ionophores and phorbol myristate acetate.

    abstract：:Mouse B cells cultured with either phorbol myristate acetate (PMA), or with Ca2+ ionophores enter a transitional activated state, between quiescence (G0) and G1, but do not synthesize DNA. It is shown here that the combination of PMA plus the ionophore ionomycin induces resting B cells to synthesize DNA, but not to se...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830160118

    authors： Klaus GG,O'Garra A,Bijsterbosch MK,Holman M

    更新日期：1986-01-01 00:00:00

  • FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells.

    abstract：:The immunosuppressive drugs FK506 and rapamycin bind to a family of intracellular proteins termed FK506-binding proteins (FKBP). FK506 and rapamycin inhibit lymphocyte-activation pathways by forming complexes with an FKBP; subsequently, the drug/FKBP complexes interact with target molecules involved in signal transduc...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830250239

    authors： Fruman DA,Wood MA,Gjertson CK,Katz HR,Burakoff SJ,Bierer BE

    更新日期：1995-02-01 00:00:00

  • Anti-idiotypes against anti-H-2 antibodies VI. Detection of shared idiotypes among monoclonal anti-H-2 antibodies.

    abstract：:Anti-idiotypes produced against monoclonal anti-H-2 antibodies have been used to examine idiotope sharing among a panel of anti-major histocompatibility complex (MHC) antibodies detecting the same and different specificities. Both xenogeneic anti-100-30 and anti-3-83, which did not react with predominant idiotypes in ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830130611

    authors： Bluestone JA,Auchincloss H Jr,Sachs DH,Fibi M,Hämmerling GJ

    更新日期：1983-06-01 00:00:00

  • Immunoglobulin VH region genes of the mouse are organized in overlapping clusters.

    abstract：:Restriction fragment length polymorphism has been compared between the Igh loci of C57BL/6 and MOLF/EI (Mus musculus molossinus) mice utilizing probes which detect the C gamma 2b gene and genes from nine VH-gene families. Distinct restriction site patterns were found for the CH genes and for VH families PC7183, Q52 an...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830170920

    authors： Blankenstein T,Krawinkel U

    更新日期：1987-09-01 00:00:00

  • IFN-γ directly inhibits murine B-cell precursor leukemia-initiating cell proliferation early in life.

    abstract：:The early-life immune environment has been implicated as a modulator of acute lymphoblastic leukemia (ALL) development in children, with infection being associated with significant changes in ALL risk. Furthermore, polymorphisms in several cytokine genes, including IL-10 and IFN-γ, are associated with leukemia develop...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201646806

    authors： Fidanza M,Seif AE,Jo S,Kariminia A,Rolf N,Sly LM,Grupp SA,Reid GSD

    更新日期：2017-05-01 00:00:00

  • Anti-peroxidase antibody-secreting hybrid lines. I. Identification, cloning and cell characterization.

    abstract：:Anti-peroxidase antibody (Ab)-secreting hybrids have been produced by fusion of peroxidase (PO)-immunized mouse lymph node cells and immunoglobulin (Ig)-secreting P3-X63-Ag8 (X63) myeloma cells. Identification of Ab-secreting hybrids can be performed as early as day 5 after cell fusion by the hemolytic plaque assay. I...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830090102

    authors： Zagury D,Phalente L,Bernard J,Hollande E,Buttin G

    更新日期：1979-01-01 00:00:00

  • CD2 physically associates with CD5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains.

    abstract：:T lymphocytes can be activated and induced to proliferate through stimulation of the CD2 glycoprotein with functional combinations of CD2 antibodies. However, this mechanism of signal transduction via CD2 is still not fully understood. We have investigated which molecules on the T cell surface preferentially associate...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200205)32:5<1509::AID-IMMU1509>3

    authors： Castro MA,Tavares PA,Almeida MS,Nunes RJ,Wright MD,Mason D,Moreira A,Carmo AM

    更新日期：2002-05-01 00:00:00

  • Recombinant CD40 ligand stimulation of murine B cell growth and differentiation: cooperative effects of cytokines.

    abstract：:The ligand for the B cell surface antigen CD40 was recently cloned from a murine thymoma cDNA library and shown to be expressed on activated T cells. In this study, we investigate the biological effects of murine recombinant CD40 ligand. The recombinant CD40 ligand expressed on the CV-1/EBNA monkey fibroblast cell lin...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830230510

    authors： Maliszewski CR,Grabstein K,Fanslow WC,Armitage R,Spriggs MK,Sato TA

    更新日期：1993-05-01 00:00:00

  • Surface receptors identify mouse NK1.1+ T cell subsets distinguished by function and T cell receptor type.

    abstract：:Natural killer T (NKT) lymphocytes rapidly produce several cytokines, including IL-4 and IFN-gamma, upon activation, and act as regulatory cells at an early interphase of innate and adaptive immune responses. They have been implicated as important elements in diverse immune responses including the regulation of autoim...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200323963

    authors： Stenström M,Sköld M,Ericsson A,Beaudoin L,Sidobre S,Kronenberg M,Lehuen A,Cardell S

    更新日期：2004-01-01 00:00:00

  • Impaired dendritic cell differentiation of CD16-positive monocytes in tuberculosis: role of p38 MAPK.

    abstract：:Tuberculosis (TB) is one of the world's most pernicious diseases mainly due to immune evasion strategies displayed by its causative agent Mycobacterium tuberculosis (Mtb). Blood monocytes (Mos) represent an important source of DCs during chronic infections; consequently, the alteration of their differentiation constit...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201242557

    authors： Balboa L,Romero MM,Laborde E,Sabio Y García CA,Basile JI,Schierloh P,Yokobori N,Musella RM,Castagnino J,de la Barrera S,Sasiain MC,Alemán M

    更新日期：2013-02-01 00:00:00