Abstract:
:High frequencies of CD5+TcR alpha/beta- T cells were induced in the peritoneal cavity of rats immunized with syngeneic W439 lymphoma cells. These TcR alpha/beta- cells expressed TcR delta mRNA as analyzed by the polymerase chain reaction technique. The delta + (TcR gamma/delta +) T cells were of the CD2+, CD3+, CD4-, CD8+, CD45RB+ phenotype and showed stronger anti-tumor cytotoxicity compared to the TcR alpha/beta + T cells. The cytotoxic effects of both alpha/beta and gamma/delta T cells were selective for the W439 lymphoma cells and were not directed to other syngeneic tumors, natural killer targets and syngeneic or allogeneic normal cells. T cells, including both alpha/beta and gamma/delta cells, were induced when WF rats were immunized with allogeneic BN spleen cells. In this case the gamma/delta T cells showed allo-selective cytotoxicity, although weaker compared to the TcR alpha/beta + T cells. The gamma/delta T cells, induced by immunization with either W439 cells or BN spleen cells, were selective for the immunogen used and had no effect on irrelevant target cells, indicating that these effector cells were not activated by a shared gamma/delta T cell-related superantigen. Since highly potent tumor-selective gamma/delta cytotoxic T lymphocytes could be induced by syngeneic lymphoma cells, we suggest a role for gamma/delta T cells in the defense against certain types of tumors.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Ericsson PO,Hansson J,Widegren B,Dohlsten M,Sjögren HO,Hedlund Gdoi
10.1002/eji.1830211122subject
Has Abstractpub_date
1991-11-01 00:00:00pages
2797-802issue
11eissn
0014-2980issn
1521-4141journal_volume
21pub_type
杂志文章abstract::Although most cells of the T cell receptor (TcR) gamma/delta lineage are CD4-CD8-, some gamma/delta cells express CD8. We show here that mouse thymic gamma/delta cells express CD8 following in vitro activation by concanavalin A. Staining with monoclonal and polyclonal antibodies to the CD8 alpha (Ly-2) and CD8 beta (L...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200431
更新日期:1990-04-01 00:00:00
abstract::The development and the differentiation of CD8(+) T cells are dependent on IL-15. Here, we have studied the source and mechanism of how IL-15 modulates CD8(+) T cell-mediated Th1 immune responses by employing two delayed-type hypersensitivity (DTH) models. IL-15-deficient (IL-15(-/-)) mice or mice treated with soluble...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200324545
更新日期:2003-12-01 00:00:00
abstract::Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells elaborate a cytolytic protein named perforin or cytolysin. It was widely held that, in vivo, high quantities of perforin are not present in resting lymphocytes and are usually produced only by activated lymphocytes found under pathological conditions. Until n...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230907
更新日期:1993-09-01 00:00:00
abstract::In previous studies, Saimiri sciureus boliviensis monkeys have been immunized with four recombinant proteins reproducing part of the circumsporozoite (CS) protein of Plasmodium vivax sporozoites (NS1(81) V20, rPvCS-1, rPvCS-2, rPv-CS-3), or with irradiated sporozoites of P. vivax Salvador I strain. To analyze the anti...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220234
更新日期:1992-02-01 00:00:00
abstract::An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells and regulates activation and migration of immune cells through activating Ras-related C3 botulinum toxin substrate (Rac). Dock2 was shown to be critical in the development of various inflammatory diseases, including allergic di...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201747157
更新日期:2018-06-01 00:00:00
abstract::The immune system has developed several regulatory mechanisms to maintain homeostasis of adaptive immune responses. T-cell programmed death (PD)-1 recognition of B7-H1 (PD-L1) expressed on APC and non-lymphoid tissue regulates T-cell activation. We show that B7-H1(-/-) mice exhibit exacerbated proteoglycan (PG)-induce...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040690
更新日期:2010-11-01 00:00:00
abstract::Previous studies suggested that trinitrophenyl (TNP)-modified syngeneic red cells induced humoral autoimmune response in mice with defective T cell function but not in normal mice. The ability of modified self antigen to induce autoimmune response in immunodeficient mice was further explored using the delayed-type hyp...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830121112
更新日期:1982-11-01 00:00:00
abstract::Propionibacterium acnes-primed mice develop an IFN-gamma-dependent hypersensitivity towards LPS. Since CD14 plays a key role in LPS-induced cell activation the regulation and function of CD14 in this sensitization process were studied in IFN-gamma R-/- and the respective wild-type (wt) mice. In unprimed mice, CD14 (mR...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200203)32:3<761::AID-IMMU761>3.0
更新日期:2002-03-01 00:00:00
abstract::B cells and regulatory T (Treg) cells can both facilitate remission from experimental auto immune encephalomyelitis (EAE), a disease of the central nervous system (CNS) used as a model for multiple sclerosis (MS). Considering that B-cell-depletion therapy (BCDT) is used to treat MS patients, we asked whether Treg-cell...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142242
更新日期:2012-05-01 00:00:00
abstract::Programmed cell death (PCD) is involved in the physiological regulation of lymphocyte turnover, as well in the antigen-driven selection of T and B cells. Here it is shown that the immunomodulator linomide (quinoline-3-carboxamide) inhibits the apoptotic decay of peripheral T lymphocytes in response to three different ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830240108
更新日期:1994-01-01 00:00:00
abstract::Fas is a cell surface molecule that is expressed on a wide array of cell types and triggers apoptosis. While in most situations Fas ligation activates programmed cell death, on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex. This incongruity suggests that Fas may eli...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260505
更新日期:1996-05-01 00:00:00
abstract::The receptor for the inflammatory peptide C3a has scarcely been examined on human cells. This work demonstrates that human tumor-derived basophilic granulocytes express C3a receptors, and presents parts of the hitherto unknown C3a-signal transduction. When incubated with IL-3, these cells specifically liberated histam...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230239
更新日期:1993-02-01 00:00:00
abstract::Lipid antigens are presented to T cells by the non-polymorphic MHC class I-related CD1 molecules. Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident chaperone that has been shown to lipidate the group 2 CD1 molecule CD1d and thus to regulate its function. We now report that MTP al...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200738102
更新日期:2008-08-01 00:00:00
abstract::Mouse B cells cultured with either phorbol myristate acetate (PMA), or with Ca2+ ionophores enter a transitional activated state, between quiescence (G0) and G1, but do not synthesize DNA. It is shown here that the combination of PMA plus the ionophore ionomycin induces resting B cells to synthesize DNA, but not to se...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160118
更新日期:1986-01-01 00:00:00
abstract::Secretion of type I interferon (IFN) is the first cellular reaction to invading pathogens. Despite the protective function of these cytokines, an excessive response to their action can contribute to serious pathologies, such as autoimmune diseases. Transcripts of most cytokines contain adenylate-uridylate (A/U)-rich e...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201444979
更新日期:2015-05-01 00:00:00
abstract::The fate of the T cell receptor (TcR)/CD3 complex was examined on a cytotoxic T lymphocyte (CTL) clone (KB5.C20) activated either via binding of an anti-TcR monoclonal antibody (mAb) or by a Ca2+ ionophore and phorbol 12-myristate 13-acetate (PMA). After binding of the anti-TcR mAb, electron microscopy revealed intern...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210707
更新日期:1991-07-01 00:00:00
abstract::MS is a multifactorial disease in which a series of genetic and non-genetic, environmental factors plays a role in its etiology. In particular, HLA class II alleles, mainly HLADRB1*15:01 (HLA-DR15), increase the risk for this disease. Out of several environmental factors, and with regard to infections, EBV remains to ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.202049030
更新日期:2020-12-22 00:00:00
abstract::Lymphocyte function-associated-antigen-1 (LFA-1) is able to bind selectively to its ligands intercellular adhesion molecules 1 and 3 (ICAM-1 and ICAM-3), suggesting that LFA-1 can exist in distinct ligand-specific binding states. In the case of ICAM-1, apart from ligand itself and the recently cloned molecule cytohesi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270423
更新日期:1997-04-01 00:00:00
abstract::The in vitro recognition of acetylsalicilyl ovalbumin, penicilloylated bovine IgG (BPO-BGG) and the multichain copolymer poly-L-(Tyr, Glu)-poly-D L-Alapoly-L-Lys [(T, G)-A-L] by primed (2 x 13) F1 cells could be markedly and specifically blocked by alloantisera directed against "receptors" (R) or recognition structure...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830051012
更新日期:1975-10-01 00:00:00
abstract::The existence of a functional receptor for secretory component (SC) on the eosinophil membrane might explain the preferential degranulation induced by secretory IgA (sIgA) when compared to serum IgA. Indeed, flow cytometry analysis revealed that purified human SC could bind to a subpopulation (4-59%) of blood eosinoph...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250121
更新日期:1995-01-01 00:00:00
abstract::The study of the immunology of schistosomiasis has allowed a clear understanding of the basic mechanisms of resistance, emphasizing the important role played by cellular and humoral factors. Whereas the production of polyclonal or monoclonal antibodies and the precise inventory of immune effector mechanisms in the rat...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830151205
更新日期:1985-12-01 00:00:00
abstract::Cartilage-specific proteins are considered potential autoantigens that could continuously fuel autoimmune responses directed to the joints in rheumatoid arthritis (RA). Using recombinant chimeric collagen type II we have identified one major type II collagen (CII) epitope (denoted U1) recognized by RA sera. The U1 epi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200106)31:6<1666::aid-immu1666>3
更新日期:2001-06-01 00:00:00
abstract::To estimate the extent of the TRG gamma variable (V) gene repertoire used in human T cell ontogeny, we have analyzed the variety of V gamma gene rearrangements in a large series of T and non-T acute and chronic leukemias. A limited heterogeneity of rearranged fragments was observed: only 13 types of differently rearra...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830180126
更新日期:1988-01-01 00:00:00
abstract::Naive and memory CD4 T cells differ in cell surface phenotype, function, activation requirements, and modes of regulation. To investigate the molecular bases for the dichotomies between naive and memory CD4 T cells and to understand how the T cell receptor (TCR) directs diverse functional outcomes, we investigated pro...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270838
更新日期:1997-08-01 00:00:00
abstract::Current models of lymphocyte traffic suggest that homing specificities of T cells to tissues such as skin are generated outside the thymus as a result of activation of naive T cells by antigen in lymph nodes. Virgin T cells are thought to home to high endothelial venules in lymph nodes, but are thought to be unable to...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250314
更新日期:1995-03-01 00:00:00
abstract::An abnormal protein, from a petient with mu-chain disease has been studied: protein BUR. It is devoid of the F (ab'')2 mu fragment; molecular weight determinations and immunological data identify the protein as a F(c) 5 mu fragment. Similarly, carbohydrate determinations and proteolysis experiments relate it to a Fcmu...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830050306
更新日期:1975-03-01 00:00:00
abstract::Despite all the structural and functional data that have been accumulated regarding major histocompatibility complex (MHC) class II molecules during recent years, the relative contribution of putative T cell receptor (TcR)-contacting residues and peptide-binding MHC polymorphisms to MHC-restricted and allospecific T c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230207
更新日期:1993-02-01 00:00:00
abstract::Pathogens have developed a plethora of strategies to undermine host immune defenses in order to guarantee their survival. For large DNA viruses, these immune evasion mechanisms frequently rely on the expression of genes acquired from host genomes. Horizontally transferred genes include members of the immunoglobulin su...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201746984
更新日期:2017-05-01 00:00:00
abstract::CD27, which belongs to the tumor necrosis factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260508
更新日期:1996-05-01 00:00:00
abstract::Incomplete allelic exclusion of TCRa gene rearrangement permits the generation of dual Valpha T cells, though the issues of their frequency and whether both alphabeta pairs participate in thymic selection have not been resolved. Both questions have been investigated using lymphocytes from mice hemizygous at the TCRa l...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199807)28:07<2115::AID-IMM
更新日期:1998-07-01 00:00:00